Life, Volume 15, Issue 11

Background: Platelets have conventionally been viewed as cellular fragments crucial for hemostasis; nonetheless, their extensive secretome of cytokines and growth factors has been increasingly acknowledged as a significant regulator of inflammation a...

Background: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have demonstrated significant benefits in cardiovascular outcomes trials, but their effect on atherosclerotic plaques remains unclear. This review aims to summarize the current evidence o...

Background: The purpose of this study was to assess differences in clinical symptoms and signs of DED in non-adherent to treatment patients to describe long-term disease progression. Methods: 120 patients previously diagnosed with Dry Eye Disease (DE...

Phototaxis, the movement toward or away from light, is a fundamental behavior with ecological and evolutionary relevance. In Drosophila melanogaster, phototactic choice shows individual variability and has been linked to serotonergic signaling. Using...

Corneoscleral-ring-derived extracellular vesicles represent a potential therapeutic strategy for promoting in vitro corneal wound healing. In this study, we successfully isolated and characterized extracellular vesicles from human corneolimbal tissue...

Background: Vulvar squamous cell carcinoma (VSCC) is an uncommon yet increasingly relevant malignancy characterized by two distinct etiopathogenetic pathways: HPV-associated and HPV-independent. Data from Eastern Europe remain scarce, where demograph...

The effect of cyclic pig slurry (PS) application in long-term crop rotations with alfalfa is poorly recognized, particularly with regard to nitrogen use efficiency (NUE) in crops requiring relatively high nitrogen (N) inputs. A long-term field experi...

Background/Objectives: This study’s objective was to analyze the reading ability in patients with intermittent exotropia using an eye tracker and determine how the clinical characteristics of intermittent exotropia may affect reading ability. M...

Background: Laser hemorrhoidoplasty (LHP) is a minimally invasive alternative to excisional hemorrhoidectomy, with promising short-term outcomes. However, predictors of postoperative pain, bleeding, and recovery remain insufficiently characterized. M...

Glutamate-related excitotoxicity represents a fundamental pathological process underlying both acute and chronic disorders of the central nervous system. Excessive stimulation of ionotropic and metabotropic glutamate receptors induces ionic dysregula...

Number processing offers significant adaptive advantages, enabling animals to navigate their environment and maximize survival outcomes. Extensive evidence across species demonstrates that numerical cognition is a ubiquitous cognitive trait that enha...

Tree pollen is the most abundant in the Community of Madrid (CAM), and specifically, pollen types from Olea, Cupressaceae, and Platanus are the most allergenic, after Gramineae, in this Spanish region. Air pollutants are one of the most significant s...

Gestational weight gain (GWG) is a critical determinant of maternal and neonatal health, yet its patterns and consequences in displaced populations remain understudied. This study examined the association between GWG and birth outcomes among Forcibly...

Testicular tumors are, after skin tumors, the most common neoplasms in male dogs. Among all animals, these tumors occur most frequently within dogs. The etiology remains unclear, although the ectopic (non-scrotal) positioning of the testicles has an...

In the published publication [...]

In this study, we applied eight different light quality treatments and investigated their effects on the proliferation and physiological characteristics of Aquilaria sinensis group-cultivated seedlings in order to screen the best light quality for op...

Background: National Health Insurance Herbal prescriptions (NHPs) are widely used; however, their multi-component composition complicates mechanistic interpretation and impedes the development of evidence-based approaches in traditional medicine and...

Atherosclerosis is a progressive arterial disease characterized by chronic inflammation, with interleukin-27 (IL-27) implicated as both a pro- and anti-inflammatory cytokine. This prospective cohort study evaluated association of circulating IL-27 le...

PF4-dependent disorders encompass a heterogeneous group of immune-mediated thrombotic syndromes, including heparin-induced thrombocytopenia (HIT), its autoimmune variants such as spontaneous HIT, and vaccine-induced immune thrombotic thrombocytopenia...

The growing body of biomedical research reveals that many biological processes are governed by quantum physical principles, including the effects of weak magnetic fields (MFs) at or below geomagnetic strength. Given that life evolved within the geoma...

Pararenal abdominal aortic aneurysm/pseudoaneurysms (PAAA/PAAP) are rare, high-risk complex aortic lesions involving the renal arteries. Management includes open surgical repair (OSR), endovascular aortic repair (EVAR), or hybrid repair, each with sp...

Pressure-overload-induced heart failure is characterized by pathological ventricular remodeling, including hypertrophy and fibrosis, which compromise cardiac function and worsen outcomes. Vericiguat, a soluble guanylate cyclase (sGC) stimulator, has...

Metabolic dysfunction-associated steatotic liver disease (MASLD) is an escalating global health burden and a leading cause of chronic liver disease. Without intervention, MASLD can progress to steatohepatitis, fibrosis, cirrhosis, and hepatocellular...

Periprosthetic joint infection (PJI) remains one of the most serious complications after total joint arthroplasty. This retrospective 1:1 matched case–control study investigated preoperative predictors and patient phenotypes associated with PJI...

Given the limited data in the recent literature regarding spirulina cultivated in Greece, the present study aimed to investigate physicochemical parameters (pH, color), antioxidant activity, and phytochemical content (total phenolic content, querceti...

Purpose: Post-stroke spasticity (PSS) substantially affects functional recovery and quality of life in stroke survivors. However, the current clinical assessment methods exhibit certain subjectivity and equipment limitations. Human pose estimation pr...

