Is There a Correlation between the Second-to-Four Digit Ratio (2D:4D) and Endometriosis? Results of a Case-Control Study
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Characteristics | n |
---|---|
Diagnostic method: | |
- Ultrasonography | 132 |
- Magnetic resonance imaging (MRI) | 1 |
Type of endometriosis: | |
- Ovarian endometriomas (OMA) | 81 |
- Rectovaginal endometriosis (RV) | 23 |
- Parametrial | 4 |
- Ureteral endometriosis | 2 |
- Bowel endometriosis | 2 |
- Douglas pouch lesions | 1 |
- Combined forms | |
• OMA + RV | 13 |
• OMA + Douglas pouch lesions | 4 |
• OMA + Douglas + parametrial | 3 |
Characteristics * | Endometriosis n = 212 | Controls n = 212 |
---|---|---|
Age (years) | 37 [32–42] | 34 [28–39] |
BMI (kg/m2) | 21.9 [20.0–24.2] | 21.5 [19.5–24.2] |
Ethnicity: | ||
Caucasian | 193 (91%) | 199 (94%) |
African | 2(1%) | 5 (2%) |
Asian | 6(3%) | 6 (3%) |
Latino | 11 (5%) | 2 (1%) |
Smoking | ||
Yes | 39 (18%) | 43 (20%) |
No | 158 (75%) | 152 (72%) |
Previous smoker | 15 (7%) | 17 (8%) |
Age at menarche | 12 [11–13] | 12 [11–13] |
Parity | ||
Nulliparous | 158 (75%) | 160 (75%) |
Pluriparous | 54 (25%) | 52 (24%) |
Previous Miscarriages | 22 (10%) | 25 (12%) |
Previous IVF | 78 (37%) | 72 (34%) |
Characteristics * | Endometriosis (n = 212) | Controls (n = 212) | p |
---|---|---|---|
Whole study groups | |||
Length index finger (2D) | 66.75 [63.00–70.29] | 66.18 [62.92–69.19] | 0.16 |
Length ring finger (4D) | 67.00 [63.79–70.41] | 66.97 [64.09–70.17] | 0.81 |
2D:4D digit ratio | 1.00 [0.97–1.03] | 0.99 [0.96–1.02] | 0.002 |
Ovarian endometriomas (OMAs) | n = 114 | n = 212 | |
Length of the index finger (2D) | 67.10 [63.00–70.75] | 66.18 [62.92–69.19] | 0.09 |
Length of the ring finger (4D) | 67.20 [63.22–71.69] | 66.97 [64.09–70.17] | 0.82 |
2D:4D digit ratio | 1.00 [0.98–1.03] | 0.99 [0.96–1.02] | 0.002 |
Deep endometriosis (DE) | n = 98 | n = 212 | |
Length of the index finger (2D) | 66.19 [62.93–69.44] | 66.18 [62.92–69.19] | 0.59 |
Length of the ring finger (4D) | 66.77 [64.27–69.04] | 66.97 [64.09–70.17] | 0.51 |
2D:4D digit ratio | 1.00 [0.97–1.03] | 0.99 [0.96–1.02] | 0.07 |
Characteristics | Endometriosis | Controls | p |
---|---|---|---|
(n = 212) | |||
Patients with surgical diagnosis (n = 79) | |||
Length index finger (2D) | 67.05 [62.49–71.99] | 66.18 [62.92–69.19] | 0.20 |
Length ring finger (4D) | 66.95 [62.83–71.39] | 66.93 [64.00–70.17] | 0.86 |
2D:4D digit ratio | 1.01 [0.98–1.03] | 0.99 [0.96–1.02] | 0.001 |
OMA + OMA/DE (n = 173) | |||
Length index finger (2D) | 66.85 [63.06–70.46] | 66.18 [62.92–69.19] | 0.10 |
Length ring finger (4D) | 67.10 [63.76–71.00] | 66.93 [64.00–70.17] | 0.89 |
2D:4D digit ratio | 1.00 [0.97–1.03] | 0.99 [0.96–1.02] | 0.004 |
DE (n = 39) | |||
Length index finger (2D) | 65.91 [62.77–69.19] | 66.18 [62.92–69.19] | 0.98 |
Length ring finger (4D) | 66.60 [63.97–67.71] | 66.93 [64.00–70.17] | 0.28 |
2D:4D digit ratio | 1.01 [0.97–1.03] | 0.99 [0.96–1.02] | 0.08 |
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Buggio, L.; Reschini, M.; Viganò, P.; Dridi, D.; Galati, G.; Chinè, A.; Giola, F.; Somigliana, E.; Benaglia, L. Is There a Correlation between the Second-to-Four Digit Ratio (2D:4D) and Endometriosis? Results of a Case-Control Study. J. Clin. Med. 2023, 12, 2040. https://doi.org/10.3390/jcm12052040
Buggio L, Reschini M, Viganò P, Dridi D, Galati G, Chinè A, Giola F, Somigliana E, Benaglia L. Is There a Correlation between the Second-to-Four Digit Ratio (2D:4D) and Endometriosis? Results of a Case-Control Study. Journal of Clinical Medicine. 2023; 12(5):2040. https://doi.org/10.3390/jcm12052040
Chicago/Turabian StyleBuggio, Laura, Marco Reschini, Paola Viganò, Dhouha Dridi, Giulia Galati, Alessandra Chinè, Francesca Giola, Edgardo Somigliana, and Laura Benaglia. 2023. "Is There a Correlation between the Second-to-Four Digit Ratio (2D:4D) and Endometriosis? Results of a Case-Control Study" Journal of Clinical Medicine 12, no. 5: 2040. https://doi.org/10.3390/jcm12052040
APA StyleBuggio, L., Reschini, M., Viganò, P., Dridi, D., Galati, G., Chinè, A., Giola, F., Somigliana, E., & Benaglia, L. (2023). Is There a Correlation between the Second-to-Four Digit Ratio (2D:4D) and Endometriosis? Results of a Case-Control Study. Journal of Clinical Medicine, 12(5), 2040. https://doi.org/10.3390/jcm12052040