Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Feature Papers in the Natural and Bio-Derived Molecules Section submission deadline 31 Dec 2025 | 9 articles | Viewed by 35378 | Submission Open
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Biochemistry in Medicine—Honorary Special Issue Commemorating Research and Work of Professors Jan O. Aaseth and Jan Alexander
edited by Sonia Distante and
submission deadline 31 Dec 2025 | 5 articles | Viewed by 31173 | Submission Open
Keywords: medical biochemistry; endocrinology; neurotoxic metals
(This special issue belongs to the Section Molecular Medicine)
Molecular Advances in Mechanism and Regulation of Lifespan and Aging
edited by Mark McCormick
submission deadline 31 Dec 2025 | 7 articles | Viewed by 23826 | Submission Open
Keywords: aging; lifespan; healthspan
(This special issue belongs to the Section Molecular Biology)
Tissue Calcification in Normal and Pathological Environments
edited by
submission deadline 31 Dec 2025 | 9 articles | Viewed by 17131 | Submission Open
Keywords: calcification; ectopic mineralization; bone; heterotopic ossification; calcium phosphate; calcium carbonate; calcium oxalate; procalcific cell death
(This special issue belongs to the Section Molecular Medicine)
Insights from the Editorial Board Members
edited by
submission deadline 31 Dec 2025 | 11 articles | Viewed by 14034 | Submission Open
Keywords: structure and function; bioactive and biogenic substances; molecular mechanisms; biomaterials
Molecular Mechanisms in DNA and RNA Damage and Repair submission deadline 31 Dec 2025 | 8 articles | Viewed by 13785 | Submission Open
Keywords: reactive oxygen species; DNA damage; DNA repair; RNA damage; RNA repair; molecular mechanisms; biomarkers; antioxidant and redox strategies; oxidative stress
(This special issue belongs to the Section Molecular Biomarkers)
Cell Biology and Biomedical Application of Galectins submission deadline 31 Dec 2025 | 6 articles | Viewed by 13157 | Submission Open
Keywords: galectins; cell differentiation; stem cells; apoptosis; autophagy; cell adhesion; glycobiology; post-translational modifications; transmembrane signaling; protein trafficking; cancer; heart diseases; fibrosis; inflammation; targeted therapeutics; galectin inhibitors
(This special issue belongs to the Section Chemical Biology)
Neuroimmune Interactions in Neuropsychiatric Diseases
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 13057 | Submission Open
Keywords: neurology; psychiatry; immunity; glia
(This special issue belongs to the Section Molecular Biology)
Cellular and Molecular Mechanism of Spermatogenesis
edited by Yanhe Lue
submission deadline 31 Dec 2025 | 4 articles | Viewed by 12135 | Submission Open
Keywords: spermatogenesis; regulation; biomolecules
(This special issue belongs to the Section Molecular Reproduction)
New Insight into the Molecular Genetics of Neurodevelopmental Disorders
edited by and Flavio Faletra
submission deadline 31 Dec 2025 | 4 articles | Viewed by 11067 | Submission Open
Keywords: neurodevelopmental disorders; next generation sequencing; pathomechanisms; phenotypic spectra; phenotype-genotype correlation
(This special issue belongs to the Section Molecular Genetics)
Cardiometabolic Disease: Molecular Basis and Therapeutic Approaches
edited by and Maria Nikolaou
submission deadline 31 Dec 2025 | 4 articles | Viewed by 10934 | Submission Open
Keywords: cardiometabolic medicine; preventive cardiology; cardiovascular endocrinology and metabolism; obesity; diabetes mellitus; cardiovascular disease
(This special issue belongs to the Section Molecular Medicine)
Molecular Insights into Sex and Evolution
edited by and
submission deadline 31 Dec 2025 | 3 articles | Viewed by 9791 | Submission Open
Keywords: sex determination; sex chromosome evolution; reproduction; hybridization; speciation; evolution; animals; vertebrates
(This special issue belongs to the Section Molecular Genetics)
Genetic and Structural Analyses of Coronaviruses: Insights into SARS-CoV-2 and Beyond
edited by
submission deadline 31 Dec 2025 | 6 articles | Viewed by 9528 | Submission Open
Keywords: SARS-CoV-2 variants; protein variants; protein structure; virus evolution; mutations; structural bioinformatics; molecular phylogenesis; host– pathogen molecular interactions; molecular immunology; drug discovery
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Mitochondrial Proteins: From Import and Biogenesis to Complex Functional Network submission deadline 31 Dec 2025 | 4 articles | Viewed by 9249 | Submission Open
