2025 April - 66 articles
The rapid identification of stroke is critical to improving stroke patient outcomes. Existing protocols for assessing the risk of stroke are subjective and may be further complicated by nonspecific symptoms, increasing the risk of misdiagnosis. Neuro...
In the current study, the Prussian blue analog decorated with zinc oxide (PBA@ZnO) was produced using a simple chemical co-precipitation method. The nanohybrid was examined using XRD, EDX, SEM, and TEM techniques, where it exhibited a polycrystalline...
We report an optical immunosensing system for oxytocin (OXT) based on image analysis of color reactions in an enzyme-linked immunosorbent assay (ELISA). We employed a miniaturized optical immunosensing unit that was functionally connected to an LED a...
Wireless microsystems for neural signal recording have emerged as a solution to overcome the limitations of tethered systems, which restrict the mobility of subjects and introduce noise interference. However, existing microsystems often face data thr...
Soil and sediment contamination with heavy metals (HMs) is a critical environmental issue, posing significant risks to both ecosystems and human health. Whole-cell bioreporter (WCB) technology offers a promising alternative to traditional detection t...
In low-resource and point-of-care settings, traditional PCR often faces challenges of poor sample preparation, adverse environmental conditions, and long assay times. We have previously described a laboratory-based instrument to achieve “adapti...
To enhance wrist impairment rehabilitation efficiency, self-rehabilitation training using healthy-side forearm sEMG was introduced, improving patient engagement and proprioception. A sEMG-based movement recognition and muscle force estimation algorit...
Innovative biosensor technologies are revolutionizing cancer detection by offering non-invasive, sensitive, and rapid diagnostic tools, addressing the limitations of conventional screening. Non-invasive samples like breath, saliva, urine, and sweat,...
This study seeks to develop and implement a non-enzymatic fluorescent labeling for immunoassay and immunochromatographic assay (ICAs) targeting SARS-CoV-2, to meet the extensive interest and need for effective COVID-19 diagnosis. In this manuscript,...
Diabetes is a growing global health concern, affecting millions and leading to severe complications if not properly managed. The primary challenge in diabetes management is maintaining blood glucose levels (BGLs) within a safe range to prevent compli...
Noninvasive blood glucose monitoring is crucial for diabetes management, and photoacoustic spectroscopy (PAS) offers a promising solution by detecting glucose levels through human skin. However, weak acoustic signals in PAS systems require optimized...
The growing burden of degenerative, cardiovascular, neurodegenerative, and cancerous diseases necessitates innovative approaches to improve our pathophysiological understanding and ability to modulate biological processes. Organic bioelectronics has...
Antibiotics can accumulate in the body via ingestion, presenting serious health and safety risks to humans, and have garnered extensive international attention in recent years. Meanwhile, aptamers have been applied in the detection of antibiotics, ma...
The production of advanced therapy medicinal products (ATMP) is a long and highly technical process, resulting in a high cost per dose, which reduces the number of eligible patients. There is a critical need for a closed and sample-free monitoring sy...
This paper introduces a novel-shaped, compact, multiband monopole antenna sensor incorporating an irregular curved split-ring resonator (SRR) design for non-invasive, continuous monitoring of human blood glucose levels (BGL). The sensor operates at m...
Amperometric biosensors (ABSs) and enzymatic biofuel cells (BFCs) share several fundamental principles in their functionality, despite serving different primary purposes. Both devices rely on biorecognition, redox reactions, electron transfer (ET), a...
von Willebrand factor (vWF) is a large glycoprotein in the circulation system, which senses hydrodynamic force at vascular injuries and then recruits platelets in assembling clots. How vWF mechanosenses shear flow for molecular unfolding is an import...
The measurement of electrical potentials in the human body is becoming increasingly important in healthcare as a valuable diagnostic parameter. In ophthalmology, while these signals are primarily used to assess retinal function, other applications, s...
Background/Objectives: In this study, AuDNs/EPLE composite electrodes with hierarchical dendritic nanogold structures were fabricated using the in situ electrodeposition of gold nanoparticles through the i-t method. Methods: A conductive polymer comp...
Surface plasmon resonance (SPR) aptasensors benefit from the SPR phenomenon in measuring aptamer interactions with specific targets. Integrating aptamers into SPR detection enables extensive applications in clinical analysis. Specifically, virus apta...
Molecular analyses of individual cells with high resolution, specificity, and sensitivity can not only reveal cellular heterogeneity but also provide a better understanding of diseases and accelerate drug discoveries. Single-cell endoscopy is an adva...
With the gradual maturation of optically pumped magnetometer (OPM) technology, the use of OPMs to acquire weak magnetocardiography (MCG) signals has started to gain widespread application. Due to the complexity of magnetic environments, MCG signals a...
Brain aging is a complex process regulated by genetic, environmental, and metabolic factors, and increasing evidence suggests that environmental pollutants can significantly accelerate this process by interfering with oxidative stress, neuroinflammat...
Optical microfiber biosensors demonstrate exceptionally ultra-high sensitivity at the dispersion turning point (DTP). However, the DTP is highly susceptible to variations in dimensional and external environmental factors, and the spectral response is...
Aging and poor sleep quality are associated with altered brain dynamics, yet current electroencephalography (EEG) analyses often overlook regional complexity. This study addresses this gap by introducing a novel integration of intra- and inter-region...
