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Nanomaterials
Special Issues
Design and Applications of Protein/Peptide Nanomaterials
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Design and Applications of Protein/Peptide Nanomaterials

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 20 June 2025 | Viewed by 2631

Special Issue Editors

Dr. Yongchun Liu

E-Mail Website
Guest Editor
Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710119 China
Interests: nanomaterials; interface; biomineralization; anti-fouling; amyloid-like assemble; nanofilm
Dr. Hao Su

E-Mail Website
Guest Editor
State Key Laboratory for Crop Stress Resistance and High-Efficiency Production, College of Chemistry & Pharmacy, Northwest Agriculture & Forestry University, Yangling 712100, China
Interests: protein; amyloid-like aggregation; surface/interface; green agriculture; agrochemicals; nanomaterials

Special Issue Information

Dear Colleagues,

Protein-/peptide-based nanomaterials are gaining attention for their biocompatibility, self-assembly, and adaptability, making them ideal for applications in biomedicine, environmental science, agriculture, and energy. As demand for sustainable materials grows, research in this field is driving transformative solutions in healthcare, environmental sustainability, green agriculture, renewable energy, and so on.

We are pleased to invite you to contribute to this Special Issue, which will cover a broad array of topics related to the design, synthesis, and multifaceted applications of protein/peptide nanomaterials. This Special Issue will highlight pioneering methodologies, explore unique material properties, and delve into their potential implementations in diverse fields.

This Special Issue aims to explore the latest breakthroughs and emerging trends in protein/peptide nanomaterials, providing comprehensive insights into their future applications and development.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Synthesis and design of protein/peptide nanomaterials;
  • Functionalization and modification techniques;
  • Biomedical applications;
  • Renewable energy;
  • Green agriculture;
  • Biosensing and diagnostic applications;
  • Environmental and industrial applications;
  • Catalytic properties and applications.

We look forward to receiving your contributions.

Dr. Yongchun Liu
Dr. Hao Su
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • protein
  • peptide
  • self-assembly
  • nanostructures
  • biomimetic
  • green agriculture
  • renewable energy
  • drug delivery
  • biosensing
  • catalysis

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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21 pages, 5851 KiB  
Article
A Janus Amyloid-like Nanofilm Inhibits Colorectal Cancer Postoperative Recurrence and Abdominal Adhesion via Synergistic Enzyme Cascade
by Man Zhang, Junhao Kou, Zhenyi Song, Ling Qiu, Chunzhao Yang and Qi Xue
Nanomaterials 2025, 15(9), 670; https://doi.org/10.3390/nano15090670 (registering DOI) - 28 Apr 2025
Viewed by 30
Abstract
Postoperative peritoneal adhesion and high recurrence rates are critical challenges in the clinical treatment of colorectal cancer. In this study, based on amyloid-like protein self-assembly technology, a novel Janus protein film was developed. The protein film encapsulates glucose oxidase (GOx) and catalase (CAT), [...] Read more.
Postoperative peritoneal adhesion and high recurrence rates are critical challenges in the clinical treatment of colorectal cancer. In this study, based on amyloid-like protein self-assembly technology, a novel Janus protein film was developed. The protein film encapsulates glucose oxidase (GOx) and catalase (CAT), which is named PTL@GC. Through a one-step method involving cysteine-reduced lysozyme-induced amyloid-like self-assembly, the film was co-loaded with GOx and CAT to achieve synergistic anti-adhesion and anti-tumor recurrence effects. The Janus film features a hydrophobic side that stably adheres to the intestinal surface without exogenous chemical modification and a hydrophilic side that prevents adhesion. The loaded GOx selectively induces disulfidptosis in SLC7A11-overexpressing tumor cells, while CAT degrades H2O2 to alleviate hypoxia and inhibit oxidative stress, significantly reducing adhesion-related fibrosis. The experimental results demonstrate that PTL@GC exhibited excellent mechanical properties, high enzyme activity retention (>90%), and controllable degradability (complete metabolism within 50 days). In animal models, PTL@GC reduced postoperative adhesion area by 22.77%, decreased local tumor burden to 28.42% of the control group, and achieved an inhibition rate of 58.49%, without inducing systemic toxicity. This study presents a biologically safe and functionally synergistic approach to addressing dual complications following colorectal cancer surgery, offering potential insights for future research on multifunctional Janus materials. Full article
(This article belongs to the Special Issue Design and Applications of Protein/Peptide Nanomaterials)
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Review