Keywords: mitochondrial proteins; import; biogenesis; metabolism; functional network; oxidative stress; small molecules; mitochondrial protein quality control; mitophagy
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Molecular and Toxicological Profiling of Drugs of Abuse—in Honor of Professor Félix Carvalho submission deadline 31 Dec 2025 | 3 articles | Viewed by 8978 | Submission Open
Keywords: toxicodynamic; toxicokinetic; amphetamine-type stimulants; cannabis and cannabinoids; cocaine; hallucinogens; new psychoactive substances; opioids; immune modulation
(This special issue belongs to the Section Molecular Medicine)
Natural Bioactives as Leading Molecules for Drug Development
edited by , and
submission deadline 31 Dec 2025 | 6 articles | Viewed by 8843 | Submission Open
Keywords: drug discovery; natural products; leading molecules; isolation and identification; phytochemical investigation; omics approaches
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Molecular Diagnosis and Regulation of Mitochondrial Dysfunction
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 8376 | Submission Open
Keywords: metabolic conditions; neurological conditions; genetic diseases; mitochondrial dysfunction; mitochondrial disorders; diagnostics; therapies
(This special issue belongs to the Section Biological Factors)
Advances in Melanoma Targeted Therapy
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 7803 | Submission Open
Keywords: melanoma; drug discovery; new targets; target discovery
(This special issue belongs to the Section Molecular Medicine)
Integrating Genetics, Immune Dysregulation, and the Gut Microbiome: Advances in Elucidating IBD Pathophysiology and Emerging Therapeutic Strategies submission deadline 31 Dec 2025 | 3 articles | Viewed by 7753 | Submission Open
Keywords: microbiome; biomarkers; Crohn’ s disease; ulcerative colitis; indeterminate colitis; multiomics; gastrointestinal (GI disease); immunology; gut– brain axis; neuropsychology
(This special issue belongs to the Section Molecular Genetics)
Antitumor Agents from Natural Sources 2024–2025 submission deadline 31 Dec 2025 | 2 articles | Viewed by 7666 | Submission Open
Keywords: antitumor agents; natural sources; cancer prevention and therapy
(This special issue belongs to the Section Natural and Bio-derived Molecules)
The Role of Non-Coding RNAs in Health and Disease submission deadline 31 Dec 2025 | 6 articles | Viewed by 7481 | Submission Open
Keywords: non-coding RNA; microRNA (miRNA); long noncoding RNA (lncRNA); circular RNA (circRNA); gene expression regulation; epigenetic modifications
(This special issue belongs to the Section Molecular Genetics)
Molecular Mechanisms of Cardiovascular Remodeling
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 7452 | Submission Open
Keywords: vascular remodeling aging; extracellular matrix; atherosclerosis peripheral; artery disease; chronic heart failure; cardiovascular associated cognitive decline
(This special issue belongs to the Section Molecular Biology)
Biosynthesis and Function of Thyroid Hormones
edited by and Eva K. Wirth
submission deadline 31 Dec 2025 | 4 articles | Viewed by 6908 | Submission Open
Keywords: thyroid gland; thyroid follicle; TH release; iodide; deiodinase; TH transmembrane transport; TH receptors; intracellular TH binding proteins; thyroglobulin; sodium– iodide symporter; thyroperoxidase; dual oxidase; thyroid-relevant trace elements
(This special issue belongs to the Section Biological Factors)
Melatonin in Normal Physiology and Disease, 2nd Edition
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 6772 | Submission Open
Keywords: circadian rhythms; immunity; skin; reproduction; aging; viral and bacterial infection; inflammation; mesenchymal stem cells; cancer; neurodegenerative diseases; osteoporosis
(This special issue belongs to the Section Molecular Biology)
Innate Immunomodulation and Inflammation: From Molecular Mechanisms to Pre-Clinical Insights submission deadline 31 Dec 2025 | 3 articles | Viewed by 6763 | Submission Open
Keywords: innate immunity; therapy; immune checkpoints; cancer; autoimmunity; inflammation; infection; danger-associated molecular patterns; pattern recognition receptors
(This special issue belongs to the Section Molecular Medicine)
Human Reproductive Biology: Uncertainties and Controversies
edited by , and Paola Bianchi
submission deadline 31 Dec 2025 | 3 articles | Viewed by 6645 | Submission Open
Keywords: molecular reproduction; endometriosis; endometrium; implantation; decidualization; placenta; cellular senescence; prostaglandin; inflammation; pregnancy; reproduction; implantation; decidualization; endometriosis; assisted reproductive technology; molecular reproductive biology; reproductive biology; reproductive immunology; reproductive medicine; reproductive endocrinology; molecular regulation of reproductive processes; embryo development; reproductive biology; gametogenesis and fertilization
