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Biomolecules 2018, 8(4), 179; https://doi.org/10.3390/biom8040179

Intrinsically Disordered Proteins and the Janus Challenge

1
Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA
2
Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
3
Laboratory of New methods in Biology, Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino 142290, Moscow Region, Russia
*
Authors to whom correspondence should be addressed.
Received: 12 December 2018 / Accepted: 13 December 2018 / Published: 18 December 2018
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Abstract

To gain a new insight into the role of proteins in the origin of life on Earth, we present the Janus Challenge: identify an intrinsically disordered protein (IDP), naturally occurring or synthetic, that has catalytic activity. For example, such a catalytic IDP may perform condensation reactions to catalyze a peptide bond or a phosphodiester bond formation utilizing natural/un-natural amino acids or nucleotides, respectively. The IDP may also have autocatalytic, de novo synthesis, or self-replicative activity. Meeting this challenge may not only shed new light and provide an alternative to the RNA world hypothesis, but it may also serve as an impetus for technological advances with important biomedical applications. View Full-Text
Keywords: intrinsically disordered protein; catalytic activity; conformational dynamics; origin of life theory intrinsically disordered protein; catalytic activity; conformational dynamics; origin of life theory
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Kulkarni, P.; Uversky, V.N. Intrinsically Disordered Proteins and the Janus Challenge. Biomolecules 2018, 8, 179.

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