Novel Mechanisms in Renal Blood Pressure Regulation: From Neuropeptides to Angiotensin II and Dopamine Receptors
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: 23 January 2026 | Viewed by 14
Special Issue Editors
Interests: neuropeptides; dopamine receptor; blood pressure; autophagy; sorting nexin; renal physiology; cardiovascular research
Interests: hypertension; renal physiology; ion transport; oxidative stress; pharmacogenomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Many neuropeptides, including angiotensin II and neurotransmitters such as dopamine, were originally found in the brain and later found in peripheral organs and tissues, including the kidney. The kidney plays an important role in the regulation of blood pressure. Healthy kidneys maintain blood pressure within a normal range by controlling the balance of fluids and electrolytes. Dopamine is locally generated in the kidney, and its five receptors, D1R, D2R, D3R, D4R, and D5R, are expressed in specific segments of the nephron. Angiotensin II is also synthesized in the kidney and its receptors. AT1R and AT2R are also expressed in specific segments of the nephron. The intrarenal dopaminergic and angiotensin systems are important in the regulation of water and electrolyte transport and ultimately blood pressure. Mice with germline or nephron segment silencing in any one of the dopamine or angiotensin receptors are impacted in their ability to excrete a sodium load and regulate their blood pressure. Recently, neuropeptide FF (NPFF) has been found to be synthesized by the kidney, and its receptors, NPFFR and NPFFR2, are expressed in specific segments of the nephron. NPFF and its receptors can regulate renal sodium transport and blood pressure per se and through their interactions with the renal dopaminergic and angiotensin systems. However, the underlying mechanisms by which NPFF and its receptors regulate renal sodium transport and blood pressure are still unclear. For this Special Issue, we invite original and review articles on all aspects related to NPFF, angiotensin II, and dopamine in the regulation of renal function and blood pressure.
Dr. Hewang Lee
Prof. Dr. Pedro A. José
Guest Editors
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Keywords
- neuropeptides
- dopamine
- blood pressure
- G protein-coupled receptors
- oxidative stress kidney
- vasculature
- brain
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