Search Results (15,116)

Red microalga Porphyridium cruentum produces a sulfated exopolysaccharide (EPS), which enables its survival in challenging intertidal and spray zones. Extracellular polysaccharide hyaluronic acid (HA) plays important roles in skin hydration, elasticity, and volume. However, with aging, HA decreases and loses effectiveness, reducing skin moisture retention and firmness, and increasing signs of aging. An effective topical alternative to injectable HA replacement remains a largely unmet need. An extract of Porphyridium cultivated in natural sunlight, rich in EPS and polydeoxyribonucleotides (PDRNs), significantly activated the ADORA2A receptor in a CHO model, as well as reduced inflammation and increased collagen and HA production, autophagic flux, and key autophagy gene expression in dermal fibroblast cultures. In a double-blind clinical trial with placebo and HA benchmark controls, the Porphyridium extract delivered significant HA-like skin plumpness, hydration, and radiance benefits, and reduced signs of aging. The extract generally equaled or exceeded the HA benchmark. Its meaningful, swift HA-like activity shows potential for a safe, natural, and arguably more powerful HA-like alternative. Full article

We derive a few extended versions of the Kraft inequality for information lossless finite-state encoders. The main basic contribution is in defining a notion of a Kraft matrix and in establishing the fact that a necessary condition for information losslessness of a finite-state encoder is that none of the eigenvalues of this matrix have modulus larger than unity, or equivalently, the spectral radius of the Kraft matrix cannot exceed one. We then derive several equivalent forms of this condition, which are based on well-known formulas for spectral radius. Even stronger results are presented for the important special case where the finite-state encoder is assumed irreducible. Finally, two extensions are outlined—one concerns the case of side information available to both encoder and decoder, and the other is for lossy compression. Full article

University admission exams can be understood as information systems in which subject areas act as components intended to convey predictive signals about students’ future academic performance. However, the informational effectiveness of these subject areas is rarely evaluated using data-driven approaches. This study proposes a data-driven framework for assessing the informational effectiveness of admission exam subject areas by analyzing their empirical relationships with subsequent academic performance. Institutional data of 2197 students across 33 undergraduate programs from two cohorts after four semesters of study are used. Each academic program is represented as a vector of correlations linking performance in admission subject areas to long-term academic outcomes. The importance of each subject area in the admission exam is contrasted with empirically observed correlations to identify mismatches in informational effectiveness. Additionally, similarity analysis is applied to uncover affinities among academic programs. The results reveal substantial heterogeneity in the informational effectiveness of admission exam subject areas, indicating that predefined subject-area weightings do not consistently reflect their empirical contribution. Similarity patterns further identify groups of programs, suggesting opportunities for program-specific optimization of admission exam design. The proposed framework provides a replicable approach for evaluating and refining admission exams as information systems, contributing to data-driven decision-making in educational assessment design. Full article

Fenton-like reactions are broadly employed in advanced oxidation processes (AOPs) for the degradation of organic pollutants through catalytic peroxide activation. In this study, NiO was precipitated on a wrinkled SiO₂ to improve catalytic performance. The kinetics and reaction mechanism between the catalyst and S₂O₈²⁻ were studied via following the degradation of methylene blue as a model organic pollutant. The findings indicate that the excellent catalytic activity of Ni/SiO₂ and highly active sulfate radicals enhanced the degradation of methylene blue for environmental remediation. Moreover, the cost-effectiveness, and eco-friendly characteristics of the prepared Ni@SiO₂-persulfate system represents a substantial advancement in the field of catalytic oxidation, contributing valuable knowledge to the development of next-generation catalytic systems. Full article

This article examines interpretations of the walkability-oriented linear new town model over a span of fifty years. It addresses the values embedded in the model and the ways they are expressed over time. The model’s implementation is analyzed in two new towns, established five decades apart, without reliance on high-end technologies or mega-structures. The results reveal that different interpretations of the model emerge as a result of the zeitgeist and its encounter with real-life conditions. The discussion shows that an “either–or” approach to planning, which characterized the earlier town, gave way to a more mature “both–and” perspective in the later one. The conclusions highlight the problematics of applying this specific model in the construction of new towns due to the many years required for a new town to reach its population target. During these years, extending the central business district (CBD) dilutes human encounters and undermines the urban experience. Moreover, given that construction densities in new towns are typically moderate, a long and narrow form—characteristic of the walkability-oriented linear new town—may fail to generate a population large enough to sustain a CBD running along its entire length. Full article

This qualitative study explores the construction of financial literacy in the context of retirement among young women in Israel, in light of available cultural schemas. The research challenges economic models that rely solely on assumptions of rationality and self-interest, offering a qualitative expansion of the behavioral foundations of financial literacy. Drawing on in-depth interviews of 46 young women, the findings reveal that their perceptions and choices in the financial domain are profoundly shaped by gendered “schemas of devotion”: devotion to work and devotion to family. These schemas give rise to two orientations: women who are more engaged in the financial sphere, characterized by initiative and reflexivity (resistance to the gendered schemas), and women who are more detached, displaying passivity and emotional distance (adoption of these schemas). The study demonstrates how these cultural models contribute to either the reproduction or transformation of gender inequality in retirement. Its main contribution lies in broadening the discipline of economics and positioning gender as a central analytical category—one that is vital for developing more sensitive policies capable of improving the functioning of the economic system and reducing gender gaps. Full article

Background/Objectives: Lung cancer is one of the major causes of mortality worldwide despite breakthroughs in screening, diagnosis, and treatment. These advances have not been evenly spread, and discrepancies between populations remain concerning. This article examines lung cancer discrepancies in epidemiology, risk factors, screening, diagnosis, treatment access and quality, and survival outcomes, and identifies the main causes. Methods: An extensive narrative evaluation of peer-reviewed literature, national cancer surveillance reports, and large population-based research was searched. The evidence on lung cancer disparities by race, ethnicity, socioeconomic status, sex, geography, and healthcare access was synthesized. Disparities in prevention, early identification, treatment, and outcomes were organized into this paper. Results: Lung cancer incidence, stage, treatment, and survival showed persistent differences. Racial and ethnic minority groups, people on low-incomes, uninsured people, and rural or resource-limited people had higher disease burden and worse outcomes. Access to low-dose computed tomography screening, rapid diagnostic follow-up, surgical resection, molecular testing, targeted medicines, immunotherapy, palliative care, and clinical trials was unequal. When guidelines are followed, survival outcomes are similar across races and ethnicities. Conclusions: Lung cancer disparities are mostly caused by structural, social, and healthcare system factors, not biology. Coordinated measures to provide equitable screening, prompt and high-quality treatment, research inclusion, and culturally sensitive and policy-driven actions are needed to enhance lung cancer outcomes. Full article

The mean-variance rule (M-V) conforms with the expected utility paradigm only in limited and economically unacceptable scenarios. Thus, the most widely employed portfolio-selection rule seemingly loses ground. We show with the commonly employed utility functions in economics, with a preference for a positive skewness, that choosing from the M-V efficient frontier conforms with expected utility maximization even with long investment horizon and skewed distributions of returns. The economic loss induced by choosing from the M-V frontier is negligible. Thus, the M-V rule is universal, or almost universal, provided that the commonly employed utility functions in economics are employed. This is an astonishing result that even Markowitz has not dreamed of. Full article

Background/Objectives: Revascularization of the left anterior descending (LAD) artery can be achieved by either percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). Minimally invasive direct CABG (MIDCAB) enables LAD revascularization via a small thoracotomy without sternotomy or cardiopulmonary bypass. To compare long-term survival following LAD revascularization by MIDCAB or following PCI using drug-eluting stents (DES), of the historic cohort we reported in 2006. Methods: Data were assessed of 272 patients who underwent LAD PCI with DES, and 104 patients who underwent MIDCAB using the left internal thoracic artery (LITA) to LAD, in two major centers, between May 2002 and December 2003. Matching for age, sex, and extent of coronary disease yielded two balanced groups of 83 patients each. Results: Baseline characteristics were similar with a mean age ± standardized difference (SD) of 64.70 ± 12.52 of the MIDCAB group vs. 63.59 ± 12.06 of the Cypher group and an identical male to female ratio of 66 to 83 (79.5%), except for a higher prevalence of EF < 35% in the MIDCAB group and prior PCI in the DES group. Thirty-day mortality was 1.1% after MIDCAB and 0% after DES-PCI (p = 0.11). At 2 years, the proportion of recurrent angina was lower after MIDCAB (8.4% vs. 35%; p < 0.001), as was the proportion of re-interventions (3.6% vs. 16.8%; p = 0.005). Over a mean follow-up of 16 years, 10-year survival was 77.1 ± 4.6% for the MIDCAB and 81.0 ± 4.3% for the DES group (p = 0.48). The rates of 20-year survival were 60.2 ± 5.4% and 56.1 ± 5.5%, respectively (p = 0.73). In multivariable analysis, advanced age and prior myocardial infarction independently predicted mortality while treatment with MIDCAB showed a trend toward improved survival (p = 0.053). Conclusions: Long-term survival rates after LAD revascularization with MIDCAB and after DES-PCI were comparable. MIDCAB demonstrated a non-significant trend toward lower mortality. Limitations include the retrospective design and lack of detailed late event adjudication. Full article

Protein C (PC) and its activated form, activated protein C (APC), are well-established regulators of coagulation and cytoprotection. While their systemic functions are extensively characterized, their physiological roles in the retina have only recently begun to be explored. This gap persists despite the observation that congenital PC deficiency is consistently associated with severe ocular complications. Emerging evidence, including the development of a murine model of severe protein C deficiency (SPCD), indicates that APC contributes to retinal integrity and vascular homeostasis under physiological conditions. Beyond its physiological function, APC has shown therapeutic activity in several models of retinal disease. Recent findings from our group further demonstrated that intravenously administered APC and its cytoprotective analog, 3K3A-APC, can cross the blood–retina barrier via the endothelial protein C receptor (EPCR), despite their relatively large molecular weight (~62 kDa), and induce cytoprotective activities in the retina. These findings highlight the translational potential of 3K3A-APC and support its further development as a systemically delivered therapeutic approach for retinal pathologies. This review integrates current knowledge of the molecular biology of the PC/APC pathways with its emerging physiological functions in the retina, and the accumulating preclinical and early clinical evidence that supports its therapeutic relevance. Full article

Background/Objectives: Cesarean deliveries (CD) have been associated with an increased risk for offspring long-term respiratory morbidity. We sought to evaluate whether children born via CD in different stages of labor, and partially exposed to vaginal flora, would differ in their long-term respiratory morbidity. Methods: A population-based study comparing long-term respiratory morbidity of children according to their mode of delivery and CD indication was conducted. Children born via CD for first stage non-progressive labor (CD-NPL1) and children born via CD for non-progressive labor in the second stage (CD-NPL2) were compared with children born vaginally (VD) as a reference group. Offspring hospitalizations up to 18 years involving respiratory morbidities were evaluated. Results: 313,782 deliveries were included; 97.7% were VD, 1.6% were CD for NPL1 and 0.7% were CD for NPL2. The overall respiratory-related hospitalization rates as well as the cumulative incidence of respiratory hospitalizations were significantly higher in children born via CD, with a graded association, related to fetal exposure to vaginal flora, noted between VD, CD-NPL2 and CD-NPL1 with the highest incidence. In a Cox model, controlling for multiple confounding variables, NPL1 (vs. VD) was associated with an increased risk for offspring long-term respiratory morbidity (aHR 1.15), while NPL2 did not differ in risk. Conclusions: The risk for respiratory morbidity is increased for NPL1 offspring (with lower exposure to vaginal flora) as compared with NPL2 and VD offspring, with a graded association noted between exposure to vaginal flora during labor and the risk for offspring long-term respiratory morbidity. Full article

Background/Objectives: Research on children’s eating has primarily focused on parental feeding practices and dietary outcomes, with less attention to how young children themselves understand parental food-related messages and relate them to their own food choices. Recognizing children as active participants in food socialization, this study aimed to examine preschool children’s representations of parental feeding strategies alongside their expressed food-choice considerations. Methods: A qualitative, exploratory, multi-method design was employed within a constructivist framework. Forty kindergarten children aged 4 years 10 months to 5 years 8 months participated in individual, play-based sessions conducted in familiar educational settings. Data were generated using two complementary tools: a doll role-play task eliciting children’s representations of parental feeding strategies and a simulated grocery shopping task eliciting food-choice considerations. All sessions were audio-recorded, transcribed verbatim, and analyzed using reflexive thematic analysis. Results: During role-play, children frequently portrayed parents as emphasizing health-related arguments, control, and negotiation when guiding food intake. Less frequently, they represented strategies such as encouragement to try, deception, or references to body weight. In contrast, during the food-choice task, children’s selections were primarily guided by personal preference, with health considerations mentioned less often. For most participants, the feeding strategies attributed to parents did not closely align with the considerations guiding their own food choices. Conclusions: The findings highlight young children’s active and selective engagement with parental feeding discourse and underscore the contextual nature of food-related meaning-making in early childhood. Rather than reflecting a straightforward transmission of parental messages, children’s food choices appear shaped by situational affordances and perceived autonomy, supporting child-centered approaches to nutrition education and health promotion. Full article

