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Life, Volume 15, Issue 7

July 2025 - 170 articles

Cover Story: Cholinergic projections from the basal forebrain to the cortex and hippocampus play a critical role in cognitive functions, many of which rely on signaling through the alpha7 nicotinic acetylcholine receptor (α7nAChR). The Alzheimer’s disease (AD) brain is characterized by profound impairment of the basal forebrain cholinergic system, including alterations in the levels of α7nAChR, which may impact cognition. Importantly, α7nAChR has also been identified as a potential receptor for Aβ, and while their interaction supports neurotransmission, plasticity and memory function under normal physiological conditions, it leads to deleterious effects when Aβ is pathologically elevated. This article discusses the contributions of neuronal, astrocytic and microglial α7nAChR to AD pathophysiology with an emphasis on interactions of α7nAChR with Aβ. View this paper
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Articles (170)

  • Article
  • Open Access
748 Views
10 Pages

Mortality from Pleural and Lung Cancer in Railway Maintenance Workers

  • Leonardo Scarso,
  • Marco Novelli,
  • Eva Lorenza Negri,
  • Carlotta Zunarelli,
  • the Pleural Cancer 2024 Study Group and
  • Francesco Saverio Violante

21 July 2025

(1) Background: Occupational exposure to asbestos remains a significant public health concern due to its association with pleural cancer and other cancers. This cohort study examines the incidence of asbestos-related diseases among railway carriage m...

  • Article
  • Open Access
869 Views
22 Pages

Studies on Host–Parasite Relationship Between Soybean Plants and Aphelenchoides besseyi

  • Neveen Atta Elhamouly,
  • Nehal Atta,
  • Shiming Liu and
  • Deliang Peng

21 July 2025

Aphelenchoides besseyi is considered a highly prevalent facultative plant-parasitic nematode and has a significant impact on various economically important crops globally. Due to the lack of knowledge on the efficacy of various management techniques,...

  • Article
  • Open Access
815 Views
13 Pages

Relationship Between Subclinical Renal Damage and Maximum Rate of Blood Pressure Variation Assessed by Fourier Analysis of 24-h Blood Pressure Curve in Patients with Essential Hypertension

  • Caterina Carollo,
  • Alessandra Sorce,
  • Maria Giovanna Vario,
  • Emanuele Cirafici,
  • Davide Bologna,
  • Maria Elena Ciuppa,
  • Salvatore Evola,
  • Guseppe Mulè and
  • Giulio Geraci

21 July 2025

Background: Blood pressure (BP) variability has been increasingly recognized as a predictor of cardiovascular and renal outcomes. However, the relevance of specific dynamic indices such as the maximum slope of systolic blood pressure (max SBP slope),...

  • Article
  • Open Access
1 Citations
1,805 Views
13 Pages

Curcumin Ameliorates DSS-Induced Colitis in Mice Through Modulation of Gut Microbiota and Metabolites

  • Chengxue Yi,
  • Yuxuan Xia,
  • Jiajing Yan,
  • Wen Xia,
  • Haoyu Wang,
  • Fei Mao and
  • Pan Huang

21 July 2025

In this study, we established a mouse colitis model using DSS to investigate the impact of curcumin on gut injury, the intestinal microbiota, and fecal metabolites. The findings indicated that curcumin effectively mitigated weight loss and colon shor...

  • Case Report
  • Open Access
1,319 Views
7 Pages

Spontaneous Improvement of Hypogonadotropic Hypogonadism in a Patient with PCSK1 and HS6ST1 Mutations: A Case Report

  • Alanna Asgeirsson,
  • Eujean Park,
  • Vinicius Seidel,
  • Mathew Shedd,
  • Matheni Sathananthan,
  • Tania Arous,
  • Kevin Codorniz,
  • Silvana Giannelli,
  • Justin Do and
  • Wyut Yi Thin
  • + 2 authors

21 July 2025

Kallmann syndrome (KS) is a form of hypogonadotropic hypogonadism (HH) characterized by gonadotropin-releasing hormone (GnRH) deficiency and anosmia due to defective neuronal migration. While traditionally considered irreversible, cases of spontaneou...

  • Article
  • Open Access
2 Citations
968 Views
21 Pages

Genetic Variants Linked with the Concentration of Sex Hormone-Binding Globulin Correlate with Uterine Fibroid Risk

  • Marina Ponomarenko,
  • Evgeny Reshetnikov,
  • Maria Churnosova,
  • Inna Aristova,
  • Maria Abramova,
  • Vitaly Novakov,
  • Vladimir Churnosov,
  • Alexey Polonikov,
  • Denis Plotnikov and
  • Mikhail Churnosov
  • + 1 author

21 July 2025

In this study we searched for correlations between polymorphic variants that determine sex hormone-binding globulin concentration (SHBGcon) and uterine fibroids (UFs). The work was performed on a sample of 1542 women (569 with UFs and 973 without UFs...

  • Article
  • Open Access
1 Citations
3,520 Views
12 Pages

21 July 2025

Cellulite is a widespread aesthetical dermatological condition affecting a significant proportion of postpubertal women, characterized by dimpled skin, primarily on the thighs, buttocks, and hips, which has an important psychological impact. Cellulit...

  • Systematic Review
  • Open Access
2 Citations
10,251 Views
15 Pages

Exercise as Modulator of Brain-Derived Neurotrophic Factor (BDNF) in Children: A Systematic Review of Randomized Controlled Trials

  • Markel Rico-González,
  • Daniel González-Devesa,
  • Carlos D. Gómez-Carmona and
  • Adrián Moreno-Villanueva

21 July 2025

Background: Brain-derived neurotrophic factor (BDNF) plays a pivotal role in neuroplasticity and cognitive development. While exercise has been shown to modulate BDNF levels in adults, evidence in children remains limited and heterogeneous. Methods:...

  • Comment
  • Open Access
1 Citations
816 Views
8 Pages

21 July 2025

This comment focuses on the contribution of experimental brain ischemia to the overwhelming incidence of Alzheimer’s disease in women as presented by Lohkamp et al. in Life 2025, 15, 333. The authors showed that in Alzheimer’s disease and...

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Life - ISSN 2075-1729