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37 pages, 5579 KiB  
Review
Progress in the Development of Flexible Devices Utilizing Protein Nanomaterials
by Chunhong Zhang, Chenxi Zhang and Yongchun Liu
Nanomaterials 2025, 15(5), 367; https://doi.org/10.3390/nano15050367 - 27 Feb 2025
Viewed by 644
Abstract
Flexible devices are soft, lightweight, and portable, making them suitable for large-area applications. These features significantly expand the scope of electronic devices and demonstrate their unique value in various fields, including smart wearable devices, medical and health monitoring, human–computer interaction, and brain–computer interfaces. [...] Read more.
Flexible devices are soft, lightweight, and portable, making them suitable for large-area applications. These features significantly expand the scope of electronic devices and demonstrate their unique value in various fields, including smart wearable devices, medical and health monitoring, human–computer interaction, and brain–computer interfaces. Protein materials, due to their unique molecular structure, biological properties, sustainability, self-assembly ability, and good biocompatibility, can be applied in electronic devices to significantly enhance the sensitivity, stability, mechanical strength, energy density, and conductivity of the devices. Protein-based flexible devices have become an important research direction in the fields of bioelectronics and smart wearables, providing new material support for the development of more environmentally friendly and reliable flexible electronics. Currently, many proteins, such as silk fibroin, collagen, ferritin, and so on, have been used in biosensors, memristors, energy storage devices, and power generation devices. Therefore, in this paper, we provide an overview of related research in the field of protein-based flexible devices, including the concept and characteristics of protein-based flexible devices, fabrication materials, fabrication processes, characterization, and evaluation, and we point out the future development direction of protein-based flexible devices. Full article
(This article belongs to the Special Issue Design and Applications of Protein/Peptide Nanomaterials)
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31 pages, 2715 KiB  
Review
Lactoferrin as a Versatile Agent in Nanoparticle Applications: From Therapeutics to Agriculture
by Emir Akdaşçi, Furkan Eker, Hatice Duman, Priyanka Singh, Mikhael Bechelany and Sercan Karav
Nanomaterials 2024, 14(24), 2018; https://doi.org/10.3390/nano14242018 - 16 Dec 2024
Cited by 2 | Viewed by 1607
Abstract
Nanoparticles (NPs) have emerged as a potent choice for various applications, from drug delivery to agricultural studies, serving as an alternative and promising methodology for future advancements. They have been widely explored in delivery systems, demonstrating immense promise and high efficiency for the [...] Read more.
Nanoparticles (NPs) have emerged as a potent choice for various applications, from drug delivery to agricultural studies, serving as an alternative and promising methodology for future advancements. They have been widely explored in delivery systems, demonstrating immense promise and high efficiency for the delivery of numerous biomolecules such as proteins and anticancer agents, either solely or modified with other compounds to enhance their capabilities. In addition, the utilization of NPs extends to antimicrobial studies, where they are used to develop novel antibacterial, antifungal, and antiviral formulations with advanced characteristics. Lactoferrin (Lf) is a glycoprotein recognized for its significant multifunctional properties, such as antimicrobial, antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. Its activity has a broad distribution in the human body, with Lf receptors present in multiple regions. Current research shows that Lf is utilized in NP technology as a surface material, encapsulated biomolecule, and even as an NP itself. Due to the abundance of Lf receptors in various regions, Lf can be employed as a surface material in NPs for targeted delivery strategies, particularly in crossing the BBB and targeting specific cancers. Furthermore, Lf can be synthesized in an NP structure, positioning it as a strong candidate in future NP-related applications. In this article, we explore the highlighted and underexplored areas of Lf applications in NPs research. Full article
(This article belongs to the Special Issue Design and Applications of Protein/Peptide Nanomaterials)
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