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Biomolecules 2018, 8(4), 148; https://doi.org/10.3390/biom8040148

Dual-Family Peptidylprolyl Isomerases (Immunophilins) of Select Monocellular Organisms

3780 Pelham Drive, Mobile, AL 36619, USA
Received: 25 October 2018 / Revised: 8 November 2018 / Accepted: 12 November 2018 / Published: 15 November 2018
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Abstract

The dual-family peptidylprolyl cis-trans isomerases (immunophilins) represent a naturally occurring chimera of the classical FK506-binding protein (FKBP) and cyclophilin (CYN), connected by a flexible linker. They are found exclusively in monocellular organisms. The modular builds of these molecules represent two distinct types: CYN-(linker)-FKBP and FKBP-3TPR (tetratricopeptide repeat)-CYN. Abbreviated respectively as CFBP and FCBP, the two classes also exhibit distinct organism preference, the CFBP being found in prokaryotes, and the FCBP in eukaryotes. This review summarizes the mystery of these unique class of prolyl isomerases, focusing on their host organisms, potential physiological role, and likely routes of evolution. View Full-Text
Keywords: peptidylprolyl isomerase; chaperone; immunophilin; extremophile; intrinsic disorder peptidylprolyl isomerase; chaperone; immunophilin; extremophile; intrinsic disorder
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Barik, S. Dual-Family Peptidylprolyl Isomerases (Immunophilins) of Select Monocellular Organisms. Biomolecules 2018, 8, 148.

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