Intrinsically Disordered Proteins and the Janus Challenge
AbstractTo gain a new insight into the role of proteins in the origin of life on Earth, we present the Janus Challenge: identify an intrinsically disordered protein (IDP), naturally occurring or synthetic, that has catalytic activity. For example, such a catalytic IDP may perform condensation reactions to catalyze a peptide bond or a phosphodiester bond formation utilizing natural/un-natural amino acids or nucleotides, respectively. The IDP may also have autocatalytic, de novo synthesis, or self-replicative activity. Meeting this challenge may not only shed new light and provide an alternative to the RNA world hypothesis, but it may also serve as an impetus for technological advances with important biomedical applications. View Full-Text
Share & Cite This Article
Kulkarni, P.; Uversky, V.N. Intrinsically Disordered Proteins and the Janus Challenge. Biomolecules 2018, 8, 179.
Kulkarni P, Uversky VN. Intrinsically Disordered Proteins and the Janus Challenge. Biomolecules. 2018; 8(4):179.Chicago/Turabian Style
Kulkarni, Prakash; Uversky, Vladimir N. 2018. "Intrinsically Disordered Proteins and the Janus Challenge." Biomolecules 8, no. 4: 179.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.