Efficacy and Safety of Pharmacological Treatment in Patients with Complex Regional Pain Syndrome: A Systematic Review and Meta-Analysis
Abstract
:1. Introduction
2. Results
2.1. Eligible Studies and the Characteristics
2.2. Risk of Bias
2.3. Pairwise Meta-Analysis of Treatments on CRPS
2.4. Network Meta-Analysis of Treatments on CRPS
2.5. Consistency and Convergence Analysis
2.6. Additional Outcomes
3. Discussion
4. Materials and Methods
4.1. Search Strategy and Selection Criteria
4.2. Data Extraction and Quality Assessment
4.3. Assessment of Certainty of Evidence
4.4. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Treatment | Direct Effect | Indirect Effect | Overall | p-Value | GRADE |
---|---|---|---|---|---|
Short-term | |||||
BPs, GCs | 0.65 (−3.81, 5.24) | −1.51 (−5.97, 2.55) | −0.49 (−3.55, 2.30) | 0.42 | Low |
BPs, Placebo | −0.90 (−4.24, 2.34) | 1.39 (−3.57, 6.44) | −0.14 (−2.91, 2.43) | 0.40 | Moderate |
Clonidine, GCs | −0.45 (−4.26, 3.53) | −6.04 (−10.67, −0.63) | −2.52 (−5.96, 1.24) | 0.09 | Low |
Clonidine, NSAIDs | −1.52 (−5.25, 2.06) | 3.96 (−1.61, 8.92) | 0.30 (−3.21, 3.79) | 0.09 | Low |
GCs, NSAIDs | 5.08 (1.60, 8.57) | −0.75 (−5.08, 3.69) | 2.79 (−0.57, 5.92) | 0.05 | Low |
GCs, Placebo | 0.56 (−2.10, 3.21) | −0.48 (−5.02, 4.49) | 0.33 (−1.78, 2.52) | 0.68 | Moderate |
NSAIDs, Placebo | 0.08 (−8.32, 8.43) | −2.94 (−7.27, 1.23) | −2.47 (−5.97, 1.41) | 0.52 | Low |
Long-term | |||||
BPs, GCs | 0.59 (−2.54, 3.78) | 3.07 (−0.14, 5.49) | 1.90 (−0.75, 4.27) | 0.20 | Low |
BPs, Placebo | 3.40 (0.77, 5.03) | 0.94 (−3.08, 4.55) | 2.55 (0.20, 4.43) | 0.18 | Moderate |
GCs, Placebo | 0.30 (−1.80, 2.00) | 2.78 (−1.87, 6.08) | 0.63 (−1.38, 2.55) | 0.19 | Moderate |
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Zhu, H.; Wen, B.; Xu, J.; Zhang, Y.; Xu, L.; Huang, Y. Efficacy and Safety of Pharmacological Treatment in Patients with Complex Regional Pain Syndrome: A Systematic Review and Meta-Analysis. Pharmaceuticals 2024, 17, 811. https://doi.org/10.3390/ph17060811
Zhu H, Wen B, Xu J, Zhang Y, Xu L, Huang Y. Efficacy and Safety of Pharmacological Treatment in Patients with Complex Regional Pain Syndrome: A Systematic Review and Meta-Analysis. Pharmaceuticals. 2024; 17(6):811. https://doi.org/10.3390/ph17060811
Chicago/Turabian StyleZhu, He, Bei Wen, Jijun Xu, Yuelun Zhang, Li Xu, and Yuguang Huang. 2024. "Efficacy and Safety of Pharmacological Treatment in Patients with Complex Regional Pain Syndrome: A Systematic Review and Meta-Analysis" Pharmaceuticals 17, no. 6: 811. https://doi.org/10.3390/ph17060811
APA StyleZhu, H., Wen, B., Xu, J., Zhang, Y., Xu, L., & Huang, Y. (2024). Efficacy and Safety of Pharmacological Treatment in Patients with Complex Regional Pain Syndrome: A Systematic Review and Meta-Analysis. Pharmaceuticals, 17(6), 811. https://doi.org/10.3390/ph17060811