Next Article in Journal
Anticancer Activity of Polysaccharides Produced from Glycerol and Crude Glycerol by an Endophytic Fungus Chaetomium globosum CGMCC 6882 on Human Lung Cancer A549 Cells
Previous Article in Journal
Clinical Significance of Serum NEDD9 Levels in Patients with Pancreatic Cancer
Previous Article in Special Issue
Giantin Is Required for Post-Alcohol Recovery of Golgi in Liver Cells
Article Menu
Issue 4 (December) cover image

Export Article

Open AccessReview
Biomolecules 2018, 8(4), 170; https://doi.org/10.3390/biom8040170

Role of HIF-1α in Alcohol-Mediated Multiple Organ Dysfunction

1
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA 30322, USA
2
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Atlanta Veterans Affairs Health Care System, Decatur, GA 30033, USA
*
Author to whom correspondence should be addressed.
Received: 19 October 2018 / Revised: 30 November 2018 / Accepted: 6 December 2018 / Published: 10 December 2018
(This article belongs to the Collection Multi-Organ Alcohol-Related Damage: Mechanisms and Treatment)
Full-Text   |   PDF [391 KB, uploaded 10 December 2018]   |  
  |   Review Reports

Abstract

Excess alcohol consumption is a global crisis contributing to over 3 million alcohol-related deaths per year worldwide and economic costs exceeding $200 billion dollars, which include productivity losses, healthcare, and other effects (e.g., property damages). Both clinical and experimental models have shown that excessive alcohol consumption results in multiple organ injury. Although alcohol metabolism occurs primarily in the liver, alcohol exposure can lead to pathophysiological conditions in multiple organs and tissues, including the brain, lungs, adipose, liver, and intestines. Understanding the mechanisms by which alcohol-mediated organ dysfunction occurs could help to identify new therapeutic approaches to mitigate the detrimental effects of alcohol misuse. Hypoxia-inducible factor (HIF)-1 is a transcription factor comprised of HIF-1α and HIF-1β subunits that play a critical role in alcohol-mediated organ dysfunction. This review provides a comprehensive analysis of recent studies examining the relationship between HIF-1α and alcohol consumption as it relates to multiple organ injury and potential therapies to mitigate alcohol’s effects. View Full-Text
Keywords: ethanol; alcohol; HIF-1α ethanol; alcohol; HIF-1α
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Morris, N.L.; Yeligar, S.M. Role of HIF-1α in Alcohol-Mediated Multiple Organ Dysfunction. Biomolecules 2018, 8, 170.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Biomolecules EISSN 2218-273X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top