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Biosensors
Special Issues
Nanosensors for Bioanalysis
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Nanosensors for Bioanalysis

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 980

Special Issue Editors

Dr. Shuo Yin

E-Mail Website
Guest Editor
Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794, USA
Interests: single-cell spatical omics; biosensors; DNA nanotechnology
Dr. Zunliang Wang

E-Mail Website
Guest Editor
State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China
Interests: biosensors; PCR

Special Issue Information

Dear Colleagues,

Nanosensors integrate sensor recognition elements with advanced nanomaterials, making them powerful tools in bioanalysis. By utilizing the unique properties of nanomaterials, nanosensors enable the precise detection of biological targets. As the demand for more efficient, rapid, accurate, and sensitive analytical techniques grows, the role of nanosensors in bioanalysis continues to expand, driving significant advancements in both research and clinical practices.

We are pleased to invite you to contribute to our Special Issue, "Nanosensors for Bioanalysis". This Special Issue aims to present and highlight a collection of high-quality articles that explore the novel methodologies, developments, and applications of nanosensors in bioanalytical chemistry. Original research articles and reviews are both welcome in this Special Issue. Potential research areas may include (but are not limited to) the following:

  • Development of novel nanosensors for drug, metabolite, protein, nucleic acid, and other biomolecule detection in various biological matrices;
  • Emerging nanomaterial preparation, characterization, and applications in bioanalysis;
  • Applications of nanosensors in clinical diagnostics, disease biomarker detection, and Point-of-Care testing (POCT);
  • Integration of microchips/microfluidics and nanosensors for advanced bioanalysis;
  • Innovations in DNA/RNA nanotechnologies for sensing detection;
  • Advances, challenges, and future trends in nanosensors for bioanalysis.

I look forward to receiving your valuable contributions to this Special Issue and advancing bioanalytical nanosensor research together.

Dr. Shuo Yin
Dr. Zunliang Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanosensor
  • bioanalysis
  • nanotechnology
  • nanofabrication
  • biosensor
  • diagnosis
  • clinical analysis

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Published Papers (2 papers)

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Research

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15 pages, 3378 KiB  
Article
Dendritic Gold Nanoparticles Loaded on 3D Graphene-like Surface and Layer-by-Layer Assembly for Enhanced Glucose Biosensing
by Zifeng Zhu, Yiming Zhao, Yongming Ruan, Xuexiang Weng and Gesmi Milcovich
Biosensors 2025, 15(4), 246; https://doi.org/10.3390/bios15040246 - 12 Apr 2025
Viewed by 268
Abstract
Background/Objectives: In this study, AuDNs/EPLE composite electrodes with hierarchical dendritic nanogold structures were fabricated using the in situ electrodeposition of gold nanoparticles through the i-t method. Methods: A conductive polymer composite membrane, PEDOT, was synthesized via the electropolymerization of EDOT and [...] Read more.
Background/Objectives: In this study, AuDNs/EPLE composite electrodes with hierarchical dendritic nanogold structures were fabricated using the in situ electrodeposition of gold nanoparticles through the i-t method. Methods: A conductive polymer composite membrane, PEDOT, was synthesized via the electropolymerization of EDOT and the negatively charged PSS−. The negatively charged SO3− groups on the surface of the PEDOT membrane were electrostatically adsorbed with the glucose oxidase (GOD) enzyme and a positively charged chitosan co-solution (GOD/chit+). Using a layer-by-layer self-assembly approach, GOD was incorporated into the multilayers of the composite electrode to create the composite GOD/chit+/PEDOT/AuDNs/EPLE. Results: Electrochemical analysis revealed a GOD surface coverage of 8.5 × 10−10 mol cm−2 and an electron transfer rate of 1.394 ± 0.02 s−1. The composite electrode exhibited a linear response to glucose in the concentration range of 6.923 × 10−2 mM to 1.54 mM, with an apparent Michaelis constant of 0.352 ± 0.02 mM. Furthermore, the GOD/chit+/PEDOT/AuDNs/EPLE also showed good accuracy of glucose determination in human serum samples. Conclusions: These findings highlight the potential of the GOD/chit+/PEDOT/AuDNs/EPLE composite electrode in the development of efficient enzymatic biofuel cells for glucose sensing and energy harvesting applications. Full article
(This article belongs to the Special Issue Nanosensors for Bioanalysis)
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Review

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26 pages, 7293 KiB  
Review
Advances in Virus Biorecognition and Detection Techniques for the Surveillance and Prevention of Infectious Diseases
by Shuwen Luo, Lihong Yin, Xiaohui Liu and Xuemei Wang
Biosensors 2025, 15(3), 198; https://doi.org/10.3390/bios15030198 - 20 Mar 2025
Viewed by 542
Abstract
Viral infectious diseases pose a serious threat to global public health due to their high transmissibility, rapid mutation rates, and limited treatment options. Recent outbreaks of diseases such as plague, monkeypox, avian influenza, and coronavirus disease 2019 (COVID-19) have underscored the urgent need [...] Read more.
Viral infectious diseases pose a serious threat to global public health due to their high transmissibility, rapid mutation rates, and limited treatment options. Recent outbreaks of diseases such as plague, monkeypox, avian influenza, and coronavirus disease 2019 (COVID-19) have underscored the urgent need for efficient diagnostic and surveillance technologies. Focusing on viral infectious diseases that seriously threaten human health, this review summarizes and analyzes detection techniques from the perspective of combining viral surveillance and prevention advice, and discusses applications in improving diagnostic sensitivity and specificity. One of the major innovations of this review is the systematic integration of advanced biorecognition and detection technologies, such as bionanosensors, rapid detection test strips, and microfluidic platforms, along with the exploration of artificial intelligence in virus detection. These technologies address the limitations of traditional methods and enable the real-time monitoring and early warning of viral outbreaks. By analyzing the application of these technologies in the detection of pathogens, new insights are provided for the development of next-generation diagnostic tools to address emerging and re-emerging viral threats. In addition, we analyze the current progress of developed vaccines, combining virus surveillance with vaccine research to provide new ideas for future viral disease prevention and control and vaccine development, and call for global attention and the development of new disease prevention and detection technologies. Full article
(This article belongs to the Special Issue Nanosensors for Bioanalysis)
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