Next Article in Journal
Biosynthetic Oligoclonal Antivenom (BOA) for Snakebite and Next-Generation Treatments for Snakebite Victims
Next Article in Special Issue
Central Effects of Botulinum Neurotoxin—Evidence from Human Studies
Previous Article in Journal
Acute Toxicity of the Recombinant and Native Phα1β Toxin: New Analgesic from Phoneutria nigriventer Spider Venom
Previous Article in Special Issue
Botulinum Toxin in Restless Legs Syndrome—A Randomized Double-Blind Placebo-Controlled Crossover Study
 
 
Article

Spatiotemporal Gait Analysis and Lower Limb Functioning in Foot Dystonia Treated with Botulinum Toxin

1
Rehabilitation Medicine, The Queen Elizabeth Hospital, 28 Woodville Road, Adelaide 5011, Australia
2
Discipline of Medicine, University of Adelaide, Adelaide 5005, Australia
3
National Health and Medical Research Council Centre of Research Excellence in Frailty and Healthy Aging, University of Adelaide, Adelaide 5005, Australia
4
Director Stroke Research Programme, South Australian Health & Medical Research Institute (SAHMRI), GPO Box 11060, Adelaide 5001, Australia
5
Director Aged and Extended Care, The Queen Elizabeth Hospital, 28 Woodville Road, Adelaide 5011, Australia
6
Head John Walsh Centre for Rehabilitation Research, Sydney Medical School, University of Sydney, Sydney 2006, Australia
*
Author to whom correspondence should be addressed.
Toxins 2018, 10(12), 532; https://doi.org/10.3390/toxins10120532
Received: 17 November 2018 / Revised: 9 December 2018 / Accepted: 10 December 2018 / Published: 12 December 2018
(This article belongs to the Special Issue Botulinum Toxin Treatment of Movement Disorders)
Foot dystonia (FD) is a disabling condition causing pain, spasm and difficulty in walking. We treated fourteen (14) adult patients experiencing FD with onabotulinum toxin A injection into the dystonic foot muscles. We analyzed the spatiotemporal gait utilizing the GaitRite system pre- and 3 weeks post-botulinum toxin injection along with measuring dystonia by the Fahn–Marsden Dystonia Scale (FMDS), pain by the Visual Analog Scale (VAS) and other lower limb functional outcomes such as gait velocity, the Berg Balance Scale (BBS), the Unified Parkinson’s Disease Rating Scale–Lower Limb Score (UPDRS–LL), the Timed Up and Go (TUG) test and the Goal Attainment Scale (GAS). We found that stride length increased significantly in both the affected (p = 0.02) and unaffected leg (p = 0.01) after treatment, and the improvement in stride length was roughly the same in each leg. Similar results were found for step length (p = 0.02) with improvement in the step length differential (p = 0.01). The improvements in the lower limb functional outcomes were also significant—FMDS, VAS, TUG, and UPDRS–LL decreased significantly after treatment (all p < 0.001), and BBS (p = 0.001), GAS (p < 0.001) except cadence (p = 0.37). BT injection improved walking in foot dystonia as evidenced through gait analysis, pain and lower limb functional outcomes. Main study limitations were small sample size and lack of control. View Full-Text
Keywords: botulinum toxin; foot dystonia; gait analysis botulinum toxin; foot dystonia; gait analysis
Show Figures

Figure 1

MDPI and ACS Style

Datta Gupta, A.; Tucker, G.; Koblar, S.; Visvanathan, R.; Cameron, I.D. Spatiotemporal Gait Analysis and Lower Limb Functioning in Foot Dystonia Treated with Botulinum Toxin. Toxins 2018, 10, 532. https://doi.org/10.3390/toxins10120532

AMA Style

Datta Gupta A, Tucker G, Koblar S, Visvanathan R, Cameron ID. Spatiotemporal Gait Analysis and Lower Limb Functioning in Foot Dystonia Treated with Botulinum Toxin. Toxins. 2018; 10(12):532. https://doi.org/10.3390/toxins10120532

Chicago/Turabian Style

Datta Gupta, Anupam, Graeme Tucker, Simon Koblar, Renuka Visvanathan, and Ian D. Cameron. 2018. "Spatiotemporal Gait Analysis and Lower Limb Functioning in Foot Dystonia Treated with Botulinum Toxin" Toxins 10, no. 12: 532. https://doi.org/10.3390/toxins10120532

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop