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Biosensors
Special Issues
Innovative Strategies for Cancer Biosensing
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Innovative Strategies for Cancer Biosensing

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 4530

Special Issue Editors

Dr. Carlos Torres-Torres

E-Mail Website
Guest Editor
Laboratory of Optics, Instituto Politécnico Nacional, Mexico City 07738, Mexico
Interests: optics; nonlinear optics; interferometry; spectroscopy; biosensors; instrumentation of biosignals; biophotonics; nanotechnology; signal processing; artificial intelligence
Special Issues, Collections and Topics in MDPI journals
Dr. Blanca Estela García-Pérez

E-Mail Website
Guest Editor
Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City 11340, Mexico
Interests: biosensors; biosignals; confocal microscopy; plasmonics; fluorescence; nanosciences; microbiology; virology; immunology; authophagy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue entitled “Innovative Strategies for Cancer Biosensing” is devoted to describing the progress in technological tools and original methods for cancer biosensing. Cancer is capable of transforming biological functions, which can transform living cells into dead cells. The identification and prediction of processes involved in cancer at an early stage represents a major challenge for scientific research. The impact of advanced biosensors for detecting and diagnosing different cancer phenomena is key to improving the quality of life of cancer patients. In this direction, achieving fundamental aspects for cancer biosensing is crucial. Original or review papers related to the study of this important topic of cancer biosensing, including limitations and advantages are welcome to provide promising opportunities for diagnosis and treatments as a basis for future research.

Dr. Carlos Torres-Torres
Dr. Blanca Estela García-Pérez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer
  • cell biology
  • biosensors
  • biosignals
  • instrumentation systems
  • signal processing
  • nanoscale effects
  • immunology

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Published Papers (4 papers)

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Research

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11 pages, 4041 KiB  
Article
High-Precision Field- Effect Transistor Biosensor for Analyzing Differential Effects of Anti-Cancer Drugs on Cancerous and Non-Cancerous Cells
by Can Li, Can Hu, Ling Li, Feng He and Xiaofei Li
Biosensors 2025, 15(2), 125; https://doi.org/10.3390/bios15020125 - 19 Feb 2025
Viewed by 486
Abstract
A high-precision biosensor technique is introduced, offering the capability to independently evaluate the effects of anti-cancer drugs on both cancerous (RAJI) and non-cancerous (WIL2S) cells. By analyzing and fitting current change curves and transfer characteristic curves under two drugs, camptothecin and doxorubicin, this [...] Read more.
A high-precision biosensor technique is introduced, offering the capability to independently evaluate the effects of anti-cancer drugs on both cancerous (RAJI) and non-cancerous (WIL2S) cells. By analyzing and fitting current change curves and transfer characteristic curves under two drugs, camptothecin and doxorubicin, this technique quantifies both the magnitude of drug-induced current changes in cells and the rate of drug entry into cells. Flow cytometry was utilized to validate the entry rates of two drugs, camptothecin and doxorubicin, into the cells. The biosensor leverages the exceptional sensitivity of two-dimensional electron gas to detect proximal charge variations at ultralow concentrations, even in fluids with high ionic strength. The findings reveal that anti-cancer drugs have a more pronounced impact on tumor cells, with the effects and interaction speeds differing across normal cells and tumor cells. This innovative approach not only enhances our understanding of the specificity and action mechanisms of anti-cancer drugs but also provides a valuable tool for screening potential tumor anti-cancer drugs and advancing targeted cancer therapies. Full article
(This article belongs to the Special Issue Innovative Strategies for Cancer Biosensing)
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15 pages, 4445 KiB  
Article
Automated Uniform Spheroid Generation Platform for High Throughput Drug Screening Process
by Kelvin C. C. Pong, Yuen Sze Lai, Roy Chi Hang Wong, Alan Chun Kit Lee, Sam C. T. Chow, Jonathan C. W. Lam, Ho Pui Ho and Clarence T. T. Wong
Biosensors 2024, 14(8), 392; https://doi.org/10.3390/bios14080392 - 15 Aug 2024
Viewed by 1701
Abstract
Three-dimensional (3D) spheroid models are crucial for cancer research, offering more accurate insights into tumour biology and drug responses than traditional 2D cell cultures. However, inconsistent and low-throughput spheroid production has hindered their application in drug screening. Here, we present an automated high-throughput [...] Read more.
Three-dimensional (3D) spheroid models are crucial for cancer research, offering more accurate insights into tumour biology and drug responses than traditional 2D cell cultures. However, inconsistent and low-throughput spheroid production has hindered their application in drug screening. Here, we present an automated high-throughput platform for a spheroid selection, fabrication, and sorting system (SFSS) to produce uniform gelatine-encapsulated spheroids (GESs) with high efficiency. SFSS integrates advanced imaging, analysis, photo-triggered fabrication, and microfluidic sorting to precisely control spheroid size, shape, and viability. Our data demonstrate that our SFSS can produce over 50 GESs with consistent size and circularity in 30 min with over 97% sorting accuracy while maintaining cell viability and structural integrity. We demonstrated that the GESs can be used for drug screening and potentially for various assays. Thus, the SFSS could significantly enhance the efficiency of generating uniform spheroids, facilitating their application in drug development to investigate complex biological systems and drug responses in a more physiologically relevant context. Full article
(This article belongs to the Special Issue Innovative Strategies for Cancer Biosensing)
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Review

