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Biosensors
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Nanomaterial-Enhanced Biosensing for Point-of-Care Diagnostics
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Nanomaterial-Enhanced Biosensing for Point-of-Care Diagnostics

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 4705

Special Issue Editors

Dr. Pramod Gupta

E-Mail Website
Guest Editor
Fraunhofer USA Center Midwest, East Lansing, MI, USA
Interests: nanomaterials; nanozymes (enzyme mimics); nano-bio interfaces; electrochemical; colorimetric; fluorometric; photothermal assays/immunoassays for point-of-care diagnostics
Dr. Prabir Kumar Kulabhusan

E-Mail Website
Guest Editor
INL-International Iberian Nanotechnology Laboratory, Braga, Portugal
Interests: nanobioscience; diagnostics; antibody engineering; biosensor; aptamer; SELEX
Dr. Debasis Maity

E-Mail Website
Guest Editor
Department of Biosystems Science and Engineering, ETH Zürich, Zürich, Switzerland
Interests: wearable sensor; flexible sensor; bio fuel; gas sensor; biosensor

Special Issue Information

Dear Colleagues,

The rapid development of nanotechnology has significantly advanced the field of biosensing, enabling the creation of highly sensitive and rapid diagnostic tools that are essential for point-of-care (POC) applications. This Special Issue is dedicated to exploring the latest breakthroughs in nanomaterial-enhanced biosensing technologies, with a focus on their practical applications in POC diagnostics. These advancements have the potential to revolutionize healthcare by providing timely, cost-effective, and reliable diagnostic solutions that improve patient outcomes.

Scope and Objectives:

This Special Issue aims to gather cutting-edge research and reviews on the integration of nanomaterials, such as nanoparticles, nanowires, and nanosheets, into biosensing platforms. These materials are known for their unique properties, including enhanced sensitivity, specificity, and speed in detecting biomarkers at ultra-low concentrations. The ultimate goal of this Special Issue is to showcase the current state of the art in this field and explore the potential ability of these technologies to transform POC diagnostics.

Key Topics:

Researchers and experts are invited to submit original research articles, comprehensive reviews, and case studies on a range of topics that include, but are not limited to, the following:

  • Novel Nanomaterials: The development and characterization of innovative nanomaterials for enhanced biosensing.
  • Biosensing Platforms: The integration of nanomaterials with optical, electrochemical, and microfluidic systems for enhanced diagnostics.
  • Point-Of-Care Devices: The design of portable, user-friendly diagnostic devices for real-time, on-site testing.
  • Applications: Case studies on clinical and environmental uses of nanomaterial-enhanced biosensors.
  • Challenges and Future Directions: Addressing commercialization, regulatory challenges, and comparisons with traditional diagnostics.

Aim:

This Special Issue aims to provide a comprehensive overview of the advancements in nanomaterial-enhanced biosensing and their implications for POC diagnostics. By collating the work of leading researchers and practitioners, this Special Issue seeks to foster collaboration, inspire innovative approaches, and drive the development of next-generation POC biosensors that are more sensitive, rapid, and accessible to all.

Dr. Pramod Gupta
Dr. Prabir Kumar Kulabhusan
Dr. Debasis Maity
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • biosensing
  • point-of-care diagnostics
  • nanoparticles
  • microfluidics
  • clinical applications
  • electrochemical sensors
  • lab-on-a-chip
  • portable devices
  • early diagnosis

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (4 papers)

