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  • Article
  • Open Access
7 Citations
3,766 Views
13 Pages

Clinical and Ultrasound Thyroid Nodule Characteristics and Their Association with Cytological and Histopathological Outcomes: A Retrospective Multicenter Study in High-Resolution Thyroid Nodule Clinics

  • María Molina-Vega,
  • Carlos Antonio Rodríguez-Pérez,
  • Ana Isabel Álvarez-Mancha,
  • Gloria Baena-Nieto,
  • María Riestra,
  • Victoria Alcázar,
  • Ana Reyes Romero-Lluch,
  • Juan C. Galofré and
  • José C. Fernández-García

9 December 2019

Introduction: Thyroid nodules are a common finding. A high-resolution thyroid nodule clinic (HR-TNC) condenses all tests required for the evaluation of thyroid nodules into a single appointment. We aimed to evaluate the clinical outcomes at HR-TNCs....

  • Article
  • Open Access
4 Citations
3,395 Views
10 Pages

Weighty Matters: The Obesity–Thyroid Nodule Connection Unveiling the Impact of Obesity on Thyroid Cancer Risk

  • Saad M. Alqahtani,
  • Bassam A. Altalhi,
  • Yousef S. Alalawi,
  • Areej A. AlFattani and
  • Saif S. Al-Sobhi

14 September 2023

Background and Objectives: The effect of obesity on the development/progression of thyroid nodules with uncertain cytology is unknown. Therefore, our objective was to assess the role of body mass index (BMI) in predicting malignancy in patients with...

  • Article
  • Open Access
7 Citations
7,570 Views
17 Pages

False-Positive Malignant Diagnosis of Nodule Mimicking Lesions by Computer-Aided Thyroid Nodule Analysis in Clinical Ultrasonography Practice

  • Krisztián Molnár,
  • Endre Kálmán,
  • Zsófia Hári,
  • Omar Giyab,
  • Tamás Gáspár,
  • Károly Rucz,
  • Péter Bogner and
  • Arnold Tóth

This study aims to test computer-aided diagnosis (CAD) for thyroid nodules in clinical ultrasonography (US) practice with a focus towards identifying thyroid entities associated with CAD system misdiagnoses. Two-hundred patients referred to thyroid U...

  • Article
  • Open Access
7 Citations
3,655 Views
25 Pages

1 April 2025

Early diagnosis of increasingly common thyroid nodules is crucial for effectively and accurately managing the disease’s monitoring and treatment process. In practice, manual segmentation methods based on ultrasound images are widely used; howev...

  • Article
  • Open Access
693 Views
10 Pages

Thyroid Nodule Surveillance in Transfusion-Dependent Thalassemia: A Comparative Ultrasonographic Study

  • Maddalena Casale,
  • Martina Errico,
  • Raffaella Origa,
  • Paolo Mureddu,
  • Francesca Allosso,
  • Lucia Digitale Selvaggio,
  • Graziella Grande,
  • Claudia Di Ludovico,
  • Raffaele Navarra and
  • Daniela Pasquali
  • + 3 authors

15 October 2025

Background: Thyroid nodules are common in the general population, and up to 15% may be malignant. Patients with transfusion-dependent thalassemia (TDT) are predisposed to endocrine complications, raising concern for thyroid malignancy. This study com...

  • Interesting Images
  • Open Access
3 Citations
2,772 Views
4 Pages

An Exceptional Cause of Increased 18F-Fluorodeoxyglucose Uptake on PET/CT in a Thyroid Nodule

  • Ringo Manta,
  • Raoul Muteganya,
  • Abraham J. Beun,
  • Jennifer Fallas and
  • Kris G. Poppe

A 41-year-old female underwent a cervical spine CT for the workup of posterior neck pain irradiating to the shoulders for several months. An incidental thyroid nodule was found and classified as Bethesda III on the Fine-needle aspiration cytology (FN...

