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Metabolites, Volume 16, Issue 1

2026 January - 89 articles

Cover Story: Longitudinal stability of untargeted plasma and cerebrospinal fluid (CSF) metabolites was assessed using samples from participants enrolled in the Wisconsin Registry for Alzheimer’s Prevention (WRAP) and the Wisconsin Alzheimer’s Disease Research Center (ADRC) studies. To identify metabolites most suitable for longitudinal analysis, we developed a composite score that integrates within- and between-batch reliability with measures of technical variance, highlighting metabolites that are temporally stable and robust to batch effects. This composite score is readily applicable to other longitudinal or multi-batch metabolomic datasets, where it can be used retrospectively to evaluate the reliability of key findings or prospectively to prioritize stable metabolites, thereby supporting more informed study design and interpretation. View this paper
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Articles (89)

  • Correction
  • Open Access
100 Views
1 Page

22 January 2026

References [...]

  • Systematic Review
  • Open Access
162 Views
18 Pages

21 January 2026

Background: High-intensity interval training (HIT) is a time-efficient strategy to improve metabolic health in children, but its impact on inflammatory markers is still unclear. Therefore, we conducted a meta-analysis to examine the role of HIT on pr...

  • Review
  • Open Access
119 Views
23 Pages

21 January 2026

In Pteropus spp., metabolic bone disease has been consistently associated with fruit-based diets that are deficient in calcium, vitamin D precursors, and protein, as well as limited ultraviolet B (UVB) exposure, as reported in zoological surveys and...

  • Article
  • Open Access
150 Views
20 Pages

21 January 2026

Background: Rhodopseudomonas palustris is a metabolically versatile bacterium with significant biotechnological potential, including the ability to catabolize lignin and its heterogeneous breakdown products. Understanding the molecular determina...

  • Article
  • Open Access
140 Views
14 Pages

21 January 2026

Background/Objectives: The quality of dried chili peppers is critically influenced by geographical origin, yet the metabolic basis for these differences remains insufficiently explored. This study sought to elucidate the region-specific metabolic pro...

  • Article
  • Open Access
119 Views
21 Pages

Chemical Attributes of UK-Grown Tea and Identifying Catechin and Metabolite Dynamics in Green and Black Tea Using Metabolomics and Machine Learning

  • Amanda J. Lloyd,
  • Jasen Finch,
  • Alina Warren-Walker,
  • Alison Watson,
  • Laura Lyons,
  • MJ Pilar Martinez Martin,
  • Thomas Wilson and
  • Manfred Beckmann

21 January 2026

The Dartmoor Estate Tea plantation in Devon, UK, benefits from a unique microclimate and diverse soil conditions, which, together with its different processing methods, contribute to the distinctive flavours and chemical profiles of its teas. Objecti...

  • Article
  • Open Access
156 Views
14 Pages

Vitamin D Status in People Living with HIV: Assessment of 25(OH)D Levels and Associated Factors—A Cross-Sectional Study

  • Florentina Dumitrescu,
  • Eugenia-Andreea Marcu,
  • Vlad Pădureanu,
  • Livia Dragonu,
  • Ilona-Andreea Georgescu,
  • Lucian Giubelan,
  • Rodica Pădureanu and
  • Sineta Cristina Firulescu

21 January 2026

Background: Vitamin D deficiency (VDD) is highly prevalent among people living with human immunodeficiency virus (HIV), with reported rates of insufficiency and deficiency substantially higher than in many general-population cohorts. This study aims...

  • Article
  • Open Access
180 Views
14 Pages

Distinct Metabolic Signatures Linked to High-Resolution Computed Tomography Radiographic Phenotypes in Stable and Progressive Fibrotic Lung Disease

  • Girish B. Nair,
  • Faizan Faizee,
  • Zachary Smith,
  • Sayf Al-Katib,
  • Nadia Ashrafi,
  • Ali Yilmaz,
  • Romana Ashrafi Mimi,
  • Sarayu Bhogoju,
  • Vilija Lomeikaite and
  • Stewart F. Graham
  • + 2 authors

19 January 2026

Background: This study aimed to identify distinct metabolic signatures associated with disease progression by integrating high-resolution computed tomography (HRCT) visual scoring with comprehensive metabolomic profiling. Materials and Methods: This...

  • Article
  • Open Access
288 Views
31 Pages

19 January 2026

Background/Objectives: Watermelon (Citrullus lanatus) processing generates substantial quantities of rind, seeds, and residual pulp that are typically discarded despite being rich in polyunsaturated fatty acids, polar lipids, carotenoids, and phenoli...

  • Article
  • Open Access
285 Views
19 Pages

Spatial Heterogeneity of Metabolic Response to Drought Stress in Medicago lupulina L. Leaves

  • Xinglin Wang,
  • Ning Lv,
  • Yuyun Xu,
  • Xingpan Meng,
  • Yukun Jin,
  • Hongbin Gao,
  • Fei Li,
  • Yin Yi,
  • Lunxian Liu and
  • Tie Shen

17 January 2026

Background: Drought stress is a primary environmental constraint limiting crop growth and productivity. Current drought-related plant research predominantly focuses on whole-leaf analyses, neglecting the spatial heterogeneity of metabolites within le...

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Metabolites - ISSN 2218-1989