You are currently viewing a new version of our website. To view the old version click .

Life, Volume 15, Issue 7

July 2025 - 170 articles

Cover Story: Cholinergic projections from the basal forebrain to the cortex and hippocampus play a critical role in cognitive functions, many of which rely on signaling through the alpha7 nicotinic acetylcholine receptor (α7nAChR). The Alzheimer’s disease (AD) brain is characterized by profound impairment of the basal forebrain cholinergic system, including alterations in the levels of α7nAChR, which may impact cognition. Importantly, α7nAChR has also been identified as a potential receptor for Aβ, and while their interaction supports neurotransmission, plasticity and memory function under normal physiological conditions, it leads to deleterious effects when Aβ is pathologically elevated. This article discusses the contributions of neuronal, astrocytic and microglial α7nAChR to AD pathophysiology with an emphasis on interactions of α7nAChR with Aβ. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (170)

  • Article
  • Open Access
1,648 Views
12 Pages

Neural Pathways of Visual Face Recognition Immediately After Birth

  • Carlo Lai,
  • Chiara Ciacchella,
  • Daniela Altavilla,
  • Giorgio Veneziani,
  • Giuseppe Marano,
  • Gaia Romana Pellicano,
  • Giacomo Della Marca,
  • Federico Tonioni,
  • Paola Aceto and
  • Marco Cecchini
  • + 3 authors

21 July 2025

The present study aimed to investigate the electrophysiological correlates of face-identity recognition in newborn infants immediately after birth. Electroencephalographic acquisition was continuously recorded in 23 newborn infants (3 < age < 2...

  • Article
  • Open Access
1,358 Views
12 Pages

Impact of Functional Therapy on Skeletal Structures and Airways in Patients with Class II Malocclusion: Comparison of Treatment in Prepubertal and Pubertal Phases

  • Gianna Dipalma,
  • Grazia Marinelli,
  • Paola Bassi,
  • Rosalba Lagioia,
  • Francesca Calò,
  • Mirka Cavino,
  • Francesco Inchingolo,
  • Franceska Vinjolli,
  • Ioana Roxana Bordea and
  • Giuseppe Minervini
  • + 5 authors

20 July 2025

This study aimed to assess skeletal and upper airway modifications induced by the Twin Block appliance in patients with Class II malocclusion due to mandibular retrusion, using two-dimensional imaging techniques. A total of 11 patients (6 males, 5 fe...

  • Article
  • Open Access
1 Citations
916 Views
28 Pages

Profiling Plant circRNAs Provides Insights into the Expression of Plant Genes Involved in Viral Infection

  • Ghyda Murad Hashim,
  • Travis Haight,
  • Xinyang Chen,
  • Athanasios Zovoilis and
  • Srividhya Venkataraman

20 July 2025

Investigations of endogenous plant circular RNAs (circRNAs) in several plant species have revealed changes in their circular RNA profiles in response to biotic and abiotic stresses. Recently, circRNAs have emerged as critical regulators of gene expre...

  • Systematic Review
  • Open Access
2,120 Views
14 Pages

20 July 2025

Obesity-related low-grade inflammation is a significant factor responsible for the development of metabolic syndrome and chronic diseases, which can begin even in early childhood. Recently, there has been growing interest in the impact of vitamin D3...

  • Article
  • Open Access
1,584 Views
14 Pages

20 July 2025

Due to advances in molecular technologies and the expanding knowledge of biomarkers, their use in patient screening, diagnosis, prognosis, and targeted therapy is continuously increasing. Biomarker characteristics play a crucial role across all areas...

  • Article
  • Open Access
1 Citations
1,845 Views
24 Pages

Ultrasound Phenotype-Based Approach to Treatment Choice in Osteoarthritis

  • Rositsa Karalilova,
  • Velichka Popova,
  • Konstantin Batalov,
  • Dimitar Kolev,
  • Lyatif Kodzhaahmed,
  • Dimitrina Petrova-Stoyankova,
  • Nikola Tepeliev,
  • Tsvetelina Kostova,
  • Lili Mekenyan and
  • Zguro Batalov

19 July 2025

Introduction/Objectives: Osteoarthritis (OA) is a chronic systemic disease that affects the entire array of joint structures. It is one of the most common chronic, socially significant diseases, associated with a decline in the quality of life of pat...

  • Article
  • Open Access
660 Views
14 Pages

GSNO as a Modulator of Vascular Tone in Human Saphenous Veins: Potential Implications for Graft Spasm

  • Deniz Kaleli Durman,
  • Nurdan Dağtekin,
  • Erkan Civelek,
  • Taner İyigün,
  • Önder Teskin and
  • Birsel Sönmez Uydeş Doğan

19 July 2025

S-nitrosoglutathione (GSNO), a promising S-nitrosothiol, has been recognized for its ability to modulate vascular tone through its vasodilatory, antiplatelet, and antiproliferative effects. However, data on its vasodilatory effects in human vessels r...

  • Article
  • Open Access
1,749 Views
13 Pages

Outcomes of Traumatic Liver Injuries at a Level-One Tertiary Trauma Center in Saudi Arabia: A 10-Year Experience

  • Nawaf AlShahwan,
  • Saleh Husam Aldeligan,
  • Salman T. Althunayan,
  • Abdullah Alkodari,
  • Mohammed Bin Manee,
  • Faris Abdulaziz Albassam,
  • Abdullah Aloraini,
  • Ahmed Alburakan,
  • Hassan Mashbari and
  • Abdulaziz AlKanhal
  • + 1 author

19 July 2025

Traumatic liver injury remains a significant contributor to trauma-related morbidity and mortality worldwide. In Saudi Arabia, motor vehicle accidents (MVAs) are the predominant mechanism of injury, particularly among young adults. This study aimed t...

  • Review
  • Open Access
1,891 Views
22 Pages

Pulmonary Hypertension: Let’s Take Stock!

  • Michele Cacia,
  • Egidio Imbalzano,
  • Vincenzo Antonio Ciconte and
  • Marco Vatrano

18 July 2025

Pulmonary hypertension (PH) encompasses a group of conditions characterized by elevated pulmonary arterial pressure, with pulmonary arterial hypertension (PAH) representing a distinct and severe subset. This review provides a comprehensive overview o...

  • Article
  • Open Access
756 Views
15 Pages

18 July 2025

Background: While Asia contributes 44.3% of traumatic brain injuries (TBI) worldwide, data regarding Asian TBI inpatient rehabilitation length of stay (RLOS) is scarce. A retrospective cohort study was conducted to determine correlates of inpatient R...

of 17

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Life - ISSN 2075-1729