Table of Contents
Toxins, Volume 10, Issue 12 (December 2018)
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Cover Story (view full-size image) Chlorotoxin is a disulfide-rich stable peptide derived from the venom of the Israeli scorpion, [...] Read more. Chlorotoxin is a disulfide-rich stable peptide derived from the venom of the Israeli scorpion, Leiurus quinquestriatus. Many studies demonstrated chlorotoxin could preferentially binds to neuroectodermal tumors, such as glioblastoma, without cross-reactivity to normal brain cells. Because it has the ability to penetrate the blood–brain barrier, and its tyrosine residue allows covalent conjugation with functional moieties, chlorotoxin is an attractive platform to explore development of diagnostic and therapeutic agents for gliomas. In this review, we outline the chlorotoxin structure and its molecular targets, summarize molecular variations of chlorotoxin developed for glioma imaging, and discuss future trends and perspectives for chlorotoxin conjugates as a theranostic agent. View this paper.