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Biomolecules 2018, 8(4), 134; https://doi.org/10.3390/biom8040134

Dietary Nitrate from Beetroot Juice for Hypertension: A Systematic Review

1
Research Division, DBSS, 110861 Bogotá, Colombia
2
Research Group in Biochemistry and Molecular Biology, Universidad Distrital Francisco José de Caldas, 110311 Bogotá, Colombia
3
Research Group in Physical Activity, Sports and Health Sciences (GICAFS), Universidad de Córdoba, 230002 Montería, Colombia
4
Institución Educativa CCAPF, 111511 Bogotá, Colombia
5
Molecular Biology Laboratory, Dr. Félix Gómez Endocrinometabolic Research Center, University of Zulia, 15424 Maracaibo, Venezuela
6
EADE-University of Wales Trinity Saint David, 29017 Málaga, Spain
7
Move Nutrition, 050021 Medellin, Colombia
*
Author to whom correspondence should be addressed.
Received: 9 October 2018 / Accepted: 29 October 2018 / Published: 2 November 2018
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Abstract

According to current therapeutic approaches, a nitrate-dietary supplementation with beetroot juice (BRJ) is postulated as a nutritional strategy that might help to control arterial blood pressure in healthy subjects, pre-hypertensive population, and even patients diagnosed and treated with drugs. In this sense, a systematic review of random clinical trials (RCTs) published from 2008 to 2018 from PubMed/MEDLINE, ScienceDirect, and manual searches was conducted to identify studies examining the relationship between BRJ and blood pressure. The specific inclusion criteria were: (1) RCTs; (2) trials that assessed only the BRJ intake with control group; and (3) trials that reported the effects of this intervention on blood pressure. The search identified 11 studies that met the inclusion criteria. This review was able to demonstrate that BRJ supplementation is a cost-effective strategy that might reduce blood pressure in different populations, probably through the nitrate/nitrite/nitric oxide (NO3/NO2/NO) pathway and secondary metabolites found in Beta vulgaris. This easily found and cheap dietary intervention could significantly decrease the risk of suffering cardiovascular events and, in doing so, would help to diminish the mortality rate associated to this pathology. Hence, BRJ supplementation should be promoted as a key component of a healthy lifestyle to control blood pressure in healthy and hypertensive individuals. However, several factors related to BRJ intake (e.g., gender, secondary metabolites present in B. vulgaris, etc.) should be studied more deeply. View Full-Text
Keywords: Beta vulgaris; hypertension; dietary supplements; nitric oxide; blood pressure Beta vulgaris; hypertension; dietary supplements; nitric oxide; blood pressure
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Bonilla Ocampo, D.A.; Paipilla, A.F.; Marín, E.; Vargas-Molina, S.; Petro, J.L.; Pérez-Idárraga, A. Dietary Nitrate from Beetroot Juice for Hypertension: A Systematic Review. Biomolecules 2018, 8, 134.

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