Implantable, Wireless Biosensors and Biodevices for Neuroscience Research, 2nd Edition

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 215

Special Issue Editors


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Guest Editor
Institutes of Brain Science, Fudan University, Shanghai, China
Interests: neurobiology
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Center for Biomedical Engineering, Brown University, Providence, RI, USA
Interests: neuroengineering, neuromotor disease, neuroprosthetics, responsive neuromodulation, spinal cord injury
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
School of Biomedical Engineering, Hainan University, Haikou, China
Interests: wireless implantable biomedical sensors; neural recording; stimulation systems; implantable neural interfaces; brain-computer interfaces

Special Issue Information

Dear Colleagues,

With the rapidly increasing promise of cutting-edge neuroscience research to achieve translational success, biosensing and neuromodulation technologies have seen rapid and significant innovation. Among the key innovations driving new research and future therapies is the development of implantable, wireless tools to interact with the nervous system. Implantable systems enable proximal access to biological signal sources and offer high spatial and temporal signal resolution with unmatchable quality compared with other modalities. Additionally, cellular-level optical functional imaging can further help dissect neural circuits using recordings from genetically targeted neuronal types. These systems, however, present significant technological challenges, such as miniaturization, biocompatibility, high-speed yet low-power data communication, wireless power transfer, and hermeticity—challenges that continue to inspire biosensor researchers to use multi-disciplinary knowledge to push the limits of the field.

This Special Issue will gather advances highlighting novel device development and original work in the area of implantable biosensors and biodevices for neuroscience research. Topics of interest include, but are not limited to, implantable microsystems for biosensing; multichannel electrical, optical, or chemical electrodes and sensors; bio-interrogation devices; wireless power and data transfer for implantable neurosensors and modulators; low-power and miniaturized electronics for neural data processing; and cutting-edge applications of the aforementioned techniques.

Prof. Dr. Jiayi Zhang
Dr. David A. Borton
Prof. Dr. Ming Yin
Guest Editors

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Keywords

  • implantable
  • wireless
  • neurosensing
  • neuromodulation
  • biodevices
  • low power
  • biocompatibility
  • bidirectional interfaces

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Published Papers (1 paper)

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Research

15 pages, 3266 KiB  
Article
Distinct Neural Activities in Hippocampal Subregions Revealed Using a High-Performance Wireless Microsystem with PtNPs/PEDOT:PSS-Enhanced Microelectrode Arrays
by Peiyao Jiao, Qianli Jia, Shuqi Li, Jin Shan, Wei Xu, Yu Wang, Yu Liu, Mingchuan Wang, Yilin Song, Yulian Zhang, Yanbing Yu, Mixia Wang and Xinxia Cai
Biosensors 2025, 15(4), 262; https://doi.org/10.3390/bios15040262 - 18 Apr 2025
Viewed by 203
Abstract
Wireless microsystems for neural signal recording have emerged as a solution to overcome the limitations of tethered systems, which restrict the mobility of subjects and introduce noise interference. However, existing microsystems often face data throughput, signal processing, and long-distance wireless transmission challenges. This [...] Read more.
Wireless microsystems for neural signal recording have emerged as a solution to overcome the limitations of tethered systems, which restrict the mobility of subjects and introduce noise interference. However, existing microsystems often face data throughput, signal processing, and long-distance wireless transmission challenges. This study presents a high-performance wireless microsystem capable of 32-channel, 30 kHz real-time recording, featuring Field Programmable Gate Array (FPGA)-based signal processing to reduce transmission load. The microsystem is integrated with platinum nanoparticles/poly (3,4-ethylenedioxythiophene) polystyrene sulfonate-enhanced microelectrode arrays for improved signal quality. A custom NeuroWireless platform was developed for seamless data reception and storage. Experimental validation in rats demonstrated the microsystem’s ability to detect spikes and local field potentials from the hippocampal CA1 and CA2 subregions. Comparative analysis of the neural signals revealed distinct activity patterns between these subregions. The wireless microsystem achieves high accuracy and throughput over distances up to 30 m, demonstrating its resilience and potential for neuroscience research. This work provides a compact, adaptable solution for multi-channel neural signal detection and offers a foundation for future applications in brain–computer interfaces. Full article
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