Biomolecules and Their Impact on Biology and Translational Applications: Celebrating the Pioneering Work of Prof. Ho Jeong Kwon: 2nd Edition

Dear Colleagues,

After the first edition of our Special Issue on "Biomolecules in Biology and Translational Applications" celebrated the 27th anniversary of Professor Ho Jeong Kwon's seminal publication on depudecin (PNAS, 95:3356, 1998), we are happy to present the second edition.

Professor Kwon's groundbreaking contributions to the discipline were emphasized in the first edition, especially his identification of depudecin as a pharmacologically active substance for investigating basic biological processes. Our knowledge of histone deacetylases in gene regulation has greatly increased due to this finding, which has also created new opportunities for therapeutic intervention. The collection demonstrated how the new structure of depudecin offered distinct therapeutic possibilities and improved our understanding of the enzymatic mechanisms of deacetylase.

Building on the groundwork laid by our previous issue, this second edition delves further into the astounding advancements in biomolecular research in recent years. We still acknowledge Professor Kwon's pioneering work in the identification of biomolecules that regulate angiogenesis and autophagy, such as terpestacin, curcumin, kaempferide, Rg3, sertraline, artemisinate, daptomycin, voacangine, and cryptotashinone. His work has greatly advanced our knowledge of the "biomolecule-target-phenotype" link, which has important ramifications for fundamental biology and medical applications.

The second edition will include new findings and advancements that have surfaced after our initial publication. Comprehensive reviews and state-of-the-art original research articles exploring the molecular processes and functional effects of biomolecules in health and disease will be included. Focusing on translational applications that connect lab findings with clinical practice, we will highlight recent advances in understanding how these biomolecules interact with their targets and the ensuing biological impacts.

With an emphasis on how biomolecular research continues to revolutionize our understanding of biological processes and the creation of innovative therapeutic approaches, this issue seeks to give researchers, clinicians, and students up-to-date insights into this quickly changing subject.

Dr. Eun-Woo Lee
Prof. Dr. Jiho Yoo
Guest Editors

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