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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Application of Bioinformatics in Medicine, 2nd Edition

edited by

Le Zhang

submission deadline 31 Aug 2026 | 1 articles | Viewed by 588 | Submission Open

Keywords: computer-aided drug design (CADD); bioinformatics; systems medicine; drug discovery; computational biology

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Molecular Biomarkers of Oxidative and Nitrosative Stress: Mechanisms, Detection, and Clinical Significance

edited by

Narcyz Knap

and

Michał Woźniak

submission deadline 31 Aug 2026 | 1 articles | Viewed by 580 | Submission Open

Keywords: oxidative stress; nitrosative stress; reactive oxygen species (ROS); reactive nitrogen species (RNS); lipid peroxidation; ferroptosis; protein oxidation; DNA oxidative modifications; antioxidant defense mechanisms; free radicals; redox signaling; redox biomarkers

(This special issue belongs to the Section Molecular Biomarkers)

Protein Arginine Methylation: Functions, Mechanisms, and Therapeutic Implications

edited by Yanzhong Yang

submission deadline 31 Aug 2026 | Viewed by 411 | Submission Open

Keywords: protein arginine methyltransferases; transcription; RNA splicing; signaling transduction; DNA repair; cancer; development; small molecule inhibitor

(This special issue belongs to the Section Molecular Genetics)

Recent Advances in Immunotherapy for Mesothelioma

edited by Licun Wu

submission deadline 31 Aug 2026 | Viewed by 281 | Submission Open

Keywords: mesothelioma; immunotherapy; tumor microenvironment; biomarkers; tumor heterogeneity

(This special issue belongs to the Section Molecular Medicine)

State of the Art of Myology: 3rd Edition

edited by

Guglielmo Sorci

and

Francesca Riuzzi

submission deadline 31 Aug 2026 | Viewed by 247 | Submission Open

Keywords: embryonic myogenesis; adult myogenesis; exercise-induced muscle injury; muscular dystrophies and muscle diseases; sarcopenia; cachexia; rhabdomyosarcoma; muscle biophysics

(This special issue belongs to the Section Molecular Biology)

Nanomaterials and Iron Proteins: Molecular Interactions, Structural Characterization and Biomedical Applications

edited by

Georgia C. Papaefthymiou

submission deadline 31 Aug 2026 | Viewed by 244 | Submission Open

Keywords: iron storage (ferritin); iron transport (transferrin; ferroportin); O2 storage (myoglobin); O2 transport (hemoglobin); electron transfer (Fe-S proteins; cytochromes); ferritin degradation; (ferritinophagy); oxidative stress protection (ferritin; Dps proteins); biocompatible iron-oxide nanoparticles; magnetoferritin; biogenic magnetite by magnetotactic bacteria (magnetosomes); iron-based metal– organic frameworks (Fe-MOFs)

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Antimicrobial Activity and Resistance in Pathogens

edited by

Lia Mara Diţu

submission deadline 31 Aug 2026 | Viewed by 240 | Submission Open

Keywords: MDR profile in fungi; anti-fungal strategies; drug– target interactions; nanotechnology in antimicrobials; quorum-sensing molecular interactions; biofilm

(This special issue belongs to the Section Molecular Biology)

Pancreatic Cancer: From Molecular Mechanisms to Therapeutic Strategies

edited by

Harrys Kishore Charles Jacob

and

John Lalith Charles Richard

submission deadline 31 Aug 2026 | Viewed by 238 | Submission Open

Keywords: pancreatic cancer; multi-omics; epigenetics; single-cell transcriptomics; artificial intelligence; therapeutics

Glycans in Health and Disease: Molecular Insights and Clinical Implications

edited by

Vaibhav Tiwari

submission deadline 31 Aug 2026 | Viewed by 227 | Submission Open

Keywords: glycans; glycobiology; proteoglycans; heparan sulfate; infection; pathogen host cell interaction; disease; cancer; drug discovery

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Physiological Responses and Biomolecular Adaptations to Environmental and Biotic Stress in Aquatic Species

edited by

Eleni Golomazou

submission deadline 31 Aug 2026 | Viewed by 225 | Submission Open

Keywords: aquaculture; fish pathogens; fish welfare; health protection

(This special issue belongs to the Section Molecular Biology)