(This special issue belongs to the Section Molecular Reproduction)
Signal Transduction to Transcription Factors in Health and Disease—Honorary Special Issue Commemorating the Work of Prof. Athanasios G. Papavassiliou submission deadline 31 Dec 2025 | 3 articles | Viewed by 6610 | Submission Open
(This special issue belongs to the Section Molecular Medicine)
Matrix Metalloproteinases: Mechanisms, Functions and Therapeutic Potential
edited by , Joshua W. Ogony and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 5189 | Submission Open
Keywords: matrix metalloproteinases; endopeptidases; MMP inhibitor; tissue homeostasis; disease progression
(This special issue belongs to the Section Enzymology)
The Role of Nanoparticles in Tumor Treatment
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4954 | Submission Open
Keywords: nanoparticles; cancer therapy; nanotechnology
(This special issue belongs to the Section Chemical Biology)
Advances in Galectins
edited by Anu Paul and Diyoly Ayona
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4819 | Submission Open
Keywords: galectins; carbohydrate-binding proteins; galectin– microbe
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Cellular Signaling in Cancer
edited by , Shabana Bano and Kasturi Nayak
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4812 | Submission Open
Keywords: signaling pathways; cancer; anti-cancer
(This special issue belongs to the Section Cellular Biochemistry)
Computational Intelligence in Structure and Function Prediction and Modeling of Proteins—2nd Edition
edited by , and Haiting Chai
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4762 | Submission Open
Keywords: protein tertiary structure; protein folding; protein functions; intrinsic disorder; drug discovery; protein– drug interaction; computational intelligent algorithms; artificial intelligence for proteomics; high-throughput proteomics
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Chemical Biology and Biotechnology of Nucleosides, Nucleotides, and Nucleic Acids
edited by and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4390 | Submission Open
Keywords: nucleosides; nucleotides; nanostructure; circular ssDNA; circular RNA; quadruplex; conjugate; lncRNA; DNAzyme; ribozyme
(This special issue belongs to the Section Chemical Biology)
Biologics and Biomaterials for Periodontal Treatment: Current and Future Challenges
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4167 | Submission Open
Keywords: periodontal disease; periodontitis; periodontal regeneration; periodontal tissue engineering; biological agents; biomaterials
(This special issue belongs to the Section Bio-Engineered Materials)
Neuron–Astrocyte Interactions in Neurological Function and Disease
edited by Micaela Zonta and Alessandro Di Spiezio
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4074 | Submission Open
Keywords: astrocytes; neuron-astrocyte communication; brain function; neurological disease
(This special issue belongs to the Section Molecular Medicine)
Cellular and Molecular Biology of Neurodevelopment
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 3997 | Submission Open
Keywords: neural stem cells; neuroblasts; neurons; glia; microglia; molecular pathways; genes; mutations; pharmacology; toxicology; neurodevelopment; neurodevelopmental disorders
(This special issue belongs to the Section Molecular Biology)
Barrier Formation and Homeostasis in the Vertebrate Brain submission deadline 31 Dec 2025 | 3 articles | Viewed by 3975 | Submission Open
Keywords: brain endothelial cell; pericytes; choroid plexus; retina; lymphatic; blood; astrocytes; oligodendrocytes; brain ventricle; microglia
(This special issue belongs to the Section Cellular Biochemistry)
Recent Advances in the Enzymatic Synthesis of Bioactive Compounds submission deadline 31 Dec 2025 | 4 articles | Viewed by 3912 | Submission Open
Keywords: biocatalysis; biotransformation; enzyme-catalyzed reactions; whole-cell catalysis; green chemistry; enzymes; phenolic compounds; polyphenols; lipases; lipophilization; enzymatic synthesis; esterification; transesterification; green and sustainable chemistry approaches; lipid modification
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Necrotic Cell Death Mechanisms and Therapies
edited by and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3857 | Submission Open
