Diagnostics, Volume 15, Issue 8

Artificial intelligence (AI) is reshaping the landscape of healthcare data [...]

Background: Ethylenediaminetetraacetic acid-dependent pseudo thrombocytopenia (EDTA-PCTP) is defined as a false in vitro decrease in the platelet count performed in the EDTA tube due to the spontaneous formation of platelet aggregates that prevent a...

Background: Quantitative magnetic resonance imaging (MRI) techniques such as T₂ mapping may detect early tendon changes following biologic therapies. This study aimed to assess the structural remodeling of the supraspinatus tendon using mean T₂ value...

Background/Objectives: This study investigated the prognostic and predictive significance of Ataxia–Telangiectasia Mutated (ATM) expression in patients with metastatic non-small-cell lung cancer (NSCLC) who were treated with pembrolizumab. Meth...

Background: The glomerular filtration rate (GFR) is a universal clinical measure central to assessing kidney function and to the management of kidney disorders. Several formulas for the estimation of GFR are in use. The European Kidney Function Conso...

Background/Objectives: During retroperitoneal surgery, awareness of the anatomic variants of renal arteries (RAs) is essential. We aimed to determine the prevalence of early-branched (short) Ras, the bilateral morphologies of RAs in such cases, and t...

Since the 1990s, the global burden of cerebrovascular disease – particularly stroke – has significantly increased [...]

Multiplex Polymerase Chain Reaction (PCR) has significantly impacted the field of infectious disease diagnostics, offering rapid and precise identification of bacterial and fungal pathogens. Unlike traditional culture methods, which may take days to...

Background: Spectral detector computed tomography (SDCT) has demonstrated superior diagnostic performance and image quality in liver disease assessment compared with traditional CT. Selecting the right reconstruction algorithm and tube voltage is ess...

Background: This study investigated PD-L1 and EZH2 immunoexpressions in endometrial carcinomas (ECs) and correlated their associations with clinicopathological parameters and five-year survival outcomes. Methods: A cross-sectional, retrospective stud...

Background/Objectives: Multiple sclerosis (MS) is an autoimmune disease that damages the myelin sheath of the central nervous system, which includes the brain and spinal cord. Although MS lesions in the brain are more frequently investigated, MS lesi...

Background/Objectives: Ovarian germ cell tumors are rare, and determining prognostic factors is crucial for individualizing management strategies. We aimed to determine an optimal neutrophil-to-lymphocyte ratio (NLR) cut-off value for predicting surv...

Background/Objectives: Myxofibrosarcomas (MFSs) are aggressive soft-tissue sarcomas (STSs) that often arise in the upper and lower limbs. MFSs are a highly infiltrative sarcoma subtype with a high positive margin rate and poor clinical outcomes. Thei...

Background: Hypersensitivity pneumonitis (HP) represents a chronic lung disease with an unpredictable clinical course. There is a pressing need for clinically applicable prognostic biomarkers in patients with HP. Methods: This was an observational, r...

Medical biosensors have set the basis of medical diagnostics, and Artificial Intelligence (AI) has boosted diagnostics to a great extent. However, false results are evident in every method, so it is crucial to identify the reasons behind a possible f...

Here, we describe the case of an asymptomatic 70-year-old male patient who performed a contrast-enhanced computed tomography examination for prostate cancer staging, and an exceptional finding was reported. Specifically, a probable and never before r...

Temporomandibular disorders (TMD) are a cluster of musculoskeletal conditions that involve the overall structures of jaw movements, including the temporomandibular joint, the masticatory muscles, and the surrounding structures. The etiology of TMD-re...

Background/Objectives: The aim of this in vitro study was to determine the optimal combinations of wavelengths for short wavelength infrared (SWIR) multispectral transillumination and reflectance imaging of caries lesions on proximal and occlusal sur...

Background: Endothelial dysfunction and inflammation are associated with the progression of coronary artery disease (CAD) and the pathophysiology of acute coronary syndrome (ACS). We examined the prognostic role of endothelial function and pro-inflam...

Histopathological images stained with hematoxylin and eosin (H&E) are crucial for cancer diagnosis and prognosis. However, color variations caused by differences in tissue preparation and scanning devices can lead to data distribution discrepanci...

Background: International guidelines recommend the use of high-sensitivity cardiac troponin (hs-cTn) I and T methods for the detection of myocardial injury as a pre-requisite for the diagnosis of acute myocardial infarction (AMI) in patients admitted...

Background/Objectives: Nurses are becoming increasingly common healthcare professionals who perform sedation in digestive endoscopy services. Efficacy, safety and patient satisfaction are indicators of quality and safety in the administration of seda...

Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease characterized by a widespread accumulation of extracellular matrix components leading to fibrosis of the skin and internal organs. Vascular changes occur in all involved tissues...

Background: Breast cancer (BC) is the most common cancer among women worldwide; therefore, the efforts of many scientists are aimed at finding effective biomarkers for this disease. It is known that exosomes are nanosized extracellular vesicles (EVs)...

Background/Objectives: Clear cell sarcoma (CCS) is a very uncommon, aggressive soft-tissue sarcoma (STS) with a dismal prognosis. In the current literature, there are very limited data focused on the radiological features of CCS. Our study’s ob...

