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Toxins, Volume 10, Issue 12

December 2018 - 61 articles

Cover Story: Chlorotoxin is a disulfide-rich stable peptide derived from the venom of the Israeli scorpion, Leiurus quinquestriatus. Many studies demonstrated chlorotoxin could preferentially binds to neuroectodermal tumors, such as glioblastoma, without cross-reactivity to normal brain cells. Because it has the ability to penetrate the blood–brain barrier, and its tyrosine residue allows covalent conjugation with functional moieties, chlorotoxin is an attractive platform to explore development of diagnostic and therapeutic agents for gliomas. In this review, we outline the chlorotoxin structure and its molecular targets, summarize molecular variations of chlorotoxin developed for glioma imaging, and discuss future trends and perspectives for chlorotoxin conjugates as a theranostic agent. View this paper.
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Articles (61)

  • Article
  • Open Access
16 Citations
6,085 Views
19 Pages

Transcriptomic Characterization of the South American Freshwater Stingray Potamotrygon motoro Venom Apparatus

  • Filipe Silva,
  • Yu Huang,
  • Vítor Yang,
  • Xidong Mu,
  • Qiong Shi and
  • Agostinho Antunes

18 December 2018

Venomous animals are found through a wide taxonomic range including cartilaginous fish such as the freshwater stingray Potamotrygon motoro occurring in South America, which can injure people and cause venom-related symptoms. Ensuring the efficacy of...

  • Communication
  • Open Access
17 Citations
4,955 Views
10 Pages

Biomarker of Aflatoxin Ingestion: 1H NMR-Based Plasma Metabolomics of Dairy Cows Fed Aflatoxin B1 with or without Sequestering Agents

  • Ibukun Ogunade,
  • Yun Jiang,
  • James Adeyemi,
  • Andre Oliveira,
  • Diwakar Vyas and
  • Adegbola Adesogan

18 December 2018

The study applied 1H NMR-based plasma metabolomics to identify candidate biomarkers of aflatoxin B1 (AFB1) ingestion in dairy cows fed no sequestering agents and evaluate the effect of supplementing clay and/or a Saccharomyces cerevisiae fermentation...

  • Article
  • Open Access
40 Citations
5,029 Views
10 Pages

Fibroblast Growth Factor Receptor, a Novel Receptor for Vegetative Insecticidal Protein Vip3Aa

  • Kun Jiang,
  • Xiaoyue Hou,
  • Lu Han,
  • Tongtong Tan,
  • Zhanglei Cao and
  • Jun Cai

18 December 2018

Vegetative insecticidal proteins (Vips), which are secreted by some Bacillus thuringiensis strains during vegetative growth, exhibit high virulence to many pests. Vip3A proteins have been used commercially both in some bio-insecticides and in transge...

  • Review
  • Open Access
42 Citations
8,827 Views
19 Pages

17 December 2018

For many of the most important human bacterial infections, invasive disease severity is fueled by the cell damaging and pro-inflammatory effects of secreted pore-forming toxins (PFTs). Isogenic PFT-knockout mutants, e.g., Staphylococcus aureus lackin...

  • Article
  • Open Access
53 Citations
8,026 Views
16 Pages

Occurrence and Levels of Aflatoxins in Fish Feeds and Their Potential Effects on Fish in Nyeri, Kenya

  • Evalyn Wanjiru Mwihia,
  • Paul Gichohi Mbuthia,
  • Gunnar Sundstøl Eriksen,
  • James K. Gathumbi,
  • Joyce G. Maina,
  • Stephen Mutoloki,
  • Robert Maina Waruiru,
  • Isaac Rumpel Mulei and
  • Jan Ludvig Lyche

17 December 2018

Aflatoxins are fungal metabolites that contaminate foods and feeds, causing adverse health effects in humans and animals. This study determined the occurrence of aflatoxins in fish feeds and their potential effects on fish. Eighty-one fish feeds were...

  • Article
  • Open Access
6 Citations
4,007 Views
9 Pages

15 December 2018

Staphylococcal enterotoxins (SEs) are a food safety concern. Existing methods for biologically active SE detection rely on the emetic response in live kittens or monkeys. This method suffers from low sensitivity, poor reproducibility, and causes ethi...

  • Article
  • Open Access
11 Citations
9,651 Views
12 Pages

Impact of Naja nigricollis Venom on the Production of Methaemoglobin

  • Harry F. Williams,
  • Paul Hayter,
  • Divyashree Ravishankar,
  • Anthony Baines,
  • Harry J. Layfield,
  • Lorraine Croucher,
  • Catherine Wark,
  • Andrew B. Bicknell,
  • Steven Trim and
  • Sakthivel Vaiyapuri

15 December 2018

Snakebite envenomation is an affliction currently estimated to be killing upwards of 100,000 people annually. Snakebite is associated with a diverse pathophysiology due to the magnitude of variation in venom composition that is observed worldwide. Th...

  • Article
  • Open Access
67 Citations
5,302 Views
16 Pages

Deoxynivalenol Impairs Porcine Intestinal Host Defense Peptide Expression in Weaned Piglets and IPEC-J2 Cells

  • Shuai Wang,
  • Jiacheng Yang,
  • Beiyu Zhang,
  • Kuntan Wu,
  • Ao Yang,
  • Chong Li,
  • Jiacai Zhang,
  • Cong Zhang,
  • Shahid Ali Rajput and
  • Niya Zhang
  • + 2 authors

15 December 2018

Host defense peptides (HDPs) are efficient defense components of the innate immune system, playing critical roles in intestinal homeostasis and protection against pathogens. This study aims to investigate the interference effects of DON on the intest...

  • Article
  • Open Access
7 Citations
4,506 Views
8 Pages

Complexes of the Mycotoxins Citrinin and Ochratoxin A with Aluminum Ions and their Spectroscopic Properties

  • Julia Keller,
  • Daniel Moldenhauer,
  • Liam Byrne,
  • Hajo Haase,
  • Ute Resch-Genger and
  • Matthias Koch

14 December 2018

The sensitive detection of the mycotoxin citrinin (CIT) utilizing its fluorescence requires approaches to enhance the emission. In this respect, we studied the complexation of CIT and ochratoxin A (OTA) with Al3+ in methanol using absorption and fluo...

  • Article
  • Open Access
14 Citations
5,987 Views
11 Pages

14 December 2018

Palytoxin (PlTX) and analogues are produced by certain dinoflagellates, sea anemones, corals and cyanobacteria. PlTX can accumulate in the food chain and when consumed it may cause intoxication with symptoms like myalgia, weakness, fever, nausea, and...

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Toxins - ISSN 2072-6651Creative Common CC BY license