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Life, Volume 15, Issue 10

2025 October - 149 articles

Cover Story: Research on inter-organ crosstalk in the body is growing rapidly, especially regarding bidirectional communication between the brain and other organs. This interaction is crucial as its dysregulation may contribute to brain diseases, including neurodegenerative disorders, thus offering potential biomarkers to define strategies for prevention, diagnosis, and treatment, as well as for personalised medicine protocols. Although the central nervous system was once thought of as isolated from peripheral influences, evidence shows a complex network of signalling molecules (cytokines, growth factors, metabolites, hormones) linking the brain to peripheral organs, able to affect both brain and peripheral functions. Key communication pathways in neurodegeneration involve the gut–brain, brain–adipose tissue, brain–liver, brain–immune system, and brain–muscle axes. View this paper
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Articles (149)

  • Review
  • Open Access
2 Citations
1,302 Views
26 Pages
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Beyond the Pain: A Critical Examination of the Psychopathological and Neuropsychological Dimensions of Primary Headaches in Pediatric Populations

  • Giuseppe Accogli,
  • Valentina Nicolardi,
  • Camilla Ferrante,
  • Giorgia Carlucci,
  • Sara Scoditti and
  • Antonio Trabacca
Life2025, 15(10), 1641;https://doi.org/10.3390/life15101641

21 October 2025

Background: Primary headaches in children and adolescents impose emotional, cognitive, and functional burdens beyond pain. This review synthesizes their psychopathological and neuropsychological dimensions and outlines implications for assessment and...

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  • Article
  • Open Access
666 Views
12 Pages
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Comparison of DeltaScan® and CAM-ICU for the Assessment of Postoperative Delirium in Patients Undergoing Cardiac Surgery and Cardiac Interventions: A Prospective Observational Pilot Study

  • Astrid Bergmann,
  • Janis Fliegenschmidt,
  • Silvia Ruggeri,
  • Nikolai Hulde,
  • Catharina Middeke,
  • Claudia Bunge,
  • Maria Preising,
  • Carsten Hermes and
  • Vera von Dossow
Life2025, 15(10), 1640;https://doi.org/10.3390/life15101640

21 October 2025

Background: Postoperative delirium is frequent among elderly patients and often presents after major surgery or intervention. Validated screening tools should be routinely used to recognise this psychopathological syndrome. Delirium might be associat...

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  • Article
  • Open Access
772 Views
21 Pages
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Mineral Metabolism Assays, Central DXA, and Fracture Risk Probabilities in Menopausal Patients with Non-Functional Adrenal Tumors with/Without Mild Autonomous Cortisol Secretion: Does the Presence of Unilateral Versus Bilateral Tumors Matter?

  • Alexandra-Ioana Trandafir,
  • Mara Carsote,
  • Mihai Costachescu,
  • Oana-Claudia Sima and
  • Alexandru-Florin Florescu
Life2025, 15(10), 1639;https://doi.org/10.3390/life15101639

21 October 2025

Introduction/Background: Most adrenal incidentalomas (AIs) are non-functioning adrenal tumors (NFATs) without clinically overt hormonal hypersecretion; one-third show subtle endocrine over-activity and mild autonomous cortisol secretion (MACS). One o...

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  • Review
  • Open Access
585 Views
13 Pages
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Anticancer Activity of Demethylincisterol A3 and Related Incisterol-Type Fungal Products

  • Christian Bailly
Life2025, 15(10), 1638;https://doi.org/10.3390/life15101638

21 October 2025

Highly degraded sterols belonging to the incisterol group have been identified in a large set of microorganisms. The leading product in the family is demethylincisterol A3 (DM-A3), isolated from various fungi and endowed with marked antitumor propert...

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  • Article
  • Open Access
1,087 Views
14 Pages
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Effects of Physical Exercise on Cardiorespiratory Fitness and Cardiometabolic Outcomes in Schizophrenia Spectrum Disorders: The FitForLife National Intervention in Sweden

  • Yvonne Forsell,
  • Maria Skott,
  • Buse Yel Bektash,
  • Astrid Syvertsen,
  • Örjan Ekblom and
  • Catharina Lavebratt
Life2025, 15(10), 1637;https://doi.org/10.3390/life15101637

21 October 2025

(1) Background: Individuals affected by schizophrenia spectrum disorders (SSDs) have an increased risk for cardiometabolic diseases. Improved cardiorespiratory fitness (CRF) is associated with lower cardiometabolic risk. The aim of the study was to a...

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  • Article
  • Open Access
871 Views
15 Pages
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Casomorphine-10 (CM-10) Peptide Orchestrates Circadian and Neurodevelopmental Gene Clusters via δ-Opioid Receptor Signaling: Insights from Transcriptome Analysis with δ-Opioid Receptor-Expressing HEK293 Cells

  • Moe Fukunaga,
  • Shin Watanabe,
  • Kanami Orihara and
  • Naoyuki Yamamoto
Life2025, 15(10), 1636;https://doi.org/10.3390/life15101636

20 October 2025

Background: β-casomorphin-10 (CM-10), a peptide fragment derived from milk casein with the sequence YPFPGPIPNS, has demonstrated notable anxiolytic activity in BALB/c mice. Yet, its cellular responses and mechanistic pathways remain largely unch...

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  • Article
  • Open Access
720 Views
14 Pages
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Protocol Biopsies Reveal Progressive Arteriolar Thickening as a Predictor of Mortality in Kidney Transplant Recipients

  • Diana Rodríguez-Espinosa,
  • Evelyn Hermida,
  • Agustín Leal-Cúpich,
  • Adriana García,
  • Ana Belén Larque,
  • Elena Cuadrado-Payán,
  • Elena Guillén-Olmos,
  • Marina Moncada,
  • Pedro Ventura-Aguiar and
  • José Jesús Broseta
  • + 5 authors
Life2025, 15(10), 1635;https://doi.org/10.3390/life15101635

20 October 2025

Kidney transplant recipients remain at high risk of cardiovascular events and premature death. Whether chronic histological changes in protocol allograft biopsies provide prognostic information for patient outcomes beyond graft survival remains uncer...

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  • Review
  • Open Access
1,993 Views
21 Pages
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Translating Metabolic Interventions into Breast Cancer Therapy: A Comprehensive Review

  • Luxi Chen,
  • Stephen L. Shiao and
  • Yuan Yuan
Life2025, 15(10), 1634;https://doi.org/10.3390/life15101634

20 October 2025

Breast cancer remains a leading cause of morbidity and mortality in women worldwide. Despite significant advances in targeted therapies, therapeutic resistance, metabolic toxicities, and disease recurrence continue to limit long-term efficacy. Metabo...

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  • Article
  • Open Access
741 Views
20 Pages
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A Diffusion Tensor Imaging Study: Relation of Wisconsin Card Sorting Covariates to White Matter Abnormalities in Traumatic Brain Injury

  • Aditya Prashant Kamble,
  • Angel Liu,
  • Dean Choi and
  • Joseph Wu
Life2025, 15(10), 1633;https://doi.org/10.3390/life15101633

20 October 2025

New brain imaging modalities and neuropsychological testing tools are used to study neuronal changes in brain injuries such as mild traumatic brain injury (mTBI). Here we utilized diffusion tensor imaging (DTI) parameters and Wisconsin Card Sorting T...

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