Mutagenesis and Genetic Instability in Genome Evolution and in Cancer: Mechanisms, Consequences, and Therapeutic Perspectives
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 22
Special Issue Editors
Interests: humoral immune system response; immunoglobulin gene diversification; B cell development; B cell differentiation; B cell genome integrity and lymphomagenesis; DNA repair
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Genomic instability and mutagenesis represent dual-edged biological phenomena which drive both evolutionary processes and human diseases. The essential role of these phenomena drives genetic diversification and adaptation and immune repertoire development, yet they create various pathological states, especially cancer. The fundamental biological and medical challenge emerges from the precise management of beneficial genome evolution and adaptation against harmful genetic changes. Importantly, beyond the DNA sequence itself, epigenetic regulation is also reported to play a role in modulating genome stability and mutation rates. In addition to examining foundational mechanisms, this Special Issue explores the clinical effects of genetic instability by addressing tumor heterogeneity and the formation of resistant subclones aa well as the development of mutational signature for biomarker applications. The collection also encompasses publications that explore therapeutic applications that use synthetic lethality and target repair defects, as well as genomic scars. The objective of these applications is to facilitate patient stratification and therapy response prediction. The aim is to bring together leading-edge studies and expert contributions to decipher the complete process of both genomic adaptability and instability development from point mutations to chromosomal rearrangements and their resulting phenotypic effects, while also highlighting the epigenetic landscapes that shape genome dynamics. We accept various submission types including original research articles, comprehensive reviews, case reports, commentaries and thought-provoking proposals which challenge the prevailing view of genetic instability as a cancer driver rather than a consequence.
Dr. Said Aoufouchi
Prof. Rabii Ameziane El Hassani
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- genomic instability
- mutagenesis
- evolution
- genetic diversification DNA repair
- epigenetic
- cancers
- therapy resistance
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
