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101 Results Found

  • Article
  • Open Access
4 Citations
3,707 Views
12 Pages

Peptidomic Characterization and Amino Acid Availability after Intake of Casein vs. a Casein Hydrolysate in a Pig Model

  • Pablo Jiménez-Barrios,
  • Laura Sánchez-Rivera,
  • Daniel Martínez-Maqueda,
  • Yann Le Gouar,
  • Didier Dupont,
  • Beatriz Miralles and
  • Isidra Recio

21 February 2023

It is known that casein hydrolysis accelerates gastrointestinal transit in comparison to intact casein, although the effect of the protein hydrolysis on the composition of the digests is not fully understood. The aim of this work is to characterize,...

  • Article
  • Open Access
6 Citations
3,114 Views
11 Pages

The microbiological, rheological, and sensory properties of set-type yoghurt were investigated in the presence of camel and cow casein hydrolysates produced by the action of trypsin enzymes. The hydrolysates significantly decreased the fermentation a...

  • Systematic Review
  • Open Access
10 Citations
4,774 Views
16 Pages

9 October 2022

Casein hydrolysate has various biological functional activities, especially prominent are angiotensin I-converting enzyme inhibitory activities. Increasing evidence has reported the prominent hypotensive effect of casein hydrolysate. However, the eff...

  • Article
  • Open Access
1 Citations
3,524 Views
12 Pages

10 August 2021

Alternatives to routine antibiotic treatment of dairy cattle during the dry period before their next calving are of interest. This was a preliminary study of whether intramammary infusion of casein hydrolysate, administered alone or combined with sta...

  • Article
  • Open Access
2 Citations
1,927 Views
11 Pages

13 June 2024

The effects of using a hard (artisanal) margarine (which has a higher lipidic and lower aqueous contents) and using a soft (commercial) margarine (which has a lower lipidic and higher aqueous contents), along with a casein hydrolysate, on the rheolog...

  • Article
  • Open Access
3 Citations
4,691 Views
15 Pages

Effects of Casein Hydrolysate Ingestion on Thermoregulatory Responses in Healthy Adults during Exercise in Heated Conditions: A Randomized Crossover Trial

  • Yasuyuki Sakata,
  • Chikako Yoshida,
  • Yuka Fujiki,
  • Yutaka Matsunaga,
  • Hirohiko Nakamura,
  • Takashi Shimizu,
  • Yasuhiro Takeda and
  • Tatsuro Amano

24 March 2020

Food ingestion has been shown to affect thermoregulation during exercise, while the impact of protein degradant consumption remains unclear. We investigated the effects of casein hydrolysate ingestion on thermoregulatory responses during exercise in...

  • Article
  • Open Access
7 Citations
2,167 Views
12 Pages

20 October 2023

The effect of casein savinase hydrolysate (CSH) usage on frozen dough (1%, 1.5% and 2%, g/100 g flour) was investigated in terms of rheological, thermal and structural characteristics of wheat doughs and the textural and color properties of correspon...

  • Article
  • Open Access
40 Citations
8,001 Views
11 Pages

Improved Cordycepin Production by Cordyceps militaris KYL05 Using Casein Hydrolysate in Submerged Conditions

  • Soo Kweon Lee,
  • Ju Hun Lee,
  • Hyeong Ryeol Kim,
  • Youngsang Chun,
  • Ja Hyun Lee,
  • Hah Young Yoo,
  • Chulhwan Park and
  • Seung Wook Kim

7 September 2019

Cordycepin, a beneficial bioactive product specifically found in Cordyceps, has received attention in various bioindustrial applications such as in pharmaceuticals, functional foods, and cosmetics, due to its significant functions. However, low produ...

  • Article
  • Open Access
6 Citations
3,675 Views
11 Pages

29 March 2019

Casein hydrolysates (CH) were prepared using papain and modified by the plastein reaction (CH-P) in the presence of extrinsic phenylalanine (CH-P-Phe) or tryptophan (CH-P-Trp). The in vitro protective activity of CH and its modified products against...

  • Article
  • Open Access
32 Citations
4,996 Views
13 Pages

4 July 2019

The characterization and antioxidant activity on Maillard reaction products (MRPs) derived from xylose and bovine casein hydrolysate (BCH) was investigated at 100 °C and initial pH 8.0 as a function of reaction time. The pH values and free amino...

  • Article
  • Open Access
9 Citations
3,932 Views
17 Pages

8 April 2023

Obesity-induced adipose chronic inflammation is closely related to the development of insulin resistance and T2DM. Tripeptides l-valyl-l-prolyl-l-proline (VPP) and l-isoleucyl-l-prolyl-L-proline (IPP) derived from bovine casein have been reported to...

  • Article
  • Open Access
19 Citations
16,194 Views
15 Pages

A Double-Blind, Randomized, Placebo-Controlled Crossover Clinical Study of the Effects of Alpha-s1 Casein Hydrolysate on Sleep Disturbance

  • Hyeon Jin Kim,
  • Jiyeon Kim,
  • Seungyeon Lee,
  • Bosil Kim,
  • Eunjin Kwon,
  • Jee Eun Lee,
  • Min Young Chun,
  • Chan Young Lee,
  • Audrey Boulier and
  • Seikwan Oh
  • + 1 author

27 June 2019

This study evaluated the effects of alpha-s1 casein hydrolysate (ACH; Lactium®) on the subjective and objective sleep profiles of a community-based sample of Koreans with poor sleep quality. We performed a double-blind, randomized crossover trial...

  • Article
  • Open Access
24 Citations
5,926 Views
13 Pages

17 June 2015

Casein and soy protein were digested by papain to three degrees of hydrolysis (DH) 7.3%–13.3%, to obtain respective six casein and soy protein hydrolysates, aiming to clarify their in vitro proliferation and anti-apoptosis towards a human osteoblasti...

  • Article
  • Open Access
15 Citations
12,021 Views
15 Pages

3 February 2022

This randomized, placebo-controlled, crossover and double-blind study investigates the effects of RLX2™ containing alpha-s1-casein tryptic hydrolysate and L-theanine in working adults affected by poor sleep quality. The supplement or placebo wa...

  • Article
  • Open Access
13 Citations
4,270 Views
11 Pages

The Anxiolytic-like Properties of a Tryptic Hydrolysate of Bovine αs1 Casein Containing α-Casozepine Rely on GABAA Receptor Benzodiazepine Binding Sites but Not the Vagus Nerve

  • Simon Benoit,
  • Catherine Chaumontet,
  • Nicolas Violle,
  • Audrey Boulier,
  • Zeeshan Hafeez,
  • Céline Cakir-Kiefer,
  • Daniel Tomé,
  • Jessica Schwarz and
  • Laurent Miclo

26 May 2022

(1) Background: A tryptic hydrolysate of bovine αs1-casein (CH) exerts anxiolytic-like properties in many species, including humans. This is mainly related to the presence of α-casozepine (α-CZP), which yields these properties in ro...

  • Article
  • Open Access
26 Citations
4,382 Views
11 Pages

15 October 2019

Commercial caseinate and two gelatins from bovine and fish skin were hydrolyzed by alcalase, and used at 2 g/kg in skimmed bovine milk that was then fermented with a commercial direct vat set starter, to clarify different effects of these hydrolysate...

  • Article
  • Open Access
9 Citations
3,137 Views
14 Pages

15 December 2022

The aim of the study was to apply the bioactive components casein hydrolysate and casein–iron chelate to yoghurt and to analyze their influence on product parameters. Casein was hydrolyzed with the non-commercial protease obtained from Yarrowia...

  • Article
  • Open Access
5 Citations
2,337 Views
10 Pages

Influence of Casein Hydrolysates and Yeast on the Rheological Properties of Wheat Dough

  • Ricardo Troncoso Recio,
  • Nelson Pérez Guerra,
  • Ana Torrado Agrasar and
  • Clara Asunción Tovar Rodríguez

26 October 2022

The influence of casein hydrolysates (CHs) and yeast on the viscoelasticity of wheat dough at 25 °C were analysed. Three wheat doughs were studied: the unyeasted dough (UYD), the unyeasted dough with CHs (UYD-C) and the yeasted dough (YD). The ch...

  • Article
  • Open Access
10 Citations
3,133 Views
15 Pages

29 November 2022

During the thermal processing of dairy products, the Maillard reaction occurs between milk proteins and lactose, resulting in the formation of various products including glycated proteins. In this study, lactose-glycated casein was generated through...

  • Article
  • Open Access
15 Citations
7,463 Views
11 Pages

18 July 2020

Unspecific gastrointestinal symptoms associated with milk consumption are common. In addition to lactose, also other components of milk may be involved. We studied whether the partial hydrolysation of milk proteins would affect gastrointestinal sympt...

  • Article
  • Open Access
10 Citations
5,301 Views
18 Pages

Principal Component Analysis from Mass Spectrometry Data Combined to a Sensory Evaluation as a Suitable Method for Assessing Bitterness of Enzymatic Hydrolysates Produced from Micellar Casein Proteins

  • Dahlia Daher,
  • Barbara Deracinois,
  • Alain Baniel,
  • Elodie Wattez,
  • Justine Dantin,
  • Renato Froidevaux,
  • Sylvie Chollet and
  • Christophe Flahaut

24 September 2020

Enzymatic hydrolysis of food proteins generally changes the techno-functional, nutritional, and organoleptic properties of hydrolyzed proteins. As a result, protein hydrolysates have an important interest in the food industries. However, they tend to...

  • Article
  • Open Access
102 Citations
10,589 Views
16 Pages

Casein-derived peptides are shown to possess radical scavenging and metal chelating properties. The objective of this study was to evaluate novel anti-inflammatory properties of casein hydrolysates (CH) produced by an eco-friendly process that combin...

  • Article
  • Open Access
50 Citations
5,968 Views
15 Pages

15 January 2020

This study evaluated the effects and the underlying mechanisms of casein glycomacropeptide hydrolysate (GHP) on high-fat diet-fed and streptozotocin-induced type 2 diabetes (T2D) in C57BL/6J mice. Results showed that 8-week GHP supplementation signif...

  • Article
  • Open Access
2 Citations
2,111 Views
15 Pages

Bioactive Peptides from Sodium Caseinate Hydrolysate with High Oral Absorption Regulate Blood Glucose in Type 2 Diabetic Mice via Inhibition of DPP-IV and Stimulation of GLP-1

  • Pei-Yu Wu,
  • Cheng-Hong Hsieh,
  • Ali Iqbal,
  • Yu-Shun Lin,
  • Ming-Wei Cheng,
  • Ling-Hsuan Chang,
  • Shang-Ming Huang and
  • Kuo-Chiang Hsu

30 May 2025

Type 2 diabetes mellitus remains a critical global health challenge, driving the pursuit of novel therapeutic strategies. This study investigated the anti-diabetic efficacy of the peptide 1CBR, derived from sodium caseinate hydrolysate, administered...

  • Article
  • Open Access
15 Citations
3,407 Views
16 Pages

12 January 2022

In this study, papain-generated casein hydrolysates (CH) with a degree of hydrolysis of 13.7% were subjected to a papain-mediated plastein reaction in the absence or presence of one of the exogenous amino acids—Gly, Pro, and Hyp—to prepar...

  • Article
  • Open Access
5 Citations
3,136 Views
14 Pages

Stable primary emulsion formation in which different parameters such as viscosity and droplet size come into prominence for their characterization is a key factor in W/O/W emulsions. In this study, different emulsifiers (Crill™ 1, Crill™...

  • Article
  • Open Access
32 Citations
9,889 Views
22 Pages

Nutritional Ingredients Modulate Adipokine Secretion and Inflammation in Human Primary Adipocytes

  • Tania Romacho,
  • Philipp Glosse,
  • Isabel Richter,
  • Manuela Elsen,
  • Marieke H. Schoemaker,
  • Eric A. Van Tol and
  • Jürgen Eckel

26 January 2015

Nutritional factors such as casein hydrolysates and long chain polyunsaturated fatty acids have been proposed to exert beneficial metabolic effects. We aimed to investigate how a casein hydrolysate (eCH) and long chain polyunsaturated fatty acids cou...

  • Article
  • Open Access
22 Citations
3,822 Views
12 Pages

13 April 2021

Viola canescens Wall. ex. Roxb. is an important but threatened medicinal herb found at 1500–2400 m above mean sea level in the Himalayas. Overexploitation and habitat preference have put the plant under serious threat. Thus, the present study was und...

  • Feature Paper
  • Article
  • Open Access
15 Citations
5,721 Views
11 Pages

6 March 2019

Potential beneficial effects of bioactive peptides derived from casein on epithelial cellular wound healing in the gastrointestinal tract were studied. Bovine casein was digested by a combination of pepsin and pancreatic proteases at different time i...

  • Article
  • Open Access
10 Citations
3,824 Views
18 Pages

Identification of Immune-Active Peptides in Casein Hydrolysates and Its Transport Mechanism on a Caco-2 Monolayer

  • Haiyan Xue,
  • Jingjing Han,
  • Jun Ma,
  • Hongxin Song,
  • Baoyuan He,
  • Xiaofeng Liu,
  • Meixia Yi and
  • Lei Zhang

13 January 2023

In this study, we investigated the transport mechanism of immune-active peptide fragments isolated from casein gastrointestinal hydrolysates via a Caco-2 monolayer. The casein gastrointestinal hydrolysates could stimulate B-lymphocyte proliferation a...

  • Article
  • Open Access
8 Citations
3,350 Views
14 Pages

6 February 2022

In this study, milk protein casein was glycated by oligochitosan through the catalysis of transglutaminase (TGase) and then hydrolyzed by trypsin. The obtained glycated casein hydrolysates (GCNH) were assessed for their anti-inflammatory activities,...

  • Article
  • Open Access
25 Citations
8,501 Views
15 Pages

15 January 2017

Oxidative stress is considered as an important mediator in the progression of metabolic disorders. The objective of this study was to investigate the potential hepatoprotective effects and mechanisms of bovine casein glycomacropeptide hydrolysates (G...

  • Article
  • Open Access
21 Citations
7,218 Views
11 Pages

14 September 2017

Casein and whey proteins with and without heat treatment were obtained of whole milk and four commercial milks in Ecuador, and were hydrolyzed. Then, their capacity to inhibit the lipid peroxidation using the TBARS method was evaluated at concentrati...

  • Article
  • Open Access
1 Citations
1,912 Views
17 Pages

In this work, a new type of FE-1 COF material is prepared by a reversible imine condensation reaction with diaminoferrocene and diaminodiformaldehyde as materials. The material is connected by imine bonds to form a COF skeleton, and the presence of p...

  • Article
  • Open Access
12 Citations
3,464 Views
15 Pages

Sensopeptidomic Kinetic Approach Combined with Decision Trees and Random Forests to Study the Bitterness during Enzymatic Hydrolysis Kinetics of Micellar Caseins

  • Dahlia Daher,
  • Barbara Deracinois,
  • Philippe Courcoux,
  • Alain Baniel,
  • Sylvie Chollet,
  • Rénato Froidevaux and
  • Christophe Flahaut

7 June 2021

Protein hydrolysates are, in general, mixtures of amino acids and small peptides able to supply the body with the constituent elements of proteins in a directly assimilable form. They are therefore characterised as products with high nutritional valu...

  • Article
  • Open Access
11 Citations
3,180 Views
11 Pages

Partial-, Double-Enzymatic Dephosphorylation and EndoGluC Hydrolysis as an Original Approach to Enhancing Identification of Casein Phosphopeptides (CPPs) by Mass Spectrometry

  • Barbara Deracinois,
  • Aurélie Matéos,
  • Audrey Romelard,
  • Audrey Boulier,
  • Julie Auger,
  • Alain Baniel,
  • Rozenn Ravallec and
  • Christophe Flahaut

9 September 2021

The identification of phosphopeptides is currently a challenge when they are part of a complex matrix of peptides, such as a milk protein enzymatic hydrolysate. This challenge increases with both the number of phosphorylation sites on the phosphopept...

  • Article
  • Open Access
6 Citations
2,811 Views
14 Pages

23 October 2022

Milk protein hydrolysates are common in infant formula, but some of them retain allergenicity due to incomplete hydrolysis of the epitopes for milk allergens. This study explored a method for screening proteases that could specifically hydrolyze the...

  • Article
  • Open Access
20 Citations
4,199 Views
11 Pages

Characterization of Proteolytic Activity of Artichoke (Cynara scolymus L.) Flower Extracts on Bovine Casein to Obtain Bioactive Peptides

  • Estefanía Bueno-Gavilá,
  • Adela Abellán,
  • María Soledad Bermejo,
  • Eva Salazar,
  • José María Cayuela,
  • David Prieto-Merino and
  • Luis Tejada

25 May 2020

The aim of this work is to establish the most suitable proteolysis conditions to obtain bovine casein hydrolysates containing peptides with antioxidant and antihypertensive capacity. To this end, the proteolytic activity of Cynara scolymus L. flower...

  • Article
  • Open Access
24 Citations
4,303 Views
13 Pages

25 December 2020

The focus on natural foods and “clean” labeled products is increasing and encourages development of new biobased ingredients. Fish solubles derived from downstream processing of side stream materials in the fish filleting industries have...

  • Article
  • Open Access
10 Citations
5,240 Views
16 Pages

8 November 2016

Chum salmon skin gelatin, de-isoflavoned soy protein, and casein were hydrolyzed at two degrees of hydrolysis. Genistein, the prepared hydrolysates, and genistein-hydrolysate combinations were assessed for their proliferative and anti-apoptotic effec...

  • Article
  • Open Access
2,723 Views
14 Pages

Fish Protein Hydrolysate as Protein Enrichment in Texture-Modified Salmon Products

  • Leena Prabhu,
  • Aase Vorre Skuland,
  • Paula Varela and
  • Jan Thomas Rosnes

8 January 2025

The aim of this study was to develop a chilled, texture-modified salmon product for dysphagia patients, enriched with dairy and fish hydrolysate proteins. The challenge was to create a product with appealing sensory qualities and texture that meets l...

  • Article
  • Open Access
15 Citations
2,606 Views
19 Pages

Carbohydrate Core–Shell Electrosprayed Microcapsules for Enhanced Oxidative Stability of Vitamin A Palmitate

  • Elnaz Z. Fallahasghari,
  • Marie Højgaard Lynge,
  • Emma Espholin Gudnason,
  • Kristin Munkerup,
  • Ana C. Mendes and
  • Ioannis S. Chronakis

Vitamin A is an essential micronutrient that is readily oxidized. In this study, the encapsulation of vitamin A palmitate (AP) within a core–shell carbohydrate matrix by co-axial electrospray and its oxidative stability was evaluated. The elect...

  • Article
  • Open Access
32 Citations
9,469 Views
16 Pages

Gastric Emptying and Gastrointestinal Transit Compared among Native and Hydrolyzed Whey and Casein Milk Proteins in an Aged Rat Model

  • Julie E. Dalziel,
  • Wayne Young,
  • Catherine M. McKenzie,
  • Neill W. Haggarty and
  • Nicole C. Roy

13 December 2017

Little is known about how milk proteins affect gastrointestinal (GI) transit, particularly for the elderly, in whom digestion has been observed to be slowed. We tested the hypothesis that GI transit is faster for whey than for casein and that this ef...

  • Feature Paper
  • Article
  • Open Access
1,681 Views
16 Pages

3 February 2025

This study optimizes the process conditions for preparing angiotensin-converting enzyme (ACE) inhibitory peptides from skimmed goat milk (SGM) hydrolyzed by multi-enzymes using response surface methodology. When the enzymatic hydrolysis time was 90 m...

  • Article
  • Open Access
26 Citations
12,257 Views
17 Pages

Human Enriched Serum Following Hydrolysed Collagen Absorption Modulates Bone Cell Activity: from Bedside to Bench and Vice Versa

  • Fabien Wauquier,
  • Audrey Daneault,
  • Henri Granel,
  • Janne Prawitt,
  • Véronique Fabien Soulé,
  • Juliette Berger,
  • Bruno Pereira,
  • Jérôme Guicheux,
  • Gael Y. Rochefort and
  • Nathalie Meunier
  • + 2 authors

31 May 2019

Collagen proteins are crucial components of the bone matrix. Since collagen-derived products are widely used in the food and supplement industry, one may raise the question whether collagen-enriched diets can provide benefits for the skeleton. In thi...

  • Article
  • Open Access
35 Citations
7,589 Views
16 Pages

11 February 2022

This study determined the physicochemical properties (apparent viscosity (ηapp), turbidity (A550nm), particle size and molecular mass distribution) of hydrolysates generated from whey protein concentrate (WPC), milk protein concentrate (MPC) and...

  • Article
  • Open Access
11 Citations
4,738 Views
16 Pages

Comparison of Targeted (HPLC) and Nontargeted (GC-MS and NMR) Approaches for the Detection of Undeclared Addition of Protein Hydrolysates in Turkey Breast Muscle

  • Liane Wagner,
  • Manuela Peukert,
  • Bertolt Kranz,
  • Natalie Gerhardt,
  • Sabine Andrée,
  • Ulrich Busch and
  • Dagmar Adeline Brüggemann

8 August 2020

The adulteration of fresh turkey meat by the undeclared addition of protein hydrolysates is of interest for fraudsters due to the increase of the economic gain by substituting meat with low cost ingredients. The aim of this study was to compare the s...

  • Article
  • Open Access
9 Citations
2,914 Views
13 Pages

The Hydrolytic Peptides of Soybean Protein Induce Cell Cycle Arrest and Apoptosis on Human Oral Cancer Cell Line HSC-3

  • Cheng-Hong Hsieh,
  • Tzu-Yuan Wang,
  • Bo-Chen Tung,
  • Hui-Ping Liu,
  • Lien-Te Yeh and
  • Kuo-Chiang Hsu

29 April 2022

Protein hydrolysates from various sources, including tuna cooking juice, soy protein isolate, sodium caseinate, wheat gluten and skin gelatin from porcine, tilapia, halibut and milkfish were analyzed to screen their antiproliferative activities again...

  • Article
  • Open Access
20 Citations
4,855 Views
26 Pages

Biofunctionality of Enzymatically Derived Peptides from Codfish (Gadus morhua) Frame: Bulk In Vitro Properties, Quantitative Proteomics, and Bioinformatic Prediction

  • Ali Jafarpour,
  • Simon Gregersen,
  • Rocio Marciel Gomes,
  • Paolo Marcatili,
  • Tobias Hegelund Olsen,
  • Charlotte Jacobsen,
  • Michael Toft Overgaard and
  • Ann-Dorit Moltke Sørensen

27 November 2020

Protein hydrolysates show great promise as bioactive food and feed ingredients and for valorization of side-streams from e.g., the fish processing industry. We present a novel approach for hydrolysate characterization that utilizes proteomics data fo...

  • Article
  • Open Access
21 Citations
4,651 Views
18 Pages

Covalent Immobilization of Proteases on Polylactic Acid for Proteins Hydrolysis and Waste Biomass Protein Content Valorization

  • Eleonora Calzoni,
  • Alessio Cesaretti,
  • Silvia Tacchi,
  • Silvia Caponi,
  • Roberto Maria Pellegrino,
  • Francesca Luzi,
  • Francesco Cottone,
  • Daniele Fioretto,
  • Carla Emiliani and
  • Alessandro Di Michele

26 January 2021

The recovery of the protein component and its transformation into protein hydrolysates, generally carried out chemically, gives great added value to waste biomasses. The production of protein hydrolysates through enzymatic catalysis would guarantee t...

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