Advances in Geriatric Medicine: Risk Assessment, Biomarkers, and Management Strategies

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 26 November 2025 | Viewed by 1010

Special Issue Editors


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Guest Editor
1. Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel
2. Shmuel Harofeh Geriatric Medical Center, Be’er Ya’akov 7033001, Israel
Interests: geriatrics; emergency medicine; clinical diagnosis

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Guest Editor
1. Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel
2. Shmuel Harofeh Geriatric Medical Center, Be’er Ya’akov 7033001, Israel
Interests: geriatrics; emergency medicine; clinical diagnosis

Special Issue Information

Dear Colleagues,

The global aging population presents a growing challenge to healthcare systems worldwide. The increasing prevalence of age-related diseases, multimorbidity, and functional decline necessitates innovative approaches in geriatric medicine. This Special Issue aims to explore the latest advancements in geriatric risk assessment, the identification and clinical application of biomarkers, and the development of evidence-based management strategies tailored to older adults.

By gathering contributions from leading researchers and clinicians in geriatric medicine, this issue will provide a comprehensive platform for disseminating cutting-edge research that improves the assessment, diagnosis, and treatment of geriatric patients. The overarching goal is to enhance patient outcomes, optimize resource allocation, and inform clinical decision making.

Scope and Topics of Interest

This Special Issue invites original research articles, systematic reviews, meta-analyses, and clinical studies focused on the following areas:

  1. Risk Assessment in Geriatric Medicine
  • Predictive models for frailty and multimorbidity;
  • Machine learning and AI applications in geriatric risk stratification;
  • Falls risk assessment and prevention strategies;
  • Cognitive decline prediction and dementia risk models;
  • Assessment tools for polypharmacy and medication-related risks.
  1. Biomarkers in Geriatric Medicine
  • Novel biomarkers for early detection of age-related diseases;
  • Inflammatory and metabolic markers in frailty and sarcopenia;
  • Genetic and epigenetic biomarkers for cognitive disorders;
  • Biomarkers for cardiovascular and neurodegenerative diseases;
  • Translational research in biomarker-driven therapeutic strategies.
  1. Management Strategies and Clinical Interventions
  • Personalized medicine approaches for geriatric patients;
  • Integrated care models and multidisciplinary interventions;
  • Pharmacological and non-pharmacological management of chronic diseases;
  • Nutritional and lifestyle interventions in aging populations;
  • Rehabilitation and palliative care strategies for older adults.

Significance and Impact

This Special Issue will provide an interdisciplinary perspective on emerging trends in geriatric medicine. By integrating risk assessment tools, biomarker research, and novel management approaches, the issue aims to contribute to improving patient care, reducing hospitalizations, and enhancing the quality of life for older adults. The findings will be of significant interest to geriatricians, primary care physicians, researchers, and healthcare policymakers.

Guest Editors

We propose assembling a panel of internationally recognized experts in geriatric medicine, risk assessment, and translational research to oversee this Special Issue. Their expertise will ensure a rigorous peer-review process and the selection of high-impact contributions.

Target Audience

The Special Issue will appeal to the following:

  • Geriatricians and internists;
  • Primary care physicians;
  • Researchers in aging and longevity;
  • Healthcare policymakers and administrators;
  • Clinical pharmacists and multidisciplinary care teams.

Conclusion

This Special Issue will serve as a valuable resource for advancing clinical practice in geriatric medicine. By fostering collaboration among experts in risk assessment, biomarker discovery, and management strategies, it will contribute to the development of innovative, patient-centered care models for the aging population.

We appreciate the opportunity to propose this Special Issue and look forward to your consideration of the issue (with ISBN and indexing).

Dr. Nadya Kagansky
Dr. Yochai Levy
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • geriatric risk assessment
  • biomarkers in aging
  • personalized geriatric care

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Published Papers (2 papers)

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Research

11 pages, 266 KiB  
Article
Impact of the COVID-19 Pandemic on Functionality and Fall Risk in Institutionalized Geriatric Patients: A Longitudinal Observational Study
by Javier Torralba Estelles, Jorge Velert Belenguer, Elena Martinez Mendoza and Javier Ferrer Torregrosa
Life 2025, 15(7), 1130; https://doi.org/10.3390/life15071130 - 18 Jul 2025
Viewed by 177
Abstract
Background: The global impact of the COVID-19 pandemic has significantly influenced elderly functionality, particularly in terms of balance, gait, and independence in daily activities. This study sought to evaluate how these aspects have changed over the course of the health crisis. Methods: We [...] Read more.
Background: The global impact of the COVID-19 pandemic has significantly influenced elderly functionality, particularly in terms of balance, gait, and independence in daily activities. This study sought to evaluate how these aspects have changed over the course of the health crisis. Methods: We employed the Tinetti scale for assessing balance and gait, and the Barthel Index for measuring functional independence, conducting a comparative analysis of scores before and after the onset of the pandemic in a sample of elderly individuals. Results: Our findings indicated an increase in Tinetti scores, suggesting some improvement in balance and mobility, albeit with marked variability across participants. On the other hand, Barthel scores showed a significant decline, pointing to a reduction in functional independence. Conclusions: These results suggest that the impact of COVID-19 on elderly functionality is not uniform, highlighting the need for personalized rehabilitation strategies. Such strategies should not only focus on physical recovery but also consider the psychological and social repercussions of the pandemic to fully address the diverse needs of this vulnerable population. Full article
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15 pages, 730 KiB  
Article
Malnutrition in Elderly Patients with Chronic Kidney Disease—The Role of Albuminuria
by Diana Moldovan, Ina Kacso, Lucreția Avram, Cosmina Bondor, Crina Rusu, Alina Potra, Dacian Tirinescu, Maria Ticala, Ariana Condor, Dana Crisan and Valer Donca
Life 2025, 15(6), 898; https://doi.org/10.3390/life15060898 - 31 May 2025
Viewed by 631
Abstract
Background: The global population is rapidly aging, and an epidemic increase in chronic kidney disease (CKD) has been reported. As the presence of malnutrition in elderly CKD patients can pose serious health problems, the aim of our study was to identify, using [...] Read more.
Background: The global population is rapidly aging, and an epidemic increase in chronic kidney disease (CKD) has been reported. As the presence of malnutrition in elderly CKD patients can pose serious health problems, the aim of our study was to identify, using different assessment tools, the relationship between nutrition with kidney function and albuminuria in elderly patients. Methods: The study included 793 hospitalized patients aged 65 years and older. A comprehensive assessment of nutritional status and renal involvement was performed, and the relationship between malnutrition and kidney issues was tested. Results: CKD was highly prevalent in our geriatric population, with 39.84% having CKD G3a–5. Malnutrition, determined according to the Mini Nutritional Assessment (MNA) score, was identified in 34.6% of patients. With an increase in albuminuria, we observed worse nutrition indicators: low serum albumin; lower body fat (p = 0.002) and visceral fat (p = 0.001), assessed via bioimpedance; and lower MNA (p = 0.04) and geriatric nutritional risk index (GNRI) (p = 0.002) scores. Elderly patients with CKD G3a–5 had lower HDL-cholesterol (p < 0.001), higher triglycerides (p < 0.001), lower albumin (p = 0.011), and a lower MNA score (p = 0.001). Conclusions: Malnutrition was found to be common and more severe with increased albuminuria and decreased eGFR. Our study sheds light on a novel relationship between malnutrition, albuminuria, and renal function in a geriatric population. Full article
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