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Life
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Obstetrics and Gynecology Medicine: From Bench to Bedside—2nd Edition
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Obstetrics and Gynecology Medicine: From Bench to Bedside—2nd Edition

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 3300

Special Issue Editors

Dr. Stefano Canosa

E-Mail Website
Guest Editor
1. Obstetrics and Gynecology 1U, Physiopathology of Reproduction and IVF Unit, Department of Surgical Sciences, Sant’Anna Hospital, University of Turin, 10126 Turin, Italy
2. Livet, GeneraLife IVF, 10126 Turin, Italy
Interests: clinical embryology; fertility preservation; reproductive genetics; artificial intelligence
Special Issues, Collections and Topics in MDPI journals
Dr. Anna Maria Nuzzo

E-Mail Website
Guest Editor
Department of Surgical Sciences, University of Turin, 10126 Turin, Italy
Interests: fetal–maternal medicine; human pregnancy; placenta physiopathology and placental-derived mesenchymal stromal cells (PDMSCs)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We would like to warmly invite you to contribute to the 2nd edition of “Obstetrics and Gynecology Medicine: Go From Bench to Bedside”, following the success of the first volume: https://www.mdpi.com/journal/life/special_issues/8MJ427ATRD.

This Special Issue continues to highlight the importance of translational research, which aims to bridge the gap between laboratory studies and clinical demands by converting the achievements of basic science into everyday clinical practice. An efficient translational process is sustained by the mutual synergy of academic laboratory research and public/private hospitals. However, the process of transforming research innovation into new health products, as well as diagnostic and therapeutic strategies, remains a major issue of contemporary biomedical medicine. Among different fields of applications, over the last few decades, obstetrics and gynecology have experienced a dramatic increase in several clinical and technical upgrades based on translational research discoveries. Improvements in the quality of life of cancer patients, pathological pregnancies treatments, drug discoveries, identification of new diagnostic and/or prognostic biomarkers, stem cell applications, the discovery of new molecular pathways involved in obstetrics and gynecology pathophysiology, and automation in assisted reproductive technologies represent only a few examples of the clinical application of basic research. This Special Issue aims to collect original papers and innovative review articles detailing the use of basic research in translational studies of obstetrics and gynecology to assist and support clinical practice in the near future.

Dr. Stefano Canosa
Dr. Anna Maria Nuzzo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obstetrics
  • gynecology
  • translational research
  • translational medicine

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Published Papers (6 papers)

