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Pharmaceuticals, Volume 17, Issue 6

June 2024 - 153 articles

Cover Story: Polymersomes, self-assembled nanoparticles of amphiphilic block copolymers, are promising for drug delivery, medical imaging, and diagnostics. The copper [I]-catalysed azide-alkyne cycloaddition (CuAAC) has enhanced the functionalization and bioconjugation of polymersomes and drugs. This review examines this synergy, providing examples of click-compatible moieties (azide and alkyne groups) in polymer building blocks, enabling the “click” attachment of various functional groups and ligands. It highlights the latest combinatory usage of polymersomes with click chemistry, focusing on synthesis and functionalization strategies. View this paper
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Articles (153)

  • Article
  • Open Access
4 Citations
2,153 Views
19 Pages

Urinary tract infections (UTIs) are a widespread condition in pets, with many antibiotics being prescribed, contributing to the rise in antimicrobial resistance, which is a worldwide threat. This study’s main objective was to analyze the in vit...

  • Review
  • Open Access
5 Citations
5,206 Views
29 Pages

The enduring relationship between humanity and the cannabis plant has witnessed significant transformations, particularly with the widespread legalization of medical cannabis. This has led to the recognition of diverse pharmacological formulations of...

  • Article
  • Open Access
3 Citations
2,310 Views
18 Pages

Efforts have been made to improve the therapeutic efficiency of tumor treatments, and metal-organic frameworks (MOFs) have shown excellent potential in tumor therapy. Monotherapy for the treatment of tumors has limited effects due to the limitation o...

  • Systematic Review
  • Open Access
10 Citations
5,978 Views
14 Pages

Complex regional pain syndrome (CRPS) is a disabling condition that usually affects the extremities after trauma or surgery. At present, there is no FDA-approved pharmacological treatment for patients with CRPS. We performed this systematic review an...

  • Article
  • Open Access
4 Citations
2,438 Views
24 Pages

Pharmacological Activation of SIRT3 Modulates the Response of Cancer Cells to Acidic pH

  • Michele Aventaggiato,
  • Tania Arcangeli,
  • Enza Vernucci,
  • Federica Barreca,
  • Luigi Sansone,
  • Laura Pellegrini,
  • Elena Pontemezzo,
  • Sergio Valente,
  • Rossella Fioravanti and
  • Matteo Antonio Russo
  • + 2 authors

Cancer cells modulate their metabolism, creating an acidic microenvironment that, in turn, can favor tumor progression and chemotherapy resistance. Tumor cells adopt strategies to survive a drop in extracellular pH (pHe). In the present manuscript, w...

  • Article
  • Open Access
4 Citations
2,765 Views
18 Pages

Memory is one of the most important abilities of our brain. The process of memory and learning is necessary for the proper existence of humans in the surrounding environment. However, sometimes there are unfavourable changes in the functioning of the...

  • Article
  • Open Access
1 Citations
2,116 Views
17 Pages

Amoebicidal Effect of COVID Box Molecules against Acanthamoeba: A Study of Cell Death

  • Ines Sifaoui,
  • Rubén L. Rodríguez-Expósito,
  • María Reyes-Batlle,
  • Robert Sutak,
  • José E. Piñero and
  • Jacob Lorenzo-Morales

Acanthamoeba spp. can cause a sight threatening disease. At present, the current treatments used to treat Acanthamoeba spp. Infections, such as biguanide-based antimicrobials, remain inefficacious, with the appearance of resistant forms and high cyto...

  • Review
  • Open Access
15 Citations
17,977 Views
37 Pages

Pharmacovigilance in Vaccines: Importance, Main Aspects, Perspectives, and Challenges—A Narrative Review

  • Katharine Valéria Saraiva Hodel,
  • Bianca Sampaio Dotto Fiuza,
  • Rodrigo Souza Conceição,
  • Augusto Cezar Magalhães Aleluia,
  • Thassila Nogueira Pitanga,
  • Larissa Moraes dos Santos Fonseca,
  • Camila Oliveira Valente,
  • Cintia Silva Minafra-Rezende and
  • Bruna Aparecida Souza Machado

Pharmacovigilance plays a central role in safeguarding public health by continuously monitoring the safety of vaccines, being critical in a climate of vaccine hesitancy, where public trust is paramount. Pharmacovigilance strategies employed to gather...

  • Article
  • Open Access
4 Citations
1,881 Views
14 Pages

Potential Molecular Mechanism of Illicium simonsii Maxim Petroleum Ether Fraction in the Treatment of Hepatocellular Carcinoma

  • Sihua Zou,
  • Yanchun Wu,
  • Meiqi Wen,
  • Jiao Liu,
  • Minghui Chen,
  • Jingquan Yuan and
  • Bei Zhou

Traditional Chinese medicine (TCM) has been considered, for many years, an important source of medicine to treat different diseases. As a type of TCM, Illicium simonsii Maxim (ISM) is used as an anti-inflammatory, anti-bacterial, and anti-virus. Besi...

  • Article
  • Open Access
5 Citations
11,699 Views
15 Pages

Physicians are currently finding products for pediatric respiratory diseases of viral etiology to reduce the inappropriate use of antibiotic therapy. This study evaluated PediaFlù (Pediatrica S.r.l.), a dietary supplement already on the market...

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Pharmaceuticals - ISSN 1424-8247