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202 Results Found

  • Article
  • Open Access
2 Citations
3,621 Views
17 Pages

Comparing NIRS and Pulse Oximetry for Cerebral Oxygen Saturation During Hypoxia Testing

  • Vasilios Alevizakos,
  • Andreas Werner,
  • Lisa-Marie Schiller,
  • Constantin von See and
  • Marcus Schiller

24 October 2024

Objective: This study evaluates the suitability of cerebral oximetry using near-infrared spectroscopy (NIRS) compared to traditional pulse oximetry (SpO2) for measuring cerebral oxygen saturation during hypoxia testing, aiming to enhance safety durin...

  • Feature Paper
  • Article
  • Open Access
20 Citations
7,327 Views
19 Pages

Oxygen Saturation Behavior by Pulse Oximetry in Female Athletes: Breaking Myths

  • Pilar Martín-Escudero,
  • Ana María Cabanas,
  • Manuel Fuentes-Ferrer and
  • Mercedes Galindo-Canales

14 October 2021

The myths surrounding women’s participation in sport have been reflected in respiratory physiology. This study aims to demonstrate that continuous monitoring of blood oxygen saturation during a maximal exercise test in female athletes is highly corre...

  • Article
  • Open Access
2 Citations
5,180 Views
8 Pages

About 1/4 of all neonatal deaths in Nigeria are caused by birth asphyxia. Normal values of oxygen saturation vary according to regional altitudes. They are important for the screening of cyanotic congenital heart diseases and during newborn resuscita...

  • Article
  • Open Access
5 Citations
6,476 Views
15 Pages

Overestimation of Oxygen Saturation Measured by Pulse Oximetry in Hypoxemia. Part 1: Effect of Optical Pathlengths-Ratio Increase

  • Eyal Elron,
  • Ruben Bromiker,
  • Ori Gleisner,
  • Ohad Yosef-Hai,
  • Ori Goldberg,
  • Itamar Nitzan and
  • Meir Nitzan

28 January 2023

On average, arterial oxygen saturation measured by pulse oximetry (SpO2) is higher in hypoxemia than the true oxygen saturation measured invasively (SaO2), thereby increasing the risk of occult hypoxemia. In the current article, measurements of SpO2...

  • Article
  • Open Access
19 Citations
11,294 Views
18 Pages

Accuracy of a New Pulse Oximetry in Detection of Arterial Oxygen Saturation and Heart Rate Measurements: The SOMBRERO Study

  • Stefano Marinari,
  • Pasqualina Volpe,
  • Marzia Simoni,
  • Matteo Aventaggiato,
  • Fernando De Benedetto,
  • Stefano Nardini,
  • Claudio M. Sanguinetti and
  • Paolo Palange

3 July 2022

Early diagnosis and continuous monitoring of respiratory failure (RF) in the course of the most prevalent chronic cardio-vascular (CVD) and respiratory diseases (CRD) are a clinical, unresolved problem because wearable, non-invasive, and user-friendl...

  • Article
  • Open Access
7 Citations
6,971 Views
17 Pages

Effect of Skin Pigmentation and Finger Choice on Accuracy of Oxygen Saturation Measurement in an IoT-Based Pulse Oximeter

  • Shyqyri Haxha,
  • Chike Nwibor,
  • Mian Ali,
  • Mohamed Sakel,
  • Karen Saunders,
  • Vladimir Dyo and
  • Shakira Nabakooza

22 May 2024

Pulse oximeters are widely used in hospitals and homes for measurement of blood oxygen saturation level (SpO2) and heart rate (HR). Concern has been raised regarding a possible bias in obtaining pulse oximeter measurements from different fingertips a...