Keywords: necrosis; mitochondria; lysosomes; reactive oxygen species (ROS); calcium signalling; caspase-independent proteases: serine proteases like CELA; ELA; as well as cathepsin C and B etc.; heat shock proteins (HSPs); epigenetics; necrosis in diseases and therapeutic intervention; necroptosis; ferroptosis; paraptosis; pyroptosis
(This special issue belongs to the Section Cellular Biochemistry)
Signaling Pathways as Therapeutic Targets for Cancer
edited by Fabian Benencia
submission deadline 31 Dec 2025 | 3 articles | Viewed by 3767 | Submission Open
Keywords: cancer signaling pathways; cancer metabolism; small molecules; anticancer antibodies; tumor models; combinatorial therapies
(This special issue belongs to the Section Molecular Biology)
Alcohol-Related Organ Damage: Mechanisms, Outcomes, and Treatment Modalities submission deadline 31 Dec 2025 | 2 articles | Viewed by 3630 | Submission Open
Keywords: alcoholic liver disease (ALD); steatohepatitis; fibrosis; cirhosis; parenhymal and non-parenhymal liver cells; brain; gut; lungs; immune responses; oxidative stress; methylation; viral infections; post-translational protein modifications; treatment of ALD
(This special issue belongs to the Section Molecular Medicine)
Mechanisms of Formation of Biomolecule Complexes: Theory, Experiment, Applications submission deadline 31 Dec 2025 | 2 articles | Viewed by 3346 | Submission Open
Keywords: biomolecule complexes; biomolecule coacervates; complex stability; mechanisms of formation of biomolecule complexes; phase separation; application of biomolecule complexes in biomedical industry
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
New Insights into Molecular Mechanisms and Therapeutics for Malaria
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3336 | Submission Open
Keywords: antimalarial resistance; drug discovery; malaria epidemiology; diagnostic tools; malaria pathophysiology
(This special issue belongs to the Section Molecular Medicine)
Non-Invasive Biomarkers in Saliva or Urine: Technical and Biological Variability
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3320 | Submission Open
Keywords: saliva; urine; non-invasive diagnostics; screening; biomarkers
(This special issue belongs to the Section Molecular Biomarkers)
Molecular Biomarkers in Cardiology 2025
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2904 | Submission Open
Keywords: cardiovascular diseases; cardiovascular pathology and histology; carotid plaques and histology; endothelium and endothelial dysfunction; veins diseases; arrhythmias; heart
(This special issue belongs to the Section Molecular Biomarkers)
Tumour Suppressor Genes: The Guardians of Cell Integrity
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 2847 | Submission Open
Keywords: cell cycle; cell growth; cell integrity; cell proliferation; DNA damage; genome integrity; protein homeostasis; migration; invasion; metastasis; apoptosis; autophagy
(This special issue belongs to the Section Molecular Biology)
Calcium Signaling in Cell Function and Dysfunction
edited by and Sofia Zanin
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2706 | Submission Open
Keywords: calcium signaling; calcium regulation; cell function; human pathology
(This special issue belongs to the Section Molecular Biology)
Antimicrobial Peptides in Nature: Inspiration for Rationally Designed Antimicrobials
edited by and Rachael Dickman
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2589 | Submission Open
Keywords: antimicrobial resistance; antimicrobial peptides; rational design of peptides; antimicrobial peptide synthesis; peptidomimetic antimicrobial agents
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Neuroinflammation in Ocular Diseases: Emerging Insights into Mechanisms, Biomarkers, and Therapeutic Targets
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2129 | Submission Open
Keywords: neuroinflammation; vision; retina; optic nerve; neurodegeneration; inflammation; biomarker; therapeutic strategies; pharmacological treatments
(This special issue belongs to the Section Molecular Biomarkers)
Novel Mechanisms of Bacterial Antibiotic Resistance submission deadline 31 Dec 2025 | 1 articles | Viewed by 1973 | Submission Open
Keywords: molecular mechanisms of antibiotic resistance; bacterial resistome acquired and intrinsic; drug resistance antibiotic modification/degradation; antibiotic efflux; antibiotic target modification antibiotic permeability; antibiotic sequestration proteins; beta-lactamases; bioinformatic and phylogenetic approaches
(This special issue belongs to the Section Biological Factors)
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