  • Review
  • Open Access
47 Citations
7,055 Views
20 Pages

Thyroid Nodule Characterization: How to Assess the Malignancy Risk. Update of the Literature

  • Daniele Fresilli,
  • Emanuele David,
  • Patrizia Pacini,
  • Giovanni Del Gaudio,
  • Vincenzo Dolcetti,
  • Giuseppe Tiziano Lucarelli,
  • Nicola Di Leo,
  • Maria Irene Bellini,
  • Vito D'Andrea and
  • Vito Cantisani
  • + 6 authors

Ultrasound (US) is the first imaging modality for thyroid parenchyma evaluation. In the last decades, the role of ultrasound has been improved with the introduction of new US software, such as contrast-enhanced ultrasound (CEUS) and US-elastography (...

  • Article
  • Open Access
30 Citations
4,232 Views
19 Pages

Local and Context-Attention Adaptive LCA-Net for Thyroid Nodule Segmentation in Ultrasound Images

  • Zhen Tao,
  • Hua Dang,
  • Yueting Shi,
  • Weijiang Wang,
  • Xiaohua Wang and
  • Shiwei Ren

10 August 2022

The thyroid nodule segmentation of ultrasound images is a critical step for the early diagnosis of thyroid cancers in clinics. Due to the weak edge of ultrasound images and the complexity of thyroid tissue structure, it is still challenging to accura...

  • Article
  • Open Access
9 Citations
3,777 Views
20 Pages

Accurate segmentation of thyroid nodules in ultrasound images is crucial for the diagnosis of thyroid cancer and preoperative planning. However, the segmentation of thyroid nodules is challenging due to their irregular shape, blurred boundary, and un...

  • Review
  • Open Access
13 Citations
3,251 Views
16 Pages

Raman Spectroscopy as a Potential Adjunct of Thyroid Nodule Evaluation: A Systematic Review

  • Monika Kujdowicz,
  • Dominika Januś,
  • Anna Taczanowska-Niemczuk,
  • Marek W. Lankosz and
  • Dariusz Adamek

13 October 2023

The incidence of thyroid nodules (TNs) is estimated at 36.5% and 23% in females and males, respectively. A single thyroid nodule is usually detected during ultrasound assessment in patients with symptoms of thyroid dysfunction or neck mass. TNs are c...

  • Article
  • Open Access
1 Citations
3,556 Views
13 Pages

Integrating Clinical Parameters into Thyroid Nodule Malignancy Risk: A Retrospective Evaluation Based on ACR TI-RADS

  • Nikolaos Angelopoulos,
  • Ioannis Androulakis,
  • Dimitrios P. Askitis,
  • Nicolas Valvis,
  • Rodis D. Paparodis,
  • Valentina Petkova,
  • Anastasios Boniakos,
  • Dimitra Zianni,
  • Andreas Rizoulis and
  • Sarantis Livadas
  • + 2 authors

29 July 2025

Background/Objectives: Thyroid nodules are commonly found through sensitive imaging methods like ultrasonography. While most nodules are benign and asymptomatic, certain characteristics may indicate malignancy, prompting fine needle aspiration biopsy...

  • Article
  • Open Access
20 Citations
4,321 Views
9 Pages

Use of Diagnostic Criteria from ACR and EU-TIRADS Systems to Improve the Performance of Cytology in Thyroid Nodule Triage

  • Davide Seminati,
  • Giulia Capitoli,
  • Davide Leni,
  • Davide Fior,
  • Francesco Vacirca,
  • Camillo Di Bella,
  • Stefania Galimberti,
  • Vincenzo L’Imperio and
  • Fabio Pagni

29 October 2021

Objective: The American College of Radiology (ACR) and the European Thyroid Association (EU) have proposed two scoring systems for thyroid nodule classification. Here, we compared the ability of the two systems in triaging thyroid nodules for fine-ne...

  • Article
  • Open Access
6 Citations
2,807 Views
12 Pages

Influence of Care Pathway on Thyroid Nodule Surgery Relevance: A Historical Cohort Study

  • Solène Castellnou,
  • Jean-Christophe Lifante,
  • Stéphanie Polazzi,
  • Léa Pascal,
  • Françoise Borson-Chazot and
  • Antoine Duclos

17 July 2020

Background: Guidelines recommend using fine-needle aspiration cytology (FNAC) to guide thyroid nodule surgical indication. However, the extent to which these guidelines are followed remains unclear. This study aimed to analyze the quality of the preo...

  • Article
  • Open Access
5 Citations
2,589 Views
14 Pages

16 December 2024

Background: Thyroid nodules are common yet remain a diagnostic challenge. While ultrasound and Thyroid Imaging Reporting and Data Systems (TIRADS) are accepted as standard, the use of thyroid scintigraphy in euthyroid patients is debated. The Europea...

  • Article
  • Open Access
10 Citations
2,900 Views
13 Pages

Molecular Pathological Characteristics of Thyroid Follicular-Patterned Tumors Showing Nodule-in-Nodule Appearance with Poorly Differentiated Component

  • Mayu Ueda,
  • Katsuya Matsuda,
  • Hirokazu Kurohama,
  • Zhanna Mussazhanova,
  • Yerkezhan Sailaubekova,
  • Hisayoshi Kondo,
  • Tomoki Shimizu,
  • Nami Takada,
  • Yuki Matsuoka and
  • Masahiro Nakashima
  • + 4 authors

22 July 2022

Thyroid follicular-patterned tumors (TFTs) showing nodule-in-nodule (NN) appearance with poorly differentiated component (PDc) but neither invasion nor metastasis are diagnosed as benign nodules. Although PDc exhibits histologically aggressive featur...

  • Article
  • Open Access
8 Citations
6,279 Views
15 Pages

Impact of the Hypoechogenicity Criteria on Thyroid Nodule Malignancy Risk Stratification Performance by Different TIRADS Systems

  • Nina Malika Popova,
  • Maija Radzina,
  • Peteris Prieditis,
  • Mara Liepa,
  • Madara Rauda and
  • Kaspars Stepanovs

8 November 2021

Background: Various Thyroid Imaging and Reporting data systems (TIRADS) are used worldwide for risk stratification of thyroid nodules. Their sensitivity is high, while the specificity is suboptimal. The aim of the study was to compare several TIRADS...

  • Article
  • Open Access
1,692 Views
14 Pages

29 August 2025

Background/Objectives: Elastography is a non-invasive imaging technique that assesses tissue stiffness and elasticity. This study aimed to evaluate the diagnostic performance and clinical utility of elastography and S-detect in distinguishing benign...

  • Article
  • Open Access
82 Citations
8,511 Views
24 Pages

Artificial Intelligence-Based Thyroid Nodule Classification Using Information from Spatial and Frequency Domains

  • Dat Tien Nguyen,
  • Tuyen Danh Pham,
  • Ganbayar Batchuluun,
  • Hyo Sik Yoon and
  • Kang Ryoung Park

14 November 2019

Image-based computer-aided diagnosis (CAD) systems have been developed to assist doctors in the diagnosis of thyroid cancer using ultrasound thyroid images. However, the performance of these systems is strongly dependent on the selection of detection...

  • Article
  • Open Access
36 Citations
6,401 Views
14 Pages

Thyroid Nodule Classification for Physician Decision Support Using Machine Learning-Evaluated Geometric and Morphological Features

  • Elmer Jeto Gomes Ataide,
  • Nikhila Ponugoti,
  • Alfredo Illanes,
  • Simone Schenke,
  • Michael Kreissl and
  • Michael Friebe

27 October 2020

The classification of thyroid nodules using ultrasound (US) imaging is done using the Thyroid Imaging Reporting and Data System (TIRADS) guidelines that classify nodules based on visual and textural characteristics. These are composition, shape, size...

  • Article
  • Open Access
107 Citations
15,492 Views
23 Pages

Ultrasound Image-Based Diagnosis of Malignant Thyroid Nodule Using Artificial Intelligence

  • Dat Tien Nguyen,
  • Jin Kyu Kang,
  • Tuyen Danh Pham,
  • Ganbayar Batchuluun and
  • Kang Ryoung Park

25 March 2020

Computer-aided diagnosis systems have been developed to assist doctors in diagnosing thyroid nodules to reduce errors made by traditional diagnosis methods, which are mainly based on the experiences of doctors. Therefore, the performance of such syst...

  • Review
  • Open Access
3 Citations
4,745 Views
33 Pages

Accurate segmentation and analysis of thyroid nodules in ultrasound (US) images are essential for the diagnosis and management of thyroid conditions, including cancer. Despite advancements in medical imaging, achieving accurate and efficient segmenta...

  • Review
  • Open Access
20 Citations
5,853 Views
16 Pages

Thyroid Nodule Characterization: Overview and State of the Art of Diagnosis with Recent Developments, from Imaging to Molecular Diagnosis and Artificial Intelligence

  • Emanuele David,
  • Hektor Grazhdani,
  • Giuliana Tattaresu,
  • Alessandra Pittari,
  • Pietro Valerio Foti,
  • Stefano Palmucci,
  • Corrado Spatola,
  • Maria Chiara Lo Greco,
  • Corrado Inì and
  • Antonio Basile
  • + 4 authors

Ultrasound (US) is the primary tool for evaluating patients with thyroid nodules, and the risk of malignancy assessed is based on US features. These features help determine which patients require fine-needle aspiration (FNA) biopsy. Classification sy...

  • Article
  • Open Access
1 Citations
566 Views
15 Pages

Comparative Diagnostic Performance of Ultrasound-Based Risk Stratification Systems in Thyroid Nodule Evaluations by Otolaryngologists

  • Jiun-Yi Wu,
  • Ping-Chia Cheng,
  • Ming-Hsun Wen,
  • Chih-Ming Chang,
  • Wu-Chia Lo,
  • Po-Wen Cheng,
  • Po-Hsuan Wu and
  • Li-Jen Liao

Background/Objectives: Thyroid nodules are a prevalent condition with a high incidence rate of malignancy. Ultrasound (US)-based risk stratification systems have become widely utilized for the evaluation of thyroid nodules, including the American Thy...

  • Article
  • Open Access
1,733 Views
14 Pages

Comparison of Diagnostic Yield Between Fine Needle Aspiration Cytology and Core Needle Biopsy in the Diagnosis of Thyroid Nodule

  • Yeongrok Lee,
  • Myung Jin Ban,
  • Do Hyeon Kim,
  • Jin-Young Kim,
  • Hyung Kwon Byeon and
  • Jae Hong Park

11 October 2025

Background/Objectives: This study aimed to evaluate the effectiveness of core needle biopsy (CNB) by comparing its diagnostic yield to fine needle aspiration cytology (FNAC) across primary and secondary examinations. Methods: This retrospective revie...

  • Interesting Images
  • Open Access
1 Citations
2,146 Views
4 Pages

5 October 2023

A 66-year-old woman presented with an incidental left thyroid nodule during a health examination. She had no voice change, shortness of breath, cough, or dysphagia. Repeated sonography showed a dynamic change of the lesion, which was more evident fol...

  • Article
  • Open Access
2 Citations
1,881 Views
17 Pages

Data-Driven Thyroid Nodule Diagnosis Using Belief Rule Base

  • Jiang Jiang,
  • Ruirui Zhao,
  • Xuan Li and
  • Leilei Chang

23 September 2022

Doctors’ diagnosis preferences are different, which makes them adopt different assumptions in medical decision making. Taking the diagnosis of thyroid nodules as an example, this study compares three assumptions, namely deletion, imputation bas...

  • Interesting Images
  • Open Access
3 Citations
2,683 Views
3 Pages

Multimodal Characterization of a PSMA-Positive Thyroid Nodule Using 68Ga-PSMA and 124Iodine PET/US Fusion Imaging

  • Martin Freesmeyer,
  • Falk Gühne,
  • Robert Drescher,
  • Thomas Winkens,
  • Nikolaus Gassler and
  • Philipp Seifert

12 February 2022

A 54-year-old male diagnosed with prostate cancer was referred for 68Gallium-PSMA-11 PET/CT. The scan revealed a solitary PSMA-positive thyroid lesion. On PET/ultrasound fusion imaging, a nodule with moderate risk of malignancy (TIRADS 4B) could be u...

  • Article
  • Open Access
3 Citations
4,637 Views
10 Pages

The Size of a Thyroid Nodule with ACR TI-RADS Does Not Provide a Better Prediction of the Nature of the Nodule: A Single-Center Retrospective Real-Life Observational Study

  • Chiara Scorziello,
  • Cosimo Durante,
  • Marco Biffoni,
  • Maria Carola Borcea,
  • Fabrizio Consorti,
  • Angelo Laca,
  • Rossella Melcarne,
  • Luca Ventrone and
  • Laura Giacomelli

We investigated if thyroid nodule size has a predictive value of malignancy on a par with composition, echogenicity, shape, margin, and echogenic foci, and what would be the consequence of observing the rule of the American College of Radiology (ACR)...

