Antiretroviral therapy (ART) has dramatically improved the prognosis for people living with HIV-1, but a cure remains elusive. The largest barrier to a cure is the presence of a long-lived latent reservoir that persists within a heterogenous mix of c...
Scientific knowledge evolves in small steps, with occasional backsteps to correct inaccuracies, all occurring within a competitive environment. This perspective for the first time looks at the history of latency-related RNA (LR-RNA) that was later re...
Cells that are latently infected with HIV-1 preclude an HIV-1 cure, as antiretroviral therapy does not target this latent population. HIV-1 is highly genetically diverse, with over 10 subtypes and numerous recombinant forms circulating worldwide. In...
13 February 2022
Background: Examining the relationship between sleep and depression may be important for understanding the aetiology of affective disorders. Most studies that use electroencephalography (EEG) to objectively assess sleep have been conducted using poly...
Latency establishment is the hallmark feature of herpesviruses, a group of viruses, of which nine are known to infect humans. They have co-evolved alongside their hosts, and mastered manipulation of cellular pathways and tweaking various processes to...
Primary varicella-zoster virus (VZV) infection causes varicella (chickenpox) and the establishment of a lifelong latent infection in ganglionic neurons. VZV reactivates in about one-third of infected individuals to cause herpes zoster, often accompan...
The final obstacle to achieving a cure to HIV/AIDS is the presence of latent HIV reservoirs scattered throughout the body. Although antiretroviral therapy maintains plasma viral loads below the levels of detection, upon cessation of therapy, the late...
The latent viral reservoir represents one of the major barriers to curing HIV-1. Focus on the “kick and kill” (also called “shock and kill”) approach, in which virus expression is reactivated, and then cells producing virus ar...
Our current understanding of HSV latency is based on a variety of clinical observations, and in vivo, ex vivo, and in vitro model systems, each with unique advantages and drawbacks. The criteria for authentically modeling HSV latency include the abil...
Human cytomegalovirus (HCMV) infection can lead to either lytic or latent infection, which is dependent on the regulation of the viral major immediate early promoter (MIEP). Suppression of the MIEP is a pre-requisite for latency and is driven by repr...
Human Immunodeficiency Virus type 1 (HIV-1) latency represents a significant hurdle in finding a cure for HIV-1 infections, despite tireless research efforts. This challenge is partly attributed to the intricate nature of HIV-1 latency, wherein vario...
Eradication of latent human immunodeficiency virus (HIV) infection is a global health challenge. Reactivation of HIV latency and killing of virus-infected cells, the so-called “kick and kill” or “shock and kill” approaches, are a popular strategy for...
Human immunodeficiency virus type 1 (HIV-1) targets CD4+ T cells and cells of the monocyte/macrophage lineage. HIV pathogenesis is characterized by the depletion of T lymphocytes and by the presence of a population of cells in which latency has been...
Human T-lymphotrophic virus type 1 (HTLV-1) and Bovine leukemia virus (BLV) belong to the Deltaretrovirus genus. HTLV-1 is the etiologic agent of the highly aggressive and currently incurable cancer adult T-cell leukemia (ATL) and a neurological dise...
Varicella-zoster virus (VZV) is a human herpes virus which causes varicella (chicken pox) as a primary infection, and, following a variable period of latency in neurons in the peripheral ganglia, may reactivate to cause herpes zoster (shingles) as we...
Tactile internet applications allow robotic devices to be remotely controlled over a communication medium with an unnoticeable time delay. In bilateral communication, the acceptable round trip latency is usually 1 ms up to 10 ms, depending on the app...
Low-latency communication is becoming more popular as applications that demand real-time interaction, such as autonomous mobile vehicles and tactile Internet, have recently gained prominence. In this paper, we propose a fast autotuning algorithm to s...
Cytomegalovirus (CMV) gene expression is repressed in latency due to heterochromatinization of viral genomes. In murine CMV (MCMV) latently infected mice, viral genomes are bound to histones with heterochromatic modifications, to enzymes that mediate...
Antiretroviral therapy (ART) has brought the HIV/AIDS epidemic under control, but a curative strategy for viral eradication is still needed. The cessation of ART results in rapid viral rebound from latently infected CD4+ T cells, showing that control...
Human cytomegalovirus (HCMV) is a beta herpesvirus that establishes a life-long persistence in the host, like all herpesviruses, by way of a latent infection. During latency, viral genomes are maintained in a quieted state. Virus replication can be r...
The domain of Multi-Network Latency Prediction for IoT and Wireless Sensor Networks (WSNs) confronts significant challenges. However, continuous research efforts and progress in areas such as machine learning, edge computing, security technologies, a...
To seamlessly deliver artificial intelligence (AI) services using object detection, both inference latency from a system perspective as well as inference accuracy should be considered important. Although edge computing can be applied to efficiently o...
Gammaherpesviruses, such as Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus, are important human pathogens involved in lymphoproliferative disorders and tumorigenesis. Herpesvirus infections are characterized by a biphasic cycle...
Human T-cell leukemia virus type 1 (HTLV-1), the cause of adult T-cell leukemia/lymphoma (ATLL), is a retrovirus, which integrates into the host genome and persistently infects CD4+ T-cells. Virus propagation is stimulated by (1) clonal expansion of...
Pseudorabies virus (PRV), the causative agent of Aujeszky’s disease, is one of the most important infectious pathogens threatening the global pig industry. Like other members of alphaherpesviruses, PRV establishes a lifelong latent infection an...
The major obstacle towards HIV-1 eradication is the life-long persistence of the virus in reservoirs of latently infected cells. In these cells the proviral DNA is integrated in the host’s genome but it does not actively replicate, becoming invisible...
Kaposi’s sarcoma-associated herpesvirus (KSHV) is associated with three malignancies— Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman’s disease (MCD). Central to the pathogenesis of these dis...
Herpesviruses are ubiquitous human pathogens. After productive (lytic) infection, all human herpesviruses are able to establish life-long latent infection and reactivate from it. Latent infection entails suppression of viral replication, maintenance...
Various studies on latency in remote mixed reality collaborations (remote MR collaboration) have been conducted, but studies related to interaction latency are scarce. Interaction latency in a remote MR collaboration occurs because action detection (...
Network-on-Chips with simple topologies are widely used due to their scalability and high bandwidth. The transmission latency increases greatly with the number of on-chip nodes. A NoC, called single-cycle multi-hop asynchronous repeated traversal (SM...
The availability of secure, efficient, and reliable communication systems is critical for the successful deployment and operations of new power systems such as microgrids. These systems provide a platform for implementing intelligent and autonomous a...
Herpes simplex virus (HSV) establishes a latent infection within sensory neurons of humans. Latency is characterized by the transcriptional repression of lytic genes by the condensation of lytic gene regions into heterochromatin. Recent data suggest...
In this paper, a photosensor-based latency measurement system for head-mounted displays (HMDs) is proposed. The motion-to-photon latency is the greatest reason for motion sickness and dizziness felt by users when wearing an HMD system. Therefore, a m...
The presence of latently infected cells and reservoirs in HIV-1 infected patients constitutes a significant obstacle to achieve a definitive cure. Despite the efforts dedicated to solve these issues, the mechanisms underlying viral latency are still...
Euphorbia usambarica is a traditional medicine used for gynecologic, endocrine, and urogenital illnesses in East Africa; however, its constituents and bioactivities have not been investigated. A variety of compounds isolated from Euphorbia species ha...
Human cytomegalovirus (HCMV) latency, the means by which the virus persists indefinitely in an infected individual, is a major frontier of current research efforts in the field. Towards developing a comprehensive understanding of HCMV latency and its...
This paper proposes two new encoders for data bus inversion (DBI), which conventionally uses a majority voter to pick a data representation that minimizes switching activities and thus reduces the corresponding energy consumption. The new encoders em...
As the PCIe 6.0 specification places higher requirements on signal integrity and transmission latency, it becomes especially important to improve signal transmission performance at the physical layer of the transceiver interface. Retimer circuits are...
HIV-1 infection cannot be cured due to the presence of HIV-1 latently infected cells. These cells do not produce the virus, but they can resume virus production at any time in the absence of antiretroviral therapy. Therefore, people living with HIV (...
This study aimed to investigate the repeatability and reliability of saccadic latency and fix-ation stability as a function of sighting-dominance and contact lens wear. Eye movements were recorded in 12 healthy adults who performed a prosaccade and a...
How to guarantee the data rate and latency requirement for an application with limited energy is an open issue in wireless virtualized sensor networks. In this paper, we integrate the wireless energy transfer technology into the wireless virtualized...
Tactile Internet (TI) is a new internet paradigm that enables sending touch interaction information and other stimuli, which will lead to new human-to-machine applications. However, TI applications require very low latency between devices, as the sys...
Human cytomegalovirus (HCMV) encodes 22 mature microRNAs (miRNAs), which regulate a myriad of cellular processes, including vesicular trafficking, cell cycle progression, apoptosis, and immune evasion, as well as viral gene expression. Recent evidenc...
The demand for multimedia traffic over the Internet is exponentially growing. HTTP adaptive streaming (HAS) is the leading video delivery system that delivers high-quality video to the end user. The adaptive bitrate (ABR) algorithms running on the HT...
Human herpesvirus-6A (HHV-6A) and human herpesvirus-6B (HHV-6B) are two closely related viruses that infect T-cells. Both HHV-6A and HHV-6B possess telomere-like repeats at the terminal regions of their genomes that facilitate latency by integration...
In visible light communication (VLC), the precise latency evaluation of wireless access networks and the efficient forwarding strategy of core networks are the crux for end-to-end reliability provisioning. Leveraging martingale theory, an elegant lat...
HIV-1 latency is a major barrier to curing infections with antiretroviral therapy and, consequently, to eliminating the disease globally. The establishment, maintenance, and potential clearance of latent infection are complex dynamic processes and ca...
Internet traffic is experiencing rapid growth, with the majority of traffic generated from video steaming, web data services and Internet of Things. As these services include the transmission of small data, such as web pages, video chunks and sensing...
Recent advances in both lightweight deep learning algorithms and edge computing increasingly enable multiple model inference tasks to be conducted concurrently on resource-constrained edge devices, allowing us to achieve one goal collaboratively rath...
In this study, we consider an edge cloud server in which a lightweight server is placed near a user device for the rapid processing and storage of large amounts of data. For the edge cloud server, we propose a latency classification algorithm based o...
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