HIV-1 Latency: An Update of Molecular Mechanisms and Therapeutic Strategies
Abstract
:1. Introduction
2. Viral Persistence and Reservoirs
3. Mechanisms of Post Integration HIV-1 Latency
3.1. Integration and Chromatin Organization at the Viral Promoter
3.2. Transcription and Elongation Factors Relevant for HIV-1 Gene Expression
4. Therapeutic Approaches to Overcome Latency
4.1. Interventions to Revert the Latent State
4.2. Immune-Based Therapies
4.3. Gene Therapy Approaches
5. Conclusions and Challenges
Acknowledgments
Author Contributions
Conflicts of Interest
References and Notes
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Battistini, A.; Sgarbanti, M. HIV-1 Latency: An Update of Molecular Mechanisms and Therapeutic Strategies. Viruses 2014, 6, 1715-1758. https://doi.org/10.3390/v6041715
Battistini A, Sgarbanti M. HIV-1 Latency: An Update of Molecular Mechanisms and Therapeutic Strategies. Viruses. 2014; 6(4):1715-1758. https://doi.org/10.3390/v6041715
Chicago/Turabian StyleBattistini, Angela, and Marco Sgarbanti. 2014. "HIV-1 Latency: An Update of Molecular Mechanisms and Therapeutic Strategies" Viruses 6, no. 4: 1715-1758. https://doi.org/10.3390/v6041715