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Research

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21 pages, 1662 KiB  
Article
Genetic Variants Linked with the Concentration of Sex Hormone-Binding Globulin Correlate with Uterine Fibroid Risk
by Marina Ponomarenko, Evgeny Reshetnikov, Maria Churnosova, Inna Aristova, Maria Abramova, Vitaly Novakov, Vladimir Churnosov, Alexey Polonikov, Denis Plotnikov, Mikhail Churnosov and Irina Ponomarenko
Life 2025, 15(7), 1150; https://doi.org/10.3390/life15071150 - 21 Jul 2025
Viewed by 129
Abstract
In this study we searched for correlations between polymorphic variants that determine sex hormone-binding globulin concentration (SHBGcon) and uterine fibroids (UFs). The work was performed on a sample of 1542 women (569 with UFs and 973 without UFs [control]), from whom [...] Read more.
In this study we searched for correlations between polymorphic variants that determine sex hormone-binding globulin concentration (SHBGcon) and uterine fibroids (UFs). The work was performed on a sample of 1542 women (569 with UFs and 973 without UFs [control]), from whom we obtained experimental data on the distribution of nine single-nucleotide polymorphisms (SNPs) affecting the SHBGcon (data confirmed in genome-wide association studies [GWASs]). When searching for associations with UFs, both the independent effects of SNPs and the effects of their SNP–SNP interactions (SNP-SNPints) were taken into account during the “deep study” of the functionality of seven important UF loci and 115 strongly linked [r2 ≥ 0.80] variants (an in silico methodology was used). As the results show, two SHBGcon-related SNPs correlated with UF risk: rs3779195 [T/A] BAIAP2L1 (ORAA = 0.38; 95%CIAA = 0.20–0.91; pperm(AA) = 0.023) and rs440837 [A/G] ZBTB10 (ORGG = 1.93; 95%CIGG = 1.17–3.14; pperm(GG) = 0.010). At the same time, seven SHBGcon-related SNPs interacting with each other (four models of such SNP-SNPints [pperm ≤ 0.01)] were found to influence UF risk. These SHBGcon-related SNPs, determining susceptibility to UF, showed strong functional relevance and were involved in pathways of gene transcription regulation, interactions with hormone ligand-binding receptors, the content control of SHBG, testosterone, liver enzymes, lipids, etc. This study’s results demonstrate the effect of significant SHBGcon-related genetic determinants of UF risk. Full article
(This article belongs to the Special Issue Obstetrics and Gynecology Medicine: From Bench to Bedside—2nd Edition)
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14 pages, 885 KiB  
Article
Predicting Pre- and Post-Diagnostic Depression in Women with Abnormal Pap Screening Tests: A Neural Network Approach
by Irena Ilic, Goran Babic, Sandra Sipetic Grujicic, Ivana Zivanovic Macuzic, Milena Ilic, Ana Ravic-Nikolic and Vesna Milicic
Life 2025, 15(7), 1041; https://doi.org/10.3390/life15071041 - 30 Jun 2025
Viewed by 309
Abstract
(1) Background: After receiving an abnormal Papanicolaou smear result, very often women fail to adhere to further procedures due to depression. Using a neural network approach, this research aimed to predict pre- and post-diagnostic depressive symptoms in women with abnormal Pap screening tests. [...] Read more.
(1) Background: After receiving an abnormal Papanicolaou smear result, very often women fail to adhere to further procedures due to depression. Using a neural network approach, this research aimed to predict pre- and post-diagnostic depressive symptoms in women with abnormal Pap screening tests. (2) Methods: The study was conducted at the Clinical Center of Kragujevac, Serbia, among 172 women with a positive Pap screening result before and after diagnostic procedures (colposcopy/biopsy/endocervical curettage). Just before and 2 to 4 weeks after the diagnostic procedures, women filled out a socio-demographic questionnaire and the Hospital Anxiety and Depression Scale (HADS). Multilayer perceptron neural networks were modeled. (3) Results: Depression was present in 37.2% of women before diagnostic procedures and in 48.3% after. Feature selection showed four variables that correlated with depression before diagnostic procedures—anxiety (according to the HADS), depression according to the CESD scale, worry score on the POSM scale and use of sedatives. Model for predicting pre-diagnostic depression yielded an accuracy of 79.41%, with a value of 0.842 for area under the receiver operating characteristic curve (AUROC). The HADS anxiety score, place of residence and CESD score were the most important attributes for predicting post-diagnostic depression, with an ANN model accuracy of 88.24% and AUROC 0.939. (4) Conclusions: This research revealed a possible way of predicting depression occurrence in those women who received a positive Pap screening test and who are undergoing follow-up diagnostics, aiding medical doctors in the provision of successful and on-time psychological assistance. Full article
(This article belongs to the Special Issue Obstetrics and Gynecology Medicine: From Bench to Bedside—2nd Edition)
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13 pages, 1130 KiB  
Article
The Platelet-to-Lymphocyte Ratio (PLR) as a Non-Invasive Biomarker for Cervical Malignancy in Conization Patients
by Noémi Kalas, Verita Szabó, Balázs Vida, Zsófia Tóth, Lotti Lőczi, Barbara Sebők, Petra Merkely, Balázs Lintner, Nándor Ács, Attila Keszthelyi, Szabolcs Várbíró, Richárd Tóth and Márton Keszthelyi
Life 2025, 15(6), 971; https://doi.org/10.3390/life15060971 - 18 Jun 2025
Viewed by 449
Abstract
Background: Cervical cancer continues to pose a significant global health challenge, particularly in low-resource regions with limited access to advanced diagnostics. Cervical conization can occasionally uncover invasive carcinoma in patients initially suspected of having only pre-invasive lesions. This study assessed the platelet-to-lymphocyte ratio [...] Read more.