From Molecular Mechanisms to Therapeutics: Multidisciplinary Advances in Gene Expression Research

edited by Cristina Maracci

submission deadline 31 Aug 2026 | Viewed by 197 | Submission Open

Keywords: gene regulation; drug design; computational biology; AI modeling; protein synthesis; gene regulatory network; transcription; post-transcriptional regulation; molecular biology

(This special issue belongs to the Section Molecular Genetics)

Nutrition, Metabolism, and Obesity: Novel Strategies and Molecular Mechanisms—Future Perspectives, 2nd Edition

edited by Marion Korach-André

submission deadline 31 Aug 2026 | Viewed by 197 | Submission Open

Keywords: diet; nutrients; obesity; inflammation; fat; glucose intolerance; insulin resistance; fatty liver disease; metabolic syndrome

(This special issue belongs to the Section Molecular Medicine)

Dynamic Interactions Between Biomolecules: Insights from Bioinformatics and Computational Biology

edited by Jayadev Joshi

submission deadline 31 Aug 2026 | Viewed by 185 | Submission Open

Keywords: biomolecular interactions; molecular dynamics; structural bioinformatics; computational biology; protein interactions; conformational dynamics; machine learning; systems biology; integrative modeling; drug discovery

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Molecular Imaging Biomarkers in Inflammation and Metabolic Disorders

edited by

Uwe Himmelreich

submission deadline 31 Aug 2026 | Viewed by 163 | Submission Open

Keywords: inflammation; metabolic disorders; molecular imaging; metabolism; biomarkers

(This special issue belongs to the Section Molecular Biomarkers)

Molecular Mechanisms and Therapeutic Strategies in Pediatric Immune Dysregulation

edited by Rita Consolini and

Giorgio Costagliola

submission deadline 31 Aug 2026 | Viewed by 151 | Submission Open

Keywords: immune dysregulation; autoimmunity; inborn errors of immunity; targeted therapies; immunomodulatory treatments; genetics; gene therapy; hematopoietic stem cell transplantation

(This special issue belongs to the Section Molecular Medicine)

Next-Gen Antimicrobials: Discovery, Engineering and Synergistic Approaches

edited by

Juan Borrero

submission deadline 31 Aug 2026 | Viewed by 136 | Submission Open

Keywords: antimicrobial agents; antimicrobial discovery; antimicrobial engineering; antimicrobial applications; synergistic antimicrobial strategies

(This special issue belongs to the Section Molecular Medicine)

The Fibroblast-IL-6 Axis in Skin Cancer Microenvironment

edited by

Lukas Lacina

and

Karel Smetana, Jr.

submission deadline 31 Aug 2026 | Viewed by 135 | Submission Open

Keywords: cancer microenvironment; cancer-associated fibroblasts (CAFs); cancer supporting inflammation; malignant melanoma; non-Melanoma Skin Cancer (NMSC); IL-6 signalling pathway; IL-6 receptor; ageing; senescence associated secretory phenotype (SASP)

(This special issue belongs to the Section Cellular Biochemistry)

Copper Signaling and Redox Biology in Vascular Function and Disease

edited by Archita Das

submission deadline 31 Aug 2026 | Viewed by 120 | Submission Open

Keywords: redox signaling; endothelial cell; vascular biology; angiogenesis; atherosclerosis; diabetes; copper transporter proteins

(This special issue belongs to the Section Molecular Medicine)

The Heme Oxygenase/Biliverdin Reductase System in Human Health and Disease: New Molecular Insights and Therapeutic Targets

edited by Cesare Mancuso

submission deadline 1 Sep 2026 | 4 articles | Viewed by 3730 | Submission Open

Keywords: Alzheimer’ s disease; bilirubin; cancer; carbon monoxide; cardiovascular diseases; cerebral malaria; diabetes mellitus; drug research and development; inflammation; Parkinson’ s disease

(This special issue belongs to the Section Molecular Medicine)

