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Life, Volume 15, Issue 8

2025 August - 178 articles

Cover Story: Type 2 diabetes (T2D) is a common metabolic disorder marked by chronic hyperglycemia, hyperinsulinemia, and cardiovascular complications. A key feature is disrupted hormone balance—elevated insulin and leptin with reduced adiponectin—which critically shapes immune cell function. T2D patients show a skewed immune profile with increased pro-inflammatory cytokines such as IFN-γ, TNF-α, IL-17, and IL-6, known drivers of vascular inflammation. In addition, altered metabolic hormones foster a pro-inflammatory immune phenotype, indicating that these hormones act not only in energy regulation but also as immune activators. Their dysregulation likely plays an important, and often underrecognized, role in the development of diabetic cardiovascular disease. View this paper
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Articles (178)

  • Review
  • Open Access
2 Citations
2,676 Views
21 Pages

Physiopathology of the Brain Renin-Angiotensin System

  • Cristina Cueto-Ureña,
  • María Jesús Ramírez-Expósito,
  • María Pilar Carrera-González and
  • José Manuel Martínez-Martos

21 August 2025

The renin-angiotensin system (RAS) has evolved from being considered solely a peripheral endocrine system for cardiovascular control to being recognized as a complex molecular network with important functions in the central nervous system (CNS) and p...

  • Article
  • Open Access
1,414 Views
16 Pages

Gut Microbiota Modulation and Anti-Obesity Potential of Epigallocatechin-3-Gallate-Quercetin-Rutin Against High-Fat Diet-Induced Obesity in Rats

  • Yu-Jou Chien,
  • Ching-Chang Cho,
  • Yu-Ting Hung,
  • Li-You Chen,
  • Yue-Ching Wong,
  • Shiuan-Chih Chen and
  • Chin-Lin Hsu

21 August 2025

Polyphenols have been widely recognized for their potential anti-obesity effects. This study aimed to evaluate the impact of a polyphenol compound-epigallocatechin-3-gallate, quercetin, and rutin (EQR) on obesity-related parameters and gut microbiota...

  • Article
  • Open Access
978 Views
17 Pages

Biological Potential of Hypericum L. Sect. Drosocarpium Species

  • Nebojša Kladar,
  • Branislava Srđenović Čonić,
  • Goran Anačkov,
  • Maja Hitl,
  • Bojana Bokić,
  • Boris Radak and
  • Milica Rat

21 August 2025

The limited data on biological potential of the genus Hypericum sect. Drosocarpium species initiated the current research aimed at the chemical characterization of samples of six selected taxa (H. barbatum, H. montbretii, H. richerii subsp. grisebach...

  • Article
  • Open Access
1,196 Views
12 Pages

21 August 2025

Cognitive frailty in elders has become very common in Thailand society and is extremely difficult to manage in clinical practice due to poor detection and diagnosis. Plasma proteomic studies may be able to provide promising protein markers specific t...

  • Article
  • Open Access
1 Citations
1,229 Views
13 Pages

Evaluation of Total Homocysteine Levels in Relation to Abdominal Fat Mass and Traditional Cardiovascular Risk Factors in Overweight and Obese Adolescents

  • Małgorzata Rumińska,
  • Ewelina Witkowska-Sędek,
  • Maria Krajewska,
  • Anna Stelmaszczyk-Emmel,
  • Maria Sobol and
  • Beata Pyrżak

21 August 2025

Cardiovascular diseases remain the leading cause of mortality worldwide, with multiple risk factors contributing to their development. Among these, obesity and hyperhomocysteinemia have been recognized as significant contributors to endothelial dysfu...

  • Case Report
  • Open Access
898 Views
7 Pages

Diagnosis and Management of Struma Ovarii in Pregnancy: A Case Report

  • Isidoro Narbona Arias,
  • Lucia Castaño Frías,
  • María Marfil Gonzalez,
  • Laura Baños Cárdenas and
  • Jesús S. Jimenez Lopez

21 August 2025

Adnexal tumors during pregnancy are rare, with a prevalence ranging from 0.05% to 3%, and in most cases, they are benign. Struma ovarii, a monodermal teratoma, consists of over 50% thyroid tissue and accounts for 2.7% of ovarian teratomas. It typical...

  • Article
  • Open Access
1,521 Views
19 Pages

Integrated Proteomic and Molecular Identification of Thermophilic Geobacillus Strains from Algerian Desert Sands and Their Enzymatic Potential

  • Amaria Ilhem Hammadi,
  • Mohamed Merzoug,
  • Marwa Aireche,
  • Zohra Yasmine Zater,
  • Keltoum Bendida,
  • Chaimaa Naila Brakna,
  • Slimane Choubane,
  • Svetoslav Dimitrov Todorov and
  • Djamal Saidi

21 August 2025

Thermophilic microorganisms are among the key natural sources of thermostable enzymes, found not only in geothermal areas but also in arid environments. In this study, eight Geobacillus strains were isolated from the arid sands of Aïn Sefra (Na&...

  • Article
  • Open Access
911 Views
12 Pages

20 August 2025

Objectives: This study aimed to determine whether prior use of a beta blocker (BB) is associated with the three-year risk of total hip arthroplasty after being diagnosed with osteoarthritis of the hip and compare risks across BB subtypes. Methods: Th...

  • Article
  • Open Access
885 Views
11 Pages

Comparing Performance of NAF and NT-2013 to SGA as Nutritional Assessment Tools in Systemic Sclerosis Patients

  • Kittipadh Boonyavarakul,
  • Chingching Foocharoen,
  • Orathai Wantha and
  • Veeradej Pisprasert

20 August 2025

Malnutrition is one of the common complications of patients with systemic sclerosis (SSc). However, several nutritional assessment tools are implemented in Thailand. The study aimed to compare the performance of nutritional assessment tools including...

  • Article
  • Open Access
1,267 Views
17 Pages

Olfactory Network Functional Connectivity as a Marker for Parkinson’s Disease Severity

  • Senal Peiris,
  • Anupa Ekanayake,
  • Jiaming Lu,
  • Rommy Elyan,
  • Katie Geesey,
  • Ross Cottrill,
  • Paul Eslinger,
  • Xuemei Huang and
  • Prasanna Karunanayaka

20 August 2025

Olfactory impairment was assessed in akinetic-rigid (PDAR) and tremor-predominant (PDT) subtypes of Parkinson’s disease (PD), classified based on motor symptoms. Seventeen PDAR, fifteen PDT, and twenty-four cognitively normal (CN) participants...

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Life - ISSN 2075-1729