Next Article in Journal / Special Issue
Chromatin Dynamics during Lytic Infection with Herpes Simplex Virus 1
Previous Article in Journal
Development of a Magnetic Electrochemical Bar Code Array for Point Mutation Detection in the H5N1 Neuraminidase Gene
Previous Article in Special Issue
Chromatin, Non-Coding RNAs, and the Expression of HIV
Review

Role of Polycomb Proteins in Regulating HSV-1 Latency

Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Box 100266, Gainesville, FL 32610, USA
*
Author to whom correspondence should be addressed.
Viruses 2013, 5(7), 1740-1757; https://doi.org/10.3390/v5071740
Received: 29 May 2013 / Revised: 4 July 2013 / Accepted: 4 July 2013 / Published: 15 July 2013
(This article belongs to the Special Issue Chromatin Control of Viral Infection)
Herpes simplex virus (HSV) establishes a latent infection within sensory neurons of humans. Latency is characterized by the transcriptional repression of lytic genes by the condensation of lytic gene regions into heterochromatin. Recent data suggest that facultative heterochromatin predominates, and that cellular Polycomb proteins are involved in the establishment and maintenance of transcriptional repression during latency. This review summarizes these data and discusses the implication of viral and cellular factors in regulating heterochromatin composition. View Full-Text
Keywords: HSV; herpes; PRC; Polycomb; heterochromatin; latency; reactivation HSV; herpes; PRC; Polycomb; heterochromatin; latency; reactivation
Show Figures

Figure 1

MDPI and ACS Style

Watson, Z.; Dhummakupt, A.; Messer, H.; Phelan, D.; Bloom, D. Role of Polycomb Proteins in Regulating HSV-1 Latency. Viruses 2013, 5, 1740-1757. https://doi.org/10.3390/v5071740

AMA Style

Watson Z, Dhummakupt A, Messer H, Phelan D, Bloom D. Role of Polycomb Proteins in Regulating HSV-1 Latency. Viruses. 2013; 5(7):1740-1757. https://doi.org/10.3390/v5071740

Chicago/Turabian Style

Watson, Zachary, Adit Dhummakupt, Harald Messer, Dane Phelan, and David Bloom. 2013. "Role of Polycomb Proteins in Regulating HSV-1 Latency" Viruses 5, no. 7: 1740-1757. https://doi.org/10.3390/v5071740

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop