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Journal of Clinical Medicine, Volume 12, Issue 5

2023 March-1 - 377 articles

Cover Story: Mutational activation of the epidermal growth factor receptor (EGFR) is a frequent event in non-small cell lung cancer (NSCLC) that contributes to malignant growth. These bona fide driver mutations are important therapeutic targets. While on-target mutations that prevent EGFR inhibitor (EGFRi) binding are a frequent complication, mutational activation of bypass pathways can occur as well. Therapeutic intervention is complicated by an additional duality of resistance mechanisms that are not only mutational but can also include a significant amount of nonmutational activation. Thus, precision medicine takes center stage in defining therapeutic intervention and future drug development. To overcome resistance, we must arrive at therapeutics to encompass both genetic and nongenetic mechanisms. View this paper
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Articles (377)

  • Opinion
  • Open Access
12 Citations
4,476 Views
11 Pages

Low- vs. High-Power Laser for Holmium Laser Enucleation of Prostate

  • Vasileios Gkolezakis,
  • Bhaskar Kumar Somani and
  • Theodoros Tokas

6 March 2023

Holmium laser enucleation of the prostate (HoLEP) constitutes an established technique for treating patients with symptomatic bladder outlet obstruction. Most surgeons perform surgeries using high-power (HP) settings. Nevertheless, HP laser machines...

  • Article
  • Open Access
2 Citations
2,405 Views
6 Pages

6 March 2023

Background: We have previously reported that the incidence of postoperative conduction disorders, especially left bundle branch block (LBBB), after implantation of a rapid deployment Intuity™ Elite aortic valve prosthesis (Edwards Lifesciences,...

  • Review
  • Open Access
14 Citations
4,146 Views
15 Pages

Antiplatelet Strategies for Older Patients with Acute Coronary Syndromes: Finding Directions in a Low-Evidence Field

  • Stefano De Servi,
  • Antonio Landi,
  • Stefano Savonitto,
  • Nuccia Morici,
  • Leonardo De Luca,
  • Claudio Montalto,
  • Gabriele Crimi,
  • Roberta De Rosa and
  • Giuseppe De Luca

6 March 2023

Patients ≥ 75 years of age account for about one third of hospitalizations for acute coronary syndromes (ACS). Since the latest European Society of Cardiology guidelines recommend that older ACS patients use the same diagnostic and interventional...

  • Article
  • Open Access
7 Citations
6,409 Views
18 Pages

Brace-Free Rehabilitation after Isolated Anterior Cruciate Ligament Reconstruction with Hamstring Tendon Autograft Is Not Inferior to Brace-Based Rehabilitation—A Randomised Controlled Trial

  • Christian Schoepp,
  • Tobias Ohmann,
  • Wolfgang Martin,
  • Arthur Praetorius,
  • Christine Seelmann,
  • Marcel Dudda,
  • Dirk Stengel and
  • Jakob Hax

6 March 2023

Purpose: The postoperative use of a rehabilitative knee brace after isolated primary anterior cruciate ligament (ACL) reconstruction (ACLR) using a hamstring tendon (HT) autograft is controversial. A knee brace may provide subjective safety but can c...

  • Article
  • Open Access
3 Citations
6,502 Views
10 Pages

Surgically Treated pT2aN0M0 (Stage IB) Non-Small Cell Lung Cancer: A 20-Year Single-Center Retrospective Study

  • Monica Casiraghi,
  • Francesco Petrella,
  • Claudia Bardoni,
  • Shehab Mohamed,
  • Giulia Sedda,
  • Juliana Guarize,
  • Antonio Passaro,
  • Filippo De Marinis,
  • Patrick Maisonneuve and
  • Lorenzo Spaggiari

6 March 2023

Introduction The suitability of adjuvant therapy (AT) in patients with stage IB non-small cell lung cancer (NSCLC) is still under debate considering the cost–benefit ratio between improvement in survival and side effects. We retrospectively eva...

  • Article
  • Open Access
2,538 Views
14 Pages

Qualification of Hemophilia Treatment Centers to Enable Multi-Center Studies of Gene Expression Signatures in Blood Cells from Pediatric Patients

  • Birgit M. Reipert,
  • Christoph J. Hofbauer,
  • Bagirath Gangadharan,
  • Verena Berg,
  • Elizabeth Donnachie,
  • Shannon Meeks,
  • Maria Elisa Mancuso,
  • Joel Bowen and
  • Deborah L. Brown

6 March 2023

Hemophilia A is a rare congenital bleeding disorder caused by a deficiency of functionally active coagulation factor VIII (FVIII). Most patients with the severe form of the disease require FVIII replacement therapies, which are often associated with ...

  • Article
  • Open Access
5 Citations
4,515 Views
21 Pages

Sleep Quality Disturbances Are Associated with White Matter Alterations in Veterans with Post-Traumatic Stress Disorder and Mild Traumatic Brain Injury

  • Philine Rojczyk,
  • Johanna Seitz-Holland,
  • Elisabeth Kaufmann,
  • Valerie J. Sydnor,
  • Cara L. Kim,
  • Lisa F. Umminger,
  • Tim L. T. Wiegand,
  • Jeffrey P. Guenette,
  • Fan Zhang and
  • Inga K. Koerte
  • + 11 authors

6 March 2023

Sleep disturbances are strongly associated with mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD). PTSD and mTBI have been linked to alterations in white matter (WM) microstructure, but whether poor sleep quality has a comp...

  • Article
  • Open Access
4 Citations
2,520 Views
10 Pages

Quality of Life after Transcatheter Aortic Valve Replacement in Sarcopenic Patients Using the Toronto Aortic Stenosis Quality of Life Questionnaire

  • Gabriele Pesarini,
  • Alessandro Ruzzarin,
  • Matteo Bonatti,
  • Felix Pescoller,
  • Patrick Engl,
  • Rainer Oberhollenzer,
  • Flavio Luciano Ribichini and
  • Luca Donazzan

6 March 2023

Background: Sarcopenia is the core component of frailty; however, its role in patients undergoing transcatheter aortic valve replacement (TAVR) is a matter of debate. The Toronto Aortic Stenosis Quality of Life Questionnaire (TASQ) is a validated ins...

  • Article
  • Open Access
5 Citations
1,792 Views
9 Pages

Gender-Related Outcomes after Surgical Resection and Level of Satisfaction in Patients with Left Atrial Tumors

  • Viyan Sido,
  • Annika Volkwein,
  • Martin Hartrumpf,
  • Christian Braun,
  • Ralf-Uwe Kühnel,
  • Roya Ostovar,
  • Filip Schröter,
  • Sofia Chopsonidou and
  • Johannes Maximilian Albes

6 March 2023

Background: Cardiac tumors are rare, with a low incidence of between 0.0017 and 0.19%. The majority of cardiac tumors are benign and predominantly occur in females. The aim of our study was to examine how outcomes differ between men and women. Method...

  • Article
  • Open Access
10 Citations
4,568 Views
11 Pages

Perimount MAGNA Ease vs. INSPIRIS Resilia Valve: A PS-Matched Analysis of the Hemodynamic Performances in Patients below 70 Years of Age

  • Alessandra Francica,
  • Filippo Tonelli,
  • Cecilia Rossetti,
  • Antonella Galeone,
  • Fabiola Perrone,
  • Giovanni Battista Luciani and
  • Francesco Onorati

6 March 2023

Background: During the past decade, the Perimount Magna Ease (PME) bioprosthesis has been implanted worldwide for aortic valve replacement (AVR). Recently, the INSPIRIS Resilia (IR) valve has been introduced as the newest generation of pericardial bi...

  • Article
  • Open Access
5 Citations
2,442 Views
19 Pages

Effect of Hypercholesterolemia, Systemic Arterial Hypertension and Diabetes Mellitus on Peripapillary and Macular Vessel Density on Superficial Vascular Plexus in Glaucoma

  • María Sanz Gomez,
  • Ni Zeng,
  • Gloria Estefania Catagna Catagna,
  • Paula Arribas-Pardo,
  • Julian Garcia-Feijoo and
  • Carmen Mendez-Hernandez

6 March 2023

Background/Aims: Vascular factors are involved in the development of glaucoma, including diseases such as hypercholesterolemia (HC), systemic arterial hypertension (SAH), and diabetes mellitus (DM). The aim of this study was to determine the effect o...

  • Article
  • Open Access
6 Citations
3,602 Views
11 Pages

6 March 2023

Background: Distal radius fractures (DRFs) in the elderly are common. Recently, the efficacy of operative treatment of displaced DRFs in patients above 65 years of age has been questioned and it has been suggested that non-operative treatment should...

  • Article
  • Open Access
15 Citations
4,242 Views
10 Pages

6 March 2023

This rerandomized clinical trial evaluated the influence of soft liners (SL) on biting force, pain perception, and the oral health-related quality of life (OHRQoL) of complete denture wearers. Twenty-eight completely edentulous patients complaining o...

  • Review
  • Open Access
94 Citations
25,101 Views
26 Pages

Stage IV Colorectal Cancer Management and Treatment

  • Oscar Hernandez Dominguez,
  • Sumeyye Yilmaz and
  • Scott R. Steele

6 March 2023

(1) Background: Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related mortality worldwide. Up to 50% of patients with CRC develop metastatic CRC (mCRC). Surgical and systemic therapy advances can now o...

  • Article
  • Open Access
6 Citations
3,028 Views
9 Pages

Multimodal Imaging Based Predictors for the Development of Choroidal Neovascularization in Patients with Central Serous Chorioretinopathy

  • Sonny Caplash,
  • Thamolwan Surakiatchanukul,
  • Supriya Arora,
  • Dmitrii S. Maltsev,
  • Sumit Randhir Singh,
  • Niroj Kumar Sahoo,
  • Deepika Parameshwarappa,
  • Alexei N. Kulikov,
  • Claudio Iovino and
  • Jay Chhablani
  • + 7 authors

6 March 2023

This study evaluated predictors for choroidal neovascularization (CNV) associated with central serous chorioretinopathy (CSCR) based on multimodal imaging. A retrospective multicenter chart review was conducted on 134 eyes of 132 consecutive patients...

  • Systematic Review
  • Open Access
15 Citations
4,218 Views
15 Pages

A Systematic Review of Lung Autopsy Findings in Elderly Patients after SARS-CoV-2 Infection

  • Susa Septimiu-Radu,
  • Tejaswi Gadela,
  • Doros Gabriela,
  • Cristian Oancea,
  • Ovidiu Rosca,
  • Voichita Elena Lazureanu,
  • Roxana Manuela Fericean,
  • Felix Bratosin,
  • Andreea Dumitrescu and
  • Adelina Mavrea
  • + 3 authors

6 March 2023

Although COVID-19 may cause various and multiorgan diseases, few research studies have examined the postmortem pathological findings of SARS-CoV-2-infected individuals who died. Active autopsy results may be crucial for understanding how COVID-19 inf...

  • Article
  • Open Access
9 Citations
5,152 Views
14 Pages

Obesity Is Indirectly Associated with Sudden Cardiac Arrest through Various Risk Factors

  • Yun Gi Kim,
  • Joo Hee Jeong,
  • Seung-Young Roh,
  • Kyung-Do Han,
  • Yun Young Choi,
  • Kyongjin Min,
  • Jaemin Shim,
  • Jong-Il Choi and
  • Young-Hoon Kim

6 March 2023

Although obesity is a well-established risk factor of cardiovascular event, the linkage between obesity and sudden cardiac arrest (SCA) is not fully understood. Based on a nationwide health insurance database, this study investigated the impact of bo...

  • Review
  • Open Access
10 Citations
7,578 Views
12 Pages

Liver Injury Associated with COVID-19 Infection: Pathogenesis, Histopathology, Prognosis, and Treatment

  • Noha Mousaad Elemam,
  • Iman M. Talaat,
  • Azzam A. Maghazachi and
  • Maha Saber-Ayad

6 March 2023

Liver injury occurs frequently as a consequence of SARS-CoV-2 infection. Direct infection of the liver leads to hepatic impairment with elevated transaminases. In addition, severe COVID-19 is characterized by cytokine release syndrome, which may init...

  • Article
  • Open Access
12 Citations
4,487 Views
10 Pages

Metabolic Health, Obesity, and Intraocular Pressure

  • Younhea Jung,
  • Gyoung Nyun Kim,
  • Eun Byeol Oh,
  • Kyoung Ohn and
  • Jung Il Moon

6 March 2023

Obesity has been associated with increased intraocular pressure (IOP), but the results are inconsistent. Recently, a subgroup of obese individuals with good metabolic profiles were suggested to have better clinical outcomes than normal-weight individ...

  • Article
  • Open Access
6 Citations
3,090 Views
14 Pages

Safety Analysis of Bevacizumab in Ovarian Cancer Patients

  • Yingwen Wang,
  • Hao Lin,
  • Yuche Ou,
  • Hungchun Fu,
  • Chingchou Tsai,
  • Chanchao Chang Chien and
  • Chenhsuan Wu

6 March 2023

Bevacizumab (BEV) is beneficial for ovarian cancer patients, but the real world’s patient settings differ from those in clinical trials. This study tries to illustrate adverse events in the Taiwanese population. Patients with epithelial ovarian...

  • Article
  • Open Access
5 Citations
3,161 Views
14 Pages

Differences in Outcome of Patients with Cardiogenic Shock Associated with In-Hospital or Out-of-Hospital Cardiac Arrest

  • Jonas Rusnak,
  • Tobias Schupp,
  • Kathrin Weidner,
  • Marinela Ruka,
  • Sascha Egner-Walter,
  • Jan Forner,
  • Thomas Bertsch,
  • Maximilian Kittel,
  • Kambis Mashayekhi and
  • Ibrahim Akin
  • + 3 authors

6 March 2023

Cardiogenic Shock (CS) complicated by in-hospital (IHCA) or out-of-hospital cardiac arrest (OHCA) has a poor outcome. However, studies regarding the prognostic differences between IHCA and OHCA in CS are limited. In this prospective, observational st...

  • Review
  • Open Access
19 Citations
5,098 Views
13 Pages

Biochemical Mechanisms beyond Glycosphingolipid Accumulation in Fabry Disease: Might They Provide Additional Therapeutic Treatments?

  • Giovanni Bertoldi,
  • Ilaria Caputo,
  • Giulia Driussi,
  • Lucia Federica Stefanelli,
  • Valentina Di Vico,
  • Gianni Carraro,
  • Federico Nalesso and
  • Lorenzo A. Calò

6 March 2023

Fabry disease is a rare X-linked disease characterized by deficient expression and activity of alpha-galactosidase A (α-GalA) with consequent lysosomal accumulation of glycosphingolipid in various organs. Currently, enzyme replacement therapy i...

  • Brief Report
  • Open Access
9 Citations
4,485 Views
10 Pages

Symptomatic Characteristics of Hypozincemia Detected in Long COVID Patients

  • Yui Matsuda,
  • Kazuki Tokumasu,
  • Yuki Otsuka,
  • Naruhiko Sunada,
  • Hiroyuki Honda,
  • Yasue Sakurada,
  • Yasuhiro Nakano,
  • Toru Hasegawa,
  • Mikako Obika and
  • Fumio Otsuka
  • + 1 author

6 March 2023

Objectives: The aim of this study was to determine the characteristics of hypozincemia in long COVID patients. Methods: This study was a single-center retrospective observational study for outpatients who visited the long COVID clinic established in...

  • Article
  • Open Access
6 Citations
2,453 Views
13 Pages

Identification of MGMT Downregulation Induced by miRNA in Glioblastoma and Possible Effect on Temozolomide Sensitivity

  • Andrea Cardia,
  • Samantha Epistolio,
  • Ismail Zaed,
  • Nora Sahnane,
  • Roberta Cerutti,
  • Debora Cipriani,
  • Jessica Barizzi,
  • Paolo Spina,
  • Federico Mattia Stefanini and
  • Francesco Marchi
  • + 7 authors

6 March 2023

Glioblastoma multiforme (GBM) remains one of the tumors with the worst prognosis. In recent years, a better overall survival (OS) has been described in cases subjected to Gross Total Resection (GTR) that were presenting hypermethylation of Methylguan...

  • Case Report
  • Open Access
7 Citations
8,118 Views
5 Pages

Pancytopenia Secondary to Vitamin B12 Deficiency in Older Subjects

  • Giulia Costanzo,
  • Giada Sambugaro,
  • Giulia Mandis,
  • Sofia Vassallo and
  • Angelo Scuteri

6 March 2023

Background: Vitamin B12 (cobalamin CBL) is a water-soluble vitamin required to form hematopoietic cells (red blood cells, white blood cells, and platelets). It is involved in the process of synthesizing DNA and myelin sheath. Deficiencies of vitamin...

  • Article
  • Open Access
37 Citations
10,490 Views
11 Pages

Ultrasound Guided Parasternal Block for Perioperative Analgesia in Cardiac Surgery: A Prospective Study

  • Giuseppe Pascarella,
  • Fabio Costa,
  • Giulia Nonnis,
  • Alessandro Strumia,
  • Domenico Sarubbi,
  • Lorenzo Schiavoni,
  • Annalaura Di Pumpo,
  • Lara Mortini,
  • Stefania Grande and
  • Massimiliano Carassiti
  • + 8 authors

6 March 2023

Ultrasound guided parasternal block is a regional anaesthesia technique targeting the anterior branches of intercostal nerves, which supply the anterior thoracic wall. The aim of this prospective study is to assess the efficacy of parasternal block t...

  • Article
  • Open Access
3 Citations
3,060 Views
12 Pages

Radiomic Features from Post-Operative 18F-FDG PET/CT and CT Imaging Associated with Locally Recurrent Rectal Cancer: Preliminary Findings

  • Dajana Cuicchi,
  • Margherita Mottola,
  • Paolo Castellucci,
  • Alessandro Bevilacqua,
  • Arrigo Cattabriga,
  • Maria Adriana Cocozza,
  • Stefano Cardelli,
  • Gerti Dajti,
  • Susanna Mattoni and
  • Gilberto Poggioli
  • + 4 authors

6 March 2023

Locally Recurrent Rectal Cancer (LRRC) remains a major clinical concern; it rapidly invades pelvic organs and nerve roots, causing severe symptoms. Curative-intent salvage therapy offers the only potential for cure but it has a higher chance of succe...

  • Article
  • Open Access
5 Citations
3,125 Views
9 Pages

Evolution of the Diagnosis and Treatment of Primary Hyperparathyroidism

  • Enrico Battistella,
  • Luca Pomba,
  • Riccardo Toniato,
  • Marta Burei,
  • Michele Gregianin,
  • Sara Watutantrige Fernando and
  • Antonio Toniato

6 March 2023

This study aims to present the evolution of our center’s approach to treating primary hyperparathyroidism (PHPT) from diagnosis to intraoperative interventions. We have also evaluated the intraoperative localization benefits of indocyanine gree...

  • Article
  • Open Access
13 Citations
4,934 Views
13 Pages

6 March 2023

(1) Background: Many studies have used a well-known social exclusion task, namely Cyberball, to assess the psychophysiological reactions to ostracism in laboratory settings. However, this task has been recently criticized for its lack of realism. Ins...

  • Article
  • Open Access
5 Citations
4,913 Views
7 Pages

5 March 2023

Background: We queried a global database to understand re-intervention rates following urethroplasty with the goal of evaluating whether they align with previously published data. Methods: Using the TriNetX database and Common Procedural Terminology...

  • Article
  • Open Access
5 Citations
2,251 Views
13 Pages

5 March 2023

Background: Contrast-enhanced endoscopic ultrasound (CE-EUS) is a promising diagnostic modality for differentiating malignant and benign lymph nodes. This study aimed to evaluate the diagnostic capability of CE-EUS in differentiating indolent non-Hod...

  • Article
  • Open Access
2 Citations
3,010 Views
11 Pages

Use of Non-Contrast-Enhanced MR Angiography to Assess Recanalization after Uterine Artery Embolization

  • Juliana Yumi Ishisaki,
  • Hitomi Kato,
  • Yoshiki Kuwatsuru,
  • Hiroshi Toei,
  • Ayako Hoshina,
  • Naoki Takemasa,
  • Masafumi Arai and
  • Ryohei Kuwatsuru

5 March 2023

The purpose of this study was to examine the use of non-contrast-enhanced MR angiography (MRA) for assessing recanalization of uterine arteries (UAs) after uterine artery embolization (UAE) for symptomatic fibroids. Pre-procedural and follow-up unenh...

  • Article
  • Open Access
1 Citations
2,737 Views
11 Pages

4 March 2023

Beneficial effects have been observed following the transplant of lipoaspirates containing adipose-derived stem cells into chronic wounds caused by oncologic radiotherapy. It is not yet certain whether adipose-derived stem cells are resistant to radi...

  • Article
  • Open Access
6 Citations
2,723 Views
13 Pages

Identification of Novel Risk Variants of Non-Syndromic Cleft Palate by Targeted Gene Panel Sequencing

  • Justyna Dąbrowska,
  • Barbara Biedziak,
  • Agnieszka Bogdanowicz and
  • Adrianna Mostowska

4 March 2023

Non-syndromic cleft palate (ns-CP) has a genetically heterogeneous aetiology. Numerous studies have suggested a crucial role of rare coding variants in characterizing the unrevealed component of genetic variation in ns-CP called the “missing he...

  • Article
  • Open Access
9 Citations
2,997 Views
11 Pages

The Short-Term Results of Autologous Platelet-Rich Plasma as an Adjuvant to Re-Intervention in the Treatment of Refractory Full-Thickness Macular Holes

  • Matilde Buzzi,
  • Guglielmo Parisi,
  • Paola Marolo,
  • Francesco Gelormini,
  • Mariantonia Ferrara,
  • Raffaele Raimondi,
  • Davide Allegrini,
  • Tommaso Rossi,
  • Michele Reibaldi and
  • Mario R. Romano

4 March 2023

The purpose of this study was to investigate the short-term efficacy and safety of autologous platelet-rich plasma (a-PRP) as an adjuvant to revisional vitrectomy for refractory full-thickness macular holes (rFTMHs). We conducted a prospective, non-r...

  • Review
  • Open Access
7 Citations
6,136 Views
35 Pages

Circus Activities as a Health Intervention for Children, Youth, and Adolescents: A Scoping Review

  • Free Coulston,
  • Kate L. Cameron,
  • Kath Sellick,
  • Madeline Cavallaro,
  • Alicia Spittle and
  • Rachel Toovey

4 March 2023

Circus activities are emerging as an engaging and unique health intervention. This scoping review summarises the evidence on this topic for children and young people aged up to 24 years to map (a) participant characteristics, (b) intervention charact...

  • Article
  • Open Access
20 Citations
11,292 Views
10 Pages

Effect of Localized Vibration Massage on Popliteal Blood Flow

  • Devin Needs,
  • Jonathan Blotter,
  • Madison Cowan,
  • Gilbert Fellingham,
  • A. Wayne Johnson and
  • Jeffrey Brent Feland

4 March 2023

There is a broad scope of literature investigating whole-body vibration (WBV) effects on blood flow (BF). However, it is unclear how therapeutic localized vibrations alter BF. Low-frequency massage guns are advertised to enhance muscle recovery, whic...

  • Article
  • Open Access
2 Citations
3,219 Views
14 Pages

Current Approaches to the Management of Sentinel Node Procedures in Early Vulvar Cancer in Germany: A Web-Based Nationwide Analysis of Practices

  • Roxana Schwab,
  • Kathrin Stewen,
  • Theresa-Louise Bührer,
  • Mona W. Schmidt,
  • Josche van der Ven,
  • Katharina Anic,
  • Valerie C. Linz,
  • Bashar Haj Hamoud,
  • Walburgis Brenner and
  • Annette Hasenburg
  • + 7 authors

4 March 2023

Background: Lymph node involvement is the most important prognostic factor for recurrence and survival in vulvar cancer. Sentinel node (SN) procedure can be offered in well-selected patients with early vulvar cancer. This study aimed to assess curren...

