Biosensor-Integrated Drug Delivery Systems

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 20 October 2026 | Viewed by 1090

Special Issue Editor


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Guest Editor
Department of Bio and Fermentation Convergence Technology, Kookmin University, Seoul 02707, Republic of Korea
Interests: drug delivery; nanoparticle; stem cell; biosensors
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Special Issue Information

Dear Colleagues,

In recent years, the convergence of biosensing technology and drug delivery systems has emerged as a promising area of ​​biomedical research. While conventional biosensors enable the detection and quantification of biomarkers, physiological changes, or disease-related signals, drug delivery systems enable spatiotemporal control of therapeutic release. Combining these two fields can create responsive or smart platforms that detect biological events (or changing biomarkers) and deliver therapeutics accordingly. This integration can improve therapeutic accuracy, reduce side effects, enable personalized treatment, and enhance patient compliance.

Despite significant progress in each field individually, the convergence of biosensing and drug delivery still presents substantial challenges while also offering significant opportunities. These include sensor miniaturization and biocompatibility, carrier materials capable of releasing payloads in response to detection, robust signal transduction in physiological environments, safe and effective therapeutic release, system integration (electronics, microfluidics, micro/nanomaterials), in vivo reliability, regulatory and scalability issues, and translation to clinical applications.

This Special Issue invites research and review papers covering the full spectrum of this topic, including the design, fabrication, characterization, and application of integrated biosensor-drug delivery systems.

Dr. Hyeon-Yeol Cho
Guest Editor

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Keywords

  • biosensing
  • drug delivery
  • theranostics
  • nanocarriers
  • smart sensors
  • controlled release
  • real-time monitoring
  • microfluidics

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Published Papers (1 paper)

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Research

15 pages, 15395 KB  
Article
Development of a Sandwich-Type sxtA4 Electrochemical Biosensor for Proactive Environmental Monitoring of STX-Producing Microalgae
by Hyunjun Park, Seohee Kim, Minyoung Ju, Yunseon Han, Yoseph Seo, Junhong Min, Hyeon-Yeol Cho and Taek Lee
Biosensors 2026, 16(5), 252; https://doi.org/10.3390/bios16050252 - 30 Apr 2026
Viewed by 789
Abstract
Saxitoxin (STX), produced by certain harmful algal bloom (HAB) species, bioaccumulates through the food chain and can cause paralytic toxicity in humans, potentially resulting in fatal outcomes. To date, STX detection has primarily been conducted under laboratory-controlled conditions, and the availability of a [...] Read more.
Saxitoxin (STX), produced by certain harmful algal bloom (HAB) species, bioaccumulates through the food chain and can cause paralytic toxicity in humans, potentially resulting in fatal outcomes. To date, STX detection has primarily been conducted under laboratory-controlled conditions, and the availability of a gold-standard method for the proactive monitoring and prevention of HAB-induced secondary damage remains limited. Therefore, the present study introduces an electrochemical-based biosensor that is capable of early monitoring of STX in HAB-occurred environments. The conserved region of sxtA4, a nucleic acid precursor that is essential for STX biosynthesis, is immobilized on the sensing membrane surface in a sandwich structure. In this process, target detection is recognized as an electrochemical signal by a methylene blue-labeled detection probe, and the reliability of biosensing is supplemented by an electrochemical trend that is opposite to DNA binding. The application of an alternating current electrochemical flow technique achieves more sensitive detection at attomolar levels and rapid measurement within 10 min than a conventional DNA biosensor based on hybridization. In addition, the designed biosensing structure selectively detects STX-synthesizing and non-synthesizing dinoflagellates significantly. The proposed platform can utilize the identification of STX-induced secondary damage of HAB and provide insight into a field-ready biosensor based on its characterization and detection performance. Full article
(This article belongs to the Special Issue Biosensor-Integrated Drug Delivery Systems)
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