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Int. J. Environ. Res. Public Health 2017, 14(7), 723;

The Relationship of TPOAb and TGAb with Risk of Thyroid Nodules: A Large Epidemiological Study

Department of Endemic Diseases Control and Prevention, Hangzhou Center for Disease Control and Prevention, Hangzhou 330021, China
Department of Epidemiology & Health Statistics, School of Public Health, Zhejiang University, Hangzhou 310002, China
Author to whom correspondence should be addressed.
Academic Editor: Huixiao Hong
Received: 6 June 2017 / Revised: 26 June 2017 / Accepted: 26 June 2017 / Published: 5 July 2017
(This article belongs to the Section Global Health)
Full-Text   |   PDF [294 KB, uploaded 5 July 2017]


Objective: The association between thyroid hormones, thyroid autoantibodies, and thyroid nodules are still not clear. The cross-sectional study, conducted in Hangzhou, China in 2010, aimed to identify the relationship of thyroid hormones and autoantibodies with thyroid nodules. Methods: Information regarding social demography was collected by a questionnaire. Thyroid hormones (triiodothyronine, thyroxin, free triiodothyronine, free thyroxin, thyrotropin), thyroid autoantibodies (thyroid peroxidase antibody, antithyroglobulin antibody), and thyroid nodules (diagnosed by ultrasonography) was measured in 1271 adults. The association of thyroid hormones and thyroid autoantibodies with thyroid nodules was evaluated using multiple logistic regression models. Results: The prevalence of thyroid nodules among males and females was 29.49% and 33.15%, respectively. The thyroid hormone level in the thyroid nodules group was significantly higher than the non-nodules group (all p values < 0.05), except reversely in TSH (thyroid stimulating hormone) (p = 0.0532) and TGAb (thyroglobulin antibody) (p = 0.0004). High levels of TPOAb (thyroid peroxidase antibody) (OR (Odds Ratio) = 1.51, 95% CI (confidence interval): 0.99–2.30) and TGAb (OR = 2.86, 95% CI: 1.49–5.51) were associated with increased risk of thyroid nodules, compared with corresponding low levels. However, following sub-analyses in two genders, the similar associations were only observed in females (TPOAb: OR = 1.63, 95% CI: 0.99–2.68; TGAb: OR = 3.13, 95% CI: 1.53–6.40). Conclusions: The present study indicated that thyroid autoantibodies were positively associated with the risk of thyroid nodules in Chinese coastal adults. View Full-Text
Keywords: thyroid autoantibody; thyroid nodule thyroid autoantibody; thyroid nodule
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Xu, W.; Huo, L.; Chen, Z.; Huang, Y.; Jin, X.; Deng, J.; Zhu, S.; Yu, Y. The Relationship of TPOAb and TGAb with Risk of Thyroid Nodules: A Large Epidemiological Study. Int. J. Environ. Res. Public Health 2017, 14, 723.

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