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Research

13 pages, 3781 KiB  
Article
Nanoparticulate Copper Cluster-Mediated Biosensing of Cardiac Biomolecular Markers
by Lakshmi V. Nair, Jarred Wheeler, Yaelyn Ha, Kimberly M. Jones, Jesse Jones and Vinoy Thomas
Biosensors 2025, 15(4), 237; https://doi.org/10.3390/bios15040237 - 8 Apr 2025
Viewed by 288
Abstract
Being a leading cause of death, heart diseases across the globe need special attention to enable early diagnosis. Metal nanoparticle-mediated biosensors are useful clinical tools for the early detection of bio-analytes. The size-dependent surface plasmon resonance (SPR) of metal nanoparticles can be effectively [...] Read more.
Being a leading cause of death, heart diseases across the globe need special attention to enable early diagnosis. Metal nanoparticle-mediated biosensors are useful clinical tools for the early detection of bio-analytes. The size-dependent surface plasmon resonance (SPR) of metal nanoparticles can be effectively utilized for the same purpose. The early detection of heart diseases can be evaluated by monitoring the troponin level. A copper nanoparticle-mediated troponin biosensor was developed through antibody conjugation for troponin I and troponin T. The copper nanosensor shows a concentration-dependent SPR change towards troponin T and troponin I. Full article
(This article belongs to the Special Issue Nanomaterial-Enhanced Biosensing for Point-of-Care Diagnostics)
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18 pages, 6126 KiB  
Article
Development and Optimization of a Cost-Effective Electrochemical Immunosensor for Rapid COVID-19 Diagnosis
by Thaís Machado Lima, Daiane Martins Leal, Zirlane Coelho Ferreira, Fernando de Jesus Souza, Danilo Bretas de Oliveira, Etel Rocha-Vieira, Helen Rodrigues Martins, Arnaldo César Pereira and Lucas Franco Ferreira
Biosensors 2025, 15(2), 67; https://doi.org/10.3390/bios15020067 - 22 Jan 2025
Viewed by 1512
Abstract
The coronavirus disease (COVID-19) pandemic has created an urgent need for rapid, accurate, and cost-effective diagnostic tools. In this study, an economical electrochemical immunosensor for the rapid diagnosis of COVID-19 was developed and optimized based on charge transfer resistance (Rct) values obtained by [...] Read more.
The coronavirus disease (COVID-19) pandemic has created an urgent need for rapid, accurate, and cost-effective diagnostic tools. In this study, an economical electrochemical immunosensor for the rapid diagnosis of COVID-19 was developed and optimized based on charge transfer resistance (Rct) values obtained by electrochemical impedance spectroscopy (EIS) from the interaction between antibodies (anti-SARS-CoV-2) immobilized as a bioreceptor and the virus (SARS-CoV-2). The sensor uses modified pencil graphite electrodes (PGE) coated with poly(4-hydroxybenzoic acid), anti-SARS-CoV-2, and silver nanoparticles. The immobilization of anti-SARS-CoV-2 antibodies was optimized at a concentration of 1:250 for 30 min, followed by blocking the surface with 0.01% bovine serum albumin for 10 min. The optimal conditions for virus detection in clinical samples were a 1:10 dilution with a response time of 20 min. The immunosensor responded linearly in the range of 0.2–2.5 × 106 particles/μL. From the relationship between the obtained signal and the concentration of the analyzed sample, the limit of detection (LOD) and limit of quantification (LOQ) obtained were 1.21 × 106 and 4.04 × 106 particles/μL, respectively. The device did not cross-react with other viruses, including Influenza A and B, HIV, and Vaccinia virus. The relative standard deviation (RSD) of the six immunosensors prepared using the shared-pool sample was 3.87. Decreases of 22.3% and 12.4% were observed in the response values of the ten immunosensors stored at 25 °C and 4.0 °C, respectively. The sensor provides timely and accurate results with high sensitivity and specificity, offering a cost-effective alternative to the existing diagnostic methods. Full article
(This article belongs to the Special Issue Nanomaterial-Enhanced Biosensing for Point-of-Care Diagnostics)
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15 pages, 4798 KiB  
Article
Carboxylated Graphene: An Innovative Approach to Enhanced IgA-SARS-CoV-2 Electrochemical Biosensing