Background/Objectives: Follitropin delta is an approved recombinant follicle-stimulating hormone (rFSH) expressed in a human cell line. Correct disulfide connectivity is a critical quality attribute for rFSH, a heterodimeric glycoprotein composed of noncovalently associated α and β subunits and stabilized by an extensive network of intramolecular disulfide bonds. Disulfide characterization is typically performed by mass spectrometry (MS). However, the closely spaced disulfide bonds within the FSH α-subunit are particularly resistant to proteolytic cleavage, complicating conventional MS-based disulfide mapping. Methods: To overcome limitations of MS-based methods, an X-ray crystallography strategy was employed using a ternary complex of the recombinant FSH heterodimer with an anti-FSHα Fab and a stabilizing anti-kappa VHH. Crystals of the desialylated rFSH/Fab/VHH complex were obtained and diffraction data were collected. Results: The structure of recombinant FSH was determined at 2.29 Å resolution. Electron density surrounding cysteine residues in both the α and β subunits was well defined, allowing unambiguous assignment of all intramolecular disulfide bonds in the crystallized protein. The observed cysteine connectivity is fully consistent with the disulfide architecture of FSH from other sources and supports correct folding of the recombinant Follitropin delta. Full article

Objective: Although recognition of fibromyalgia (FMS) in men is growing, the mechanisms that contribute to their psychological distress remain poorly understood. This study aims to clarify how FMS alters men’s psychological distress and to identify potential protective and risk factors involved in this process in this often-underrepresented population. Methods: This study comprised a total of 225 men aged 18–75; of these, 102 were men with FMS (based on self-report) and 123 were healthy peers (HPs), all of whom completed questionnaires on demographics, anxiety (GAD-7), depression (PHQ-9), body appreciation (BAS-2), masculine self-esteem (MSES), illness-related shame (CISS), and pain intensity (SF-MPQ). Results: Men with FMS reported significantly higher depression and anxiety, lower body appreciation, and compromised masculine identity. Between-group analysis showed body appreciation mediated the fibromyalgia–distress relationship. However, within the FMS group, compromised masculine identity and illness-related shame were the strongest pathways to distress, while body appreciation showed no effect. Moderation analysis confirmed body appreciation buffered distress in controls but not in men with FMS. Conclusion: Masculine identity threats and illness-related shame constitute central mechanisms of psychological distress in men with FMS. Body appreciation operates differently in this population than in healthy men. Findings underscore the need for gender-sensitive interventions addressing identity disruption and emphasizing functionality over appearance-based acceptance. Full article

Sequestration of atmospheric CO₂ in the Yatir Mediterranean semi-arid Aleppo Pine Forest (Pinus halepensis) close to the border of the semi-arid timberline was characterized and quantified under field conditions. Measurements of organic and inorganic CO₂ sequestration with gas exchange, stock counting approach, and remote sensing were made in both rainfed control (~12% average annual Soil Moisture) and long-term experiment of irrigation (~10 years with ~24% annual average SM) plots, providing the opportunity to separate the effects of atmospheric water demand from soil water stress on the atmospheric CO₂ sequestration responses. Measurements yield an organic carbon sequestration (OCS) rate of ~550 g CO₂ m⁻² yr⁻¹, 60% in soil and 40% in biomass (standing and removed). In addition, measurements yield an inorganic carbon sequestration (ICS) rate of ~65 g CO₂ m⁻² yr⁻¹ (for half meter soil depth) via calcite (CaCO₃) precipitation in the soil due to root exhalation of CO₂ (25%) and microbial activity (75%). The drip-irrigated plot showed approximately 3 times higher organic CO₂ sequestration than the control plot, divided equally between the soil and the biomass. For the irrigated plot, the inorganic CO₂ sequestration rate was ~1.8 times higher than that of the control plot. These measured values demonstrate the relatively high potential for carbon sequestration in Mediterranean drylands forests under irrigated and non-irrigated conditions. Full article