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24 pages, 1661 KiB  
Review
Innovative Methodologies for the Early Detection of Breast Cancer: A Review Categorized by Target Biological Samples
by Antonella Grasso, Vittorio Altomare, Giulia Fiorini, Alessandro Zompanti, Giorgio Pennazza and Marco Santonico
Biosensors 2025, 15(4), 257; https://doi.org/10.3390/bios15040257 - 17 Apr 2025
Viewed by 191
Abstract
Innovative biosensor technologies are revolutionizing cancer detection by offering non-invasive, sensitive, and rapid diagnostic tools, addressing the limitations of conventional screening. Non-invasive samples like breath, saliva, urine, and sweat, analyzed using advanced technologies like electronic nose systems and AI, show promise for early [...] Read more.
Innovative biosensor technologies are revolutionizing cancer detection by offering non-invasive, sensitive, and rapid diagnostic tools, addressing the limitations of conventional screening. Non-invasive samples like breath, saliva, urine, and sweat, analyzed using advanced technologies like electronic nose systems and AI, show promise for early detection and frequent monitoring, though validation is needed. AI integration enhances data analysis and personalization. While blood-based methods remain the gold standard, combining them with less invasive sample types like saliva or sweat, and using sensitive techniques, is a promising direction. Conventional methods (mammography, MRI, etc.) offer proven efficacy, but are costly and invasive. Innovative methods using biosensors offer reduced infrastructure needs, lower costs, and patient-friendly sampling. However, challenges remain in validation, standardization, and low biomarker concentrations. Integrating both methodologies could create a comprehensive framework, combining reliability with accessibility. Future research should focus on robust biosensor development, standardization, expanding application to other cancers, exploring less-studied samples like sweat, and improving affordability for wider adoption, especially in resource-limited settings. The future lies in integrating diverse approaches for more sensitive, specific, and patient-friendly screening, improving early detection and outcomes. Full article
(This article belongs to the Special Issue Innovative Strategies for Cancer Biosensing)
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28 pages, 2193 KiB  
Review
Recent Advances in SAW Sensors for Detection of Cancer Biomarkers
by Manuel Aleixandre and Mari Carmen Horrillo
Biosensors 2025, 15(2), 88; https://doi.org/10.3390/bios15020088 - 5 Feb 2025
Viewed by 1839
Abstract
Surface acoustic wave (SAW) sensor technology is a promising approach to diagnosing cancer through the detection of cancer biomarkers due to its high sensitivity, potential label-free operation, and fast response times, and, fundamentally, because it is a non-invasive technique in comparison with the [...] Read more.
Surface acoustic wave (SAW) sensor technology is a promising approach to diagnosing cancer through the detection of cancer biomarkers due to its high sensitivity, potential label-free operation, and fast response times, and, fundamentally, because it is a non-invasive technique in comparison with the current traditional diagnostic techniques for cancer. This review focuses on this application, and for this purpose, the recent literature on cancer biomarkers detected by this advanced technology has been compiled, including that on volatile organic compounds (VOCs) from exhaled breath and larger biomolecules such as proteins, DNA, and microRNAs in body fluids, which demonstrates its great versatility. The conventional techniques for cancer biomarker detection in biofluids, such as ELISA, PCR, SPR, and UV absorbance, exhibit limitations including high costs, slow response times, a reduced sensitivity, the need for specialized instrumentation, and the requirement for highly trained personnel. Different SAW sensor configurations are discussed with attention paid to their specific properties, wave propagation modes, and suitability for different environments. Detailed studies are reviewed, highlighting biomarkers for lung, colorectal, prostate, breast, and ovarian cancer diagnostics, as well as the detection of circulating tumor cells and cancerous cell growth. This review identifies current challenges, including optimizing sensitivity, addressing environmental interferences, and the need for clinical validation. Finally, future research directions are proposed, emphasizing the use of VOC biomarkers and the integration of SAW technology into hybrid systems and microfluidic platforms to enable the creation of scalable, non-invasive diagnostic tools for the detection of cancer in early stages, and, in this way, to minimize the morbidity and mortality associated with this disease. Full article
(This article belongs to the Special Issue Innovative Strategies for Cancer Biosensing)
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