Background: Cervical cancer continues to pose a significant global health challenge, particularly in low-resource regions with limited access to advanced diagnostics. Cervical conization can occasionally uncover invasive carcinoma in patients initially suspected of having only pre-invasive lesions. This study assessed the platelet-to-lymphocyte ratio (PLR) as a potential predictive biomarker for identifying invasive disease in patients undergoing a loop electrosurgical excision procedure (LEEP). Methods: A retrospective study was conducted on 371 patients who underwent LEEP conization for cervical dysplasia. Preoperative PLR values were collected and compared across final histopathological categories (negative, low-grade, high-grade, invasive carcinoma) using the Kruskal–Wallis test, followed by Mann–Whitney U tests for pairwise comparisons. Receiver operating characteristic (ROC) analysis was used to evaluate diagnostic accuracy. Results: PLR values above 7.7 were significantly associated with HPV positivity, increasing with histopathological severity. There were significant PLR differences across the outcome groups (p = 0.005), with notably higher values in cases of invasive carcinoma (p < 0.01). ROC analysis showed moderate diagnostic utility (AUC ≈ 0.72); at a PLR cutoff of ~11.9, sensitivity was 65% and specificity 81%. Conclusions: The PLR cutoff of 7.7 was associated with HPV positivity, while a higher cutoff of 11.93 was identified for predicting invasive cervical cancer. These findings support that preoperative PLR is a non-invasive, clinically relevant marker correlated with lesion severity, offering potential for preoperative risk stratification, particularly where advanced diagnostics are limited. Full article
(This article belongs to the Special Issue Obstetrics and Gynecology Medicine: From Bench to Bedside—2nd Edition)
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12 pages, 648 KiB  
Article
DuoStim Shows Comparable Efficacy but Better Efficiency than Two Conventional Stimulations in Poor/Suboptimal Responders Undergoing Vitrified Oocyte Accumulation for PGT-A
by Stefano Canosa, Alberto Revelli, Danilo Cimadomo, Alberto Vaiarelli, Gianluca Gennarelli, Daniela Guidetti, Andrea Roberto Carosso, Laura Rienzi, Filippo Maria Ubaldi and Francesca Bongioanni
Life 2025, 15(6), 899; https://doi.org/10.3390/life15060899 - 31 May 2025
Viewed by 770
Abstract
This study compared the DuoStim protocol with two conventional follicular phase stimulations for vitrified oocyte accumulation in poor-prognosis patients undergoing PGT-A. A retrospective analysis of 112 IVF cycles was conducted, with 66 cycles among patients undergoing DuoStim (DS-Group) and 46 among patients undergoing [...] Read more.
This study compared the DuoStim protocol with two conventional follicular phase stimulations for vitrified oocyte accumulation in poor-prognosis patients undergoing PGT-A. A retrospective analysis of 112 IVF cycles was conducted, with 66 cycles among patients undergoing DuoStim (DS-Group) and 46 among patients undergoing conventional follicular phase stimulations (DF-Group). The primary outcome was the time to live birth, while secondary outcomes included clinical pregnancy rate, miscarriage rate, live birth rate, and cumulative live birth rate. The final analysis included 66 patients in the DS-Group and 40 in the DF-Group, as 6 women (13%) in the DF-Group discontinued treatment after the first stimulation. Oocyte yield was similar between groups (8.4 ± 3.9 in DS-Group vs. 8.2 ± 4.0 in DF-Group, p = 0.80), as was the number of euploid blastocysts (0.9 ± 1.2 vs. 1.1 ± 1.1, p = 0.37). The cumulative live birth rate was 22.7% in the DS-Group and 25% in the DF-Group (multivariate odds ratio adjusted for maternal age and male factor: 1.05, p = 0.93). The time to live birth was significantly shorter in the DS-Group (81.5 ± 15.5 days) compared to the DF-Group (153.7 ± 78.2 days, p < 0.001). DuoStim showed similar efficacy but a shorter time to live birth. Full article
(This article belongs to the Special Issue Obstetrics and Gynecology Medicine: From Bench to Bedside—2nd Edition)
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15 pages, 984 KiB  
Article
Neonatal Health Following IVF: Own Versus Donor Material in Singleton and Multiple Pregnancies
by Lucia Elena Niculae, Raluca Tocariu, Evelyn-Denise Archir, Alexandru-Ștefan Niculae, Anca-Magdalena Coricovac, Diana-Elena Comandașu, Aida Petca and Elvira Brătilă
Life 2025, 15(4), 578; https://doi.org/10.3390/life15040578 - 1 Apr 2025
Viewed by 1159
Abstract
This study investigates neonatal outcomes in singleton and multiple pregnancies following in vitro fertilization (IVF) using donor (IVF-D) versus autologous (IVF-A) material. A retrospective cohort analysis was conducted with 988 neonates born between 2017 and 2024 across three tertiary neonatal units in Romania. [...] Read more.
This study investigates neonatal outcomes in singleton and multiple pregnancies following in vitro fertilization (IVF) using donor (IVF-D) versus autologous (IVF-A) material. A retrospective cohort analysis was conducted with 988 neonates born between 2017 and 2024 across three tertiary neonatal units in Romania. The primary outcomes included preterm birth, low birthweight, neonatal asphyxia, and congenital malformations. IVF-D pregnancies were associated with a higher prevalence of adverse neonatal outcomes, particularly in multiple gestations. Preterm birth and low birthweight were more frequent in the IVF-D group, with donor-conceived neonates exhibiting increased rates of neonatal ventilation and prolonged hospitalization. Additionally, congenital anomalies, particularly cardiac malformations, were more prevalent in IVF-D pregnancies, suggesting possible immunological and epigenetic influences. Despite these differences, overall neonatal survival was comparable between groups. These findings contribute to the existing literature on assisted reproductive technologies, emphasizing the need for further research to clarify the biological mechanisms influencing neonatal outcomes and to optimize the clinical management of IVF pregnancies using donor gametes. Full article
(This article belongs to the Special Issue Obstetrics and Gynecology Medicine: From Bench to Bedside—2nd Edition)
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Review