Background/Objectives: Sepsis remains a leading cause of mortality worldwide, necessitating the development of effective prognostic markers for early risk stratification. The C-reactive protein–albumin–lymphocyte (CALLY) index is a novel...

Background/Objectives: The Tc-99m dimercaptosuccinic acid (DMSA) renal scan clearly images the renal cortex, highlighting functional tissue areas and indicating regions of renal scarring, infection, malformations, or other types of renal damage. To e...

Background/Objectives: Coated tongue is a common oral condition with notable clinical relevance, often overlooked due to its asymptomatic nature. Its presence may reflect poor oral hygiene and can serve as an early indicator of underlying systemic di...

Background/Objectives: We aim to determine if cytokeratin-18 fragment (CK-18F) could be used to diagnose metabolic dysfunction-associated steatohepatitis (MASH). Methods: A total of 289 patients with metabolic dysfunction-associated steatotic liver d...

Objectives: This paper evaluates the potential of using deep learning approaches for the detection of degenerative bone changes in the mandibular condyle. The aim of this study is to enable the detection and diagnosis of mandibular condyle degenerati...

Background: Transforaminal spinal endoscopy is a minimally invasive technique used to treat several spinal conditions. Thanks to its minimally invasive approach, it offers numerous advantages over traditional open surgery, including reduced blood los...

Introduction: Advanced magnetic resonance imaging (MRI) techniques in neuroplasticity evaluations provide important information on stroke disease and the underlying mechanisms of neuronal recovery. It has been observed that gray matter density or vol...

Background: The brain’s vascular system has recently been shown to provide an important efflux pathway for cerebral waste clearance (CWC). However, little is known about the influence of aging or diabetes on the CWC. The aim of the current stud...

Background/Objectives: Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer, with diverse clinical presentations. This study aims to correlate findings from dermoscopy, ultrasonography, ex vivo confocal microscopy, and histo...

A 56-year-old female with a history of Luminal A breast cancer, previously treated with surgery, radiotherapy, and systemic therapy, underwent palliative re-irradiation in November 2024 for painful bone metastases. Three weeks later, following the in...

Background: Diagnoses of primary gynecologic (GYN) lymphomas are rare and require a high clinical index of suspicion, with only case reports and case series being presented. The aim of this study is to assess and record the pathological distinction o...

Background/Objectives: Thyroid nodules are commonly observed in neck ultrasonography. Most nodules are benign; hence, several nodules require biopsy to accurately identify the malignant ones. Numerous risk classification guidelines have been develope...

Background/Objectives: Bone mineral density (BMD) loss leads to osteoporosis, significantly increasing fracture risk in both the axial and peripheral skeleton. The extent to which it is possible to estimate the degree of osteoporosis in the hip by de...

Objective: The aim of our study was to evaluate maternal and perinatal outcomes in pregnant women diagnosed with cancer and treated at a single referral center in Brazil. Methods: This retrospective cohort study analyzed medical records from January...

Objectives: This study used fractal dimension (FD) analysis to evaluate alveolar trabecular changes associated with gingival recessions in the mandibular incisor-canine and premolar regions in the post-orthodontic retention period, compare them to no...

Background/Objectives: In a previous study, we utilized categorical variables and machine learning (ML) algorithms to predict the success of non-surgical root canal treatments (NSRCTs) in apical periodontitis (AP), classifying the outcome as either s...

The diagnosis of cholangiocarcinoma (CCA) remains challenging. Although new technologies have been developed and validated, their routine use in clinical practice is needed. Conventional cytology obtained during endoscopic retrograde cholangiopancrea...

Background: Suppression of Tumorigenicity 2 (ST2), a member of the interleukin-1 receptor family, plays a crucial role in immune regulation. Elevated sST2 levels are associated with poor prognosis in various inflammatory and cardiovascular diseases,...

Background and Clinical Significance: The levator claviculae muscle (also known as cleidocervicalis) is a vestigial muscle located in the posterior triangle of the neck, extending from the upper cervical transverse processus to the clavicle. It has b...

Background: Electrocardiographic (ECG) screening is crucial in pre-participation evaluations (PPEs) for elite athletes, aiding in the early detection of cardiac adaptations and potential risks. Elite female gymnasts experience unique cardiovascular a...

Background: The Xpert MTB/RIF Ultra assay (Ultra) is a second-generation molecular diagnostic test for tuberculosis (TB). The “Trace Call” result was added as a semi-quantitative category for extremely low bacillary loads. The prevalence...

Background: Coronary heart disease (CHD) remains a leading cause of global mortality, often sharing pathophysiologic pathways with cerebrovascular atherosclerosis. Carotid duplex ultrasonography provides a convenient, noninvasive assessment of both v...

Background and Objectives: The assessment of dangerousness and risk of recidivism are crucial aspects of forensic psychiatric evaluations, influencing therapeutic and security measures. This study aimed to develop and validate a new tool, the Dangero...

Background: 16S rRNA analysis has been used in various diseases to identify pathogenic bacteria. In particular, pathogens that are difficult to cultivate or previously unknown can be detected with great certainty. In chronic prostatitis/chronic pelvi...

Background/Objectives: Chronic bacterial prostatitis (CBP) is a prevalent urological condition significantly impacting patients’ quality of life. Accurate diagnosis is essential to differentiate bacterial from non-bacterial prostatitis and to g...