Common and Novel Markers of Inflammation and Tissue Damage in Various Pathological Conditions—2nd Edition

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 158

Special Issue Editors


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Guest Editor
Department of Biophysics, Medical University of Białystok, Mickiewicza 2a, 15-089 Białystok, Poland
Interests: interleukin; injury; markers of inflammatory response; metalloproteinases; protein DAMPs; proteasome; wound healing process; tissue damage
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Guest Editor
Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, Waszyngtona 15A, 15-269 Bialystok, Poland
Interests: cancer; central nervous system diseases; cerebrospinal fluid; cytokines; biomarker; inflammation markers
Special Issues, Collections and Topics in MDPI journals

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Guest Editor

Special Issue Information

Dear Colleagues,

The Guest Editors are grateful to the many researchers who contributed to the success of the first volume of this Special Issue (https://www.mdpi.com/journal/life/special_issues/Z1374P2U2X). We are very pleased to announce the second volume of our Special Issue, entitled “Common and Novel Markers of Inflammation and Tissue Damage in Various Pathological Conditions—2nd Edition”.

Inflammation is a complex and necessary component of the response to pathological conditions, such as infections, burns, stress, trauma, or immunologic reactions. Inflammation has been linked to numerous diseases, including arthritis, asthma, atherosclerosis, autoimmune diseases, diabetes, and cancer, as well as to conditions associated with aging. Inflammatory responses involve the release of various inflammatory markers. The evaluation of biomarkers such as cytokines, growth factors, oxidative markers, and other molecular markers allows us to understand the progression of various disorders and tissue repair processes. Monitoring the levels of inflammatory markers in body fluids may be useful for diagnosing inflammation as well as monitoring disease treatment. The most frequently used inflammatory markers include acute-phase proteins and cytokines, predominantly TNF-α, interleukins 1β, 6, 8, 10, and 12, their receptors, and IFNγ. However, new inflammatory response and tissue damage markers that can provide valuable information about various pathological conditions are still being sought.

In this Special Issue, all articles, including original papers, reviews, and other forms of scientific communication, that present valuable observations concerning common and novel markers of inflammation and tissue damage in various pathological conditions are welcome.

Dr. Marzena Tylicka
Dr. Joanna Kamińska
Dr. Olga Koper-Lenkiewicz
Guest Editors

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Keywords

  • body fluids
  • cytokines
  • damage-associated molecular patterns (DAMPs)
  • inflammatory response
  • injury
  • markers of inflammation and tissue damage
  • metalloproteinases
  • novel markers
  • pathological conditions
  • proteasome
  • tissue damage
  • tissue repair processes
  • various diseases

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Published Papers (1 paper)

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Research

16 pages, 1691 KiB  
Article
Predictive Biomarkers of Acute Kidney Injury in COVID-19: Distinct Inflammatory Pathways in Patients with and Without Pre-Existing Chronic Kidney Disease
by Caterina Carollo, Alida Benfante, Alessandra Sorce, Katia Montalbano, Emanuele Cirafici, Leonardo Calandra, Giulio Geraci, Giuseppe Mulè and Nicola Scichilone
Life 2025, 15(5), 720; https://doi.org/10.3390/life15050720 (registering DOI) - 29 Apr 2025
Abstract
Background: Acute kidney injury (AKI) has emerged as a significant complication in patients with coronavirus disease 2019 (COVID-19). The pathophysiology of COVID-19-associated AKI is multifactorial, involving both direct viral effects on renal cells and indirect mechanisms such as systemic inflammation and cytokine storms. [...] Read more.
Background: Acute kidney injury (AKI) has emerged as a significant complication in patients with coronavirus disease 2019 (COVID-19). The pathophysiology of COVID-19-associated AKI is multifactorial, involving both direct viral effects on renal cells and indirect mechanisms such as systemic inflammation and cytokine storms. This highlights the critical need for early detection and effective management strategies to mitigate kidney injury and improve patient outcomes. The aim of our study is to assess the potential predictive role of inflammatory biomarkers in determining the risk of developing COVID-19-associated AKI in patients with and without pre-existing CKD. Methods: This study included 84 patients stratified by pre-existing chronic kidney disease (CKD) status. Demographic, clinical, and laboratory data were collected, including vital signs, hematological profiles, renal function markers, inflammatory biomarkers, coagulation parameters, and treatments. Outcomes such as acute kidney injury (AKI) and in-hospital mortality were documented. Results: In patients with pre-existing CKD, IL-6 and NLR demonstrated high predictive accuracy for AKI onset. In patients without pre-existing CKD, white blood cell (WBC) count emerged as a significant predictor of AKI onset. Conclusions: The differential roles of IL-6, NLR, and WBC in predicting AKI onset highlight distinct physiopathological pathways influenced by COVID-19. In CKD+ patients, chronic inflammation and immune dysregulation are key drivers of AKI, with IL-6 and NLR serving as robust markers of this inflammatory state. In contrast, in CKD− patients, AKI may be more influenced by acute inflammatory responses and infectious factors, as reflected by WBC count. Full article
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