Next Article in Journal
Crosstalk between PPARγ Ligands and Inflammatory-Related Pathways in Natural T-Regulatory Cells from Type 1 Diabetes Mouse Model
Next Article in Special Issue
Oxygen Availability during Growth Modulates the Phytochemical Profile and the Chemo-Protective Properties of Spinach Juice
Previous Article in Journal
Add-on Immunoadsorption Shortly-after Optimal Medical Treatment Further Significantly and Persistently Improves Cardiac Function and Symptoms in Recent-Onset Heart Failure—A Single Center Experience

Dietary Nitrate from Beetroot Juice for Hypertension: A Systematic Review

Research Division, DBSS, 110861 Bogotá, Colombia
Research Group in Biochemistry and Molecular Biology, Universidad Distrital Francisco José de Caldas, 110311 Bogotá, Colombia
Research Group in Physical Activity, Sports and Health Sciences (GICAFS), Universidad de Córdoba, 230002 Montería, Colombia
Institución Educativa CCAPF, 111511 Bogotá, Colombia
Molecular Biology Laboratory, Dr. Félix Gómez Endocrinometabolic Research Center, University of Zulia, 15424 Maracaibo, Venezuela
EADE-University of Wales Trinity Saint David, 29017 Málaga, Spain
Move Nutrition, 050021 Medellin, Colombia
Author to whom correspondence should be addressed.
Biomolecules 2018, 8(4), 134;
Received: 9 October 2018 / Accepted: 29 October 2018 / Published: 2 November 2018
According to current therapeutic approaches, a nitrate-dietary supplementation with beetroot juice (BRJ) is postulated as a nutritional strategy that might help to control arterial blood pressure in healthy subjects, pre-hypertensive population, and even patients diagnosed and treated with drugs. In this sense, a systematic review of random clinical trials (RCTs) published from 2008 to 2018 from PubMed/MEDLINE, ScienceDirect, and manual searches was conducted to identify studies examining the relationship between BRJ and blood pressure. The specific inclusion criteria were: (1) RCTs; (2) trials that assessed only the BRJ intake with control group; and (3) trials that reported the effects of this intervention on blood pressure. The search identified 11 studies that met the inclusion criteria. This review was able to demonstrate that BRJ supplementation is a cost-effective strategy that might reduce blood pressure in different populations, probably through the nitrate/nitrite/nitric oxide (NO3/NO2/NO) pathway and secondary metabolites found in Beta vulgaris. This easily found and cheap dietary intervention could significantly decrease the risk of suffering cardiovascular events and, in doing so, would help to diminish the mortality rate associated to this pathology. Hence, BRJ supplementation should be promoted as a key component of a healthy lifestyle to control blood pressure in healthy and hypertensive individuals. However, several factors related to BRJ intake (e.g., gender, secondary metabolites present in B. vulgaris, etc.) should be studied more deeply. View Full-Text
Keywords: Beta vulgaris; hypertension; dietary supplements; nitric oxide; blood pressure Beta vulgaris; hypertension; dietary supplements; nitric oxide; blood pressure
Show Figures

Figure 1

MDPI and ACS Style

Bonilla Ocampo, D.A.; Paipilla, A.F.; Marín, E.; Vargas-Molina, S.; Petro, J.L.; Pérez-Idárraga, A. Dietary Nitrate from Beetroot Juice for Hypertension: A Systematic Review. Biomolecules 2018, 8, 134.

AMA Style

Bonilla Ocampo DA, Paipilla AF, Marín E, Vargas-Molina S, Petro JL, Pérez-Idárraga A. Dietary Nitrate from Beetroot Juice for Hypertension: A Systematic Review. Biomolecules. 2018; 8(4):134.

Chicago/Turabian Style

Bonilla Ocampo, Diego A., Andrés F. Paipilla, Estevan Marín, Salvador Vargas-Molina, Jorge L. Petro, and Alexandra Pérez-Idárraga. 2018. "Dietary Nitrate from Beetroot Juice for Hypertension: A Systematic Review" Biomolecules 8, no. 4: 134.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop