37 Results Found

A set of 25 novel, silicon-based carbamate derivatives as potential acetyl- and butyrylcholinesterase (AChE/BChE) inhibitors was synthesized and characterized by their in vitro inhibition profiles and the selectivity indexes (SIs). The prepared compo...

A library of novel 4-{[(benzyloxy)carbonyl]amino}-2-hydroxybenzoic acid amides was designed and synthesized in order to provide potential acetyl- and butyrylcholinesterase (AChE/BChE) inhibitors; the in vitro inhibitory profile and selectivity index...

A series of twenty-two novel N-(disubstituted-phenyl)-3-hydroxynaphthalene- 2-carboxamide derivatives was synthesized and characterized as potential antimicrobial agents. N-[3,5-bis(trifluoromethyl)phenyl]- and N-[2-chloro-5-(trifluoromethyl)phenyl]-...

A series of new tertiary phenothiazine derivatives containing a quinoline and a pyridine fragment was synthesized by the reaction of 1-methyl-3-benzoylthio-4-butylthioquinolinium chloride with 3-aminopyridine derivatives bearing various substituents...

A series of seventeen 4-chlorocinnamanilides and seventeen 3,4-dichlorocinnamanilides were characterized for their antiplasmodial activity. In vitro screening on a chloroquine-sensitive strain of Plasmodium falciparum 3D7/MRA-102 highlighted that 23...

The aim of the paper is to examine the variability of eastern Mediterranean landscapes using a common mapping framework relying on Landscape Character Mapping (LCM). LCM was adapted to the region’s specificities placing emphasis on the area’s coastal...

With rapid economic development, extensive human activity has changed landscape patterns (LPs) dramatically, which has further influenced hydrological processes. However, the effects of LPs changes on hydrological processes, especially for the stream...

This paper presents the design of a Blockchain Readiness Index (BRI) to be used as a tool for assisting nations to monitor the level of Blockchain maturity according to their suitability on hosting blockchain-based activities, and successfully adopti...

The construction and optimization of urban green infrastructure (UGI) are regarded as effective strategies for harmonizing the natural landscape with human activities, particularly in ecologically vulnerable areas in the Upper Yellow River Basin, Chi...

With the development of urban built-up areas, accurately extracting the urban built-up area and spatiotemporal pattern evolution trends could be valuable for understanding urban sprawl and human activities. Considering the coarse spatial resolution o...

Understanding the impacts of land use and land cover changes on ecosystem service values (ESVs) is crucial for effective ecosystem management; however, the intricate relationship between these factors in coal mining regions remains underexplored. In...

The transition zone between the Mu Us Sandy Land and the Loess Plateau is considered an ecologically fragile area. However, significant changes in land use have occurred in the past few decades due to changes in land policies and the implementation o...

The uncontrolled expansion of mining activities has caused severe environmental impacts in semi-arid regions, endangering fragile ecosystems and water resources. This study aimed to propose a decision-making model to identify land use and land cover...

Due to increased levels of human activity, various pollutants are frequently detected on the Tibetan Plateau, where the environment is extremely fragile and sensitive. Therefore, this study investigated the sources, pollution, and ecological risks of...

Ecological suitability evaluation is a critical component of regional sustainable development and construction, serving as a foundation for optimizing spatial patterns of regional growth. This is particularly pertinent in karst mountainous regions ch...

Outdoor thermal comfort is an important criterion for evaluating the quality of outdoor activity environments and is also a significant indicator for assessing sustainable building design. Over the past century, more than 165 indoor and outdoor therm...

Coordination between ecological security and economic development is crucial to sustainable development, with a development strategy that should be adjusted according to the type of region. Yunnan Province, China, is a treasure trove of biodiversity...

Urban informal green spaces (IGS) represent valuable reservoirs of biodiversity within urban areas and are increasingly recognized as integral components of green infrastructure. They are perceived as temporary ecosystems, and the management of their...

Deforestation and land-use changes lead to significant soil degradation and erosion, particularly in Amazonian ecosystems, due to the region’s climate and geology. This study characterizes soil quality using physical, chemical, and biological p...

As an important target for the development of novel antibiotics, UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) has been widely studied. Pyridone methylsulfone hydroxamate (PMH) compounds can effectively inhibit the catalytic a...

The high spatial resolution and revisit time of Sentinel-2A/B tandem satellites allow a potentially improved retrieval of land surface phenology (LSP). The biome and regional characteristics, however, greatly constrain the design of the LSP algorithm...

We report a landscape-scale natural experiment that followed the abundance and demography of forest-floor small mammals and the activity of small mustelids over a 4-year period of an extreme heat wave and abundant coniferous cone crops. Deer mice (Pe...

The recent extreme wildfire seasons have overwhelmed the fire-suppression capabilities of national authorities, evidencing the need for a paradigm shift in wildfire management. Wildfire spread and behaviour simulations provide relevant information fo...

Regular detection of land-use and land-cover (LULC) changes with high accuracy is necessary for natural resources management and sustainable urban planning. The produced LULC maps from Google Earth Engine (GEE) also illustrate the transformation of t...

The Forest Stewardship Council (FSC) has initiated a new sustainability mechanism, the ecosystem-services certification. In this system, management entities who wish to be certified for the maintenance of ecosystem services (carbon, biodiversity, wat...

The planning of bicycle infrastructure across our cities remains a complex task involving many key stakeholders, including the community, who traditionally have had limited involvement in the planning process. This research develops an interactive bi...

Agricultural vegetation development and harvest date monitoring over large areas requires frequent remote sensing observations. In regions with persistent cloud coverage during the vegetation season this is only feasible with active systems, such as...

The dynamic process of the wetland can reflect its impact on the environment, and finding a balance point supporting harmonious coexistence between man and nature has become an issue of increasing concern. On the basis of previous studies that have f...

Riparian vegetation represents a protective barrier between human activities installed in catchments and capable of generating and exporting large amounts of contaminants, and stream water that is expected to keep quality overtime. This study explore...

Sentinel-2 images at 10-m resolution were used for modeling crop coefficients and biomass production with the application of the so-called SAFER (Simple Algorithm for Evapotranspiration Retrieving) and Monteith model for biomass production in an area...

Isocitrate dehydrogenase 1 (IDH1) is a necessary enzyme for cellular respiration in the tricarboxylic acid cycle. Mutant isocitrate dehydrogenase 1 (mIDH1) has been detected overexpressed in a variety of cancers. mIDH1 inhibitor ivosidenib (AG-120) w...

Habitat quality (HQ) is an important indicator to characterize the level of biodiversity and ecosystem services, and can reflect the quality of the human living environment. Changes in land use can disturb regional HQ. Current research mostly focuses...

The NLRP3 inflammasome, plays a critical role in the pathogenesis of rheumatoid arthritis (RA) by activating inflammatory cytokines such as IL1β and IL18. Targeting NLRP3 has emerged as a promising therapeutic strategy for RA. In this study, a m...

Cattle grazing is an important economic activity in the tallgrass prairie systems in the Great Plains of the United States. Tallgrass prairie may respond differently to grazing management (e.g., high and low grazing intensity) under variable climate...

Land cover plays an important role in the climate and biogeochemistry of the Earth system. It is of great significance to produce and evaluate the global land cover (GLC) data when applying the data to the practice at a specific spatial scale. The ob...

Apricot cultivation plays a significant role in Italy’s agricultural landscape, with the country hosting a wide variety of traditional and international cultivars, and their cultivation, processing and transformation offer a wide margin for mar...

Fire has historically played an important role in shaping the structure and composition of Sonoran semi-desert grassland vegetation. Yet, human use and land management activities have significantly altered arid grassland ecosystems over the last cent...