Nanomaterials, Volume 14, Issue 24
2024 December-2 - 79 articles
Cover Story: In this report, we describe the action of pleozymes, pleiotropic nanoparticles that facilitate multiple chemical reactions, on the blend of metabolic fuels used in cells. Pleozymes hold potential in correcting metabolic diseases by enhancing metabolic flexibility. By oxidizing NADH, pleozymes increase the consumption of fatty acids, which increases the production of ATP and lactate, a useful metabolic fuel in the brain through a malate-mediated pathway. Moreover, despite consuming NADH, NADH is also produced through this system. The metabolic shift created by pleozymes is part of regulating the larger molecular machine of cellular metabolism. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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