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Biosensors, Volume 15, Issue 4

April 2025 - 66 articles

Cover Story: The early and reliable detection of Alzheimer’s disease (AD) is crucial for effective treatment but is often limited by the economic and operational inaccessibility of current diagnostic methods. We address this challenge by presenting a disposable and cost-effectively produced stamp-imprinted polymer (SIP)-based biosensor targeting amyloid βeta-42(Aβ-42), a common biomarker of AD. Electrochemical impedance spectroscopy (EIS) confirmed the precise detection of Aβ-42 with a sensitivity comparable to antibody-/oligomer-based sensors, but at a fraction of the cost and with device stability at room temperature. We also confirmed the reusability of the SIP-EIS devices and the minimal interaction of serum albumin with the sensor architecture, establishing their suitability for testing real blood serum samples and showing promise for point-of-care use. View this paper
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Articles (66)

  • Article
  • Open Access
2 Citations
1,163 Views
10 Pages

Point-of-Care NSE Biosensor for Objective Assessment of Stroke Risk

  • Cheng Hsu Chen,
  • Erick Wang,
  • Tsung-Han Lee,
  • Cheng-Chieh Huang,
  • Chun-San Tai,
  • Yan-Ren Lin and
  • Wen-Liang Chen

20 April 2025

The rapid identification of stroke is critical to improving stroke patient outcomes. Existing protocols for assessing the risk of stroke are subjective and may be further complicated by nonspecific symptoms, increasing the risk of misdiagnosis. Neuro...

  • Article
  • Open Access
3 Citations
1,142 Views
16 Pages

20 April 2025

In the current study, the Prussian blue analog decorated with zinc oxide (PBA@ZnO) was produced using a simple chemical co-precipitation method. The nanohybrid was examined using XRD, EDX, SEM, and TEM techniques, where it exhibited a polycrystalline...

  • Article
  • Open Access
1 Citations
929 Views
11 Pages

Development of a Smartphone-Linked Immunosensing System for Oxytocin Determination

  • Miku Sarubo,
  • Yoka Suzuki,
  • Yuka Numazaki and
  • Hiroyuki Kudo

18 April 2025

We report an optical immunosensing system for oxytocin (OXT) based on image analysis of color reactions in an enzyme-linked immunosorbent assay (ELISA). We employed a miniaturized optical immunosensing unit that was functionally connected to an LED a...

  • Article
  • Open Access
3,093 Views
15 Pages

Distinct Neural Activities in Hippocampal Subregions Revealed Using a High-Performance Wireless Microsystem with PtNPs/PEDOT:PSS-Enhanced Microelectrode Arrays

  • Peiyao Jiao,
  • Qianli Jia,
  • Shuqi Li,
  • Jin Shan,
  • Wei Xu,
  • Yu Wang,
  • Yu Liu,
  • Mingchuan Wang,
  • Yilin Song and
  • Yulian Zhang
  • + 3 authors

18 April 2025

Wireless microsystems for neural signal recording have emerged as a solution to overcome the limitations of tethered systems, which restrict the mobility of subjects and introduce noise interference. However, existing microsystems often face data thr...

  • Review
  • Open Access
1,269 Views
16 Pages

Challenges of Using Whole-Cell Bioreporter for Assessment of Heavy Metal Bioavailability in Soil/Sediment

  • Shanshan Bai,
  • Zhipeng Liu,
  • Jiazhi Xu,
  • Yongshuo Li,
  • Zirun Zhang,
  • Zefeng Huang,
  • Williamson Gustave,
  • Boling Li,
  • Xiaokai Zhang and
  • Feng He

18 April 2025

Soil and sediment contamination with heavy metals (HMs) is a critical environmental issue, posing significant risks to both ecosystems and human health. Whole-cell bioreporter (WCB) technology offers a promising alternative to traditional detection t...

  • Article
  • Open Access
1 Citations
1,524 Views
15 Pages

Achievement of 15-Minute Adaptive PCR Benchmark with 1370 nm Laser Heating

  • Nicholas Spurlock,
  • Rosana Alfaro,
  • William E. Gabella,
  • Kunal Chugh,
  • Megan E. Pask,
  • Franz Baudenbacher and
  • Frederick R. Haselton

17 April 2025

In low-resource and point-of-care settings, traditional PCR often faces challenges of poor sample preparation, adverse environmental conditions, and long assay times. We have previously described a laboratory-based instrument to achieve “adapti...

  • Article
  • Open Access
1 Citations
1,695 Views
16 Pages

17 April 2025

To enhance wrist impairment rehabilitation efficiency, self-rehabilitation training using healthy-side forearm sEMG was introduced, improving patient engagement and proprioception. A sEMG-based movement recognition and muscle force estimation algorit...

  • Review
  • Open Access
4 Citations
3,541 Views
24 Pages

Innovative Methodologies for the Early Detection of Breast Cancer: A Review Categorized by Target Biological Samples

  • Antonella Grasso,
  • Vittorio Altomare,
  • Giulia Fiorini,
  • Alessandro Zompanti,
  • Giorgio Pennazza and
  • Marco Santonico

17 April 2025

Innovative biosensor technologies are revolutionizing cancer detection by offering non-invasive, sensitive, and rapid diagnostic tools, addressing the limitations of conventional screening. Non-invasive samples like breath, saliva, urine, and sweat,...

  • Article
  • Open Access
1 Citations
1,321 Views
21 Pages

16 April 2025

This study seeks to develop and implement a non-enzymatic fluorescent labeling for immunoassay and immunochromatographic assay (ICAs) targeting SARS-CoV-2, to meet the extensive interest and need for effective COVID-19 diagnosis. In this manuscript,...

  • Article
  • Open Access
5 Citations
3,766 Views
27 Pages

Diabetes: Non-Invasive Blood Glucose Monitoring Using Federated Learning with Biosensor Signals

  • Narmatha Chellamani,
  • Saleh Ali Albelwi,
  • Manimurugan Shanmuganathan,
  • Palanisamy Amirthalingam and
  • Anand Paul

16 April 2025

Diabetes is a growing global health concern, affecting millions and leading to severe complications if not properly managed. The primary challenge in diabetes management is maintaining blood glucose levels (BGLs) within a safe range to prevent compli...

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Biosensors - ISSN 2079-6374