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Marine Drugs, Volume 21, Issue 8

August 2023 - 38 articles

Cover Story: MariClus is an online platform that facilitates the discovery and analysis of gene clusters and molecules from marine microorganisms. These clusters encode the biosynthesis of natural products with potential applications in drug development. The platform contains data from more than 500 marine-related prokaryotes and provides a user-friendly interface for searching and visualizing them using various criteria. By integrating data from public sources and antiSMASH, a software for genome mining, MariClus, provides a valuable resource for investigating the biosynthesis and diversity of marine natural products. The platform is accessible at https://www.mariclus.com. View this paper
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Articles (38)

  • Article
  • Open Access
13 Citations
3,017 Views
11 Pages

Purification and Molecular Docking Study on the Angiotensin I-Converting Enzyme (ACE)-Inhibitory Peptide Isolated from Hydrolysates of the Deep-Sea Mussel Gigantidas vrijenhoeki

  • Seong-Yeong Heo,
  • Nalae Kang,
  • Eun-A Kim,
  • Junseong Kim,
  • Seung-Hong Lee,
  • Ginnae Ahn,
  • Je Hyeok Oh,
  • A Young Shin,
  • Dongsung Kim and
  • Soo-Jin Heo

21 August 2023

The objective of this study was to prepare an angiotensin I-converting enzyme (ACE)-inhibitory peptide from the hydrothermal vent mussel, Gigantidas vrijenhoeki. The G. vrijenhoeki protein was hydrolyzed by various hydrolytic enzymes. The peptic hydr...

  • Article
  • Open Access
6 Citations
3,988 Views
14 Pages

Lobosteroids A–F: Six New Highly Oxidized Steroids from the Chinese Soft Coral Lobophytum sp.

  • Zi-Yi Xia,
  • Man-Man Sun,
  • Yang Jin,
  • Li-Gong Yao,
  • Ming-Zhi Su,
  • Lin-Fu Liang,
  • Hong Wang and
  • Yue-Wei Guo

19 August 2023

To explore the steroidal constituents of the soft coral Lobophytum sp. at the coast of Xuwen County, Guangdong Province, China, a chemical investigation of the above-mentioned soft coral was carried out. After repeated column chromatography over sili...

  • Review
  • Open Access
6 Citations
2,646 Views
29 Pages

Unlocking the Potential of Octocoral-Derived Secondary Metabolites against Neutrophilic Inflammatory Response

  • Ngoc Bao An Nguyen,
  • Mohamed El-Shazly,
  • Po-Jen Chen,
  • Bo-Rong Peng,
  • Lo-Yun Chen,
  • Tsong-Long Hwang and
  • Kuei-Hung Lai

18 August 2023

Inflammation is a critical defense mechanism that is utilized by the body to protect itself against pathogens and other noxious invaders. However, if the inflammatory response becomes exaggerated or uncontrollable, its original protective role is not...

  • Article
  • Open Access
12 Citations
4,438 Views
21 Pages

Echinochrome Ameliorates Physiological, Immunological, and Histopathological Alterations Induced by Ovalbumin in Asthmatic Mice by Modulating the Keap1/Nrf2 Signaling Pathway

  • Islam Ahmed Abdelmawgood,
  • Noha Ahmed Mahana,
  • Abeer Mahmoud Badr,
  • Ayman Saber Mohamed,
  • Abdeljalil Mohamed Al Shawoush,
  • Tarek Atia,
  • Amir Elhadi Abdelrazak and
  • Hader I. Sakr

18 August 2023

Asthma is a persistent inflammatory disease of the bronchi characterized by oxidative stress, airway remodeling, and inflammation. Echinochrome (Ech) is a dark-red pigment with antioxidant and anti-inflammatory activities. In this research, we aimed...

  • Article
  • Open Access
1 Citations
2,386 Views
17 Pages

17 August 2023

Polar microorganisms produce biologically active compounds that enable them to survive in harsh environments. These compounds have potential biomedical applications. The green microalga Chlamydomonas latifrons KNF0041, isolated from Arctic sea ice, h...

  • Article
  • Open Access
4 Citations
2,316 Views
10 Pages

17 August 2023

Six new lipids, trichoderols B-G (1–6), along with a known one, triharzianin B (7), were isolated from the culture of Trichoderma sp. Z43 obtained from the surface of the marine brown alga Dictyopteris divaricata. Their structures and relative...

  • Review
  • Open Access
19 Citations
4,482 Views
26 Pages

Marine-Derived Components: Can They Be a Potential Therapeutic Approach to Parkinson’s Disease?

  • Joana Silva,
  • Celso Alves,
  • Francisca Soledade,
  • Alice Martins,
  • Susete Pinteus,
  • Helena Gaspar,
  • Amparo Alfonso and
  • Rui Pedrosa

16 August 2023

The increase in the life expectancy average has led to a growing elderly population, thus leading to a prevalence of neurodegenerative disorders, such as Parkinson’s disease (PD). PD is the second most common neurodegenerative disorder and is c...

  • Article
  • Open Access
12 Citations
4,631 Views
21 Pages

Growth Behavior, Biomass Composition and Fatty Acid Methyl Esters (FAMEs) Production Potential of Chlamydomonas reinhardtii, and Chlorella vulgaris Cultures

  • Itzel Y. López-Pacheco,
  • Victoria Guadalupe Ayala-Moreno,
  • Catherinne Arlette Mejia-Melara,
  • José Rodríguez-Rodríguez,
  • Sara P. Cuellar-Bermudez,
  • Reyna Berenice González-González,
  • Karina G. Coronado-Apodaca,
  • Leonardo I. Farfan-Cabrera,
  • Georgia María González-Meza and
  • Hafiz M. N. Iqbal
  • + 1 author

15 August 2023

The production of biomolecules by microalgae has a wide range of applications in the development of various materials and products, such as biodiesel, food supplements, and cosmetics. Microalgae biomass can be produced using waste and in a smaller sp...

  • Feature Paper
  • Article
  • Open Access
2 Citations
4,886 Views
13 Pages

MariClus: Your One-Stop Platform for Information on Marine Natural Products, Their Gene Clusters and Producing Organisms

  • Cedric Hermans,
  • Maarten Lieven De Mol,
  • Marieke Mispelaere,
  • Anne-Sofie De Rop,
  • Jeltien Rombaut,
  • Tesneem Nusayr,
  • Rebecca Creamer,
  • Sofie L. De Maeseneire,
  • Wim K. Soetaert and
  • Paco Hulpiau

15 August 2023

Background: The marine environment hosts the vast majority of living species and marine microbes that produce natural products with great potential in providing lead compounds for drug development. With over 70% of Earth’s surface covered in wa...

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Mar. Drugs - ISSN 1660-3397