  • Perspective
  • Open Access
17 Citations
3,516 Views
14 Pages

4 March 2023

Multiple genetic, metabolic, and environmental abnormalities are known to contribute to the pathogenesis of Alzheimer’s dementia (AD). If all of those abnormalities were addressed it should be possible to reverse the dementia; however, that would req...

  • Article
  • Open Access
12 Citations
2,460 Views
8 Pages

Spiradenocarcinoma: SEER Study of Epidemiology, Survival, and Treatment Options

  • Jérôme Martineau,
  • Solange N. Walz,
  • Matteo Scampa,
  • Salvatore Giordano,
  • Daniel F. Kalbermatten and
  • Carlo M. Oranges

4 March 2023

(1) Background: Spiradenocarcinoma is an extremely rare malignant adnexal tumor and there are only few studies on survival outcomes. Our aim was to perform an analysis of the demographic and pathological characteristics, treatment patterns, and survi...

  • Brief Report
  • Open Access
7 Citations
2,115 Views
8 Pages

Epidemiological and Immune Profile Analysis of Italian Subjects with Endometriosis and Multiple Sclerosis

  • Brunella Zizolfi,
  • Virginia Foreste,
  • Simona Bonavita,
  • Valentina Rubino,
  • Giuseppina Ruggiero,
  • Vincenzo Brescia Morra,
  • Roberta Lanzillo,
  • Antonio Carotenuto,
  • Francesca Boscia and
  • Maurizio Guida
  • + 1 author

4 March 2023

Objective: To report for the first time an Italian epidemiological analysis of the prevalence of multiple sclerosis (MS) in patients with endometriosis (EMS), through the study of the endometriosis population of our referral center; to analyze the cl...

  • Article
  • Open Access
13 Citations
3,900 Views
11 Pages

Efficacy of CDK 4/6 Inhibitors and Radiotherapy in Breast Cancer Patients with Brain Metastases

  • Marcin Kubeczko,
  • Michał Jarząb,
  • Aleksandra Krzywon,
  • Donata Gräupner,
  • Anna Polakiewicz-Gilowska and
  • Dorota Gabryś

4 March 2023

Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy are the standard of care for HR-positive/HER2-negative advanced breast cancer patients. However, their role in the treatment of brain metastases is currently unclear. We...

  • Brief Report
  • Open Access
1 Citations
1,902 Views
11 Pages

The Influence of Healthy Habits on Cognitive Functions in a Group of Hemodialysis Patients

  • Piotr Olczyk,
  • Patryk Jerzak,
  • Krzysztof Letachowicz,
  • Tomasz Gołębiowski,
  • Magdalena Krajewska and
  • Mariusz Kusztal

4 March 2023

(1) Background: Cognitive impairment (CI) is more prevalent in hemodialysis (HD) patients than in the general population. The purpose of this study was to examine if behavioral, clinical, and vascular variables are linked with CI in individuals with...

  • Article
  • Open Access
6 Citations
3,534 Views
11 Pages

Induction of Labor in Twins—Double Trouble?

  • Miriam Lopian,
  • Lior Kashani-Ligumsky,
  • Ronnie Cohen,
  • Izaak Wiener,
  • Bat-Chen Amir,
  • Yael Gold Zamir,
  • Ariel Many and
  • Hadar Rosen

4 March 2023

Objective: To determine and compare the safety and efficacy of different methods of induction of labor in twin gestations and their effect on maternal and neonatal outcomes. Methods: A retrospective observational cohort study was conducted at a singl...

  • Article
  • Open Access
2 Citations
4,327 Views
9 Pages

Is There a Correlation between the Second-to-Four Digit Ratio (2D:4D) and Endometriosis? Results of a Case-Control Study

  • Laura Buggio,
  • Marco Reschini,
  • Paola Viganò,
  • Dhouha Dridi,
  • Giulia Galati,
  • Alessandra Chinè,
  • Francesca Giola,
  • Edgardo Somigliana and
  • Laura Benaglia

4 March 2023

The second-to-four digit ratio (2D:4D) has been proposed as a marker of prenatal hormonal exposure. It is suggested that prenatal exposure to androgens results in a shorter 2D:4D ratio, whereas a prenatal oestrogenic environment results in a longer o...

  • Article
  • Open Access
2 Citations
3,202 Views
10 Pages

Delayed Surgical Treatment of Displaced Intra-Articular Calcaneal Fractures in Major Trauma Is Safe and Effective

  • Attilio Basile,
  • Riccardo Maria Lanzetti,
  • Alessio Giai Via,
  • Teresa Venditto,
  • Marco Spoliti,
  • Pasquale Sessa,
  • Mauro Tortora and
  • Nicola Maffulli

4 March 2023

Background: To assess whether delaying operative fixation through the sinus tarsi approach resulted in a decreased wound complications rate or could hinder the quality of reduction in subjects with Sanders type II and III displaced intra-articular ca...

  • Review
  • Open Access
5 Citations
2,755 Views
10 Pages

COVID-19 and the Response to Antiplatelet Therapy

  • Tomáš Bolek,
  • Matej Samoš,
  • Jakub Jurica,
  • Lucia Stančiaková,
  • Martin Jozef Péč,
  • Ingrid Škorňová,
  • Peter Galajda,
  • Ján Staško,
  • Marián Mokáň and
  • Peter Kubisz

4 March 2023

The coronavirus SARS-CoV2 disease (COVID-19) is connected with significant morbidity and mortality (3.4%), disorders in hemostasis, including coagulopathy, activation of platelets, vascular injury, and changes in fibrinolysis, which may be responsibl...

  • Brief Report
  • Open Access
7 Citations
2,470 Views
8 Pages

The Impact of COVID-19 Pandemic Lockdown on the Relationship between Pediatric MAFLD and Renal Function

  • Maria Sole Valentino,
  • Pierluigi Marzuillo,
  • Claudia Esposito,
  • Mario Bartiromo,
  • Michele Nardolillo,
  • Annalisa Valentina Villani,
  • Alessandro Maresca,
  • Giuseppe Furcolo,
  • Stefano Guarino and
  • Anna Di Sessa
  • + 1 author

4 March 2023

Background: Both direct and indirect effects of COVID-19 have been found in all age groups. In particular, adult data demonstrated significant changes in patients with chronic and metabolic disease (e.g., obesity, diabetes, chronic kidney disease (CK...

  • Review
  • Open Access
13 Citations
5,600 Views
12 Pages

Hip–Spine Syndrome: A Focus on the Pelvic Incidence in Hip Disorders

  • Tadatsugu Morimoto,
  • Takaomi Kobayashi,
  • Masatsugu Tsukamoto,
  • Hirohito Hirata,
  • Tomohito Yoshihara,
  • Yu Toda and
  • Masaaki Mawatari

3 March 2023

Since Offierski and MacNab reported a close association between the hip and spine as hip–spine syndrome in 1983, many studies on spinal alignment in hip disorders have been conducted. Notably, the pelvic incidence angle (PI) is the most importa...

  • Systematic Review
  • Open Access
14 Citations
3,463 Views
15 Pages

Molecular Signatures in Ductal Carcinoma In Situ (DCIS): A Systematic Review and Meta-Analysis

  • Drissa Ouattara,
  • Carole Mathelin,
  • Tolga Özmen and
  • Massimo Lodi

3 March 2023

Context: Adjuvant radiotherapy (RT) after breast-conserving surgery (BCS) for ductal carcinoma in situ (DCIS) is debated as benefits are inconstant. Molecular signatures for DCIS have been developed to stratify the risk of local recurrence (LR) and t...

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J. Clin. Med. - ISSN 2077-0383