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Biosensors
Special Issues
Bioelectronics and Biosensors Using Novel Metal-Oxide and Semiconductor Materials
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Bioelectronics and Biosensors Using Novel Metal-Oxide and Semiconductor Materials

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 15 October 2025 | Viewed by 4026

Special Issue Editor

Dr. Ateet Dutt

E-Mail Website
Guest Editor
Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México (UNAM), Circuito Exterior s/n. C.U., Mexico City 04510, Mexico
Interests: optical biosensors; silicon; nanowires; ZnO; material science; optics; luminescence; solar cells; CVD; spectroscopy

Special Issue Information

Dear Colleagues,

This Special Issue focuses on cutting-edge biosensors that use novel metal oxide and semiconductor materials to detect microorganisms and related diseases. Advances in microfluidics, nanofluidics, IoT, machine learning, and artificial intelligence have made biosensors more accessible, affordable, and efficient for patient diagnosis. The integration of AI is propelling the design and implementation of next-generation biosensors, presenting both exciting opportunities and unique challenges. Additionally, innovations in bioreceptor technology, such as molecular imprinting, are becoming key drivers of biosensor development. We invite contributions of original research, reviews, and expert perspectives to enhance this collection and advance the field of biosensing, with topics of interest including, but not limited to, the following topics:

  • Novel Materials: Synthesis and characterization of new metal oxide or semiconductor materials for biosensors or bioelectronic applications;
  • Device Design and Fabrication: Innovative fabrication techniques for biosensors and bioelectronics and innovative techniques, like IoT and AI, combined with biosensors and bioelectronics.
  • Biosensing Mechanisms: Mechanistic studies on the interaction of biomolecules with metal oxide and semiconductor materials.
  • Applications: Clinical applications of bioelectronics and biosensors disease diagnosis and monitoring; environmental monitoring; and food safety applications utilizing novel materials.

Dr. Ateet Dutt
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensors
  • pathogens
  • biomarkers
  • analytes
  • IoMT
  • AI
  • transducer
  • POC
  • MIP
  • wearable sensors
  • optical
  • electrochemical

