Bacterial Pore-Forming Toxins
A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".
Deadline for manuscript submissions: closed (30 September 2018) | Viewed by 32802
Special Issue Editor
Interests: pore-forming toxins; cholesterol-dependent cytolysins; membrane repair; DNases; lupus
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Pore-forming toxins (PFTs) are the largest family of bacterial toxins. They are extensively involved in the virulence of many lethal Gram positive and Gram negative bacterial infections. In some cases, their impacts appear to be independent of target cell lysis, suggesting that PFTs may affect target cells in multiple ways. Similarly, nonpathogenic bacteria also utilize a range of PFTs, indicating that PFTs provide bacteria with a survival advantage beyond pathogenesis. The evolutionary advantages of PFTs are not limited to bacteria. Bacterial PFTs bear strong structural and three-dimensional similarities to PFTs used by other organisms, and have served effectively as tools for answering broad, fundamental questions about PFT structure and mechanism of action. Three such broad outstanding questions in the field are: How do bacterial PFTs promote bacterial fitness beyond lysis of target cells? What mechanisms do competing bacteria, hosts and other organisms use to react to bacterial PFTs? Which insights and mechanisms from bacterial PFTs are also relevant to PFTs from humans and other organisms?
This Special Issue will focus on the interaction of bacterial pore forming toxins with their targets, the functional outcomes of these interactions, and target responses to these toxins. Nonlethal toxin-target interactions, and novel insights into toxin structure/function are areas of special interest.
Dr. Peter A. Keyel
Guest Editor
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Keywords
- pore-forming toxin
- cholesterol-dependent cytolysin
- hemolysin
- host-pathogen interaction
- membrane repair
- cell death
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