  • Article
  • Open Access
12 Citations
3,413 Views
15 Pages

This study investigated the diagnostic value of the Angio Planewave Ultrasensitive (AngioPLUS) Doppler ultrasound in improving the efficacy of grey scale ultrasound in thyroid nodule diagnosis. The EU TIRADS was used for the grey scale ultrasound ass...

  • Article
  • Open Access
9 Citations
4,749 Views
22 Pages

Thyroid-related diseases, particularly thyroid cancer, are rising globally, emphasizing the critical need for the early detection and accurate screening of thyroid nodules. Ultrasound imaging has inherent limitations—high noise, low contrast, a...

  • Article
  • Open Access
2 Citations
1,772 Views
11 Pages

Thyroid Nodule Detection and Region Estimation in Ultrasound Images: A Comparison between Physicians and an Automated Decision Support System Approach

  • Elmer Jeto Gomes Ataide,
  • Mathews S. Jabaraj,
  • Simone Schenke,
  • Manuela Petersen,
  • Sarvar Haghghi,
  • Jan Wuestemann,
  • Alfredo Illanes,
  • Michael Friebe and
  • Michael C. Kreissl

7 September 2023

Background: Thyroid nodules are very common. In most cases, they are benign, but they can be malignant in a low percentage of cases. The accurate assessment of these nodules is critical to choosing the next diagnostic steps and potential treatment. U...

  • Article
  • Open Access
587 Views
18 Pages

Prediction Multiscale Cross-Level Fusion U-Net with Combined Wavelet Convolutions for Thyroid Nodule Segmentation

  • Shengzhi Liu,
  • Haotian Tang,
  • Junhao Zhao,
  • Rundong Liu,
  • Sirui Zheng,
  • Kaiyao Hou,
  • Xiyu Zhang,
  • Fuyong Liu and
  • Chen Ding

20 November 2025

The precise segmentation of thyroid nodules in ultrasound images is essential for computer-aided diagnosis and treatment. Although various deep learning methods have been proposed, similar intensity distributions and variable nodule morphology often...

  • Article
  • Open Access
24 Citations
3,658 Views
11 Pages

Risk of Complications in Patients Undergoing Completion Thyroidectomy after Hemithyroidectomy for Thyroid Nodule with Indeterminate Cytology: An Italian Multicentre Retrospective Study

  • Gian Luigi Canu,
  • Fabio Medas,
  • Federico Cappellacci,
  • Alessio Biagio Filippo Giordano,
  • Angela Gurrado,
  • Claudio Gambardella,
  • Giovanni Docimo,
  • Francesco Feroci,
  • Giovanni Conzo and
  • Pietro Giorgio Calò
  • + 1 author

17 May 2022

There is still controversy as to whether patients undergoing a completion thyroidectomy after a hemithyroidectomy for a thyroid nodule with an indeterminate cytology have a comparable, increased or decreased risk of complications compared to those su...

  • Article
  • Open Access
15 Citations
4,366 Views
20 Pages

23 September 2022

Computer-aided diagnosis/detection (CADx) systems have been used to help doctors in improving the quality of diagnosis and treatment processes in many serious diseases such as breast cancer, brain stroke, lung cancer, and bone fracture. However, the...

  • Article
  • Open Access
460 Views
19 Pages

29 December 2025

Accurate differentiation of malignant from benign thyroid nodules on ultrasound remains challenging and existing deep models typically operate on isolated ROI crops or whole images, ignoring structured peri-lesional context. We present a simple, repr...

  • Article
  • Open Access
14 Citations
3,630 Views
14 Pages

Novel Human Artificial Intelligence Hybrid Framework Pinpoints Thyroid Nodule Malignancy and Identifies Overlooked Second-Order Ultrasonographic Features

  • Xiaohong Jia,
  • Zehao Ma,
  • Dexing Kong,
  • Yamin Li,
  • Hairong Hu,
  • Ling Guan,
  • Jiping Yan,
  • Ruifang Zhang,
  • Ying Gu and
  • CAAU
  • + 11 authors

13 September 2022

We present a Human Artificial Intelligence Hybrid (HAIbrid) integrating framework that reweights Thyroid Imaging Reporting and Data System (TIRADS) features and the malignancy score predicted by a convolutional neural network (CNN) for nodule maligna...