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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13 pages, 3000 KiB  
Article
The Effect of GO Flake Size on Field-Effect Transistor (FET)-Based Biosensor Performance for Detection of Ions and PACAP 38
by Seungjun Lee, Jongdeok Park, Jaeyoon Song, Jae-Joon Lee and Jinsik Kim
Biosensors 2025, 15(2), 86; https://doi.org/10.3390/bios15020086 - 5 Feb 2025
Cited by 1 | Viewed by 804
Abstract
The performance development of rGO-FET biosensors by analyzing the influence of GO flake size on biosensing efficacy. GO flakes of varying sizes, from 1 µm to 20 µm, were prepared under controlled conditions, followed by characterization through SEM and XPS to evaluate their [...] Read more.
The performance development of rGO-FET biosensors by analyzing the influence of GO flake size on biosensing efficacy. GO flakes of varying sizes, from 1 µm to 20 µm, were prepared under controlled conditions, followed by characterization through SEM and XPS to evaluate their size, surface area, and C/O ratio. The biosensing performance was systematically assessed by rGO-FET biosensors, examining the effects of GO flake size, C/O ratio, and film thickness. PACAP38 was employed as a biomarker for receptor-mediated detection, while chlorine ions served as model analytes for receptor-free small molecule detection. The results indicate that decreasing the GO flake size enhanced the performance for both target biomolecules. These findings highlight the crucial importance of selecting GO flake sizes specific to target analytes and detection strategies, thereby optimizing biosensor efficiency. Full article
(This article belongs to the Special Issue Bioelectronics and Biosensors Using Novel Metal-Oxide and Semiconductor Materials)
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14 pages, 3204 KiB  
Article
Role of en-APTAS Membranes in Enhancing the NO2 Gas-Sensing Characteristics of Carbon Nanotube/ZnO-Based Memristor Gas Sensors
by Ibtisam Ahmad, Mohsin Ali and Hee-Dong Kim
Biosensors 2024, 14(12), 635; https://doi.org/10.3390/bios14120635 - 20 Dec 2024
Cited by 3 | Viewed by 953
Abstract
NO2 is a toxic gas that can damage the lungs with prolonged exposure and contribute to health conditions, such as asthma in children. Detecting NO2 is therefore crucial for maintaining a healthy environment. Carbon nanotubes (CNTs) are promising materials for NO [...] Read more.
NO2 is a toxic gas that can damage the lungs with prolonged exposure and contribute to health conditions, such as asthma in children. Detecting NO2 is therefore crucial for maintaining a healthy environment. Carbon nanotubes (CNTs) are promising materials for NO2 gas sensors due to their excellent electronic properties and high adsorption energy for NO2 molecules. However, conventional CNT-based sensors face challenges, including low responses at room temperature (RT) and slow recovery times. This study introduces a memristor-based NO2 gas sensor comprising CNT/ZnO/ITO decorated with an N-[3-(trimethoxysilyl)propyl] ethylene diamine (en-APTAS) membrane to enhance room-temperature-sensing performance. The amine groups in the en-APTAS membrane increase adsorption sites and boost charge transfer interactions between NO2 and the CNT surface. This modification improves the sensor’s response by 60% at 20 ppm compared to the undecorated counterpart. However, the high adsorption energy of NO2 slows the recovery process. To overcome this, a pulse-recovery method was implemented, applying a −2.5 V pulse with a 1 ms width, enabling the sensor to return to its baseline within 1 ms. These findings highlight the effectiveness of en-APTAS decoration and pulse-recovery techniques in improving the sensitivity, response, and recovery of CNT-based gas sensors. Full article
(This article belongs to the Special Issue Bioelectronics and Biosensors Using Novel Metal-Oxide and Semiconductor Materials)
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Review

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46 pages, 3258 KiB  
Review
Organic Bioelectronics in Microphysiological Systems: Bridging the Gap Between Biological Systems and Electronic Technologies
by Pauline Coquart, Andrea El Haddad, Dimitrios A. Koutsouras and Johanna Bolander
Biosensors 2025, 15(4), 253; https://doi.org/10.3390/bios15040253 - 16 Apr 2025
Viewed by 1100
Abstract
The growing burden of degenerative, cardiovascular, neurodegenerative, and cancerous diseases necessitates innovative approaches to improve our pathophysiological understanding and ability to modulate biological processes. Organic bioelectronics has emerged as a powerful tool in this pursuit, offering a unique ability to interact with biology [...] Read more.
The growing burden of degenerative, cardiovascular, neurodegenerative, and cancerous diseases necessitates innovative approaches to improve our pathophysiological understanding and ability to modulate biological processes. Organic bioelectronics has emerged as a powerful tool in this pursuit, offering a unique ability to interact with biology due to the mixed ionic–electronic conduction and tissue-mimetic mechanical properties of conducting polymers (CPs). These materials enable seamless integration with biological systems across different levels of complexity, from monolayers to complex 3D models, microfluidic chips, and even clinical applications. CPs can be processed into diverse formats, including thin films, hydrogels, 3D scaffolds, and electrospun fibers, allowing the fabrication of advanced bioelectronic devices such as multi-electrode arrays, transistors (EGOFETs, OECTs), ion pumps, and photoactuators. This review examines the integration of CP-based bioelectronics in vivo and in in vitro microphysiological systems, focusing on their ability to monitor key biological events, including electrical activity, metabolic changes, and biomarker concentrations, as well as their potential for electrical, mechanical, and chemical stimulation. We highlight the versatility and biocompatibility of CPs and their role in advancing personalized medicine and regenerative therapies and discuss future directions for organic bioelectronics to bridge the gap between biological systems and electronic technologies. Full article
(This article belongs to the Special Issue Bioelectronics and Biosensors Using Novel Metal-Oxide and Semiconductor Materials)
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