by Luciana de Souza Freire, Ariamna María Dip Gandarilla, Yonny Romaguera Barcelay, Camila Macena Ruzo, Barbara Batista Salgado, Ana P. M. Tavares, Francisco Xavier Nobre, Julio Nino de Souza Neto, Spartaco Astolfi-Filho, Ștefan Țălu, Pritesh Lalwani, Niranjan Patra and Walter Ricardo Brito
Biosensors 2025, 15(1), 34; https://doi.org/10.3390/bios15010034 - 9 Jan 2025
Viewed by 942
Abstract
Biosensors harness biological materials as receptors linked to transducers, enabling the capture and transformation of primary biorecognition signals into measurable outputs. This study presents a novel carboxylation method for synthesizing carboxylated graphene (CG) under acidic conditions, enhancing biosensing capabilities. The characterization of the [...] Read more.
Biosensors harness biological materials as receptors linked to transducers, enabling the capture and transformation of primary biorecognition signals into measurable outputs. This study presents a novel carboxylation method for synthesizing carboxylated graphene (CG) under acidic conditions, enhancing biosensing capabilities. The characterization of the CG was performed using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), Raman spectroscopy, thermogravimetric analysis (TGA), and X-ray diffraction (XRD). We modified screen-printed carbon electrodes (SPCEs) with CG to immobilize the SARS-CoV-2 N-protein, facilitating targeted detection of IgA antibodies (IgA-SARS-CoV-2). The analytical performance was assessed via electrochemical techniques such as cyclic voltammetry and electrochemical impedance spectroscopy, confirming CG synthesis effectiveness and biosensor functionality. The developed biosensor efficiently detects IgA-SARS-CoV-2 across a dilution range of 1:1000 to 1:200 v/v in a phosphate-buffered saline (PBS) solution, with a limit of detection calculated at 1:1601 v/v. This device shows considerable potential because of its fast response time, miniaturized design facilitated by SPCEs, reduced sample volume requirements, high sensitivity and specificity, low detection limits, and signal enhancement achieved through nanomaterial integration. Full article
(This article belongs to the Special Issue Nanomaterial-Enhanced Biosensing for Point-of-Care Diagnostics)
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15 pages, 3817 KiB  
Article
β-Cyclodextrin Functionalized Au@Ag Core-Shell Nanoparticles: Plasmonic Sensors for Cysteamine and Efficient Nanocatalysts for Nitrobenzene-to-Aniline Conversion
by Ramar Rajamanikandan, Kandasamy Sasikumar and Heongkyu Ju
Biosensors 2024, 14(11), 544; https://doi.org/10.3390/bios14110544 - 9 Nov 2024
Cited by 2 | Viewed by 1510
Abstract
We reported the gold/silver core-shell nanoparticles (Aucore@Agshell NPs) functionalized with β-cyclodextrin (β-CD) as versatile nano-agents demonstrated for human urine-based biosensing of cysteamine and catalytic conversion from nitrobenzene (NB) to aniline. First, the hybrid bimetallic nanoparticles, i.e., β-CD-Aucore@Agshell [...] Read more.
We reported the gold/silver core-shell nanoparticles (Aucore@Agshell NPs) functionalized with β-cyclodextrin (β-CD) as versatile nano-agents demonstrated for human urine-based biosensing of cysteamine and catalytic conversion from nitrobenzene (NB) to aniline. First, the hybrid bimetallic nanoparticles, i.e., β-CD-Aucore@Agshell NPs, constituted a colorimetric sensing platform based on localized surface plasmons, enabling cysteamine (Cyst) to be detected in a remarkably rapid manner, i.e., within 2 min, which was greatly shortened in comparison with that of our previous report. This was due largely to use of β-CD being effectively replaceable by Cyst. The detection of Cyst was demonstrated using human urine specimens in the linear range of 25–750 nM with a limit of detection of 1.83 nM. Excellent specificity in detecting Cyst was also demonstrated against potential interfering molecules. Meanwhile, the β-CD-Aucore@Agshell NPs were demonstrated as nanocatalysts for converting NB to aniline with efficiency enhanced by more than three-fold over the pure gold nanoparticles previously reported, due to the dual functions of the structural core-shell. The demonstrated versatile features of the hybrid nanoparticles can find applications in human urine-based biosensors for Cyst detection, and in the screening of Cyst-containing drugs, while detoxicating NB for ecological protection in aqueous media. Full article
(This article belongs to the Special Issue Nanomaterial-Enhanced Biosensing for Point-of-Care Diagnostics)
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