  • Article
  • Open Access
52 Citations
10,765 Views
7 Pages

Assessment of Non-Invasive Measurements of Oxygen Saturation and Heart Rate with an Apple Smartwatch: Comparison with a Standard Pulse Oximeter

  • Carmen Spaccarotella,
  • Alberto Polimeni,
  • Cinzia Mancuso,
  • Girolamo Pelaia,
  • Giovanni Esposito and
  • Ciro Indolfi

8 March 2022

The most commonly used method to assess peripheral oxygen saturation (SpO2) in clinical practice is pulse oximetry. The smartwatch Apple Watch 6 was developed with a new sensor and an app that allows taking on-demand readings of blood oxygen and back...

  • Article
  • Open Access
2,827 Views
13 Pages

Statistical Description of SaO2–SpO2 Relationship for Model of Oxygenation in Premature Infants

  • Veronika Rafl-Huttova,
  • Jakub Rafl,
  • Knut Möller,
  • Thomas E. Bachman,
  • Petr Kudrna and
  • Martin Rozanek

A pulse oximeter model linking arterial (SaO2) and peripheral (SpO2) oxygen saturation is the terminal part of a mathematical model of neonatal oxygen transport. Previous studies have confirmed the overestimation of oxygen saturation measured by puls...

  • Review
  • Open Access
87 Citations
12,980 Views
28 Pages

27 August 2020

Adequate oxygen delivery to a tissue depends on sufficient oxygen content in arterial blood and blood flow to the tissue. Oximetry is a technique for the assessment of blood oxygenation by measurements of light transmission through the blood, which i...

  • Article
  • Open Access
40 Citations
14,489 Views
15 Pages

Calibration-Free Pulse Oximetry Based on Two Wavelengths in the Infrared — A Preliminary Study

  • Meir Nitzan,
  • Salman Noach,
  • Elias Tobal,
  • Yair Adar,
  • Yaacov Miller,
  • Eran Shalom and
  • Shlomo Engelberg

23 April 2014

The assessment of oxygen saturation in arterial blood by pulse oximetry (SpO2) is based on the different light absorption spectra for oxygenated and deoxygenated hemoglobin and the analysis of photoplethysmographic (PPG) signals acquired at two wavel...

  • Article
  • Open Access
8 Citations
2,846 Views
20 Pages

New Methodology of Human Health Express Diagnostics Based on Pulse Wave Measurements and Occlusion Test

  • Roman Davydov,
  • Anna Zaitceva,
  • Vadim Davydov,
  • Daria Isakova and
  • Maria Mazing

28 February 2023

Nowadays, with the increase in the rhythm of life, the relevance of using express diagnostics methods for human health state estimation has significantly increased. We present a new express diagnostics method based on non-invasive measurements (the p...

  • Article
  • Open Access
36 Citations
8,286 Views
13 Pages

Pulse Oximetry with Two Infrared Wavelengths without Calibration in Extracted Arterial Blood

  • Ohad Yossef Hay,
  • Meir Cohen,
  • Itamar Nitzan,
  • Yair Kasirer,
  • Sarit Shahroor-karni,
  • Yitzhak Yitzhaky,
  • Shlomo Engelberg and
  • Meir Nitzan

15 October 2018

Oxygen saturation in arterial blood (SaO2) provides information about the performance of the respiratory system. Non-invasive measurement of SaO2 by commercial pulse oximeters (SpO2) make use of photoplethysmographic pulses in the red and infrared re...

  • Article
  • Open Access
5 Citations
3,924 Views
17 Pages

10 January 2025

The effect of skin pigmentation on photoplethysmography and, specifically, pulse oximetry has recently received a significant amount of attention amongst researchers, especially since the COVID-19 pandemic. With most computational studies observing o...

  • Article
  • Open Access
44 Citations
12,983 Views
14 Pages

Novel Wearable and Wireless Ring-Type Pulse Oximeter with Multi-Detectors

  • Cheng-Yang Huang,
  • Ming-Che Chan,
  • Chien-Yue Chen and
  • Bor-Shyh Lin

19 September 2014

The pulse oximeter is a popular instrument to monitor the arterial oxygen saturation (SPO2). Although a fingertip-type pulse oximeter is the mainstream one on the market at present, it is still inconvenient for long-term monitoring, in particular, wi...

  • Article
  • Open Access
748 Views
11 Pages

Inter-Finger Variability of SpO2 During Hypoxemia and Step Resaturation

  • Simon Walzel,
  • Veronika Rafl-Huttova,
  • Martin Rozanek,
  • Petr Kudrna,
  • Marian Rybar and
  • Jakub Rafl

21 October 2025

Background: Pulse oximetry is a non-invasive method for continuous monitoring of peripheral blood oxygen saturation (SpO2) to estimate arterial oxygen saturation. Previous studies suggested that SpO2 measurements show variability depending on the par...

  • Systematic Review
  • Open Access
97 Citations
21,819 Views
20 Pages

Skin Pigmentation Influence on Pulse Oximetry Accuracy: A Systematic Review and Bibliometric Analysis

  • Ana M. Cabanas,
  • Macarena Fuentes-Guajardo,
  • Katina Latorre,
  • Dayneri León and
  • Pilar Martín-Escudero

29 April 2022

Nowadays, pulse oximetry has become the standard in primary and intensive care units, especially as a triage tool during the current COVID-19 pandemic. Hence, a deeper understanding of the measurement errors that can affect precise readings is a key...

  • Review
  • Open Access
19 Citations
8,575 Views
11 Pages

Accuracy of Pulse Oximetry in the Presence of Fetal Hemoglobin—A Systematic Review

  • Ena Pritišanac,
  • Berndt Urlesberger,
  • Bernhard Schwaberger and
  • Gerhard Pichler

30 April 2021

Continuous monitoring of arterial oxygen saturation by pulse oximetry (SpO2) is the main method to guide respiratory and oxygen support in neonates during postnatal stabilization and after admission to neonatal intensive care unit. The accuracy of th...

  • Article
  • Open Access
30 Citations
9,787 Views
17 Pages

4 April 2020

Photoplethysmography (PPG) is a valuable technique for noninvasively evaluating physiological parameters. However, traditional PPG devices have significant limitations in high-motion and low-perfusion environments. To overcome these limitations, we i...

  • Article
  • Open Access
3,022 Views
15 Pages

Development and Metrological Characterization of Low-Cost Wearable Pulse Oximeter

  • Andrea Cataldo,
  • Enrico Cataldo,
  • Antonio Masciullo and
  • Raissa Schiavoni

Pulse oximetry is essential for monitoring arterial oxygen saturation (SpO2) and heart rate (HR) in various medical scenarios. However, the traditional pulse oximeters face challenges related to high costs, motion artifacts, and susceptibility to amb...

  • Article
  • Open Access
1 Citations
3,106 Views
18 Pages

Autonomic Nerve Activation Observed for Hemodialysis Patients While Squeezing a Soft Ball

  • Jian-Chiun Liou,
  • Chih-Wei Peng,
  • Philippe Basset and
  • Zhen-Xi Chen

19 November 2020

In this study, a medical grade pulse rate (PR) instrument was used to monitor hemodialysis patients, and the wearable product was applied for the 4 h observation. Electrocardiogram (ECG) and photoplethysmography (PPG) data were simultaneously collect...

  • Article
  • Open Access
14 Citations
17,078 Views
12 Pages

Evaluation of Leading Smartwatches for the Detection of Hypoxemia: Comparison to Reference Oximeter

  • Simon Walzel,
  • Radek Mikus,
  • Veronika Rafl-Huttova,
  • Martin Rozanek,
  • Thomas E. Bachman and
  • Jakub Rafl

14 November 2023

Although smartwatches are not considered medical devices, experimental validation of their accuracy in detecting hypoxemia is necessary due to their potential use in monitoring conditions manifested by a prolonged decrease in peripheral blood oxygen...

  • Article
  • Open Access
2,617 Views
17 Pages

28 December 2024

The continuous monitoring of oxygen saturation (SpO2) and respiratory rates (RRs) are major clinical issues in many cardio-respiratory diseases and have been of tremendous importance during the COVID-19 pandemic. The early detection of hypoxemia was...

  • Article
  • Open Access
7 Citations
11,563 Views
10 Pages

Use of a Combined SpO2/PtcCO2 Sensor in the Delivery Room

  • Serena Antonia Rubortone,
  • Maria Pia De Carolis,
  • Serafina Lacerenza,
  • Iliana Bersani,
  • Federica Occhipinti and
  • Costantino Romagnoli

8 August 2012

Arterial oxygen saturation (SaO2) and partial arterial pressure of carbon dioxide (PaCO2) are important respiratory parameters in critically ill neonates. A sensor combining a pulse oximeter with the Stow-Severinghaus electrode, required for the meas...

  • Article
  • Open Access
3 Citations
2,462 Views
12 Pages

19 January 2025

Over the past ten years, there has been an increasing demand for reliable consumer wearables as users are inclined to monitor their health and fitness metrics in real-time, especially since the COVID-19 pandemic. Reflectance pulse oximeters in fitnes...

  • Article
  • Open Access
21 Citations
8,085 Views
17 Pages

Oxygen Saturation Measurements from Green and Orange Illuminations of Multi-Wavelength Optoelectronic Patch Sensors

  • Samah Alharbi,
  • Sijung Hu,
  • David Mulvaney,
  • Laura Barrett,
  • Liangwen Yan,
  • Panagiotis Blanos,
  • Yasmin Elsahar and
  • Samuel Adema

31 December 2018

Photoplethysmography (PPG) based pulse oximetry devices normally use red and infrared illuminations to obtain oxygen saturation (SpO 2 ) readings. In addition, the presence of motion artefacts severely restricts the utility of pulse oximetry p...

  • Article
  • Open Access
77 Views
11 Pages

25 January 2026

Background/Objectives: Red blood cell (RBC) transfusion is frequently used to treat anemia of prematurity, yet bedside metrics that capture its short-term impact on oxygenation stability are limited. We assessed whether pulse oximetry histogram-deriv...

  • Article
  • Open Access
4 Citations
3,590 Views
12 Pages

Age-Related Variation of Pulpal Oxygen Saturation in Healthy Primary and Permanent Teeth in Children: A Clinical Study

  • Andreea Igna,
  • Darian Rusu,
  • Emilia Ogodescu,
  • Ștefania Dinu,
  • Marius Boariu,
  • Adrian Voicu and
  • Ștefan-Ioan Stratul

26 December 2022

(1) Background: Pulse oximetry (PO) is an effective method of dental pulp status monitorization but still lacks practical implementation in dentistry, as well as clear reference values for different tooth types. The study’s aim was to investiga...

  • Article
  • Open Access
29 Citations
8,992 Views
19 Pages

Enabling Continuous Wearable Reflectance Pulse Oximetry at the Sternum

  • Michael Chan,
  • Venu G. Ganti,
  • J. Alex Heller,
  • Calvin A. Abdallah,
  • Mozziyar Etemadi and
  • Omer T. Inan

17 December 2021

In light of the recent Coronavirus disease (COVID-19) pandemic, peripheral oxygen saturation (SpO2) has shown to be amongst the vital signs most indicative of deterioration in persons with COVID-19. To allow for the continuous monitoring of SpO2, we...

  • Article
  • Open Access
28 Citations
8,137 Views
11 Pages

Optical Fibre-Based Pulse Oximetry Sensor with Contact Force Detection

  • Chong Liu,
  • Ricardo Correia,
  • Hattan Khaled Ballaji,
  • Serhiy Korposh,
  • Barrie R. Hayes-Gill and
  • Stephen P. Morgan

26 October 2018

A novel optical sensor probe combining monitoring of blood oxygen saturation (SpO2) with contact pressure is presented. This is beneficial as contact pressure is known to affect SpO2 measurement. The sensor consists of three plastic optical fibres (P...

  • Article
  • Open Access
2 Citations
2,219 Views
12 Pages

A Bayesian Reanalysis of the Overall and Sex-Disaggregated Results of the Neonatal Oxygenation Prospective Meta-Analysis (NeOProM)

  • Maurice Jacob Huizing,
  • Tamara Maria Hundscheid,
  • František Bartoš and
  • Eduardo Villamor

Data from the Neonatal Oxygenation Prospective Meta-analysis (NeOProM) indicate that targeting a higher (91–95%) versus lower (85–89%) pulse oximeter saturation (SpO2) range may reduce mortality and necrotizing enterocolitis (NEC) and inc...

  • Article
  • Open Access
4 Citations
2,091 Views
13 Pages

The Development of a Measuring System for Intraoral SpO2

  • Yuki Kashima,
  • Minako Onimaru,
  • Ryosuke Isogai,
  • Noboru Kawai,
  • Yoshifumi Yoshida and
  • Koutaro Maki

10 January 2024

Blood oxygen saturation (SpO2) is an essential indicator of a patient’s general condition. However, conventional measurement methods have some issues such as time delay and interference by ambient light. Improved measurement methods must be dev...

  • Article
  • Open Access
9 Citations
4,522 Views
15 Pages

2 July 2021

An increasing proportion of occupational mishaps in dynamic, high-risk operational environments have been attributed to human error, yet there are currently no devices to routinely provide accurate physiological data for insights into underlying cont...

  • Article
  • Open Access
1 Citations
2,550 Views
10 Pages

Excessive Oxygen Administration in High-Risk Patients Admitted to Medical and Surgical Wards Monitored by Wireless Pulse Oximeter

  • Clara E. Mathar,
  • Camilla Haahr-Raunkjær,
  • Mikkel Elvekjær,
  • Ying Gu,
  • Claire P. Holm,
  • Michael P. Achiam,
  • Lars N. Jorgensen,
  • Eske K. Aasvang and
  • Christian S. Meyhoff

9 February 2024

The monitoring of oxygen therapy when patients are admitted to medical and surgical wards could be important because exposure to excessive oxygen administration (EOA) may have fatal consequences. We aimed to investigate the association between EOA, m...

  • Article
  • Open Access
4 Citations
4,240 Views
13 Pages

2 June 2022

The reliability of pulse oximetry is crucial, especially in cases of rapid changes in body oxygenation. In order to evaluate the performance of pulse oximeters during rapidly developing short periods of concurrent hypoxemia and hypercapnia, 13 health...

  • Article
  • Open Access
6 Citations
5,677 Views
16 Pages

Reflection-Boosted Wearable Ring-Type Pulse Oximeters for SpO2 Measurement with High Sensitivity and Low Power Consumption

  • Min Gyu Joo,
  • Dae Hyeong Lim,
  • Kyu-Kwan Park,
  • Jiwon Baek,
  • Jong Min Choi and
  • Hyoung Won Baac

5 July 2023

In this study, we demonstrated a Monte Carlo simulation to model a finger structure and to calculate the intensity of photons passing through tissues, in order to determine optimal angular separation between a photodetector (PD) and a light-emitting...

  • Article
  • Open Access
4 Citations
5,234 Views
6 Pages

Congenital Critical Heart Defect Screening in a Health Area of the Community of Valencia (Spain): A Prospective Observational Study

  • Elena Cubells,
  • Begoña Torres,
  • Antonio Nuñez-Ramiro,
  • Manuel Sánchez-Luna,
  • Isabel Izquierdo and
  • Máximo Vento

Despite the progress in the fetal echocardiographic detection of congenital critical heart defects and neonatal physical examination, a significant number of newborn infants are discharged and readmitted to the hospital in severe condition due to car...

  • Article
  • Open Access
14 Citations
8,195 Views
21 Pages

20 April 2024

Wearable health devices (WHDs) are rapidly gaining ground in the biomedical field due to their ability to monitor the individual physiological state in everyday life scenarios, while providing a comfortable wear experience. This study introduces a no...

  • Article
  • Open Access
1,272 Views
13 Pages

A Novel Method to Determine the Respiratory Compensation Point from Percutaneous Oxygen Saturation of Healthy Adults During a Ramp-Incremental Test: A Cross-Sectional Study

  • Masatsugu Abe,
  • Kai Ushio,
  • Masaya Tsubokawa,
  • Koki Fukuhara,
  • Yoshitaka Iwamoto,
  • Daisuke Iwaki,
  • Yuki Nakashima,
  • Takeshi Nakamura and
  • Yukio Mikami

15 September 2025

Background: In exercise testing, the ventilatory threshold 1 (VT1) and ventilatory threshold 2 (VT2) are used in lifestyle-related diseases, cardiac rehabilitation, and athletic training. We investigated a VT2 measuring method using a pulse oximeter....

  • Article
  • Open Access
12 Citations
4,357 Views
8 Pages

Pulp Vitality Testing with a Developed Universal Pulse Oximeter Probe Holder

  • Živilė Grabliauskienė,
  • Roberta Zamaliauskienė and
  • Greta Lodienė

23 January 2021

Background and Objectives An accurate determination of the pulp status is relevant for a proper endodontic diagnosis. Objectives: The aim was to develop a universal pulse oximeter probe holder for measuring the oxygen saturation and to evaluate the u...

  • Article
  • Open Access
4 Citations
4,724 Views
18 Pages

Pulse Oximetry Imaging System Using Spatially Uniform Dual Wavelength Illumination

  • Riaz Muhammad,
  • Kay Thwe Htun,
  • Ezekiel Edward Nettey-Oppong,
  • Ahmed Ali,
  • Dae Keun Jeon,
  • Hyun-Woo Jeong,
  • Kyung Min Byun and
  • Seung Ho Choi

4 April 2023

Pulse oximetry is a non-invasive method for measuring blood oxygen saturation. However, its detection scheme heavily relies on single-point measurements. If the oxygen saturation is measured at a single location, the measurements are influenced by th...

  • Editorial
  • Open Access
98 Views
5 Pages

Pulsoxymetrie in der Transösophagealen Echokardiographie

  • Thomas Largiadèr,
  • Erwin Oechslin and
  • Rolf Jenni

Pulse oxymetry in transoesophageal echocardiography. Pulse oxymetry to assess oxygen saturation is an important diagnostic tool in medicine and plays a central role in monitoring patients undergoing invasive or semi invasive examinations like for ins...

  • Article
  • Open Access
27 Citations
9,092 Views
10 Pages

Near-infrared spectroscopy (NIRS) uses the relative absorption of light at 850 and 760 nm to determine skeletal muscle oxygen saturation. Previous studies have used the ratio of both signals to report muscle oxygen saturation. Purpose: The purpose of...

  • Article
  • Open Access
21 Citations
4,999 Views
15 Pages

Data-Driven Calibration Estimation for Robust Remote Pulse-Oximetry

  • Mark van Gastel,
  • Wim Verkruysse and
  • Gerard de Haan

13 September 2019

Pulse-oximetry has become a core monitoring modality in most fields of medicine. Typical dual-wavelength pulse-oximeters estimate blood oxygen saturation (SpO2) levels from a relationship between the amplitudes of red and infrared photoplethysmograph...

  • Article
  • Open Access
3 Citations
1,924 Views
23 Pages

22 May 2024

The blood oxygen saturation, which indicates the ratio of oxygenated hemoglobin to total hemoglobin in the blood, is closely related to one’s health status. Oxygen saturation is typically measured using a pulse oximeter. However, this method ca...

