Obstetrics and Gynecology Medicine: From Bench to Bedside—2nd Edition

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1053

Special Issue Editors


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Guest Editor
1. Obstetrics and Gynecology 1U, Physiopathology of Reproduction and IVF Unit, Department of Surgical Sciences, Sant’Anna Hospital, University of Turin, 10126 Turin, Italy
2. Livet, GeneraLife IVF, 10126 Turin, Italy
Interests: clinical embryology; fertility preservation; reproductive genetics; artificial intelligence
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Surgical Sciences, University of Turin, 10126 Turin, Italy
Interests: fetal–maternal medicine; human pregnancy; placenta physiopathology and placental-derived mesenchymal stromal cells (PDMSCs)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

"We invite you to publish your research in this edition of “Obstetrics and Gynecology Medicine: From Bench to Bedside—2nd Edition”, following the success of the first volume: https://www.mdpi.com/journal/life/special_issues/8MJ427ATRD".

Translational research aims to bridge the gap between laboratory studies and clinical demands by converting the achievements of basic science into everyday clinical practice. An efficient translational process is sustained by the mutual synergy of academic laboratory research and public/private hospitals. However, the process of transforming research innovation into new health products, as well as diagnostic and therapeutic strategies, remains a major issue of contemporary biomedical medicine. Among different fields of applications, over the last few decades, obstetrics and gynecology have experienced a dramatic increase in several clinical and technical upgrades based on translational research discoveries. Improvements in the quality of life of cancer patients, pathological pregnancies treatments, drug discoveries, identification of new diagnostic and/or prognostic biomarkers, stem cell applications, the discovery of new molecular pathways involved in obstetrics and gynecology pathophysiology, and automation in assisted reproductive technologies represent only a few examples of the clinical application of basic research. This Special Issue aims to collect original papers and innovative review articles detailing the use of basic research in translational studies of obstetrics and gynecology to assist and support clinical practice in the near future.

Dr. Stefano Canosa
Dr. Anna Maria Nuzzo
Guest Editors

Manuscript Submission Information

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Keywords

  • obstetrics
  • gynecology
  • translational research
  • translational medicine

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Published Papers (1 paper)

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Research

15 pages, 984 KiB  
Article
Neonatal Health Following IVF: Own Versus Donor Material in Singleton and Multiple Pregnancies
by Lucia Elena Niculae, Raluca Tocariu, Evelyn-Denise Archir, Alexandru-Ștefan Niculae, Anca-Magdalena Coricovac, Diana-Elena Comandașu, Aida Petca and Elvira Brătilă
Life 2025, 15(4), 578; https://doi.org/10.3390/life15040578 - 1 Apr 2025
Viewed by 787
Abstract
This study investigates neonatal outcomes in singleton and multiple pregnancies following in vitro fertilization (IVF) using donor (IVF-D) versus autologous (IVF-A) material. A retrospective cohort analysis was conducted with 988 neonates born between 2017 and 2024 across three tertiary neonatal units in Romania. [...] Read more.
This study investigates neonatal outcomes in singleton and multiple pregnancies following in vitro fertilization (IVF) using donor (IVF-D) versus autologous (IVF-A) material. A retrospective cohort analysis was conducted with 988 neonates born between 2017 and 2024 across three tertiary neonatal units in Romania. The primary outcomes included preterm birth, low birthweight, neonatal asphyxia, and congenital malformations. IVF-D pregnancies were associated with a higher prevalence of adverse neonatal outcomes, particularly in multiple gestations. Preterm birth and low birthweight were more frequent in the IVF-D group, with donor-conceived neonates exhibiting increased rates of neonatal ventilation and prolonged hospitalization. Additionally, congenital anomalies, particularly cardiac malformations, were more prevalent in IVF-D pregnancies, suggesting possible immunological and epigenetic influences. Despite these differences, overall neonatal survival was comparable between groups. These findings contribute to the existing literature on assisted reproductive technologies, emphasizing the need for further research to clarify the biological mechanisms influencing neonatal outcomes and to optimize the clinical management of IVF pregnancies using donor gametes. Full article
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