2026 May - 70 articles
Mastication and swallowing are complex physiological processes involving the coordinated activity of multiple tissues in the oral cavity, facial region, and laryngeal system. Some detection methods suffer from limitations such as insufficient informa...
Although compression therapy is widely used to improve wound healing, selecting the appropriate pressure remains a challenge in clinical practice. This work proposes an intelligent patch integrated into a bandage that allows for the simultaneous moni...
Ascorbic acid (AA) or vitamin C is an important biomolecule that plays a crucial role in biological and physiological systems. Deficiency and/or excess of AA in the body can lead to severe diseases such as scurvy and gastrointestinal complications. T...
This study presents a rapid, eukaryotic impedimetric biosensor that applies the yeast Saccharomyces cerevisiae as a robust, cost-effective biorecognition element for monitoring the acute toxicity of two representative pharmaceuticals, naproxen and is...
Synthetic biology is reshaping in vitro diagnostics (IVD) by enabling programmable and modular biosensing elements that can be integrated into point-of-care testing (POCT) platforms. Compared with conventional assays that depend on fixed chemistries...
Continuous intraocular pressure (IOP) monitoring is crucial for glaucoma management. Currently, traditional static IOP measurements often fail to detect circadian fluctuations, leading to a clinical dilemma where “normal IOP” is observed...
Traditional taste evaluation relies heavily on manual sensory analysis, which is highly subjective and inefficient with poor cross-individual generalization, limiting its application in industrial flavor detection. To achieve accurate cross-subject t...
Exosomes are a kind of nanoscale extracellular vesicle secreted by almost all cell types and considered promising biomarkers for disease diagnosis since they could carry abundant proteins, nucleic acids, and lipids that reflect parental cell states....
Schistosomiasis, caused by Schistosoma species, is notoriously difficult to accurately diagnose with conventional methods. In this study, we present an innovative biosensor that integrates CRISPR–Cas12a technology with nucleic acid aptamers for...
Noble metal nanostructures based on localized surface plasmon resonance (LSPR) can induce metal-enhanced fluorescence (MEF) and surface-enhanced Raman scattering (SERS), significantly improving trace detection sensitivity for biomedical and chemical...
The low signal-to-noise ratio (SNR) of existing magnetic sensors limits the detection of magnetic nanoparticles (MNPs) in microfluidic biosensing. We present a novel microfluidic coil-based impedance detection system for quantifying magnetic particle...
Understanding cell migration is essential not only for fundamental biology but also for the development of targeted disease therapies. Traditional in vitro cell migration assays typically rely on optical microscopy to capture cell movements and subse...
Background: Algorithm-based insulin dosing systems are increasingly used in hospitals and have shown the potential to efficiently and safely enable glycemic control. The goal of this study was to evaluate glycemic control using the ultralong-acting b...
The abuse of γ-hydroxybutyric acid (GHB) and its precursors, γ-butyrolactone (GBL) and 1,4-butanediol (1,4-BD), has increased in recent years, with these substances frequently being illicitly added to beverages. GHB is colorless and odorl...
Chronic kidney disease (CKD) is a progressive and irreversible disorder affecting over 850 million individuals globally and is associated with significant morbidity, mortality, and healthcare burden. Conventional diagnostic approaches rely on intermi...
A semi-distributed interferometer is a low-reflectivity device with refractive index sensing capability, exploiting the random reflectivity of a nanoparticle-doped fiber to form a weak distributed cavity. In this work, we extend this concept to an ex...
Microwave imaging is a promising non-ionizing technique for bedside follow-up of intracranial hemorrhage, but dynamic monitoring remains challenging under limited multistatic sampling because weak inter-frame changes can be obscured by measurement va...
The precise spatiotemporal monitoring of dopamine is critical for understanding neurotransmission and neurodegenerative pathologies. While traditional electrochemical methods offer excellent temporal resolution, they lack the spatial resolution requi...
Osteoarthritis (OA) and osteochondral degeneration present a significant clinical burden characterized by the complex interplay of extracellular matrix degradation and chronic inflammation. While biochemical profiling has matured, a critical translat...
Bilirubin is an important biomarker, where a small unbound fraction dissociated from albumin can cross the blood–brain barrier and induce neurotoxicity, such as kernicterus, at low nanomolar levels. Accurate detection of this low-level fraction...
Invasive fungal respiratory infections (IFRIs) remain a major cause of morbidity and mortality among immunocompromised patients, yet diagnosis continues to be hindered by nonspecific clinical features, limited sample accessibility, and the poor sensi...
Covalent organic frameworks (COFs) are one of the most important crystalline structures, having high porosity, and are mostly composed of lighter elements, such as H, C, N, O, etc., with covalent bonds between them. They are chemically synthesized in...
The safety of genetically modified crops, particularly the commercial cultivation of glyphosate-resistant genetically modified soybeans, has given rise to significant public concern. Consequently, there is an urgent need to develop efficient and prec...
Ball resonator optical fiber sensors (OFSs) can offer multiparameter sensing capability, but their non-periodic and low-finesse reflection spectra make conventional spectral demodulation unreliable. This work proposes two sensor configurations: (i) a...
Sweat is a valuable biofluid for non-invasive health monitoring, as it contains electrolytes, metabolites, and organic compounds that can correlate with blood levels, making it highly attractive for wearable sensing. Building on advances in low-cost,...
