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Diagnostics
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Advancements in the Diagnostics and Management of Musculoskeletal Diseases
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Advancements in the Diagnostics and Management of Musculoskeletal Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 560

Special Issue Editor

Dr. Alessandro de Sire

E-Mail Website
Guest Editor
Associate Prof. Department of Medical and Surgical Sciences, University of Catanzaro "Magna Graecia", 88100 Catanzaro, Italy
Interests: rehabilitation; physical exercise; osteoporosis; sarcopenia; osteoarthritis; sports medicine; pain management; fractures; musculoskeletal disorders
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Pathologies of the musculoskeletal system can and must be addressed by many professionals, such as orthopedists, traumatologists, physiatrists, physiotherapists, rheumatologists, geriatricians, radiologists, biologists, biotechnologists, bioengineers and other doctors, health professionals, and basic scientists. Their interaction in a multi- and transdisciplinary approach is very important. The aims of this Special Issue are as follows: (1) to summarize through literature reviews, or systematic or meta-analyses, the state of the art of the most interesting and current problems of the musculoskeletal system; (2) to offer the most current and innovative research through original articles. Both basic science and clinical papers are welcome to be submitted as long as they concern diagnostics of the musculoskeletal system even with therapeutic aspects.

Dr. Alessandro de Sire
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • musculoskeletal system
  • joint
  • orthopedics
  • traumatology
  • rehabilitation
  • radiology
  • fracture
  • muscle
  • connective tissues
  • regenerative medicine
  • tissue engineering

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Review

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15 pages, 285 KiB  
Review
Neurophysiological Examination for the Diagnosis of Orofacial Pain and Temporomandibular Disorders: A Literature Review
by Loredana Raciti, Martina Ferrillo, Antonio Ammendolia, Gianfranco Raciti, Claudio Curci, Dario Calafiore, Maria Pia Onesta, Rocco Salvatore Calabrò, Umile Giuseppe Longo and Alessandro de Sire
Diagnostics 2025, 15(8), 1035; https://doi.org/10.3390/diagnostics15081035 - 18 Apr 2025
Viewed by 235
Abstract
Temporomandibular disorders (TMD) are a cluster of musculoskeletal conditions that involve the overall structures of jaw movements, including the temporomandibular joint, the masticatory muscles, and the surrounding structures. The etiology of TMD-related pain may be either central or peripheral, and differential diagnoses with [...] Read more.
Temporomandibular disorders (TMD) are a cluster of musculoskeletal conditions that involve the overall structures of jaw movements, including the temporomandibular joint, the masticatory muscles, and the surrounding structures. The etiology of TMD-related pain may be either central or peripheral, and differential diagnoses with other orofacial conditions are commonly required. Central pain etiology is associated with altered brain function linked to sensitization of pain-producing centers, whereas peripheral etiology of TMD is considered multifactorial, with some predisposing factors. Differentiating between neurological conditions and TMD requires a comprehensive clinical evaluation, as overlapping symptoms can complicate the diagnostic process. The aim of this review was to summarize the current literature about the role of neurophysiological examination in the management of orofacial pain and temporomandibular disorders to provide clear data that could be useful for clinical practice and for future clinical studies in this field. Full article
(This article belongs to the Special Issue Advancements in the Diagnostics and Management of Musculoskeletal Diseases)

Other

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16 pages, 5302 KiB  
Case Report
Identification of a Musculus Levator Claviculae on Physical Exam: A Case Report and Literature Review
by Eric Smith, Erik Vanstrum and Ashley Kita
Diagnostics 2025, 15(8), 1008; https://doi.org/10.3390/diagnostics15081008 - 16 Apr 2025
Viewed by 219
Abstract
Background and Clinical Significance: The levator claviculae muscle (also known as cleidocervicalis) is a vestigial muscle located in the posterior triangle of the neck, extending from the upper cervical transverse processus to the clavicle. It has been detected in ~2% of humans, [...] Read more.
Background and Clinical Significance: The levator claviculae muscle (also known as cleidocervicalis) is a vestigial muscle located in the posterior triangle of the neck, extending from the upper cervical transverse processus to the clavicle. It has been detected in ~2% of humans, but is rarely documented in the radiologic or anatomic literature. When found on physical exam, it is usually mis-identified as lymphadenopathy, metastasis, cysts, an aneurysm, or other masses. It has been implicated in a few cases of thoracic outlet syndrome. Case Presentation: Herein, we describe a 25-year-old man with a weightlifting history, who was found to have a right levator claviculae muscle in the setting of unilateral mixed neurovascular thoracic outlet syndrome. The patient presented with right-sided extremity paresthesias, pain in the neck, shoulder, and arm, and symptom exacerbation with overhead activities. He also described intermittent unilateral pulsatile tinnitus during strenuous exercise. On physical exam, he was found to have a right carotid bruit, unequal systolic blood pressures, and positive Roos and Adson’s testing. The variant muscle was identified with a modified exam maneuver, and was further characterized with sonography and MRI. Symptoms were managed with activity restriction and NSAIDs. We reviewed 17 cases of levator claviculae variant muscles in patients. Conclusions: The presence of levator claviculae muscles has been detected in patients with thoracic outlet syndrome, but never in a patient with an audible bruit and pulsatile tinnitus. This physical exam maneuver, used in conjunction with multimodal imaging, successfully aided diagnosis and direct medical management in this case. Full article
(This article belongs to the Special Issue Advancements in the Diagnostics and Management of Musculoskeletal Diseases)
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