Background: Radial artery spasm remains a frequent complication during transradial coronary and peripheral angiography. Despite its impact on procedural success and patient discomfort, consistent predictors remain elusive, as does a standard definiti...

The spirochete Borrelia is responsible for Lyme disease, a multisystemic infection and growing public health concern. This study aimed to evaluate host response dynamics to Borrelia bavariensis by analyzing hematological parameters as potential immun...

Infections pose a major risk during long-term human spaceflight missions. By applying standard procedures in medical microbiology to a hypothetical urinary tract infection during a Mars-bound flight, important practical aspects become apparent. From...

Bacteremia is a life-threatening condition contributing significantly to sepsis-related mortality worldwide. With delayed appropriate antibiotic therapy, mortality increases by 20% regardless of antimicrobial resistance. This study evaluated the perc...

Purpose: The increasing demand for alternatives to autologous and resorbable bone grafts in the treatment of bone defects is driving research efforts. This study aims to evaluate the effects of different surface treatments on zinc-1%-magnesium (Zn-1M...

Diabetic retinopathy (DR) is a microvascular disorder of the retina due to diabetes mellitus (DM). Natural products are widely used to prevent and treat various diseases caused by DM. This study aims to evaluate the effect of buah merah (Pandanus con...

Purpose: This study aimed to develop a precise predictive model to assess the risk of radiation pneumonitis (RP) and three-year survival in patients with non-small cell lung cancer (NSCLC) following volumetric modulated arc therapy (VMAT). Radiomics...

Central nervous system disorders represent a heterogeneous set of conditions triggered by genetic alterations, environmental exposures, infections, injuries, and even iatrogenic causes. These conditions impact a significant portion of the global popu...

This study investigated the effects of eight weeks of aerobic exercise training on body composition, lipid profiles, organokines (leptin, irisin), inflammatory biomarkers (high-sensitivity C-reactive protein [hs-CRP], interleukin-6 [IL-6]), and intes...

The bidirectional link between cancer and cardiovascular disease presents a growing clinical challenge, often exacerbated by the cardiotoxic effects of many anti-cancer drugs. Simultaneously, the incidence of cardiovascular pathologies in cancer pati...

Primary cardiac tumors are rare, with an estimated incidence of 0.001% to 0.3% in autopsy series. Most are benign, the most common being cardiac myxomas, which typically originate in the left atrium. Right ventricular myxoma is among the rarest prima...

Wound healing is a tightly regulated biological process involving hemostasis, inflammation, proliferation, and tissue remodeling. When these phases are disrupted, wound repair can be delayed or become chronic. Key signaling pathways, including NF-&ka...

Background: After the implementations of Highly Active Antiretroviral Therapy (HAART) HIV infection became a chronic condition and the clinical focus on non-AIDS-related comorbidities such as hypertension and chronic kidney disease has increased. Thi...

Mitochondrial dysfunction contributes to female reproductive endocrine disorders and is frequently associated with multisystem symptoms. Insulin resistance (IR) is a common metabolic disorder strongly linked to polycystic ovary syndrome (PCOS), while...

The growing demand for sustainable alternatives to animal and synthetic leathers has accelerated interest in mycelium-based materials as an eco-friendly solution for the fashion industry. This study explores the potential of mushroom mycelium to crea...

The origin of life remains one of the most profound and enduring enigmas in the biological sciences. Despite substantial advances in prebiotic chemistry, fundamental uncertainties persist regarding the precise mechanisms that enabled the emergence of...

Scleral remodeling plays a crucial role in myopia development. Although ultrastructural collagen changes have been described, quantitative assessment at the fiber bundle level remains limited. This study quantitatively evaluated scleral collagen remo...

Colorectal cancer (CRC) is the leading cause of cancer-related death in Puerto Rico, a U.S. territory with noted disparities in CRC incidence, particularly among those with early-onset disease (EOCRC). Although EOCRC incidence has been consistently i...

Background: Charcot–Marie–Tooth disease (CMTd) is the most prevalent inherited peripheral neuropathy, often associated with foot deformities and gait and balance impairments. While the structural characteristics of the foot have been exte...

Coronary endothelial dysfunction is an early and critical vascular abnormality in cardiometabolic syndrome, intensified by irregular sleep patterns and excess adiposity. Disruption of circadian rhythm and accumulation of visceral fat impair nitric ox...

Background: Chronic total occlusion percutaneous coronary intervention (CTO PCI) is a complex revascularization procedure requiring advanced techniques to ensure procedural success and safety. Hybrid strategies combining antegrade dissection/re-entry...

Background: Exergame applications were introduced recently for orthopedic rehabilitation. This study aimed to evaluate the effectiveness of a 6-week home-based quadriceps exercise with mobile exergaming for treatment of primary knee osteoarthritis (K...

Granulocyte-macrophage colony-stimulating factor (GM-CSF) has emerged as a key cytokine in the pathogenesis of rheumatoid arthritis, an autoimmune disease distinguished by synovial inflammation and progressive joint destruction. GM-CSF orchestrates t...

Immune thrombocytopenia (ITP) is an autoimmune disorder often triggered by prior viral infections. Although there is considerable evidence suggesting platelets act as passive bystanders during viral illnesses, they are increasingly recognised as acti...