Biophysical Sensors for Biomedical/Health Monitoring Applications (2nd Edition)

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 2864

Special Issue Editor


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Guest Editor
Department of Electrical and Computer Engineering, Sungkyunkwan University, Seoul 16419, Republic of Korea
Interests: biophysical sensors; flexible microsystems; biomedical device; implantable electronics; bio-integrated electronics
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Special Issue Information

Dear Colleagues,

Engineering control over material forms and structures provides tissue-compliant, flexible, and stretchable classes of biophysical sensors and microsystems that facilitate both fundamental biological research and biomedical diagnosis. Examples of recent advanced systems combine theoretical and experimental efforts in materials (e.g., metals, semiconductors, carbon, and liquid metals) and sensory transduction (e.g., piezoresistance, acoustic waves, optics, and capacitance) for monitoring diverse biophysical signals (e.g., strain, pressure, ultrasound, temperature, and vibration). The complete systems are well configured for a range of applications, such as human health monitoring, robotic prosthesis control, acoustic-based care systems, and measuring activities inside the body. This Special Issue aims to highlight recent advanced biophysical sensors in such biocompatible configurations.

The scope of the Special Issue encompasses the following:

  • Unconventional biophysical sensor geometry and configuration;
  • Novel methodology and concepts for sensing biophysical signals (strain, pressure, ultrasound, temperature, etc.);
  • Theoretical study of sensor mechanics;
  • Biophysical sensors and systems for biomedical applications;
  • Novel methodology to process monitored biophysical datasets.

Dr. Sang Min Won
Guest Editor

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Keywords

  • biophysical sensor
  • flexible device
  • biointegrated electronics
  • stretchable microsystem
  • implantable electronics
  • biomedical device
  • health monitoring

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Published Papers (2 papers)

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Research

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13 pages, 1808 KiB  
Article
Prediction of Thrombus Formation within an Oxygenator via Bioimpedance Analysis
by Jan Korte, Tobias Lauwigi, Lisa Herzog, Alexander Theißen, Kai Suchorski, Lasse J. Strudthoff, Jannis Focke, Sebastian V. Jansen, Thomas Gries, Rolf Rossaint, Christian Bleilevens and Patrick Winnersbach
Biosensors 2024, 14(10), 511; https://doi.org/10.3390/bios14100511 - 18 Oct 2024
Viewed by 1623
Abstract
Blood clot formation inside the membrane oxygenator (MO) remains a risk in extracorporeal membrane oxygenation (ECMO). It is associated with thromboembolic complications and normally detectable only at an advanced stage. Established clinical monitoring techniques lack predictive capabilities, emphasizing the need for refinement in [...] Read more.
Blood clot formation inside the membrane oxygenator (MO) remains a risk in extracorporeal membrane oxygenation (ECMO). It is associated with thromboembolic complications and normally detectable only at an advanced stage. Established clinical monitoring techniques lack predictive capabilities, emphasizing the need for refinement in MO monitoring towards an early warning system. In this study, an MO was modified by integrating four sensor fibers in the middle of the hollow fiber mat bundle, allowing for bioimpedance measurement within the MO. The modified MO was perfused with human blood in an in vitro test circuit until fulminant clot formation. The optical analysis of clot residues on the extracted hollow fibers showed a clot deposition area of 51.88% ± 14.25%. This was detectable via an increased bioimpedance signal with a significant increase 5 min in advance to fulminant clot formation inside the MO, which was monitored by the clinical gold standard (pressure difference across the MO (dp-MO)). This study demonstrates the feasibility of detecting clot growth early and effectively by measuring bioimpedance within an MO using integrated sensor fibers. Thus, bioimpedance may even outperform the clinical gold standard of dp-MO as a monitoring method by providing earlier clot detection. Full article
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Review

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25 pages, 3044 KiB  
Review
Heavy Metal–Gut Microbiota Interactions: Probiotics Modulation and Biosensors Detection
by Liliana Anchidin-Norocel, Oana C. Iatcu, Andrei Lobiuc and Mihai Covasa
Biosensors 2025, 15(3), 188; https://doi.org/10.3390/bios15030188 - 14 Mar 2025
Viewed by 823
Abstract
This study provides a comprehensive analysis of the complex interaction between heavy metals (HMs) and the gut microbiota, adopting a bidirectional approach that explores both the influence of HMs on the gut microbiota populations and the potential role of probiotics in modulating these [...] Read more.
This study provides a comprehensive analysis of the complex interaction between heavy metals (HMs) and the gut microbiota, adopting a bidirectional approach that explores both the influence of HMs on the gut microbiota populations and the potential role of probiotics in modulating these changes. By examining these interconnected aspects, the study aims to offer a deeper understanding of how HMs disrupt microbial balance and how probiotic interventions may mitigate or reverse these effects, promoting detoxification processes and overall gut health. In addition, the review highlights innovative tools, such as biosensors, for the rapid, precise, and non-invasive detection of HMs in urine. These advanced technologies enable the real-time monitoring of the effectiveness of probiotic-based interventions, offering critical insights into their role in promoting the elimination of HMs from the body and improving detoxification. Full article
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