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Life, Volume 15, Issue 6

June 2025 - 157 articles

Cover Story: Clozapine remains the leading drug for treatment-resistant schizophrenia, yet its complex pharmacology, inconsistent efficacy, and adverse side effects hinder its adoption. In this review, we collate clinical, imaging, and molecular findings from 2013 to 2025 to address at least three factors: how clozapine’s rapid D2 drop-off but high affinity for D4, 5-HT2A/C, muscarinic, H1, and α1 receptors drives NMDA signaling, kynurenine turnover, mTOR-S6 translation, and cortical perfusion; when additional therapies such as paliperidone, amisulpride, memantine, minocycline, or rTMS rescue partial responders; and how plasma metabolite ratios, neurotrophins, brain morphometry, pharmacogenes, and polygenic risk scores can predict response and guide safer dosing. This article interweaves these strands to chart a path toward personalized, high-benefit, low-risk clozapine care. View this paper
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Articles (157)

  • Article
  • Open Access
1,166 Views
17 Pages

19 June 2025

Elsholtzia blanda (Benth.) Benth. (EBB) is a traditional plant in Nepal with bioactive properties, including antioxidant, cytotoxic, and antitumor activities. In this study, a methanol EBB extract was tested to evaluate the anti-inflammatory effect a...

  • Review
  • Open Access
1 Citations
4,041 Views
14 Pages

Platelet Transfusions: Current Practices and Emerging Alternatives in the United States

  • Mark Friedman,
  • Victoria Costa,
  • Behnam Rafiee,
  • Timothy Hilbert,
  • Mansab Jafri and
  • Ding Wen Wu

19 June 2025

Platelet transfusions are a cornerstone of hemorrhage management in patients with thrombocytopenia or platelet dysfunction, yet their indications and dosing are largely based on expert opinion and low-quality evidence. This review offers a timely and...

  • Article
  • Open Access
1 Citations
3,979 Views
12 Pages

Clinical Outcomes and Optical Bench Analysis of a Novel Enhanced Monofocal Intraocular Lens

  • Giovanni Romualdi,
  • Matilde Buzzi,
  • Pier Giuseppe Ruggeri,
  • Federico Tommasi,
  • Alessio Giorgetti,
  • Stefano Cavalieri and
  • Rita Mencucci

19 June 2025

Purpose: A novel enhanced monofocal intraocular lens (IOL) has been developed to improve functional intermediate vision, maintaining a distance vision comparable to a standard monofocal lens and avoiding the drawbacks of multifocal IOLs. The aim of t...

  • Review
  • Open Access
4,043 Views
23 Pages

The Role of Nutrition in HIV-Associated Neurocognitive Disorders: Mechanisms, Risks, and Interventions

  • Carlotta Siddi,
  • Jihane Balla,
  • Christy Agbey,
  • Paola Fadda and
  • Simona Dedoni

19 June 2025

HIV-associated neurocognitive disorders (HANDs) refer to a range of cognitive deficits that afflict people living with the Human Immunodeficiency Virus (HIV). The fundamental processes of HAND include persistent inflammation, immunological activation...

  • Article
  • Open Access
1,068 Views
32 Pages

Transcriptomic and miRNA Signatures of ChAdOx1 nCoV-19 Vaccine Response Using Machine Learning

  • Jinting Lin,
  • Qinglan Ma,
  • Lei Chen,
  • Wei Guo,
  • Kaiyan Feng,
  • Tao Huang and
  • Yu-Dong Cai

18 June 2025

Vaccination with ChAdOx1 nCoV-19 is an important countermeasure to fight the COVID-19 pandemic. This vaccine enhances human immunoprotection against SARS-CoV-2 by inducing an immune response against the SARS-CoV-2 S protein. However, the immune-relat...

  • Article
  • Open Access
877 Views
15 Pages

18 June 2025

The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has plunged the world into a major crisis of overwhelming morbidity and mortality and emerged various mutant strains. Patients recovering from SARS-CoV-2 develop...

  • Article
  • Open Access
1 Citations
799 Views
11 Pages

Endoscopic-Assisted Transoral Approach (EATA) for Extracranial Tumors: A Multicentric Case Series

  • Giovanni Motta,
  • Arianna Di Stadio,
  • Luca D’Ascanio,
  • Luigi D’avino,
  • Vincenzo della Peruta,
  • Francesco Chiari,
  • Carlo Magno,
  • Giuseppe Tortoriello and
  • Gaetano Motta

18 June 2025

Endoscopic surgery is useful and helpful especially to access areas with limited visibility. The combination of this technique with innovative approaches could be the solution to improve quality of surgery and patients’ outcome. This study aime...

  • Article
  • Open Access
1 Citations
1,260 Views
19 Pages

Low-Dose Quercetin Dephosphorylates AKT and Suppresses Proteins Related to Migration in Human Metastatic Uveal Melanoma Cells

  • Petra Fodor,
  • József Király,
  • Zsuzsanna Szabó,
  • Katalin Goda,
  • Barbara Zsebik and
  • Gábor Halmos

18 June 2025

Background: Uveal melanoma (UM) is the most common intraocular cancer of the eye, with high metastatic potential in adults. In 50% of patients, UM spreads to other tissues, causing a fatal outcome. Flavonoids are bioactive phenolic compounds found in...

  • Article
  • Open Access
2 Citations
2,685 Views
9 Pages

Maternal and Clinical Outcomes of Placenta Accreta Spectrum: Insights from a Retrospective Study in Bahrain

  • Kareeza Selby Chacko,
  • Reem Satam AlSubeaei,
  • Soumya Sunil Nair,
  • Nusrat Khalil Kazi and
  • Rafiea Jeddy

18 June 2025

Placenta accreta spectrum (PAS) refers to a group of abnormal placental attachments in which the placenta adheres too deeply to the uterine wall, with varying degrees of invasion classified as accreta, increta, or percreta. Increased rates of uterine...

  • Article
  • Open Access
2 Citations
1,764 Views
16 Pages

18 June 2025

Background: Chronic pain is an unpleasant sensory and emotional experience that greatly affects functioning and well-being. Studies link chronic pain and violence against women, with an odds ratio of 2.08 and a 26% prevalence rate. The bio-psycho-soc...

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Life - ISSN 2075-1729