Cost-effective, fluorescence-based biodiagnostic devices have the potential to expand point-of-care (POC) testing in resource-limited settings, thereby creating new opportunities for accessible and decentralised diagnostics. The objective of this stu...
Atrial fibrillation (AF) is a prevalent cardiac arrhythmia associated with an elevated risk of severe complications, including stroke and heart failure. Due to its paroxysmal nature and the inherent complexity of electrocardiogram (ECG) signals, deve...
Thyroxine (T4) is a key hormone regulating metabolic, cardiovascular, and neurodevelopmental processes, yet its clinical quantification still relies on centralized immunoassays that limit rapid or point-of-care monitoring. Here, we present a label-fr...
In this study, we present a novel microfluidic platform for tunable size-based particle separation within a straight microchannel using symmetrical viscoelastic sheath flows. The device incorporates two pairs of symmetrical microchannels for sheath f...
Spirometry is widely regarded as the clinical gold standard for quantifying lung function. It plays a central role in the diagnosis and management of cardiopulmonary disorders, including asthma and chronic obstructive pulmonary disease (COPD). Howeve...
Alzheimer’s disease (AD) seriously affects human health worldwide. Nicotinamide adenine dinucleotide (NADH) and glutamate are important biomarkers of AD, which play an indispensable role in the pathogenesis of AD. Herein, two ligands were used...
Accurate biomolecule quantification at ultralow concentrations remains a major challenge because conventional ensemble assays report population averaged signals and therefore lose sensitivity in low-abundance regimes. Single molecule fluorescence cou...
Decentralized diagnostics is undergoing a transformative shift from qualitative screening to high-precision quantification, driven by the clinical demand for rapid, point-of-care (POC) syndromic triage. Multiplexed lateral flow immunoassays (mLFIAs)...
Drinking behavior is an important parameter in laboratory animal experiments. Traditionally, the amount of fluid consumed is recorded manually by the experimenter, who weighs the bottle at predetermined timepoints to calculate the intake. This approa...
Rapid and accurate pathogen detection serves as a core component in infectious disease prevention and control, clinical diagnosis and treatment, and public health surveillance systems. Although traditional detection methods have been widely adopted i...
Psychosis presents significant treatment challenges, and standard Cognitive Behavioral Therapy for psychosis often faces limitations due to patient engagement issues and reliance on subjective self-reporting. The integration of Virtual Reality (VR),...
Metabolic heterogeneity within the cell microenvironment is a key driver of cancer progression and resistance to therapy. However, current approaches lack the spatial and temporal resolution required to capture its dynamics in living systems. While r...
The development of highly sensitive and reliable strategies for microcystin-LR (MC-LR) monitoring remains critical for environmental safety and public health protection. Herein, we report a metallene-enabled electrochemiluminescence (ECL) biosensing...
Phototherapy is a physical treatment modality that utilizes natural or artificial light sources and harnesses radiant energy to treat diseases. Dynamic monitoring of the actual light dose received by tissues is crucial to the success of phototherapy....
To address the issue of motion artifact interference faced by wearable ECG monitoring devices in dynamic environments, this paper proposes an adaptive motion artifact removal framework based on improved Variational Mode Decomposition (VMD). By design...
The overexpression of hypoxia-inducible factor-1α (HIF-1α) suppresses STING signaling and modulates lipid metabolism in tumor cells, leading to abnormal lipid droplet (LD) accumulation. Herein, we constructed a manganese dioxide (MnO2)-ba...
Seismocardiography (SCG) is a promising noninvasive modality for cardiovascular monitoring. By capturing subtle chest wall vibrations induced by the mechanical pumping activity of the heart at the body surface, SCG is of considerable value for blood...
Ciprofloxacin residues in chicken blood pose a potential food safety risk; however, rapid detection methods for complex chicken blood matrices are lacking. This study aimed to establish a surface-enhanced Raman spectroscopy (SERS) method for the rapi...
Differentiating Alzheimer’s disease (AD) from frontotemporal dementia (FTD) using resting-state electroencephalography (EEG) remains clinically challenging because of their overlapping electrophysiological characteristics. Although EEG suits la...
Biomarker detection demands low cost, rapid turnaround, interference resistance, and wide dynamic range. However, traditional immunoassays and nucleic acid amplification methods remain constrained by complex matrices, batch stability, and portability...
Accurate monitoring of respiratory rates is critical for early detection of a range of clinical conditions. However, standard manual counting or inadequate clinical monitoring often fails to provide reliable measurements. This study evaluated and val...
Dopamine (DA) is essential for motor control, motivation, and cognition, and its dysregulation is associated with neurological and psychiatric disorders such as Parkinson’s disease, schizophrenia, and addiction. Accurate and selective DA quanti...
Oral diseases remain highly prevalent worldwide and require early diagnosis and continuous monitoring to improve clinical outcomes. Conventional diagnostic methods are often invasive, time-consuming, and limited in their capacity for real-time assess...
A cell-based screening system for viral protease inhibitors was developed using firefly luciferase fragment complementation and validated on the SARS-CoV-2 3CLpro model. The optimal luciferase variant incorporating the VLQSGF proteolytic site (Luc II...
Saxitoxin (STX), produced by certain harmful algal bloom (HAB) species, bioaccumulates through the food chain and can cause paralytic toxicity in humans, potentially resulting in fatal outcomes. To date, STX detection has primarily been conducted und...
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