  • Article
  • Open Access
10 Citations
15,266 Views
8 Pages

Are Bethesda III Thyroid Nodules More Aggressive than Bethesda IV Thyroid Nodules When Found to Be Malignant?

  • Sena Turkdogan,
  • Marc Pusztaszeri,
  • Veronique-Isabelle Forest,
  • Michael P. Hier and
  • Richard J. Payne

9 September 2020

The Bethesda classification system for thyroid fine needle aspirate (FNA) is used to predict the risk of malignancy and to guide the management of thyroid nodules. We postulated that thyroid malignancies characterized as Bethesda III on FNA have more...

  • Article
  • Open Access
3 Citations
1,444 Views
12 Pages

Exploring the Potential of ChatGPT-4o in Thyroid Nodule Diagnosis Using Multi-Modality Ultrasound Imaging: Dual- vs. Triple-Modality Approaches

  • Ziman Chen,
  • Nonhlanhla Chambara,
  • Shirley Yuk Wah Liu,
  • Tom Chi Man Chow,
  • Carol Man Sze Lai and
  • Michael Tin Cheung Ying

20 June 2025

Background/Objectives Recent advancements in large language models, such as ChatGPT-4o, have created new opportunities for analyzing complex multi-modal data, including medical images. This study aims to assess the potential of ChatGPT-4o in distingu...

  • Article
  • Open Access
202 Views
13 Pages

Thyroid Nodule Detection and Classification on Small Datasets: An Ensemble Deep Learning Approach with Attention Mechanism and Focal Loss

  • Wei-Chen Hung,
  • Yi-Kai Chang,
  • Chih-Ming Chang,
  • Po-Wen Cheng,
  • Wu-Chia Lo,
  • Ping-Chia Cheng and
  • Li-Jen Liao

Background: Thyroid nodule classification on ultrasound remains challenging due to limited labeled data and marked class imbalance. This study proposes an integrated deep learning framework combining YOLO-based region-of-interest detection with an en...

  • Article
  • Open Access
23 Citations
3,407 Views
9 Pages

Reproducibility of Ablated Volume Measurement Is Higher with Contrast-Enhanced Ultrasound than with B-Mode Ultrasound after Benign Thyroid Nodule Radiofrequency Ablation—A Preliminary Study

  • Simone Schiaffino,
  • Francesca Serpi,
  • Duccio Rossi,
  • Valerio Ferrara,
  • Ciriaco Buonomenna,
  • Marco Alì,
  • Lorenzo Monfardini,
  • Luca Maria Sconfienza and
  • Giovanni Mauri

The reproducibility of contrast-enhanced ultrasound (CEUS) and standard B-mode ultrasound in the assessment of radiofrequency-ablated volume of benign thyroid nodules was compared. A preliminary study was conducted on consecutive patients who underwe...

  • Review
  • Open Access
17 Citations
8,887 Views
14 Pages

Thyroid Nodules and Obesity

  • Elpida Demetriou,
  • Maria Fokou,
  • Savvas Frangos,
  • Panagiotis Papageorgis,
  • Panayiotis A. Economides and
  • Aliki Economides

31 May 2023

A widely discussed topic in the pathophysiology of thyroid nodules is the role of obesity, a state that leads to increased systemic inflammatory markers. Leptin plays a vital role in forming thyroid nodules and cancer through several mechanisms. Toge...

  • Article
  • Open Access
4 Citations
2,842 Views
15 Pages

Reducing Operation Costs of Thyroid Nodules Using Machine Learning Algorithms with Thyroid Nodules Scoring Systems

  • Erdal Ayvaz,
  • Kaplan Kaplan,
  • Fatma Kuncan,
  • Ednan Ayvaz and
  • Hüseyin Türkoğlu

14 November 2022

Continuous advancement in the health sector is essential to reduce costs and increase efficiency and quality of service. The widespread use of ultrasonography (USG) has made it possible to detect thyroid nodules with higher success rates. Some standa...