  • Case Report
  • Open Access
1 Citations
588 Views
6 Pages

Acquired Methaemoglobinaemia—A Case Report

  • Anna Paczek,
  • Liliana Wawrzyńska,
  • Ewa Mendek-Czajkowska,
  • Jarosław Kober and
  • Adam Torbicki

19 March 2010

Methaemoglobinaemia is a rarely diagnosed, life-threatening pathology and involves the presence of more than 1% of oxidised haemoglobin in the blood that is unable to carry oxygen. We report the case of a 49-year-old male who developed fulminant symp...

  • Communication
  • Open Access
2,296 Views
8 Pages

No Difference in Sleep Desaturations Severity between Patients with Wake-Up and Non-Wake-Up Stroke: A PRESS Study Results

  • Katarína Klobučníková,
  • Branislav Kollár,
  • Matúš Jurík,
  • Katarína Valovičová,
  • Miroslava Hardoňová,
  • Michal Poddaný,
  • Miroslav Tedla,
  • Michal Riant,
  • Pavel Klail and
  • Pavel Šiarnik
  • + 1 author

13 February 2023

Background: Wake-up stroke (WUS) is a certain type of ischemic stroke in which a patient wakes up with a new neurological deficit due to cerebral ischemia. Sleep-disordered breathing is an independent risk factor for stroke, but the role of nocturnal...

  • Article
  • Open Access
1,147 Views
12 Pages

Short-Term Observation of Heart Rate and Oxygen Saturation in Relation to Masticatory Muscle Activity in Temporomandibular Disorders

  • Grzegorz Zieliński,
  • Michał Ginszt,
  • Marcin Wójcicki,
  • Jacek Szkutnik,
  • Monika Litko-Rola and
  • Piotr Gawda

(1) Background: The present study was designed to analyze the relationship between masticatory muscle activity, oxygen body saturation, and heart rate in patients with temporomandibular disorders (TMDs). (2) Methods: A total of 104 individuals with a...

  • Case Report
  • Open Access
3 Citations
2,585 Views
7 Pages

Methemoglobinemia Secondary to Inhalation of Automobile Emissions with Suicide Motivations

  • Manuel Antonio Tazón-Varela,
  • Ángel Padilla-Mielgo,
  • Raquel Villaverde-Plazas,
  • Fabiola Espinoza-Cuba,
  • Nekane Gallo-Salazar and
  • Pedro Muñoz-Cacho

17 January 2023

Background: Methemoglobinemia (MetHb) is a rare and potentially severe dyshemoglobinemia that can be induced by exposure to oxidizing agents, decreasing the functional capacity of the hemoglobin molecule to transport and release oxygen into the tissu...

  • Communication
  • Open Access
40 Citations
7,921 Views
10 Pages

12 September 2021

Oxygen saturation (SPO2) is an important indicator of health, and is usually measured by placing a pulse oximeter in contact with a finger or earlobe. However, this method has a problem in that the skin and the sensor must be in contact, and an addit...

  • Case Report
  • Open Access
349 Views
10 Pages

First Symptomatic Pediatric Case of Hb Rothschild (HBB: c.112T>C, p.Trp38Arg): Low-Oxygen-Affinity Hemoglobin Presenting with Persistent Pseudohypoxemia

  • Ekaterina Nuzhnaya,
  • Andrey Marakhonov,
  • Artem Ivanov,
  • Yulia Lashkova,
  • Ivan Kuznetsov,
  • Tatiana Kulichenko,
  • Ksenya Zabudskaya,
  • Oxana Ryzhkova,
  • Nikolay Zernov and
  • Natalia Semenova

12 December 2025

Background: Hemoglobin Rothschild (Hb Rothschild), NM_000518.5(HBB):c.112T>C, is an ultra-rare low-oxygen-affinity hemoglobin variant that persistently causes reduced peripheral oxygen saturation on pulse oximetry despite normal arterial oxygenati...

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