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Metabolites, Volume 13, Issue 6

June 2023 - 96 articles

Cover Story: This study explores the relationship between metabolomic profiles, genetics, and lifestyle factors in age-related macular degeneration (AMD). A total of 5923 individuals were included, and blood metabolomics was assessed using a nuclear magnetic resonance platform. Associations were studied using regression analyses. The results show that metabolomic profiles differ between AMD stages and mostly reflect lifestyle factors. The severity-specific profiles spur further interest in the systemic effects related to disease conversion. View this paper
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Articles (96)

  • Review
  • Open Access
14 Citations
4,309 Views
23 Pages

Gut Microbiota and Neuroinflammation in Acute Liver Failure and Chronic Liver Disease

  • Lucia Giuli,
  • Marta Maestri,
  • Francesco Santopaolo,
  • Maurizio Pompili and
  • Francesca Romana Ponziani

Acute liver failure and chronic liver disease are associated with a wide spectrum of neurological changes, of which the best known is hepatic encephalopathy (HE). Historically, hyperammonemia, causing astrocyte swelling and cerebral oedema, was consi...

  • Article
  • Open Access
6 Citations
2,938 Views
23 Pages

Fish are exposed to xenobiotics in the water. Uptake occurs mainly through the gills, which function as an exchange point with the environment. The gills’ ability to detoxify harmful compounds by biotransformation is an essential protection mec...

  • Article
  • Open Access
5 Citations
2,484 Views
18 Pages

Aluminum (Al) toxicity is a major threat to global crop production in acidic soils, which can be mitigated by natural substances such as pyroligneous acid (PA). However, the effect of PA in regulating plant central carbon metabolism (CCM) under Al st...

  • Article
  • Open Access
1 Citations
2,025 Views
10 Pages

Novel Metabolomic Approach for Identifying Pathology-Specific Biomarkers in Rare Diseases: A Case Study in Oculopharyngeal Muscular Dystrophy (OPMD)

  • Pradeep Harish,
  • Alberto Malerba,
  • Rosemarie H. M. J. M. Kroon,
  • Milad Shademan,
  • Baziel van Engelan,
  • Vered Raz,
  • Linda Popplewell and
  • Stuart G. Snowden

The identification of metabolomic biomarkers relies on the analysis of large cohorts of patients compared to healthy controls followed by the validation of markers in an independent sample set. Indeed, circulating biomarkers should be causally linked...

  • Article
  • Open Access
2 Citations
1,939 Views
19 Pages

A GC-MS Chemotaxonomic Study on Lipophilic Compounds in the Bark of S. aucuparia subsp. sibirica Trees from the Population Growing in Akademgorodok, Novosibirsk (Russia)

  • Asya R. Vasilieva,
  • Nikolay M. Slynko,
  • Ljudmila E. Tatarova,
  • Vadim M. Efimov,
  • Leonid V. Kuibida,
  • Sergey V. Asbaganov and
  • Sergey E. Peltek

Determination of chemotypes and of their role in the polymorphism of populations is an important field in the research on secondary metabolites of plants. In the present study, by gas chromatography coupled with mass spectrometry, the composition of...

  • Review
  • Open Access
7 Citations
3,786 Views
10 Pages

Several recent studies have suggested selenium (Se) as a potential risk factor for diabetes mellitus (DM); however, the relationship between high Se levels and type 2 diabetes mellitus (T2DM) risk remains unclear. This review article aimed to provide...

  • Article
  • Open Access
5 Citations
2,859 Views
13 Pages

The Selective LAT1 Inhibitor JPH203 Enhances Mitochondrial Metabolism and Content in Insulin-Sensitive and Insulin-Resistant C2C12 Myotubes

  • Caroline N. Rivera,
  • Carly E. Smith,
  • Lillian V. Draper,
  • Gabriela E. Ochoa,
  • Rachel M. Watne,
  • Andrew J. Wommack and
  • Roger A. Vaughan

Population data have shown an association between higher circulating branched-chain amino acids (BCAA) and the severity of insulin resistance in people with diabetes. While several studies have assessed BCAA metabolism as a potential target for regul...

  • Article
  • Open Access
4 Citations
3,088 Views
28 Pages

Lactic acid bacteria is well-known as a vital strategy to alleviate or prevent diabetes. Similarly, the plant Saussurea costus (Falc) Lipsch is a preventive power against diabetes. Here, we aimed to determine whether lactic acid bacteria or Saussurea...

  • Article
  • Open Access
17 Citations
2,626 Views
21 Pages

Exogenous TiO2 Nanoparticles Alleviate Cd Toxicity by Reducing Cd Uptake and Regulating Plant Physiological Activity and Antioxidant Defense Systems in Rice (Oryza sativa L.)

  • Anas Iqbal,
  • Zhaowen Mo,
  • Sheng-Gang Pan,
  • Jian-Ying Qi,
  • Tian Hua,
  • Muhammad Imran,
  • Meiyang Duan,
  • Qichang Gu,
  • Xiang-Bin Yao and
  • Xiangru Tang

Cadmium (Cd) is a potentially hazardous element with significant biological toxicity, negatively affecting plant growth and physio-biochemical metabolism. Thus, it is necessary to examine practical and eco-friendly approaches to reduce Cd toxicity. T...

  • Article
  • Open Access
6 Citations
5,260 Views
13 Pages

Untargeted Metabolomics Approach for the Differentiation between Panax vietnamensis var. vietnamensis and Panax vietnamensis var. fuscidiscus

  • Huy Truong Nguyen,
  • Long Ke Phan,
  • Kim-Long Vu Huynh,
  • Thuc-Huy Duong,
  • Huong Thuy Le,
  • Nguyen Trang Hai-Yen,
  • Nguyen Thi Hai Yen,
  • Nguyen Phuoc Long and
  • Minh Duc Nguyen

Panax vietnamensis var. vietnamensis (PVV) and Panax vietnamensis var. fuscidiscus (PVF) both belong to Panax vietnamensis species and are chemically and morphologically similar, making it hard to distinguish for the consumer. Herein, 42 PVF and 12 P...

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Metabolites - ISSN 2218-1989Creative Common CC BY license