Molecular Profiling and Identification of Molecular Signatures Associated with Natural Products: 2nd Edition

edited by

Juei-Tang Cheng

submission deadline 1 Sep 2026 | 1 articles | Viewed by 2513 | Submission Open

Keywords: natural product; molecular mechanisms; repurposed molecules; disease model; human health

Molecular Mechanisms and Microenvironmental Regulation in Bone-Related Diseases and Muscle Atrophy

edited by Haitao Wang

submission deadline 1 Sep 2026 | 2 articles | Viewed by 2169 | Submission Open

Keywords: bone diseases; muscle atrophy; osteoporosis; osteoarthritis; osteosarcoma; sarcopenia; heterotopic ossification; molecular mechanisms; microenvironment; therapeutic targets

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms and Drug Research in Alzheimer’s Disease

edited by

Xudong Huang

submission deadline 1 Sep 2026 | 2 articles | Viewed by 1678 | Submission Open

Keywords: Alzheimer's disease; molecular mechanisms; drug discovery; Aβ amyloid; tau protein; neuroinflammation; oxidative stress; metal homeostasis; blood– brain barrier; dysbiosis

(This special issue belongs to the Section Molecular Medicine)

Digital Twins in Biomedical and Pharmaceutical Research

edited by Shuxing Zhang and Yinan Sun

submission deadline 1 Sep 2026 | Viewed by 130 | Submission Open

Keywords: digital twins; artificial intelligence (AI); big data; drug discovery and development; clinical trials; personalized medicine

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Cellular and Molecular Mechanisms of Endometriosis: 2nd Edition

edited by

Luciana Bordin

, Alessandra Andrisani and Chiara Sabbadin

submission deadline 15 Sep 2026 | 3 articles | Viewed by 5711 | Submission Open

Keywords: endocrine disfunction in endometriosis; glycosylphosphatidylinositols (GPIs) and GPI-anchored proteins; oxidative stress markers (glutathione; carbonic anhydrase; etc.); endometriosis and deep endometriosis; endometriosis-related immune system

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Bronchiolitis Obliterans

edited by Ralf Schubert and Silvija-Pera Jerkic

submission deadline 15 Sep 2026 | 2 articles | Viewed by 997 | Submission Open

Keywords: bronchiolitis obliterans (BO); inflammation; fibrosis; molecular mechanisms

(This special issue belongs to the Section Molecular Medicine)

Prion Biology and Disease: Molecular Mechanisms and Emerging Technologies

edited by Takashi Onodera and

Akikazu Sakudo

submission deadline 15 Sep 2026 | Viewed by 618 | Submission Open

Keywords: prions; PrPC; PrPSc; prion strain diversity; neurodegeneration; immunodetection methods; nonthermal gas plasma; protein misfolding cyclic amplification (PMCA); real-time quaking-induced conversion (RT-QuIC)

Microbial Extracellular Vesicles: From Virulence Factors to Therapeutic Targets

edited by

Daria Nicolosi

submission deadline 15 Sep 2026 | Viewed by 142 | Submission Open

Keywords: microbial extracellular vesicles; virulence factors; host– pathogen interaction; drug delivery; biomarkers

Epigenetic and Pharmacological Insights into Cognitive Dysfunction Driven by Genetic and Environmental Factors

edited by

Pei Li

submission deadline 15 Sep 2026 | Viewed by 135 | Submission Open

Keywords: cognitive dysfunction; epigenetic regulation; genetic risk; environmental exposure

(This special issue belongs to the Section Molecular Genetics)

Extracellular Matrix Components and Glycobiology in Cancer: From Mechanisms to Therapeutic Targeting

edited by

Achilleas Theocharis

submission deadline 15 Sep 2026 | Viewed by 128 | Submission Open

Keywords: extracellular matrix; glycobiology; glycoconjugates; proteoglycans; tumor microenvironment

(This special issue belongs to the Section Molecular Medicine)

Extracellular Non-Coding RNAs as Key Regulators and Biomarkers in Reproductive Processes

edited by Rosalia Battaglia

submission deadline 15 Sep 2026 | Viewed by 122 | Submission Open

Keywords: extracellular non-coding RNAs; reproductive biology; extracellular vesicles; biomarkers; assisted reproductive technology

(This special issue belongs to the Section Molecular Reproduction)

Targeting Protein Misfolding: From Alzheimer's Amyloids to Therapeutic Peptides

edited by

Dariusz Stępkowski

submission deadline 16 Sep 2026 | 2 articles | Viewed by 4093 | Submission Open

Keywords: amyloidogenesis; amyloidosis; amyloid fibrils; dissolution of amyloid fibrils; beta-sheet breakers; peptide inhibitors; small molecule inhibitors

Novel Diagnostic Tools and Biomarkers in Hematology

edited by Lars Kaestner

submission deadline 17 Sep 2026 | 1 articles | Viewed by 753 | Submission Open

Keywords: blood-based biomarkers; diagnostic innovation; omics technologies; microfluidics; photonics; machine learning; hematology; precision medicine

(This special issue belongs to the Section Molecular Biomarkers)

Evolutionary Genomics of Bacterial Endosymbionts: From Mutualism to Parasitism

edited by

Amit Sinha

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1496 | Submission Open

Keywords: host– symbiont coevolution; metabolic pathways; horizontal DNA transfer; phylogenetics

Biotherapeutic Analysis: Precision Characterization and Quality Control

edited by

Jared Auclair

submission deadline 20 Sep 2026 | 2 articles | Viewed by 890 | Submission Open

Keywords: biotherapeutics; analytical characterization; quality control; mass spectrometry; cell therapy; gene therapy; biologics; process analytical technology; regulatory science

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Angiogenin: From Molecular Mechanisms to Clinical Implications

edited by

Iogann Tolbatov

submission deadline 20 Sep 2026 | Viewed by 224 | Submission Open

Keywords: angiogenin; angiogenesis; neuroprotection; cancer; neurodegeneration; biomarker; therapeutic target

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Experimental and Theoretical Approaches to Protein-Targeting Drug Discovery: 3rd Edition

edited by

Caterina Vicidomini

and

Giovanni N. Roviello

submission deadline 20 Sep 2026 | Viewed by 174 | Submission Open

Keywords: proteins; peptides; amyloid; aptamers; molecular docking; Alzheimer disease; Parkinson’ s disease; neurodrugs; biotechnological enzymes; antiviral drugs; vaccines; biomolecular targets; COVID-19; infectious diseases; peptide aggregation; drug repurposing; natural products; synthetic antivirals; anticancer therapeutics

(This special issue belongs to the Section Chemical Biology)

Nitrogen Signaling, Transport, and Function in Plants, 2nd Edition

edited by

Takushi Hachiya

submission deadline 20 Sep 2026 | Viewed by 170 | Submission Open

Keywords: nitrogen assimilation; nitrogen sensing; nitrogen transport; nitrogen signaling; primary nitrate response; systemic nitrogen signaling

(This special issue belongs to the Section Biological Factors)

Advances in Molecular Mechanisms of Hearing Loss

edited by

Sten Hellström

submission deadline 20 Sep 2026 | Viewed by 127 | Submission Open

Keywords: molecular signaling pathways; inflammation in hearing loss; genetic mutations; neurotransmitter dysregulation; cellular mechanotransduction

(This special issue belongs to the Section Molecular Genetics)

CD5 and CD6 Immunobiology: Multitask Immunomodulatory Molecules in Infection, Cancer and Autoimmunity

edited by Lozano Francisco and María Velasco-de Andrés

submission deadline 24 Sep 2026 | 1 articles | Viewed by 1000 | Submission Open

Keywords: CD5; CD6; T cells; B1a cells; NK cells; immunomodulation; infection; cancer; autoimmunity; immunotherapy

(This special issue belongs to the Section Biological Factors)

Functional Analysis of Genes Related to DNA Damage

edited by Ryan P. Barnes and Amy M. Whitaker

submission deadline 25 Sep 2026 | 5 articles | Viewed by 5323 | Submission Open

Keywords: DNA damage; DNA repair; genome stability; DNA replication stress

(This special issue belongs to the Section Molecular Biology)