Interleukin-12 (IL-12), a crucial biomarker for immune and inflammatory responses, plays a pivotal role in diagnosing and managing diverse pathological conditions. Although colorimetric enzyme-linked immunosorbent assays (CELISAs) have been extensive...
MicroRNAs (miRNAs), which circulate in the serum and plasma, play a role in several biological processes, and their levels in body fluids are associated with the pathogenesis of various diseases, including different types of cancer. For this reason,...
Being a leading cause of death, heart diseases across the globe need special attention to enable early diagnosis. Metal nanoparticle-mediated biosensors are useful clinical tools for the early detection of bio-analytes. The size-dependent surface pla...
Dengue is a neglected disease mainly affecting tropical and subtropical countries. The diagnosis of dengue fever is still a problem since most of it is made from whole or recombinant DENV proteins, which present cross-reactions with other members of...
In this study, an electrochemical non-enzymatic glucose sensor based on cobalt oxide was developed using a simple chemical bath deposition method. The as-synthesized material exhibited no significant sensitivity; the latter emerged only after subsequ...
In the original publication [...]
Changes in microRNA (miRNA) levels are closely associated with the pathological processes of many diseases. The sensitive and fast detection of miRNAs is critical for diagnosis and prognosis. Here, we report a platform employing CRISPR/Cas12a to reco...
In the 21st century, the demographic shift toward an aging population has posed a significant challenge, particularly with respect to age-related diseases, which constitute a major threat to human health. Accordingly, the detection, prevention, and t...
Disease diagnosis is not only related to individual health but is also a crucial part of public health prevention. Electrochemical biosensors combine the high sensitivity of electrochemical methods with the inherent high selectivity of biological com...
CRISPR/Cas-based diagnostics offer unparalleled specificity, but their reliance on fluorescently labeled probes and complex nucleic acid extraction limits field applicability. To tackle this problem, we have developed a label-free, equipment-free pla...
Lateral flow tests (LFTs) had a pivotal role in combating the spread of the SARS-CoV-2 virus throughout the COVID-19 pandemic thanks to their affordability and ease of use. Most of LFT devices were based on nitrocellulose membrane strips whose indust...
Surface-imprinted polymers (SIPs) represent an exciting and cost-effective alternative to antibodies for electrochemical impedance spectroscopy (EIS)-based biosensing. They can be produced using simple printing techniques and have shown high efficacy...
Doping undermines fairness in sports and threatens athlete health, while conventional detection methods like LC-MS and GC-MS face challenges such as complex procedures, matrix interferences, and lengthy processing times, limiting on-site applications...
In this study, a RGB based ternary-emission molecularly imprinted ratiometric fluorescence (MI-RFL) sensor was facilely constructed by using a post-imprinting mixing strategy for the sensitive detection of enrofloxacin (ENR). Upon excitation at 365 n...
Analyzing metabolite levels in bodily fluids is essential for disease diagnosis and surveillance. Electrochemical biosensors are ideal for monitoring metabolite levels due to their high sensitivity, rapid response, and low cost. The magnetic microbea...
In this study, we present a proof-of-concept neuroelectronic interface (NEI) for extracellular stimulation and recording of neurophysiological activity in spiral ganglion neurons (SGNs) cultured in vitro on three-dimensional, micro-patterned substrat...
Herein, we proposed a versatile G-quadruplex (G4)-tetrahedral DNA framework (G4-TDF) nanostructure functionalized origami microfluidic paper-based device (μPADs) for fluorescence detection of K+ by lighting up thioflavin T (ThT). In this work, TDF...
The growing demand for real-time, non-invasive, and cost-effective health monitoring has driven significant advancements in portable point-of-care testing (POCT) devices. Among these, optical biosensors have emerged as promising tools for the detecti...
Transcription factor-based biosensors (TFBs) are powerful tools in microbial biosensor applications, enabling dynamic control of metabolic pathways, real-time monitoring of intracellular metabolites, and high-throughput screening (HTS) for strain eng...
Circulating tumor cells (CTCs) are vital indicators of metastasis and provide a non-invasive method for early cancer diagnosis, prognosis, and therapeutic monitoring. However, their low prevalence and heterogeneity in the bloodstream pose significant...
Blood coagulation tests are crucial in the clinical management of cardiovascular diseases and preoperative diagnostics. However, the widespread adoption of existing detection devices, such as thromboelastography (TEG) instruments, is hindered by thei...
Enzymatic biofuel cells (EBFCs) have emerged as a transformative solution in the quest for sustainable energy, offering a biocatalyst-driven alternative for powering wearable and implantable self-powered biosensors. These systems harness renewable en...
Recent advancements in nanomechanical microcantilever biosensors open new possibilities for clinical applications, permitting precise analysis of molecular interactions. The technology enables tracking gene expression, molecular conformational change...
Animal-derived foods constitute a crucial source of nutrients for humans. The judicious application of steroid hormones in the breeding process can serve multiple purposes, including growth promotion, weight gain, and anti-inflammatory effects, among...
Freestanding electrode designs, cost-effective catalysts, and enhanced electrical conductivity are crucial for improving the performance of fourth-generation non-enzymatic glucose electrochemical sensors. These factors enable more efficient, scalable...
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