  • Review
  • Open Access
38 Citations
9,022 Views
12 Pages

30 January 2022

Thyroid nodules are common in iodine deficient areas, in females, and in patients undergoing neck irradiation. High-resolution ultrasonography (US) is important for detecting and evaluating thyroid nodules. US is used to determine the size and featur...

  • Article
  • Open Access
845 Views
12 Pages

Intra- and Inter-Observer Reliability of ChatGPT-4o in Thyroid Nodule Ultrasound Feature Analysis Based on ACR TI-RADS: An Image-Based Study

  • Ziman Chen,
  • Nonhlanhla Chambara,
  • Shirley Yuk Wah Liu,
  • Tom Chi Man Chow,
  • Carol Man Sze Lai and
  • Michael Tin Cheung Ying

17 October 2025

Background/Objectives: Advances in large language models like ChatGPT-4o have extended their use to medical image analysis. Accurate assessment of thyroid nodule ultrasound features using ACR TI-RADS is crucial for clinical practice. This study aims...

  • Review
  • Open Access
28 Citations
4,394 Views
16 Pages

Imaging and Imaging-Based Management of Pediatric Thyroid Nodules

  • Ioannis Iakovou,
  • Evanthia Giannoula and
  • Christos Sachpekidis

1 February 2020

Thyroid nodules are less frequent in children than adults. Childhood thyroid nodules carry specific features, including a higher risk of malignancy than nodules in adults, rendering them unique in terms of management. Subsequently, they should be con...

  • Article
  • Open Access
19 Citations
6,287 Views
11 Pages

The Relationship of TPOAb and TGAb with Risk of Thyroid Nodules: A Large Epidemiological Study

  • Weimin Xu,
  • Liangliang Huo,
  • Zexin Chen,
  • Yangmei Huang,
  • Xingyi Jin,
  • Jing Deng,
  • Sujuan Zhu and
  • Yunxian Yu

Objective: The association between thyroid hormones, thyroid autoantibodies, and thyroid nodules are still not clear. The cross-sectional study, conducted in Hangzhou, China in 2010, aimed to identify the relationship of thyroid hormones and autoanti...

  • Article
  • Open Access
7 Citations
2,754 Views
13 Pages

27 October 2022

There are data indicating the coexistence of papillary thyroid carcinoma and autoimmune thyroiditis (AIT) in children. The aim of the study was elastographic evaluation of thyroid nodules in children and adolescents with AIT and nodular goiter in rel...

  • Article
  • Open Access
4 Citations
3,087 Views
18 Pages

15 February 2023

The thyroid nodule risk stratification guidelines used in the literature are based on certain well-known sonographic features of nodules and are still subjective since the application of these characteristics strictly depends on the reading physician...

  • Article
  • Open Access
26 Citations
3,987 Views
9 Pages

Radiofrequency Ablation of Indeterminate Thyroid Nodules: The First North American Comparative Analysis

  • Peter P. Issa,
  • Mahmoud Omar,
  • Chad P. Issa,
  • Yusef Buti,
  • Mohammad Hussein,
  • Mohamed Aboueisha,
  • Ali Abdelhady,
  • Mohamed Shama,
  • Grace S. Lee and
  • Emad Kandil
  • + 1 author

29 September 2022

Thyroid nodules can be classified as benign, malignant, or indeterminate, the latter of which make up 10–30% of nodules. Radiofrequency ablation (RFA) has become an attractive and promising therapy for the treatment of benign thyroid nodules. H...

  • Article
  • Open Access
6 Citations
4,851 Views
17 Pages

Thyroid Cancer Risk Factors in Children with Thyroid Nodules: A One-Center Study

  • Iwona Ben-Skowronek,
  • Joanna Sieniawska,
  • Emilia Pach,
  • Wiktoria Wrobel,
  • Anna Skowronek,
  • Zaklina Tomczyk,
  • Anna Mlodawska,
  • Magdalena Makuch,
  • Magdalena Malka and
  • Pawel Nachulewicz
  • + 1 author

28 September 2021

Thyroid nodules are common in the adult population (13%), but in childhood, they are relatively rarely diagnosed (0.2–5%). The risk factors and diagnostic and therapeutic algorithms are well-known and effectively used in adults, but no clear procedur...

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