Dietary Polyphenols and Their Impact on Inflammation and Cardiovascular Metabolic Health

edited by Sonila Alia and

Arianna Vignini

submission deadline 25 Sep 2026 | 1 articles | Viewed by 781 | Submission Open

Keywords: dietary polyphenols; inflammation; cardiometabolic health; cardiovascular diseases; oxidative stress; antioxidant activity; molecular mechanisms; nutritional interventions

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Focus on Perineural Invasion in Pancreatic Cancer

edited by

Ingrid Garajová

submission deadline 25 Sep 2026 | Viewed by 473 | Submission Open

Keywords: pancreatic cancer; perineural invasion; pain; NGF; neutrophins

(This special issue belongs to the Section Molecular Medicine)

Endocrine Regulation of Reproductive Tissues: From Molecular Mechanisms to Therapies

edited by

Waldemar Grzegorzewski

submission deadline 25 Sep 2026 | Viewed by 346 | Submission Open

Keywords: hormone signaling; reproductive physiology; steroid receptors; infertility; endocrine disruptors; epigenetic regulation; gonadal steroids; hormone-dependent cancers; therapeutic targeting; gametogenesis

(This special issue belongs to the Section Biological Factors)

Advances in Plant Genetic Engineering

edited by

Bin Li

submission deadline 25 Sep 2026 | Viewed by 122 | Submission Open

Keywords: plant genetic engineering and biotechnology; CRISPR-Cas system; precise genome editing; synthetic biology; plant transformation and modification; genetically modified plants; plant improvement; biofactories

(This special issue belongs to the Section Molecular Genetics)

Advances in Drosophila Models for Amyloid and Neurodegenerative Diseases

edited by Ann Christin Brorsson

submission deadline 28 Sep 2026 | 1 articles | Viewed by 1013 | Submission Open

Keywords: neurodegeneration; protein aggregation; amyloid structures; neurotoxicity; Drosophila melanogaster; model organism

Molecular Advances in Wound Healing and Skin Regeneration

edited by

Hiroyuki Ijima

and Muhammad Shafiq

submission deadline 30 Sep 2026 | 3 articles | Viewed by 39968 | Submission Open

Keywords: artificial dressings; electrospun fiber-based wound dressings; artificial skin equivalents; wound healing; instructive biomaterials for in situ skin repair; microneedles for skin therapy; drug delivery systems for wound healing; cell-free approaches for skin repair; stem cell therapy for wound healing; scarless skin repair

(This special issue belongs to the Section Biological Factors)

Biologics and Biomaterials for Periodontal Treatment: Current and Future Challenges

edited by

Atsushi Saito

submission deadline 30 Sep 2026 | 3 articles | Viewed by 13086 | Submission Open

Keywords: periodontal disease; periodontitis; periodontal regeneration; periodontal tissue engineering; biological agents; biomaterials

(This special issue belongs to the Section Bio-Engineered Materials)

Alcohol-Related Organ Damage: Mechanisms, Outcomes, and Treatment Modalities

edited by

Natalia Osna

and

Kusum K. Kharbanda

submission deadline 30 Sep 2026 | 4 articles | Viewed by 8050 | Submission Open

Keywords: alcoholic liver disease (ALD); steatohepatitis; fibrosis; cirhosis; parenhymal and non-parenhymal liver cells; brain; gut; lungs; immune responses; oxidative stress; methylation; viral infections; post-translational protein modifications; treatment of ALD

(This special issue belongs to the Section Molecular Medicine)

Feature Papers in Section "Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates"

edited by

Valentyn Oksenych

submission deadline 30 Sep 2026 | 6 articles | Viewed by 5854 | Submission Open

Keywords: biomacromolecules; proteins; DNA; RNA; chromatin; epigenetics; gene regulation; genomics; proteomics; metabolomics; computational approaches; molecular biotechnology; molecular therapeutics

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Natural Products and Their Derivatives with Antiviral Activity

edited by

Zhijun Zhang

submission deadline 30 Sep 2026 | 2 articles | Viewed by 5528 | Submission Open

Keywords: natural products; synthetic antivirals; antiviral drugs; antiviral strategies; influenza; HBV; HIV; RSV; COVID-19; SARS-CoV-2

(This special issue belongs to the Section Natural and Bio-derived Molecules)

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