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15 pages, 1024 KiB  
Review
The Impact of Endocrine Disruptors on the Female Genital Tract Microbiome: A Narrative Review
by Efthalia Moustakli, Themos Grigoriadis, Anastasios Potiris, Eirini Drakaki, Athanasios Zikopoulos, Ismini Anagnostaki, Athanasios Zachariou, Ekaterini Domali, Peter Drakakis and Sofoklis Stavros
Life 2025, 15(8), 1177; https://doi.org/10.3390/life15081177 - 24 Jul 2025
Abstract
Background/Objectives: Endocrine disruptors (EDs) are xenobiotic chemicals that disrupt hormone signaling and homeostasis within the human body. Accumulative evidence proposes that EDs could affect systemic hormone balance and local microbial communities, including the female genital tract (FGT) microbiome. The FGT microbiome, and especially [...] Read more.
Background/Objectives: Endocrine disruptors (EDs) are xenobiotic chemicals that disrupt hormone signaling and homeostasis within the human body. Accumulative evidence proposes that EDs could affect systemic hormone balance and local microbial communities, including the female genital tract (FGT) microbiome. The FGT microbiome, and especially the vaginal microbiota, contributes significantly to reproductive health maintenance, defense against infection, and favorable pregnancy outcomes. Disruption of the delicate microbial environment is associated with conditions like bacterial vaginosis, infertility, and preterm birth. Methods: The present narrative review summarizes the existing literature on EDs’ potential for changing the FGT microbiome. We discuss EDs like bisphenol A (BPA), phthalates, and parabens and their potential for disrupting the FGT microbiome through ED-induced hormone perturbations, immune modulation, and epithelial barrier breach, which could lead to microbial dysbiosis. Results: Preliminary evidence suggests that ED exposure–microbial composition changes relationships; however, robust human evidence for EDs’ changes on the FGT microbiome remains scarce. Conclusions: Our review addresses major research gaps and suggests future directions for investigation, such as the necessity for longitudinal and mechanistic studies that combine microbiome, exposome, and endocrine parameters. The relationship between EDs and the FGT microbiome could be critical for enhancing women’s reproductive health and for steering regulatory policies on exposure to environmental chemicals. Full article
(This article belongs to the Special Issue Obstetrics and Gynecology Medicine: From Bench to Bedside—2nd Edition)
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