Table of Contents
Biomolecules, Volume 8, Issue 4 (December 2018)
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Cover Story (view full-size image) The Golgi apparatus is the central sorting and transportation hub involved in the posttranslational [...] Read more. The Golgi apparatus is the central sorting and transportation hub involved in the posttranslational modification of cargo molecules, which determines their subsequent delivery to appropriate compartments or to the exocytic and endocytic pathways. In the liver, chronic alcohol consumption impairs the structure of the Golgi and alters intracellular trafficking of hepatic proteins. Abstinence is the most important therapeutic intervention for patients with alcoholic liver disease, but the mechanism of Golgi recovery was largely unknown. Here, using both in vitro and in vivo models of ethanol administration, we found that the largest Golgi matrix protein, giantin, is essential for post-alcohol recovery of Golgi. View this paper.